Odontogenesis

Today no universal theory explains biomineralization. Teeth, including dentin, enamel, cementum and bone of attachment constitute the most powerful model for analyzing these processes in normal and pathological (inherited or noninherited) conditions. Structural and compositional (analytical) comparisons in vivo as well as indiction of mineralization in reduced in vitro systems have to be further investigated. For obvious reasons the molecular mechanisms of fluoride action have to be investigated. It is also of importance to evaluate the risk of anticancer therapy on children`s dentition. specialists in complementary domains (proteoglycans, glycosaminoglycans, non collagenous proteins, collagens, enamel proteins, Ca-channels, specific enzymes ...) will interact.

Drittmittelgeber:

Europäische Union, Deutsche Forschungsgemeinschaft

Beteiligte Wissenschaftler:

Dr. Siegfried Arnold (Physikalisches Institut), Prof. Dr. Hans-Jürgen Höhling (Institut für Medizinische Physik und Biophysik), Prof. Dr. Dr. Dr. Ulrich Joos, Prof. Dr. Helmut Kohl (Physikalisches Institut), Dr. Ulrich Plate (Institut für Medizinische Physik und Biophysik), PD Dr. Udo Stratmann (Institut für Anatomie), Dr. Hans-Peter Wiesmann

Veröffentlichungen:

Arnold, S., U. Plate, H.P. Wiesmann, H. Kohl, H.J. Höhling: Quantitative electron-spectroscopic diffraction (ESD) and electron-spectroscopic imaging (ESI) analyses of dentine mineralisation in rat incisors. Cell Tissue Res. 288, 1997, S.185-90

Höhling, H.J., S. Arnold, U. Plate, U. Stratmann, H.P. Wiesmann: Analysis of a general principle of crystal nucleation, formation in the different hard tissues. Adv Dent Res. 11, 1997, S.462-6.

Plate, U., S. Arnold, U. Stratmann, H.P. Wiesmann, H.J. Höhling: General prinziple of ordered apatitic crystal formation in enamel and collagen rich hard tissues. Connect Tissue Res. 38, 1998, S.149-157

Stratmann, U., K. Schaarschmidt, H.P. Wiesmann, U. Plate, H.J. Höhling, T. Szuwart: The mineralization of mantle dentine and of circumpulpal dentine in the rat: an ultrastructural and element-analytical study. Anat Embryol Berl. 195, 1997, 289-297.

Wiesmann, H.P., T. Tkotz, U. Joos, K. Zierold, U. Stratmann, T. Szuwart, U. Plate, H.J. Höhling: Magnesium in newly formed dentin mineral of rat incisor. J Bone Miner Res. 12, 1997, S.380-383.

Wiesmann, H.P., U. Plate, K. Zierold, H.J. Höhling: Potassium is involved in apatite biomineralization. J Dent Res. 77, 1998, S.1654-1657