Université Paris Descartes, Paris, France

Group Description

Brief description of legal entity
The Laboratory for Imaging Research (LRI) is one of the 14 teams in the Paris Cardiovascular Research Center (PARCC; www.parcc.inserm.fr) opened in 2009 at the European Hospital Georges Pompidou in Paris by a partnership between the National Institute for Health and Medical Research (Inserm) and the University Paris Descartes. More than 250 scientists, students, technicians and administrative staff, who initially were housed in several locations in Paris, were brought together under one roof on a 4200 m² site. LRI) focuses on developing, validating and applying in vivo imaging technologies. LRI is headed by Prof O. Clément and has five appointed senior scientists: Prof O. Clément (Imaging of cell migration); Prof B. Tavitian (PET and molecular imaging); Prof C.A. Cuénod (microvascularization); Dr L. Fournier (cancer and angiogenesis); Dr N. Siauve (placenta). LRI is a member of the Paris Descartes Small Animal Imaging facility (SAIF), a network initiated in 2005 with the objective to give access to small animal imaging techniques to research teams affiliated either to University Paris Descartes, and to Academic institutions and Industrial partners. This facility gathers multiple imaging teams on multiple sites of the University Paris Descartes, with imaging systems and expertise for different modalities (MRI, CT, ultrasound, EPR, optical); PARCC houses a small animal imaging 4.7T MRI, a confocal fibered Cellvizio Lab system, and a micro PET-CT. SAIF provides strong inter-faculty and interdisciplinary links between basic researchers and medical imaging scientists involving the faculties of medicine, chemistry and pharmacy, mathematics and computer sciences and physics, and a broad spectrum of expertise from medicine, natural and computer sciences. Pr Clément is the head of the SAIP (www.ipa.medecine.univ-paris5.fr). Prof Tavitian was project coordinator of FP6 NoE “European Molecular Imaging Laboratories” (EMIL) and founding member and past president of the European Society for Molecular Imaging (ESMI; www.e-smi.eu).

Main tasks
Development of molecular imaging of disease-specific molecular alterations in the major disease areas (cardiovascular disease, oncology, inflammation, neurodegeneration). Important applications include the development of new imaging methods (targeting MMP, TSPO), imaging studies in rodent model systems and translation into clinical application to serve imaging-guided patient-tailored diagnosis and treatment.

Participation in INMiND: WP3 / WP4 / WP5 / WP7 / WP8 / WP10 / WP12 (leader month 13-24).

Previous experience relevant to INMiND tasks

Multi-modal imaging of experimental models by μPET, μCT, μMRI, ultrasound and optical imaging, and of patients by SPECT/CT, PET/CT; quantification of therapy response. LRI together with the Assistance Publique has established a multicenter clinical research programme on the Impact of Predicting Anti-Angiogenic Response in mRCC Using Functional Imaging (REMISCAN).

University Paris Descartes
Paris Cardiovascular Research Center
Prof Bertrand TAVITIAN
INMiND Office
European Institute for Molecular Imaging (EIMI) Waldeyerstr. 15
· 48149 Münster
Tel: +49 251 83 49300 · Fax: +49 251 83 49313