Shyam Bandari University of Münster Department of Plant Biology and Biotechnology Nanobiotechnology Group Schlossgarten 3 48149 Münster Germany
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Novel compounds from traditional medicinal plants with anti-quorum sensing activity and their nanoencapsulation in polysaccharide-based materials

Current advances

Qin/Goycoolea aims to discover new anti-quorum sensing glycosylated compounds (AHL-receptors antagonists and AHL-degrading enyzmes) derived from indigenous medicinal plants (col. Hensel). Ongoing molecular simulation (docking) studies are aiming to identify potential candidate compounds (training Fuenzalida) with the affinity for the luxR receptor involved in acyl-homoserine-lactone (AHL) quorum-sensing autoinduction in Gram-negative bacteria. In parallel, synthetic compounds with suspected anti-quorum sensing activity (col. Balamurugan, Ramu Sridhar) have been sent to our laboratory for testing their anti-quorum sensing activity. These will be tested on a recombinant E. coli biosensor AHL-controlled quorum-sensing and in a subsequent stage, the most active compounds will be nanoencapsulated into chitosan-based nanostructured devices (col. Moerschbacher) that would enhance or control their activity (e.g. by controlled or “smart” release).

Last update 18.04.2013

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