Dr. Kimberley Prior (Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, The University of Edinburgh, UK)

in: 'Frontiers in Ecology and Evolution': "The role of daily rhythms in host-parasite interactions: taking a closer look at malaria."

Mit Dr. Kimberley Prior (Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, The University of Edinburgh, UK)

Parasite rhythms matter for their fitness, but how malaria parasites coordinate with their mammalian host is unknown. Malaria parasites have development cycles that are both synchronous and timed to the host circadian rhythm, and last multiples of 24h (depending on the parasite species). Parasites have specific requirements throughout their development cycle, and the timing of the appearance in the blood of each stage is determined by the daily feeding rhythm of the host. While parasites get many resources from digesting the host red blood cell haemoglobin, parasites must scavenge various resources/metabolites from the extracellular environment during infection, such as amino acids, glucose, purines and phospholipids. It is unknown if these metabolites appear rhythmically in the blood and if they associate with the timing of host feeding and are thus capable of explaining parasite rhythms. We use a combination of metabolomics and ex vivo culture to test the effects of candidate metabolite/s on the parasite development cycle. We find that the essential amino acid isoleucine is crucial for the successful completion of the parasite development cycle and, by being rhythmic in the blood of hosts, isoleucine provides a general explanation for the timing of parasite rhythms.

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Di 26.11.2019, 16 Uhr - 18 Uhr
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