Scientific career and Publications - Prof. Dr. Bettina Tudzynski

Prof. Dr. Bettina Tudzynski
Prof. Dr. Bettina Tudzynski
Institut für Biologie und Biotechnologie der Pflanzen
Molecular Biology and Biotechnology of Fungi
Raum 130.301a
Schlossplatz 8
48143 Münster
Tel: +49 251 83-24801
Fax: +49 251 83-21601

Scientific Curriculum Vitae:

  • Study of biology at the Moscow State University 1970-1975
  • PhD at the Friedrich-Schiller-University in Jena 1980
  • Habilitation for Mikrobiology at the Friedrich-Schiller-Universität in Jena 1991
  • Re-habilitation at the University of Münster 1994
  • Group-leader in the Institute of Botany, University of Münster
  • Apl. Prof. 2006

Research Interests:

  • physiology, genetics and molecular genetics of fungi, strain optimization, secondary metabolism, regulation of gene expression, molecular mechanisms of pathogenicity on plants, signal transduction and pathogenicity

Running projects:

Membership in scientific organisations:

  • Society for General and Applied Microbiology (VAAM)
  • American Society for Microbiology (ASM)

Membership in Editorial boards:

  • Applied Biotechnology and Biochemistry

Student advisory service for Bachelor-students (Biology)

Recent publications:

Troncoso, C.,  González, X., Bömke, C., Tudzynski, B., Hedden, P., Gong, F., and Rojas, M.C. (2010). Gibberellin biosynthesis and gibberellin oxidase activities in Fusarium
, Fusarium konzum and Fusarium subglutinans strains. Phytochem. 71: 1322-1331.

Wagner, D., Schmeinck, A., Mos,M., Morozov, I.Y., Caddick, M.X., Tudzynski, B. (2010). The bZIP transcription factor MeaB mediates nitrogen metabolite repression at specific loci. Euk. Cell 9: 1588-1601.

Dalmais, B., Schumacher, J., Moraga, J., Le Pecheur, P., Tudzynski, B., Collado, I.G., and Viaud, M. 2011. The Botrytis cinerea botcinic acid reqires two polyketide synthases for production and has a redundant role in virulence with botrydial. Mol. Plant Pathol. 12: 564-579.

Brock, N.L., Tudzynski, B. and Dickschat, J.S. (2011) Biosynthesis of Sesqui- and Diterpenes by the Gibberellin Producer Fusarium fujikuroi. ChemBioChem 12: 2667-2676.

Dickschat, J.S., Brock, N.L., Citron, C.A. and Tudzynski, B. (2011) Biosynthesis of  sesquiterpenes by the Fungus Fusarium verticillioides. ChemBioChem 12: 2088-2095.

Amselem J, Cuomo CA, van Kan JA, Viaud M, Benito EP, Couloux A, Coutinho PM, de Vries RP, Dyer PS, Fillinger S, Fournier E, Gout L, Hahn M, Kohn L, Lapalu N, Plummer KM, Pradier JM, Quévillon E, Sharon A, Simon A, ten Have A, Tudzynski B, Tudzynski P, Rollins JA, Lebrun MH, Dickman M. (2011) Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea. PLoS Genet. 2011 7(8): e1002230.

Tsavkelova, E., Oeser, B., Oren-Young, L., Israeli, M., Sasson, Y., Tudzynski, B., Sharon, A. (2011) Identification and functional characterization of indole-3-acetamide-mediated IAA biosynthesis in plant-associated Fusarium species. Fungal Genet Biol. 49: 48-57.

Xu, M., Galhano, R., Wiemann, P., Bueno, E., Tiernan, M.,Wu, W., Chung, I.-M., Gershenzon, J., Tudzynski, B., Sesma, A., Peters, R.J. (2012) Genetic evidence for natural product mediated plant-plant allelopathy 1 in rice. New Phytologist 193(3):570-575.

Studt, L. Wiemann, P., Kleigrewe, K., Humpf, H.-U., Tudzynski, B. (2012) Biosynthesis of fusarubins accounts for pigmentation of Fusarium fujikuroi perithecia. Appl Environ Microbiol. 78: 4468-4480.

Wiemann, P., Albermann, S., Niehaus, E. M.; Studt, L., von Bargen, K., Brock, N.L., Humpf, H.-U., Dickschat, J.S., Tudzynski, B. (2012) The Sfp-type 4'-phosphopantetheinyl transferase Ppt1 of Fusarium fujikuroi controls development, secondary metabolism and pathogenicity. PLoS ONE 7(5):e37519.

Studt, L., Troncoso, C., Gong, F., Hedden, P., Toomajian, C., Leslie, J.F., Humpf, H.-U.,  Rojas, M.C., and Tudzynski, B. (2012) Segregation of Secondary Metabolite Biosynthesis in Hybrids of Fusarium fujikuroi and Fusarium proliferatum. Fungal Genetics and Biology 49: 567-577.

Butchko, R.A., Brown, D.W., Busman, M., Tudzynski, B., Wiemann P. (2012) Lae1 regulates expression of multiple secondary metabolite gene clusters in Fusarium verticillioides. Fungal Genet Biol. 49(8):602-612.

Harren, K., Schumacher, J. and Tudzynski, B. (2012) The Ca2+/calcineurin-dependent signaling pathway in the gray mold Botrytis cinerea: the role of calcipressin in modulating calcineurin activity. PLoS ONE 7(7):e41761.

Bhattacharya, A., Kourmpetli, S., Ward, D.A., Thomas, S.G., Gong, F., Powers, S.J., Carrera, E., Taylor, B., Nuñez de Caceres Gonzalez, F., Tudzynski, B., Phillips, A.L., Davey, M.R., and  Hedden, P. (2012) Characterisation of the fungal gibberellin desaturase as a 2-oxoglutarate-dependent dioxygenase and its utilisation for enhancing plant growth. Plant Physiol. 160(2):837-845.

Albermann, S.; Linnemannstöns, P., and Tudzynski, B. 2012. Strategies for strain improvement in Fusarium fujikuroi: overexpression and localization of key enzymes of the isoprenoid pathway and their impact on gibberellin biosynthesis. Appl. Microbiol. Biotechnol. 97(7):2979-2995.

Schumacher J, Pradier JM, Simon A, Traeger S, Moraga J, Collado IG, Viaud M, Tudzynski B. (2012) Natural Variation in the VELVET Gene bcvel1 affects virulence and light-dependent differentiation in Botrytis cinerea. PLoS One 7(10):e47840.

Kleigrewe K, Niehaus EM, Wiemann P, Tudzynski B, Humpf HU. (2012). New Approach via gene knockout and single-step chemical reaction for the synthesis of isotopically labeled Fusarin C as an internal standard for the analysis of this Fusarium mycotoxin in food and feed samples. J Agric Food Chem. 60 (34), 8350–8355

Brock, N.L., Huß, K., Tudzynski, B. and Dickschat, J.S. (2013) Genetic Dissection of sesquiterpene Biosynthesis by Fusarium fujikuroi. ChemBioChem 14(3):311-315.

Albermann, S., Elter, T., Teubner, A., Krischke, W., Hirth, T., and Tudzynski, B. (2013).  Characterization of novel mutants with an altered gibberellin spectrum in comparison to different wild-type strains of Fusarium fujikuroi. Appl. Microbiol. Biotechnol. 97(17):7779-7790.

Harren, K. and Tudzynski, B. (2013) Cch1 and Mid1 are functionally required for vegetative growth under low-calcium conditions in the phytopathogenic ascomycete Botrytis cinerea. Eukaryot Cell. 12: 712-724.

Studt L, Humpf HU, Tudzynski B. (2013). Signaling governed by G proteins and cAMP is crucial for growth, secondary metabolism and sexual development in Fusarium fujikuroi. PLoS One 8(2):e58185.

Wiemann, P., Sieber, CMK., von Bargen, KW., Studt, L., Niehaus, E.M., Espino, JJ, Huß, K., Michielse, CB, Albermann, S., Wagner, D., Bergner, SV,  Connolly, LR., Fischer, A., Reuter, G., Kleigrewe, K., Bald, T., Wingfield, BD., Ophir, R., Freeman, S., Hippler, M., Smith, KM.,  Brown, DW.,Proctor, RH., Münsterkötter, M., Freitag, M., Humpf, H.-U., Güldener, U., and Tudzynski, B.  2013. Deciphering the Cryptic Genome: Genome-wide Analyses of the Rice Pathogen Fusarium fujikuroi Reveal Complex Regulation of Secondary Metabolism and Novel Metabolites. PLoS Pathog 9(6): e1003475.

Niehaus, EM, Kleigrewe, K, Wiemann, P, Studt, L, Sieber, C, Freitag, M, Güldener, U, Tudzynski, B, Humpf, H.-U. (2013). Genetic manipulation of the Fusarium fujikuroi fusarin gene cluster yields insight into the regulation and fusarin biosynthetic pathway. Chem. Biol. 20(8):1055-1066

Harren, K., Brandhoff, B, Knödler, M and Tudzynski, B. (2013) The high-affinity phosphodiesterase BcPde2 has impact on growth, differentiation and virulence of the phytopathogenic ascomycete Botrytis cinerea. PLoS One 8: e78525.

Studt L, Schmidt FJ, Jahn L, Sieber CM, Connolly LR, Niehaus EM, Freitag M, Humpf HU, Tudzynski B. (2013) Two histone deacetylases, FfHda1 and FfHda2, are important for secondary metabolism and virulence in Fusarium fujikuroi. Appl Environ Microbiol. 79: 7719-7734.

von Bargen, K., Niehaus, E-M., Bergander, K. Tudzynski, B. and Humpf, H-U. (2013) Structure elucidation of apicidin F: A new apicidin-like compound produced by Fusarium fujikuroi. J. Natural Products 76: 2136-2140.

Wagner, D., Wiemann, P., Huß, K., Brandt, U., Fleißner, A. and Tudzynski, B. (2013).  A sensing role of the glutamine synthetase in the nitrogen regulation network in Fusarium fujikuroi. PLoS ONE 8(11): e80740.

Niehaus, E.M., von Bargen, K., Espino, J.J., Pfannmüller, A., Humpf, H.-U., Tudzynski, B. (2014)  Characterization of the fusaric acid gene cluster in Fusarium fujikuroi. Appl. Microbiol. Biotechnol. 98: 1749–1762

Michielse, C.B., Pfannmüller, A., Macios, M., Rengers, P., Dzikowska, A., Tudzynski, B. (2014) The interplay between the GATA transcription factors AreA, the global nitrogen regulator and AreB in Fusarium fujikuroi. Mol Microbiol. 91(3), 472–493.

Niehaus EM, Janevska S, von Bargen KW, Sieber CM, Harrer H, Humpf HU, Tudzynski B. (2014) Apicidin F: Characterization and Genetic Manipulation of a New Secondary Metabolite Gene Cluster in the Rice Pathogen Fusarium fujikuroi. PLoS One , 24; 9(7):e103336. doi: 10.1371/journal.pone.0103336. eCollection 2014.

Citron, CA, Brock, NL, Tudzynski, B, Dickschat JS (2014). Labelling studies on the biosynthesis of terpenes in Fusarium fujikuroi. Chem. Comm. Chem Commun (Camb). 50(40): 5224-5226. doi: 10.1039/c3cc45982a. Epub 2013 Sep 19.

Michielse, CB, Studt, L, Janevska S, Sieber CM, Arndt B, Espino JJ, Humpf HU, Güldener U, Tudzynski B. (2014) The global regulator FfSge1 is required for expression of secondary metabolite gene clusters but not for pathogenicity in Fusarium fujikuroi. Environ Microbiol. DOI: 10.1111/1462-2920.12592 (ahead of print)

Hansen, FT, Gardiner, DM, Lysøe, E, Fuertes, PR, Tudzynski, B, Wiemann, P, Sondergaard, TE, Giese, H, Brodersen, DE, Sørensen, JL. (2014) An update to polyketide synthase and non-ribosomal synthetase genes and nomenclature in Fusarium. Fungal Genet Biol. S1087-1845(14)00219-9. doi: 10.1016/j.fgb.2014.12.004. [Epub ahead of print]

Tudzynski, B. (2014) Nitrogen regulation of secondary metabolism in fungi. Front Microbiol. doi: 10.3389/fmicb.2014.00656. eCollection 2014. Review.

Studt, L. and Tudzynski, B. (2014) Gibberellins and the red oigments bikaverin and fusarubin. In: Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites. Series “Fungal Biology”; Martín, J.-F. García-Estrada, C., Zeilinger, S.(Eds.); Springer  New York 2014.

Niehaus EM, Díaz-Sánchez, V., von Bargen, K., Kleigrewe,K., Humpf, H-U.,  Limón, MC, and Tudzynski, B. (2014) Fusarins and Fusaric Acid in Fusaria. In: Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites. Series “Fungal Biology”; Martín, J.-F., García-Estrada, C., Zeilinger, S.(Eds.); Springer  New York 2014.

Tudzynski, B., Studt, L. and Rojas, M.C. (2015) Gibberellins in fungi, bacteria and lower plants - biosynthesis, function and evolution. In: The Gibberellins, Annual Plant Reviews, Volume 49, eds Hedden P and Thomas S.G., Wiley-Blackwell, in press.