Consiglio Nazionale Delle Ricerche - Instituto Di Biostrutture e Bioimmagini, Naples, Italy

Group Description

Brief description of legal entity
The Institute of Biostructure and Bioimaging (IBB) of the National Research Council (CNR) has a multidisciplinary staff including researchers with different expertise such as medicine, biology, chemistry, physics and computer science. The IBB is located in the Dept. of Biomorphological and Functional Sciences of the University "Federico II" of Naples and is partner of CEINGE-Advanced Biotechnologies for the study of animal models of human diseases. IBB was coordinator of the FP5 project "Enhancement of Clinical Value of Functional Imaging through Automated Removal of Partial Volume Effect" (PVEOut) and is partner of the FP6 NoE “Diagnostic Molecular Imaging” (DiMI). Available equipment includes: two-heads SPECT, CT-PET, Cyclotron Unit and radiochemistry lab. ([18F]FDG, [18F]FLT, [13N]H3, [18F]peptides, [18F]DPA714), MRI (1.5T and 3T), μPET-CT, high-resolution CT, high-resolution ultrasounds, optical imaging, PhosporImager, fully equipped laboratories for cell culture, tissue analysis and probe development and characterization. An animal dedicated MR 9.3 T is being installed.

Main tasks
To explore the relationship between neuroinflammation (NI) and neurodegenerative (ND) phenomena using MRI and PET in experimental and human studies. In mice with EAE, SOD1 mutation and MCAO different aspects of neuroinflammation (including selective microglial activation, machrophage migration, and BBB leak) will be evaluated in vivo with microPET ([18F]DPA714) and MRI and correlated to the concurrent degree of atrophy. In humans, strategies for integrated analysis of MRI / PET studies will be developed and adapted to correlate quantitatively data from structural MRI, DTI and PET.

Participation in INMiND:  WP5 / WP6 / WP7 / WP10.

Previous experience relevant to INMiND tasks

Expertises on the development and/or application of MRI /PET/SPECT tools for quantitative structural, metabolic and receptor characterization including methodological aspects (MRI segmentation and quantification of atrophy, Partial Volume Effect correction, PET/SPECT receptor quantification), preclinical ([18F]FDG and [18F]DPA714 PET, MRI) and clinical application (MS, AD and PD).

Institute of Biostructure and Bioimaging
INMiND Office
European Institute for Molecular Imaging (EIMI) Waldeyerstr. 15
· 48149 Münster
Tel: +49 251 83 49300 · Fax: +49 251 83 49313