SFB 1348 Seminar | Damian Brunner

The Cell Biology of Midgut Closure

Host: Roland Wedlich-Söldner

Midgut closure in Drosophila melanogaster is a tissue closure event in mid-embryogenesis of which little is known. I will present data highlighting the crucial role of the yolk cell in this morphogenesis process. This cell, so far believed to be a passive nutrient source, generates pulsed contractile, forces required for midgut closure. For this it forms distinct domains within its plasma membrane that orgaise the actin cytoskeleton. Simultaneously the yolk cell acts as a phagocyte to support the overlying process of dorsal closure.

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