Pathophysiologie intrazellulärer Elektrolyte

Messung intrazellulärer und Plasma-Elektrolytkonzentrationen mittels Atomabsorptionsspektroskopie bei Hypertonie, Diabetes mellitus, Anorexie, Präeklampsie und Alkoholismus. Osteoporosediagnostik mittels Ultraschall am Calcaneus und Knochenstoffwechsel bei Niereninsuffizienz und Nierentransplantation.

Drittmittelgeber:

Förderverein der WWU

Beteiligte Wissenschaftler:

PD Dr. Klaus Kisters, Dr. Jens Köneke, Dr. Faruk Tokmak, Dr. Martin Hausberg, Dr. Manuela Kempkes, PD Dr. Michael Barenbrock, PD Dr. Peter Maria Rob, Dr. Kiumars Schodjaian, Dr. Frank Louwen, Dr. Karl Heinz Dietl

Veröffentlichungen:

Kisters, K., C. Spieker, K.H. Rahn, W. Zidek: Intrazelluläre Mg++- Spiegel bei Hypertonie und Niereninsuffizienz. Nieren- und Hochdruckkrankheiten 2: 66-68 (1997)

Kisters, K., C. Spieker, M. Tepel, W. Zidek: Determination of plasma and intracellular Ca++ in normotension and essential and renal hypertension: a lymphocytic cell model in hypertension. Trace Elemements and Electrolytes 1: 27-29 (1997)

Kisters, K., M. Tepel, C. Spieker, K.H. Dietl, M. Barenbrock, K.H. Rahn, W. Zidek: Decreased cellular Mg++ concentrations in a subgroup of hypertensives - cell models for the pathogenesis of primary hypertension. Journal of Human Hypertension 11: 367-372 (1997)

Kisters, K., M. Tepel, C. Spieker, W. Zidek: Mg++ concentrations in plasma, platelets and lymphocytes in essential and renal hypertension. Trace Elements and Electrolytes 1: 1-5 (1997)

Kisters, K., E.R. Krefting, C. Spieker, W. Zidek, K.H. Dietl, M. Barenbrock, K.H. Rahn: Increased Na+ and decreased Mg++ intracellular concentrations in vascular smooth muscle cells from spontaneously hypertensive rats. Clinical Science 95 (5): 583-587 (1998)

Kisters, K., M. Tepel, G. Hahne, C. Wibbeke, C. Spieker, W. Zidek: Chloride concentrations in plasma, erythrocytes and lymphocytes indicating different chloride fluxes: measurements using SPQ and coulorimetric titration. Trace Elements and Electrolytes 2: 55-57 (1997)

Kisters, K., M. Tepel, M. Barenbrock, G. Westermann, K.H. Rahn, W. Zidek, C. Spieker: Mg++ status in normotensive and essential hypertensive patients - different cell models. Medical Science Research 25: 397-398 (1997)

Kisters, K., C. Spieker, J. Bachmann, G. Westermann, W. Zidek: Mg++ concentrations in plasma and erythrocytes in borderline hypertensive patients. Trace Elements and Electrolytes 2: 102-106 (1997)

Kisters, K., J. Körner, F. Louwen, R. Witteler, C. Spieker, W. Zidek, M. Barenbrock, K.H. Rahn: Plasma, intracellular and membrane Mg++ concentrations in normal pregnancy and in preeclampsia. Hypertension in pregnancy 17 (2): 169-178 (1998)

Kisters, K., J. Körner, F. Louwen, C. Spieker, W. Zidek: Plasma and membrane Mg++ concentrations in normal pregnancy and in preeclampsia as compared to healthy female subjects - a plasmalemmal membrane model. Trace Elements and Electrolytes 3: 109-112 (1997)

Kisters, K., K. Schodjaian, S. Quang Nguyen, J. Küneke, M. Hausberg, G. Westermann, C. Spieker, M. Barenbrock: Effects of alcohol on plasma and intracellular magnesium status in patients with steatosis or cirrhosis of the liver. Medical Science Research 25: 805-806 (1997)

Kisters, K., K. Schodjaian, S. Quang Nguyen, J. Küneke, G. Westermann, C. Spieker, M. Barenbrock: Plasma and intracellular magnesium status in patients with alcoholic steatosis or cirrhosis of liver with and without essential hypertension. Trace Elements and Electrolytes 4: 163-166 (1997)

Kisters, K., K. Schodjaian, J. Köneke, G. Westermann, F. Tokmak, K.H. Rahn, M. Barenbrock: Plasma and intracellular magnesium status in alcoholism and essential hypertension. Magnesium Bulletin 20,1: 1-4 (1998)

Kisters, K., E.R. Krefting, C. Spieker, W. Zidek, M. Barenbrock, K.H. Rahn: Vascular smooth muscle and striated heart muscle cell magnesium content in SHR. Magnesium Bulletin 19,4: 106-109 (1997)

Kisters, K., J. Körner, F. Louwen, R. Witteler, C. Jakisch, W. Zidek, S. Ott, G. Westermann, M. Barenbrock, K.H. Rahn: Plasma and membrane Ca++ and Mg++ concentrations in normal pregnancy and in preeclampsia. Gynaecolic and Obstetric Investigation 46: 158-163 (1998)

Kisters, K., J. Körner, F. Louwen, R. Witteler, C. Jakisch, S. Ott, M. Barenbrock, C. Spieker, W. Zidek, K.H. Rahn: Plasma and membrane Ca++ concentrations in normal pregnancy and in preeclampsia. Trace Elements and Elektrolytes 1: 1-4 (1998)

Kisters, K., M. Tepel, C. Spieker, W. Zidek, M. Barenbrock, F. Tokmak, M. Kosch, M. Hausberg, K.H. Rahn: Decreased membrane Mg++ concentrations in a subgroup of hypertensives - membrane model for the pathogenesis of primary hypertension. American Journal of Hypertension 11: 1390-1393 (1998)

Kisters, K., K.H. Rahn, F. Tokmak, G. Westermann, J. Köneke, M. Hausberg, M. Barenbrock: Lowered erythrocyte membrane Mg++ concentrations in a subgroup of essential hypertensives. Trace Elements and Electrolytes 2: 55-57 (1998)

Kisters, K., E.R. Krefting, M. Barenbrock, W. Zidek: Electronprobe X-ray microanalysis of sodium ion content in vascular smooth muscle cells from SHR and normotensive rats of different ages. Trace Elements and Electrolytes 3: 109-110 (1998)

Kisters, K., J. Köneke, M. Tepel, F. Tokmak, G. Westermann, M. Kosch, K.H. Rahn, M. Barenbrock: Decreased cellular and membrane Mg++ concentrations in a subgroup of hypertensives - cell models for the pathogenesis of primary hypertension. Magnesium-Bulletin 20(3): 53-58 (1998)

Kisters, K., E.R. Krefting, C. Spieker, W. Zidek, K.H. Rahn: Mg++- und Na+- Gehalt in glatten Gefäßmuskelzellen normotensiver (WKY) und spontan hypertensiver (SHR) Ratten. Nieren- und Hochdruckkrankheiten 7: 341-344 (1998)

Kisters, K., F. Louwen, R. Witteler, M. Hausberg, M. Barenbrock, K.H. Rahn: High blood pressure in pregnancy: role of Ca++ and Mg++. CORRESPONDENCE letter Journal of Hypertension 16: 1561-1562 (1998)

Kisters, K., R. Welslau, F. Tokmak, G. Westermann, J. Köneke, M. Hausberg, D. Lang, W. Zidek, K.H. Rahn: Increased intracellular calcium and decreased intracellular magnesium in lymphocytes as a cell model in the pathogenesis of essential hypertension: a possible calcium magnesium antagonism. Trace Elements and Electrolytes 3: 116-119 (1998)

Kisters, K., E.R. Krefting, W. Zidek, G. Westermann, M. Barenbrock, M. Kosch, M. Hausberg, K.H. Rahn: Mg++/Na+ exchange and ratio in the spontaneously hypertensive rat (SHR). Magnesium Bulletin 4: 97-100 (1998)

Westerman, G.W., M. Tepel, F. Tokmak, M. Hausberg, K.H. Rahn, K. Kisters: Magnesiumgehalt von Plasma, Zytosol und Zellmembranen bei chronischer Niereninsuffizienz. Nieren- und Hochdruckkrankheiten 27(11): 486-490 (1998)

Kisters, K., W. Zidek, C. Spieker: Plasma and cellular lead in hypertension. TEMA 9 Proceedings Trace Elements in Man and Animals Edited by P. W. F. Fischer, M.R.L.'Abbe, K. A. Cockell, R.S. Gibson. NRC Research Press, Ottawa, Canada, 562-563 (1997)

Kisters, K., K. Schodjaian, J. Köneke, G. Westermann, K.H. Rahn, C. Spieker, M. Barenbrock: Plasma and cellular magnesium concentrations in patients with alcoholic steatosis or cirrhosis of liver with and without primary hypertension. Mengen- und Spurenelemente, Harald Schubert Verlag, Leipzig, 358-364 (1997)

Kisters, K., G. Westermann, C. Spieker, F. Tokmak, K.H. Rahn, W. Zidek, M. Barenbrock: Plasma and intracellular Ca++ concentrations in normotension, essential and renal hypertension: a lymphocytic cell model. Mengen- und Spurenelemente, Harald Schubert Verlag, Leipzig, 326-331 (1997)

Kisters, K., E.R. Krefting, C. Spieker, G. Westermann, M. Barenbrock, W. Zidek, M. Hausberg, K.H. Rahn: Vascular smooth muscle and striated heart muscle cell Mg++ concentrations in SHR. Metal Ions in Biology and Medicine. Vol. 5., Eds., P. Collery, P. Brätter, V. Negretti de Brätter, L. Khassanova, J.C. Etienne, John Libbey Eurotext Paris, 677-680 (1998)

Kisters, K., E.R. Krefting, F.K. Matzkies, C. Spieker, N. Senninger, K.H. Dietl, K.H. Rahn: Increased Mg++/Na+ exchange in the development of hypertension in a subgroup of spontaneously hypertensive rats (SHR). Mengen- und Spurenelemente, Harald Schubert Verlag, Leipzig, 49-56 (1998)

Dietl, K.H., B. Winterberg, H.P. Bertram, C. Spieker, K. Kisters: Aluminum bone disease improved after kidney transplantation - determination by atomic absorption spectroscopy. Trace Elements and Electrolytes 3: 113-115 (1997)

Kisters, K., B. Winterberg, M. Barenbrock, K.H. Rahn, K.H. Dietl: Bone aluminium status improves after kidney transplantation. Medical Science Research 25: 741-742 (1997)

Kisters, K., N. Lügering, S. Neumann, C. Spieker, M. Barenbrock, C. Müller, B. Winterberg, W. Zidek, K.H. Rahn, K.H. Dietl: B- and T-lymphocyte aluminum concentrations in controls and in patients on regular hemodialysis treatment. Trace Elements and Electrolytes 4: 169-172 (1997)

Kisters, K., K.H. Dietl, M. Barenbrock, K.H. Rahn, B. Winterberg: Bone aluminum status after successful kidney transplantation. Transplantationsmedizin 10: 143-145 (1998)

Dietl, K.H., E.R. Krefting, G. Westermann, M. Barenbrock, N. Senninger, K.H. Rahn, K. Kisters: Age dependent decreased intracellular Mg++ concentrations in vascular smooth muscle cells of the abdominal aorta from normotensive (WKY) and spontaneosly hypertensive rats (SHR). Magnesium Bulletin 20(4): 92-96 (1998)

Dietl, K.H., B. Winterberg, M. Barenbrock, K. Kisters: Aluminum bone disease after kidney transplantation is improved.Mengen- und Spurenelemente, Harald Schubert Verlag, Leipzig, 311-316 (1997)

Dietl, K.H., P. Rottmann, B. Marschall, H. Wolters, M. Arlt, M. Hübschen, K. Schierbaum, N. Senninger, M. Barenbrock, M. Hausberg, K.H. Rahn, K. Kisters: Secondary hyperparathyroidism, calcium disorders and brown tumors after renal replacement therapy. Trace Elements and Electrolytes 15 (4): 173-176 (1998)

Kisters, K., M. Barenbrock, B. Winterberg: Aluminum bone disease after kidney transplantation. Metal Ions in Biology and Medicine. Vol. 5., Eds. P. Collery P. Brätter, V. Negretti de Brätter, L. Khassanova, J.C. Etienne, John Libbey Eurotext Paris, 651-654 (1998)