Project C12

The Role of Circulating Monocytes in the Post-Ischaemic Myocardium

Principal investigators: Johannes Waltenberger, Evangelia Pardali, Lars Stegger
Project time: 07/2013–06/2017



Monocytes are a therapeutic target after acute myocardial infarction, because they contribute to i) reperfusion injury (hours after reperfusion), and ii) repair (days - weeks after reperfusion). There is no data available concerning the (transient) accumulation of monocytes or monocyte subsets in the myocardium following (reperfused) acute myocardial infarctions. Imaging of monocytes will allow the detection of these cells in the heart and their association with either the infarct zone or border zone and the remote myocardium. We aim to investigate the localisation of mononuclear cell types in the post-ischaemic myocardium and their contribution to post-infarct healing using imaging.


Dunaeva M, Waltenberger J. Hh signaling in regeneration of the ischemic heart. Cell Mol Life Sci 2017;74: 3481-3490. Abstract
Noto B, Buther F, Auf der Springe K, Avramovic N, Heindel W, Schafers M, Allkemper T, Stegger L. Impact of PET acquisition durations on image quality and lesion detectability in whole-body 68Ga-PSMA PET-MRI. EJNMMI Res 2017;7: 12. Abstract


Pardali E, Schmitz T, Borgscheiper A, Iking J, Stegger L, Waltenberger J. Cryopreservation of primary human monocytes does not negatively affect their functionality or their ability to be labelled with radionuclides: basis for molecular imaging and cell therapy. EJNMMI Res 2016;6: 77. Abstract


Principal investigators

Evangelia Pardali

Evangelia Pardali, PhD
Department of Cardiology and Angiology
Tel.: +49 251 83-57089

Lars Stegger

Univ.-Prof. Dr. rer. medic. Dr. med. Lars Stegger
Department of Nuclear Medicine
Tel.: +49 251 83-47840

Scientific staff

Dr. rer. nat. Lisa Honold
European Institute for Molecular Imaging (EIMI)
Tel.: +49 251 83-49309

Alexis Vrachimis

Dr. med. Alexis Vrachimis
Department of Nuclear Medicine
Tel.: +49 251 83-47362

Janette Iking

Janette Iking, M.Sc.
Department of Cardiology and Angiology
Tel.: +49 251 83-48408 (office) or -44901 (lab)

Non-scientific staff


Univ.-Prof. Dr. med. Michael Schäfers
Tel.: +49 251 83-49300
SFB 656 MoBil
Waldeyerstraße 15
· D-48149 Münster
Tel: +49 251 83-49314 · Fax: +49 251 83-49313