VU University Medical Centre, Amsterdam, The Netherlands

Group Description

Brief description of legal entity
The Department of Radiology & Nuclear Medicine of the VU University Medical Centre (VUmc;, part of the Stichting VU-VUmc, in Amsterdam is dedicated to both development and application of molecular imaging procedures with an emphasis on PET. This mission is reflected in the multi-disciplinary character of the department, which consists of radiochemists, radiopharmacists, biologists, physicists, computer scientists and nuclear medicine physicians. The department is equipped with two PET/CT scanners, one PET/MRI scanner, and preclinical PET/CT and PET/MRI scanners enabling studies in humans and experimental animals with high spatial resolution. For radiochemistry purposes the department has access to five on-site cyclotrons and, apart from the usual radiochemistry facilities, is equipped with a fully GMP compliant hotlab with 12 hotcells. For clinical research, the department closely collaborates with the Department of Neurology of VUmc, with research lines focussing on Alzheimer’s disease (AD), Parkinson’s disease (PD) and Multiple Sclerosis (MS). The VUmc has large dedicated AD (Director: Prof. Dr. P. Scheltens) and MS (Director: Prof. Dr. C. Polman) centres.

Main tasks
Research themes of the department include chemical development of new PET radiotracers, development of new quantitative tracer kinetic PET procedures, use of PET in drug development and evaluation, use of PET for pathophysiological studies in neurology, and assessment of existing PET tracers for both diagnosis and monitoring response to treatment.

Participation in INMiND: WP3 (leader) / WP7 (leader) / WP8 / WP10 / WP12.

Previous experience relevant to INMiND tasks

The Department of Radiology & Nuclear Medicine has extensive experience in the use of PET tracers of neuroinflammation in healthy subjects (aging) and patients with neurodegenerative disorders, in particular AD and minimal cognitive impairment. Previous research has led to a PhD thesis on neuroinflammation in Alzheimer’s disease (2012) and another 2 PhD theses in 2015, one on methodology and the other on neuroinflammation in traumatic brain injury. The principal investigator has been workpackage leader in several concerted actions since the introduction of European Framework Programmes.

VU University Amsterdam
VU University Medical Centre
Prof Albert Windhorst
INMiND Office
European Institute for Molecular Imaging (EIMI) Waldeyerstr. 15
· 48149 Münster
Tel: +49 251 83 49300 · Fax: +49 251 83 49313