Zielgruppennavigation: 


Project B07

Mathematical Modelling of Atherosclerotic Plaque Formation Based on Data from Multiparametric Imaging

Principal investigator: Mario Ohlberger
Project time: 07/2013–06/2017

Numerical validation for a simplified model of the inflammation process in atherosclerosis using the software framework DUNE

Numerical validation for a simplified model of the inflammation process in atherosclerosis using the software framework DUNE

Project

Most vascular pathologies arise from atherosclerosis. Atherogenesis is an inflammatory process mainly triggered by low-density lipoproteins entering the intimal layer of arteries. This phenomenon in turn is regionally related to a blood flow dependent change in endothelial shear stress. We aim at numerical modeling of atherogenesis based on multiparametric imaging data of vessel architecture, blood flow and vascular inflammation. Simulation-based characterisation of the dependence of plaque formation on critical parameters should finally support our understanding of plaque development.

2017

Dedner A, Girke S, Klöfkorn R, Malkmus T. The Dune-Fem-DG module. Archive of Numerical Software 2017;5: 1–62.

2014

Girke S, Klöfkorn R, Ohlberger M. Efficient Parallel Simulation of Atherosclerotic Plaque Formation Using Higher Order Discontinuous Galerkin Schemes. PROM 2014;78: 617-625. Abstract

Team

Principal investigator

Mario Ohlberger

Univ.-Prof. Dr. rer. nat. Mario Ohlberger
Institute for Computational and Applied Mathematics
Tel.: +49 251 83-33775

Scientific staff

Stefan Girke

Dipl.-Math. Stefan Girke
Institute for Computational and Applied Mathematics
Doctoral student
Tel.: +49 251 83-35119
stefan.girke@uni-muenster.de

Cooperation partners

Michael Schäfers

Univ.-Prof. Dr. med. Michael Schäfers
Department of Nuclear Medicine
European Institute for Molecular Imaging (EIMI)
Tel.: +49 251 83-49300
schafmi@uni-muenster.de

Christina Surulescu

Univ.-Prof. Dr. rer. nat. Christina Surulescu
Felix-Klein-Centre for Mathematics
Technische Universität Kaiserslautern
Tel.: +49 631 205 5312
surulescu@mathematik.uni-kl.de


Contact

Univ.-Prof. Dr. med. Michael Schäfers
Tel.: +49 251 83-49300
schafmi@uni-muenster.de
SFB 656 MoBil
Waldeyerstraße 15
· D-48149 Münster
Tel: +49 251 83-49314 · Fax: +49 251 83-49313
E-Mail: