Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain

Group Description

Brief description of legal entity
IDIBAPS is a consortium between the University of Barcelona, the Spanish Research Council (CSIC), the Hospital Clinic and the local Government (Generalitat de Catalunya). IDIBAPS carries research activity in the biomedical field with a strong activity in translational research resulting from close collaborative work between clinical and basic researchers. In 2008, IDIBAPS published a total of 736 original articles in international journals, with a global impact factor of 3,421 (average per article 4.65 points). The Director of IDIBAPS is Prof. Dr. Ramon Gomis. IDIBAPS research is structured in six main areas of interest, including the Area of Clinical and Experimental Neurosciences coordinated by Dr. Anna Planas. Therefore, one of the strongest and characteristic values of IDIBAPS research is its translational approach. To achieve this, imaging technology is supported as a research tool that can be applied non-invasively in experimental animals and in humans. IDIBAPS has a Medical Imaging Platform coordinated by Dr. Javier Pavia that includes research units devoted to human studies (like the 3T MRI Unit directed by Dr. N. Bargallo, and the PET Unit directed by Dr. Francisco Lomena, amongst others), and the Experimental Unit specifically dedicated to animal studies (like the Experimental MRI Unit coordinated by Dr. Anna Planas). All imaging units work in strong collaboration within the Medical Imaging Platform, which has a strategic plan for further technological developments including those directed towards Molecular Imaging.

Main tasks
The main task of IDIBAPS is to encourage translational research, innovation and technological progress in the field of biomedicine, through different programmes addressing diseases with a high prevalence, morbidity and mortality. This area of Clinical and Experimental Neurosciences specialises in the study of neurological and psychiatric diseases. Based on the excellent cooperation between the experimental and clinical units, its 11 teams conduct research into topics ranging from the study of the structure/function relationship in the nervous system and its basic molecular mechanisms for neurotransmission, cell death, and brain dysfunction to the development and evaluation of new experimental therapies.

Participation in INMiND: WP1 / WP2 / WP5 (leader) / WP7 / WP10 / WP12.

Previous experience relevant to INMiND tasks

Neuroinflammation is one of the major focuses of our studies, mainly applied to the investigation of cerebrovascular diseases including chronic cerebrovascular pathology and stroke. We use experimental neuroimaging and have an animal dedicated 7T-MRI for this purpose. We also use microPET and confocal microscopy to image the brain of living animals. We work in strong collaboration with the neurologists of our hospital. We are interested in unravelling the involvement of neuroinflammation in brain diseases and its possible contribution to progression of brain pathology. We carry translational research aimed to find diagnostic and therapeutic applications that can be useful in the clinics.

August Pi i Sunyer Biomedical Research Institute
Prof Anna PLANAS
INMiND Office
European Institute for Molecular Imaging (EIMI) Waldeyerstr. 15
· 48149 Münster
Tel: +49 251 83 49300 · Fax: +49 251 83 49313