Forschungsbericht 1995-96
	Organisch-Chemisches Institut Corrensstraße 40 D-48149 Münster Tel.: (0251) 83 - 3 32 10 Fax: (0251) 83 - 3 97 72

Forschungsschwerpunkte 1995 - 1996 Fachbereich 17 - Chemie The Organisch-Chemisches Institut Research group Dr. S. Laschat

Research group Dr. S. Laschat

LASCHAT, Sabine; b. 1963; Dr. rer. nat. 1990 (Univ. Mainz, H. Kunz); Postdoctoral Research 1990 - 91 (University of California Irvine, L. E. Overman); independent research since 1991 (Univ. Münster); Habilitation 1995; since 1997 Universitätsprofessorin (Technische Universität Braunschweig); Awards: ADUC-Jahrespreis für Habilitanden 1994, Benningsen-Foerder-Preis 1995, Gerhard-Hess-Preis 1996, Heisenberg-Stipendium 1996. ORGANIC STEREOCHEMISTRY: hetero-Diels-Alder and hetero-ene reactions; cyclization reactions of imines; Lewis acid-catalyzed reactions; stereoselective synthesis; ORGANOMETALLICS IN ORGANIC SYNTHESIS: synthetic applications of chromium arene complexes; NATURAL PRODUCT SYNTHESIS; Adress at Braunschweig: Institut für Organische Chemie, Technische Universität Braunschweig, Hagenring 30, D-38106 Braunschweig, Tel.: 053 - 391 5264; FAX 0251 - 391 5388; Email: S.Laschat@tu-bs.de

Publications:

Laschat, S., M. Grehl: "Diastereoselektive Synthese von Amino-substituierten Indolizidinen und Chinolizidinen aus Prolinalimin bzw. 2-Piperidincarbaldimin durch intra-molekulare Hetero-En-Reaktion", Angew. Chem. 1994, 106, 475; Angew. Chem. Int. Ed. Engl. 1994, 33, 458.

Linkert, F., S. Laschat: "Intramolecular Hetero-Diels-Alder Reaction of Prolinal-Derived N-Arylimines. Lewis Acid-Dependent Reversal of the Diastereoselectivity", Synlett 1994, 125.

Fröhlich, R., M. Grehl, S. Kramm-Glade, S. Laschat: "Structure of Two Octahydro-acridines". Acta Cryst. C 1994, 50, 1798.

Laschat, S., F. Narjes, L.E. Overman: "Application of Intramolecular Heck Reactions to the Preparation of Steroid and Terpene Intermediates Having cis A-B Ring Fusions. Model Studies for the Total Synthesis of Complex Cardenolides", Tetrahedron 1994, 50, 347.

Laschat, S., M. Grehl: "Diastereoselective Synthesis of a-Hydroxy- and a-Amino-indolizidines and -quinolizidines. Evidence for a Novel Cyclization/Hydride Migration Mechanism in the TiCl₄-Induced Reaction of Prolinal Benzylimines by Deuterium Labeling Studies." Chem. Ber. 1994, 127, 2023.

Temme, O., S. Laschat: "Effect of Molecular Sieves on the Formation and Acid-Catalyzed Mono- and Biscyclization of N-Arylimines. An Easy Entry to Polycyclic Ring Systems by a Novel Cascade Reaction", J. Chem. Soc. Perkin Trans. 1995, 125.

Linkert, F., S. Laschat, M. Knickmeier: "Chelation Control by a Second Nitrogen Atom in Formal Hetero Diels-Alder Reactions of N-Arylimines", Liebigs Ann. Chem. 1995, 985.

Linkert, F., S. Laschat, S. Kotila, T. Fox: "Evidence for a Stepwise Mechanism in Formal Hetero-Diels-Alder Reactions of N-Arylimines", Tetrahedron 1996, 52, 955.

Laschat, S.: "Pericyclische Reaktionen in biologischen Systemen - Kennt die Natur die Diels-Alder-Reaktion?", Angew. Chem. 1996, 108, 313; Angew. Chem. Int. Ed. Engl. 1996, 35, 289.

Laschat, S., R. Fröhlich, B. Wibbeling: "Preparation of 2,3,4-Trisubstituted Piperidines by a Formal Hetero-Ene Reaction of Amino Acid Derivatives", J. Org. Chem. 1996, 61, 2829.

Schulte, J.L., S. Laschat, S. Kotila, J. Hecht, R. Fröhlich, B. Wibbeling: "Synthesis of ⁶-(Octahydroacridine)chromiumtricarbonyl Complexes with Non-Polar Tails via Molecular Sieves-Catalyzed Cyclization of N-Arylimines and Subsequent Diastereoselective Complexation", Heterocycles 1996, 43, 2713.

Dissertations:

Oliver Temme: "Entwicklung neuartiger Rezeptorsysteme auf der Basis von Azapolycyclen".

(Funding: Alfried Krupp von Bohlen und Halbach-Stiftung; Ministerium für Wissenschaft und Forschung des Landes Nordrhein-Westfalen; Deutsche Forschungsgemeinschaft; Fonds der Chemischen Industrie)