Decorin and the transcription factor Tbx21

Delayed type hypersensitivity (DTH) is a mouse model for studying T-cell mediated immune responses in vivo. All steps during the DTH model could be modulated by different types of proteoglycans which are located either on the cellular surface or in the extracellular matrix. The lack of decorin results in a reduced edema formation, an increased adhesion of granulocytes to endothelial cells and reduced extravasations of leucocytes into the inflamed tissue. Furthermore, the cytokine profile was altered, too. The expression of interferon γ (Ifn-γ) and its downstream cytokine chemokine ligand 10 (CXCL-10) were reduced in vivo. To further analyze the mechanism how Ifn-γ signaling is affected by the loss of decorin the transcription factor Tbet21 is characterized during DTH. In vitro endothelial cells and fibroblasts are involved in Ifn-γ synthesis. To support the impact of endothelial cells or fibroblasts in this context, the regulation of Tbx21 expression is characterized in these cells types too.

Last update 18.06.2013

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