WORK PACKAGE 4

Probes for NIND detection by MRI and OI

Seven INMiND partner institutions from five countries (Belgium, France, Hungary, Italy, Sweden) are involved in the research activities of this work package. Leader of this work package is Enzo TERRENO, head of the Centre for Preclinical Imaging (CEIP) at the University of Torino (Italy).

The main objectives of this work package are:

  • WP4 aims to develop imaging procedures to visualize molecular and cellular targets for non-invasive detection (diagnosis and therapy follow-up) of NIND by magnetic resonance (MRI) and optical (OI) imaging modalities.
  • Imaging probes will be designed according to both well-established targets and novel molecular NI markers identified from the research carried out within WP1.
  • The in vivo assessment and validation of  the probes will be performed in close collaboration with WP5/6.
  • Joint work with WP3 will be carried out especially for achieving the WP tasks that involves PET/SPECT common targets and the design of dual probes.

WP4 Related papers


Epub ahead of print

Garello F, Pagoto A, Arena F, Blasi F, Buffo A, Terreno E. MRI visualization of neuroinflammation using VCAM-1 targeted paramagnetic micelles. Nanomedicine. 2017 pii: S1549-9634(17)30181-8; epub ahead of print.
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2018

Szigeti K, Hegedűs N, Rácz K, Horváth I, Veres DS, Szöllősi D, Futó I, Módos K, Bozó T, Karlinger K, Kovács N, Varga Z, Babos M, Budán F, Padmanabhan P, Gulyás B, Máthé D. Thallium labelled citrate coated Prussian blue nanoparticles as potential imaging agent. Contrast Media Mol Imaging. 2018;2018:2023604.
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2017

Filippi M, Catanzaro V, Patrucco D, Botta M, Tei L, Terreno E. First in vivo MRI study on theranostic dendrimersomes. J Control Release. 2017; 248: 45-52.
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Lauber DT, Fülöp A, Kovács T, Szigeti K, Máthé D, Szijártó A. State of the art in vivo imaging techniques for laboratory animals. Lab Anim. 2017;51(5):465-478.
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2016

Filippi M, Boido M, Pasquino C, Garello F, Boffa C, Terreno E. Successful in vivo MRI tracking of MSCs labeled with Gadoteridol in a Spinal Cord Injury experimental model. Exp Neurol. 2016;282:66-77.
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Pagoto A, Stefania R, Garello F, Arena F, Digilio G, Aime S, Terreno E. Paramagnetic Phospholipid-Based Micelles Targeting VCAM-1 Receptors for MRI Visualization of Inflammation. Bioconjug Chem. 2016;27(8):1921-30.
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2015

Chirizzi C, Dastrù W, Delli Castelli D, Menchise V, Aime S, Terreno E. Glucan particles loaded with fluorinated emulsions: A sensitivity improvement for the visualization of phagocytic cells by 19F-MRI. Curr Mol Imaging. 2015;4(1):29-34.
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Farde L. Spotlight: TSPO binding may also represent ‘resting’ microglia. Clin Transl Imaging. 2015;3(6):491-492.
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Filippi M, Patrucco D, Martinelli J, Botta M, Castro-Hartmann P, Tei L, Terreno E. Novel stable dendrimersome formulation for safe bioimaging applications. Nanoscale. 2015;7(30):12943-54.
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Filippi M, Remotti D, Botta M, Terreno E, Tei L. GdDOTAGA(C18)2: an efficient amphiphilic Gd(iii) chelate for the preparation of self-assembled high relaxivity MRI nanoprobes. Chem Commun (Camb). 2015;51(98):17455-8.
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Garello F, Arena F, Cutrin JC, Esposito G, D'Angeli L, Cesano F, Filippi M, Figueiredo S, Terreno E. Glucan particles loaded with a NIRF agent for imaging monocytes/macrophages recruitment in a mouse model of rheumatoid arthritis. RSC Adv. 2015;5(43):34078-34087.
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2014

Filippi M, Martinelli J, Mulas G, Ferraretto M, Teirlinck E, Botta M,Tei L, Terreno E. Dendrimersomes: a new vesicular nano-platform for MR-Molecular Imaging applications. Chem Commun (Camb). 2014;50(26):3453-6.
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Garello F, Stefania R, Aime S, Terreno E, Delli Castelli D. Successful entrapping of liposomes in glucan particles: An innovative micron-sized carrier to deliver water-soluble molecules. Mol Pharm. 2014;11(10):3760-5.
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Minazzi P, Lattuada L, Menegotto IG, Giovenzana GB. An enzymatic approach to bifunctional chelating agents. Org Biomol Chem. 2014;12(35):6915-21.
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Veres DS, Máthé D, Futó I, Horváth I, Balázs A, Karlinger K, Szigeti K. Quantitative liver lesion volume determination by nanoparticle-based SPECT. Mol Imaging Biol. 2014;16(2):167-72.
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2013

Cerutti E, Damont A, Dollé F, Baroni S, Aime S. Synthesis and characterization of an MRI Gd-based probe designed to target the translocator protein. Magn Reson Chem. 2013;51(2):116-22.
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Dewitte H, Geers B, Liang S, Himmelreich U, Demeester J, De Smedt SC, Lentacker I. Design and evaluation of theranostic perfluorocarbon particles for simultaneous antigen-loading and ¹⁹F-MRI tracking of dendritic cells. J Control Release. 2013;169(1-2):141-9.
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Figueiredo S, Cutrin JC, Rizzitelli S, De Luca E, Moreira JN, Geraldes CF, Aime S, Terreno E. MRI tracking of macrophages labeled with glucan particles entrapping a water insoluble paramagnetic Gd-based agent. Mol Imaging Biol. 2013;15:307-15.
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2012

Abourbeh G, Thézé B, Maroy R, Dubois A, Brulon V, Fontyn Y, Dollé F, Tavitian B, Boisgard R. Imaging microglial/macrophage activation in spinal cords of experimental autoimmune encephalomyelitis rats by positron emission tomography using the mitochondrial 18 kDa translocator protein radioligand [¹⁸F]DPA-714. J Neurosci. 2012;32(17):5728-36.
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Jacobs AH, Tavitian B; INMiND consortium. Noninvasive molecular imaging of neuroinflammation. J Cereb Blood Flow Metab. 2012;32(7):1393-415.
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