Research topics

Synthesis of nucleoside diphosphate activated deoxy sugars, Use of bacterial enzymes: tools in carbohydrate chemistry, Syntheses of biologically active glycosides, Modification of plant and bacterial polysaccharides for consumer markets, Synthesis of glycoside mimetics, Investigation of the Maillard reaction by robotic synthesis and high throughput measurement, Mathematical modelling of complex chemical networks, Analysis of Carbohydrates in the hair fibre.

Veröffentlichungen:

A. Naundorf und W. Klaffke: Syntheses of inhibitors for the enzyme dTDP-glucose-4,6-dehydratase (EC 4.2.1.46), Carbohydr. Res., 318 (1999) 38-51.

U. Diederichsen, T.K. Lindhorst, B. Westermann, Eds.: The enzyme dTDP-glucose-dehydratase as a tool for the synthesis of deoxy sugars, in New Perspectives in Bioorganic Chemistry", Wiley-VCH, Weinheim, 1999, p. 174-183.

J.J. Turner, N. Wielschut, H.S. Overkleeft, W. Klaffke, G.A. van der Marel, J.H. van Boom: Mitsunobu Glycosylation of Nitrobenzenesulfonamides: Novel Route to Amadori Rearrangement Products, Tetrahedron Lett., 40 (1999) 7039-7042.

A. Naundorf, S. Natsch und W. Klaffke: A Convenient Route to Keto-Glycosyl Phosphates, Tetrahedron Lett., 41 (2000) 189-192.

D. Ramos, P. Rollin, W. Klaffke: Enzymatische Synthese von Neoglycopeptid-Bausteinen; Enzymatic Synthesis of Neoglycopeptide Building Blocks, Angew. Chem., 112 (2000) 406-408; Angew. Chem. Int. Ed. Engl. 39 (2000) 396-398.

W. Klaffke, S. Chambon: Chemo-enzymatic Synthesis of TDP-b-L-Ascarylose, Tetrahedron Asymmetry 11 (2000) 639-644.

T. Schmelter, R. Vreeker and W. Klaffke: Characterisation of a Novel Gel System Containing Pectin, Heat Inactivated Pectin Methylesterase and NaCl, Carbohydrate Polymers, in press 12/2000.

Book Review: Carbohydrate Biotechnology Protocols. Angew. Chem. In press 06/2000

S. Patel, S. Russell, J. Tissen, W. Klaffke: Process for Preparing Flavour Compounds, Eur. Pat. Appl., first filing 21.07.2000; EP 00 30 6249

S. Patel, S. Russell, J. Tissen, W. Klaffke: Method for simulating chemical reactions, Eur. Pat. Appl., first filing 21.07.2000; EP 00 30 6250

T. Schmelter, R. Wientjes, R. Vreeker, W. Klaffke: Enzymatic modifications of Pectins and the Impact on their rheological Properties, Carbohydrate Polymers, accepted 01/01, in press.

Shail Patel, Jeremy Rabone, Stephen Russell, Jos Tissen, and Werner Klaffke: Iterated Reaction Graphs: Simulating Complex Maillard Reaction Pathways, J. Chem. Inform Comp. Science, accepted 12/00.

Delphine Ramos, Patrick Rollin, Werner Klaffke: Chemo-enzymatic synthesis of neoglycopeptides: application to an a-Gal terminated neoglycopeptide, J. Org. Chem., accepted 01/01, in press.

Aad Visser, Pieter Braat, Jos Tissen, Werner Klaffke: Process for preparing flavouring compositions, Eur. Pat. Appl., first filing 01/01

Christiane Ernst and Werner Klaffke: A short route to nucleoside diphosphate activated D- and L-hexoses, Tetrahedron Latt., submitted 01/01