RNAi project
„RNAi suppression of complex-type N-glycosylation in transgenic plants for modulation of allergenic potential of homologous and heterologous glycoproteins“
Further reading:
Waterhouse PM, Wang MB, Lough T (2001)
Gene silencing as an adaptive defence against viruses
http://www.sfb363.uni-halle.de/mod-path/silencing/waterhouse01b.pdf
In this project we try to reduce the allergenic potential of plant-derived foodstuff (exemplarily for the Solanaceae). This involves the suppression/elimination of cross-reacting carbohydrates (CCD) by compromozing the formation of complex-type N-glycans. Patient sera that recognize or bind to CCD epitopes of plant glycoproteins (or insects, with partially overlapping core fucose specificty) serve as diagnostic tools.
3rd party Funding:
Deutsche Forschungsgemeinschaft (DFG)
Involved scientists:
Prof. Dr. Antje von Schaewen, Dr. Heidi Kaulfürst-Soboll
Cooperations:
Prof. Dr. Randolf Brehler, Doktorand: Dipl. Biol. Benedikt Stöcker (UKM, Hautklinik, Allergologie)
PROvendis:
HypoPlant
