Fachbereich 12 - Chemie und Pharmazie
Institut für Pharmazeutische und Medizinische Chemie
Analytik

Stereoselektive Biotransformation von Arzneistoffen

Es wird die Biotransformation von Arzneistoffen einschließlich chiraler Aspekte untersucht.

Drittmittelgeber:

Deutsche Forschungsgemeinschaft, Industrie

Beteiligte Wissenschaftler:

Prof. Dr. G. Blaschke (Leiter), D. Strickmann, Chr. Horstkötter, D. Schepmann, M. Meyring, T. Goedecke, Prof. Dr. B. Chankvetadze (Univ.Tiflis/Georgien)

Veröffentlichungen:

D. Strickmann, G. Blaschke: Isolation of an unknown metabolite of the non-steroidal anti-inflammatory drug etodolac and its identification as 5-hydroxy etodolac. J. Pharm. Biomed. Anal. 25, 977-984, 2001.

Chr. Horstkötter, G. Blaschke: Stereoselecitve determination of ofloxacin and its metabolites in human urine by capillary electrophoresis using laser-induced fluorescence detection. J. Chromatogr. B 754, 169-178, 2001.

Chr. Horstkötter, S. Kober, H. Spahn-Langguth, E. Mutschler, G. Blaschke: Determination of triamterene and its main metabolite hydroxytriamterene sulfate in human urine by capillary electrophoresis using UV- and laser-induced fluorescence detection. J. Chromatogr. B 769, 107-117, 2002.

M. Meyring, J. Mühlbacher, N. Kastner-Pustet, G. Bringmann, A. Mannschreck, G. Blaschke: In vitro biotransformation of (R)- and (S)-thalidomide: Application of circular dichroism spectroscopy to the stereochemical characterization of the hydroxylated metabolites. Anal. Chem. 74, 3726-3735, 2002.

D. Schepmann, G. Blaschke: Isolation and identification of 8-hydroxypraziquantel as a metabolite of the antischistosomal drug praziquantel. J. Pharmac. Biomed. Anal. 791-799, 2001.

G. Blaschke, M. Meyring, C. Mühlenbrock, B. Chankvetadze: Recent results of biotransformation of drugs: investigation of the in vitro biotransformation of thalidomide using a dual cyclodextrin system in capillary electrophoresis. Il Farmaco 57, 551-554, 2002.

Chr. Horstkötter, E. Jiménez-Lozano, D. Barrón, J. Barbosa, G. Blaschke: Determination of residues of enrofloxacin and its metabolite ciprofloxacin in chicken muscle by capillary eletrophoresis using laser-induced fluorescence detection. Electrophoresis 23, 3078-3083, 2002.