Main Objectives

The INMiND project will focus on the following objectives, which are embedded within a translational and reverse-translational strategy of INMiND (see figure below):

  1. identify novel mechanisms of regulation and function of microglia under inflammatory stimuli and in ND-models (WP1/2),
  2. identify the interplay between microglial activation and neuroregeneration induced by neural stem cells (WP2),
  3. identify molecular targets for ND therapeutics and advanced imaging probes which bind to activated microglia and BMD cells (WP1/2/3/4),
  4. quantitatively assess dynamics of microglial activation in various ND models in conjunction with other disease specific imaging markers (e.g. Aβ, neurotransmitter function) using standard and newly developed probes (WP5/6/7),
  5. translate new imaging paradigms for microglial activation into patients with various ND (AD, MCI, PD, HD, ALS) and multiple sclerosis (MS) with and without immunomodulatory therapies (WP7/8/9),
  6. validate protective strategies for neurons and axons for improved disease outcome (WP1/2/5/6/8/9),
  7. train a new generation of cross-disciplinary scientists in the field of NIND for biomedical research (WP12).

Translational reverse-translational strategy of INMiND
Translational and reverse-translational strategy of INMiND

INMiND Office
European Institute for Molecular Imaging (EIMI) Waldeyerstr. 15
· 48149 Münster
Tel: +49 251 83 49300 · Fax: +49 251 83 49313
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