Further Affiliation at the University of MünsterCenter for Soft NanoscienceDoctoral AbstractThesis(-)-Sparteine-Induced Enantioselective Homoaldol Reactions and Their ApplicationsSupervisorsHoppe, Dieter>Doctoral SubjectChemieDoctoral DegreeDr. rer. nat.Awarded byDepartment 12 – Chemistry and PharmacyProjectsGeneration of 3D Bioprinted Gradient, Chiral, and Stimuli-Responsive Nanocomposite Hydrogels as Multifunctional Biomaterials for Cell-Biomaterial Interaction Studies (2018 – 2021)Individual Granted Project: DFG - Individual Grants Programme | Project Number: KE 1577/7-2Synthesen von Nanokomposit-Hydrogelen mit enanantioselektiv funktionalisierten nanoskaligen Objekten und die Wirkung der Stereochemie der Oberflächen auf das Verhalten der Zellen (2015 – 2018)Individual Granted Project: DFG - Individual Grants Programme | Project Number: KE 1577/7-1Synthesis of new nanocomposite hydrogels through hostguest interaction of nanoparticles with polymers (2010 – 2012)Own Resources ProjectCRC TRR 61 A01 - Photo- and electroresponsive molecules and polymers in nanochannels (2008 – 2012)Subproject in DFG-Joint Project Hosted at the University of Münster: DFG - Collaborative Research Centre | Project Number: INST 211/444-1:2Publications 202120202019201820172016201520142013201220112010200920082007200520042003200220012021Rizzo, . and Kehr, ., 2021. Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery: Advanced Healthcare Materials, 10(1), p. 2001341. doi: 10.1002/adhm.202001341.2020Kehr, A.M., 2020. Injectable Oxygen-Generating Nanocomposite Hydrogels with Prolonged Oxygen Delivery for Enhanced Cell Proliferation under Hypoxic and Normoxic Conditions: Journal of Materials Chemistry B, 2020 doi: 10.1039/D0TB00885K.Motealleh, ., Czieborowski, ., Philipp, ., Nowak, . and Kehr, .S., (in press) Bifunctional Nanomaterials for Enhanced Cell Proliferation and for the Reduction of Bacterial Bioluminescence/Fitness: Adv. Mater. Interfaces, 2020Motealleh, ., Dorri, . and Kehr, .S., 2020. Injectable Polymer/Nanomaterial Composites for the Fabrication of Three-Dimensional Biomaterial Scaffolds: Biomed. Mater, 2020 doi: 10.1088/1748-605X/ab82ea.Schlicke, ., Hoffmann, ., Lorenz, ., Schönhoff, . and Cramer, ., 2020. Ionic Conductivity Enhancement of Polyelectrolyte Multilayers by Variation of Charge Balance: Journal of Physical Chemistry C, 124(31), pp. 16773–16783. doi: 10.1021/acs.jpcc.0c03043.Motealleh, . and Kehr, .S., (in press) Directed vertical cell migration via bifunctionalized nanomaterials in 3D step-gradient nanocomposite hydrogels: Biomater. Sci., 2020 doi: 10.1039/d0bm01133a.2019Kehr, .S., 2019. Periodic Mesoporous Organosilica-Based Nanocomposite Hydrogels for Enhanced Cell Adhesion in 3D Hydrogel Network: Journal of Applied Biological Sciences, 13, pp. 133–137.Nureddin Ashammakhi, M.A., Nermin Seda Kehr, A.E., Shau-Kai Hu, M.R. and Ali S. Nasr, A.K., 2019. “Advances in Controlled Oxygen-Generating Biomaterials for Tissue Engineering and Regenerative Therapy: Biomacromolecules, 21, pp. 56–72.Tutar, ., A.Motealleh and Kehr*, A.a., 2019. Functional Nanomaterials on 2D Surfaces and in 3D Nanocomposite Hydrogels for Biomedical Applications: Advanced Functional Materials, 2019Motealleh, ., Celebi-Saltik, ., Ermis, ., Nowak, ., Khademhosseini, . and Kehr, .S., 2019. 3D Printing of Step-Gradient Nanocomposite Hydrogels for Controlled Cell Migration: Biofabrication, 11(4), p. 045015. doi: 10.1088/1758-5090/ab3582.Nureddin Ashammakhi, M.A., Nermin Seda Kehr, A.E., Shau-Kai Hu, M.R. and Ali S. Nasr, A.K., 2019. Advances in Controlled Oxygen-Generating Biomaterials for Tissue Engineering and Regenerative Therapy: Biomacromolecules, -Motealleh, ., Marco, .De. and Kehr, a.N., 2019. Stimuli-responsive Local Drug Molecule Delivery to Adhered Cells in a 3D Nanocomposite Scaffold: J. Mater. Chem. B., DOI: 10.1039/C9TB00591A doi: 10.1039/C9TB00591A.Motealleh, ., Dorri, . and Kehr, .S., 2019. Self Assembled Monolayers of Chiral Periodic Mesoporous Organosilica as Stimuli Responsive Local Drug Delivery System: J. Mater. Chem. B., 7, pp. 2362–2371.Motealleh, ., Dorri, ., Schäfer, .H. and Kehr, .S., 2019. 3D Bioprinting of Triphasic Nanocomposite Hydrogels and Scaffolds for Cell Adhesion and Migration: Biofabrication, doi.org/10.1088/1758-5090/ab15ca doi: 10.1088/1758-5090/ab15ca.2018Motealleh, ., Hermes, ., Jose, . and Kehr, ., 2018. Chirality-dependent cell adhesion and enrichment in Janus nanocomposite hydrogels: Nanomedicine: Nanotechnology, Biology and Medicine, 14(2), pp. 247–256. doi: 10.1016/j.nano.2017.10.014.2017N., K., 2017. Janus enantiomorphous nanomaterial assembly on substrate surfaces for chirality-dependent cell adhesion: Colloids and Surfaces B: Biointerfaces, 159(null), pp. 125–130. doi: 10.1016/j.colsurfb.2017.07.062.Kehr, . and Motealleh, ., 2017. Nanocomposite (Janus) paper as 3D cell culture system: Colloids and Surfaces B: Biointerfaces, 156, pp. 236–242. doi: 10.1016/j.colsurfb.2017.05.010.Motealleh, . and Kehr, ., 2017. Janus nanocomposite hydrogels for chirality-dependent cell adhesion and migration: ACS applied materials & interfaces, 9(39), pp. 33674–33682. doi: 10.1021/acsami.7b10871.Kehr, . and Jose, ., 2017. Chirality-dependent cellular uptake of chiral nanocarriers and intracellular delivery of different amounts of guest molecules: Applied Surface Science, 425, pp. 432–439. doi: 10.1016/j.apsusc.2017.07.052.2016Ergün, ., De Cola, ., Galla, . and Kehr, ., 2016. Surface-Mediated Stimuli Responsive Delivery of Organic Molecules from Porous Carriers to Adhered Cells: Advanced Healthcare Materials, 5(13), pp. 1588–1592. doi: 10.1002/adhm.201600098.N., K., 2016. Enantiomorphous Periodic Mesoporous Organosilica-Based Nanocomposite Hydrogel Scaffolds for Cell Adhesion and Cell Enrichment: Biomacromolecules, 17(3), pp. 1117–1122. doi: 10.1021/acs.biomac.5b01739.Seda, K.N. and Riehemann, ., 2016. Controlled Cell Growth and Cell Migration in Periodic Mesoporous Organosilica/Alginate Nanocomposite Hydrogels: Advanced Healthcare Materials, 5(2), pp. 193–197. doi: 10.1002/adhm.201500638.Kehr, ., Motealleh, . and Schäfer, ., 2016. Cell Growth on (“Janus”) Density Gradients of Bifunctional Zeolite L Crystals: ACS applied materials & interfaces, 8(51), pp. 35081–35090. doi: 10.1021/acsami.6b13667.2015Kehr, ., Atay, . and Ergün, ., 2015. Self-assembled monolayers and nanocomposite hydrogels of functional nanomaterials for tissue engineering applications: Macromolecular Bioscience, 15(4), pp. 445–463. doi: 10.1002/mabi.201400363.Kehr, ., Galla, ., Riehemann, . and Fuchs, ., 2015. Self-assembled monolayers of enantiomerically functionalized periodic mesoporous organosilicas and the effect of surfacechirality on cell adhesion behaviour: RSC Advances, 5(8), pp. 5704–5710. doi: 10.1039/C4RA11451E.2014Mauro, ., Aliprandi, ., Septiadi, ., Kehr, . and De Cola, ., 2014. When self-assembly meets biology: Luminescent platinum complexes for imaging applications: Chemical Society Reviews, 43(12), pp. 4144–4166. doi: 10.1039/c3cs60453e.Kehr, ., Ergün, ., Lülf, . and De Cola, ., 2014. Spatially controlled channel entrances functionalization of zeolites l: Advanced Materials, 26(20), pp. 3248–3252. doi: 10.1002/adma.201305745.Benson, ., Galla, . and Kehr, ., 2014. Cell adhesion behavior in 3D hydrogel scaffolds functionalized with D - Or L -aminoacids: Macromolecular Bioscience, 14(6), pp. 793–798. doi: 10.1002/mabi.201300485.2013Kehr, ., Prasetyanto, ., Benson, ., Ergün, ., Galstyan, . and Galla, ., 2013. Periodic mesoporous organosilica-based nanocomposite hydrogels as three-dimensional scaffolds: Angewandte Chemie International Edition, 52(4), pp. 1156–1160. doi: 10.1002/anie.201206951.Glotzbach, ., Kauscher, ., Voskuhl, ., Kehr, ., Stuart, ., Frohlich, ., Galla, ., Ravoo, ., Nagura, ., Saito, ., Yamaguchi, . and Wurthwein, E.-U., 2013. Fluorescent modular boron systems based on NNN- and ONO-tridentate ligands: Self-assembly and cell imaging: Journal of Organic Chemistry, 78(9), pp. 4410–4418. doi: 10.1021/jo4003745.2012Benson, ., Prasetyanto, ., Galla, H.-J. and Kehr, ., 2012. Self-assembled monolayers of bifunctional periodic mesoporous organosilicas for cell adhesion and cellular patterning: Soft Matter, 8(42), pp. 10845–10852. doi: 10.1039/c2sm26563j.Versluis, ., Voskuhl, ., Stuart, ., Bultema, ., Kehr, ., Ravoo, . and Kros, ., 2012. Power struggles between oligopeptides and cyclodextrin vesicles: Soft Matter, 8(33), pp. 8770–8777. doi: 10.1039/c2sm26090e.Fisher, ., Larson, ., Hill, ., Graupner, ., Nguyen-Kim, ., Kehr, ., De Cola, ., Langer, . and Anderson, ., 2012. Melanin-like hydrogels derived from gallic macromers: Advanced Materials, 24(22), pp. 3032–3036. doi: 10.1002/adma.201104437.Ruiz-Sanchez, ., Montañez, ., Mayorga, ., Torres, ., Kehr, ., Vida, ., Collado, ., Najera, ., De Cola, . and Perez-Inestrosa, ., 2012. Dendrimer-modified solid supports: Nanostructured materials with potential drug allergy diagnostic applications: Current Medicinal Chemistry, 19(29), pp. 4942–4954. doi: 10.2174/0929867311209024942.El-Gindi, ., Benson, ., De Cola, ., Galla, . and Seda, K.N., 2012. Cell Adhesion Behavior on Enantiomerically Functionalized Zeolite L Monolayers.: Angewandte Chemie International Edition, 51, pp. 3716–3720. doi: 10.1002/anie.201109144.2011Kehr, ., El, G.J., Galla, . and De Cola, ., 2011. Click chemistry on Self-assembled Monolayer of Zeolite L Crystals by Microcontact Chemistry – Applications in Nanobiotechnologies.: Micropor.Mesopor.Mater, 144, pp. 9–14. doi: 10.1016j.micromeso.2010.11.30.2010Kehr, ., Schafer, ., Ravoo, . and De Cola, ., 2010. Asymmetric printing of molecules and zeolites on self assembled monolayers: Nanoscale, 2(4), pp. 601–605. doi: 10.1039/b9nr00285e.Kehr, ., Riehemann, ., El-Gindi, ., Schäfer, ., Fuchs, ., Galla, H.-J. and De Cola, ., 2010. Cell adhesion and cellular patterning on a self-assem bled monolayer of zeolite L crystals: Advanced Functional Materials, 20(14), pp. 2248–2254. doi: 10.1002/adfm.201000205.Devaux, ., Cucinotta, ., Kehr, . and De Cola, ., 2010. Functionalization and Assembling of Inorganic Nanocontainers for Optical and Biomedical Applications. in: P. Samorì and F. Cacialli eds. Volume 1: Functional Supramolecular Architectures: For Organic Electronics and Nanotechnology. New York City: John Wiley & Sons. pp. 281–342. doi: 10.1002/9783527689897.ch09.2009Versluis, ., Tomatsu, ., Kehr, ., Fregonese, ., Tepper, ., Stuart, ., Ravoo, ., Koning, . and Kros, ., 2009. Shape and release control of a peptide decorated vesicle through pH sensitive orthogonal supramolecular interactions.: Journal of the American Chemical Society, 131(37), pp. 13186–13187. doi: 10.1021/ja9026264.2008Lange, ., Bergander, ., Fröhlich, ., Kehr, ., Nakamura, ., Shibata, ., Toru, . and Hoppe, ., 2008. Highly enantioselective reactions of configurationally labile epimeric diamine complexes of lithiated S-benzyl thiocarbamates: Chemistry - An Asian Journal, 3(1), pp. 88–101. doi: 10.1002/asia.200700262.Nienkemper, ., Kehr, ., Kehr, ., Fröhlich, . and Erker, ., 2008. (N-Arylaminomethyl)pyridine-N-oxides: Synthesis and characterization of potential ligand systems and the formation of their N,O-chelate aluminum complexes: Journal of Organometallic Chemistry, 693(18), pp. 3063–3073. doi: 10.1016/j.jorganchem.2008.05.032.Spannhoff, ., Kehr, ., Kehr, ., Fröhlich, . and Erker, ., 2008. Functionalized phosphorus analogues of the β-diketiminato ligand systems: Bis(N-arylphosphinimino)acetonitrile-derived complexes of rhodium and iridium: Dalton Transactions, null(25), pp. 3339–3344. doi: 10.1039/b802032a.2007Spies, ., Kehr, ., Kehr, ., Fröhlich, . and Erker, ., 2007. Formation and structural and dynamic features of atropisomeric η2-iminoacyl zirconium complexes: Organometallics, 26(23), pp. 5612–5620. doi: 10.1021/om7005968.Kehr, . and Luftmann, ., 2007. Polymer characterization by electrospray-mass-spectrometry - Shifting the upper mass limit: e-polymers, null(null), pp. 1–2.2005Özlügedik, ., Ünaldi, ., Wibbeling, . and Hoppe, ., 2005. Synthesis of enantioenriched trans-fused bicyclo[4.4.0]-dec-3-enes and bicyclo[4.3.0]non-3-enes bearing a 1,5-lactone bridge: Advanced Synthesis and Catalysis, 347(null), pp. 1627–1631. doi: 10.1002/adsc.200505143.Ünaldi, ., Fröhlich, . and Hoppe, ., 2005. Synthesis of enantioenriched and diastereomerically pure cis-fused bicyclic α-oxy-substituted γ-lactones via epoxidation of optically active homoaldol products: Synthesis, null(15), pp. 2507–2520. doi: 10.1055/s-2005-872080.Unaldi, ., Ozlugedik, ., Frohlich, . and Hoppe, ., 2005. Diastereoselective synthesis of enantioenriched, annulated tetrahydrofurans by simultaneous formation of the O-1-C-5 and the C-5-C-4 bonds: Advanced Synthesis and Catalysis, 347(11-13), pp. 1621–1626. doi: 10.1002/adsc.200505142.Kalkofen, ., Brandau, ., Unaldi, ., Frohlich, . and Hoppe, ., 2005. Enantio- and diastereoselective synthesis of highly substituted acylcyclopropanes from homoaldol products by stereospecific homoallylic cyclization: European Journal of Organic Chemistry, 2005(21), pp. 4571–4580. doi: 10.1002/ejoc.200500283.2004Sierra, ., Kehr, ., Fröhlich, . and Erker, ., 2004. A fulvene route to group 4 metallocene complexes bearing 4,7-bis(dimethylamino)-substituted indenyl ligands: European Journal of Inorganic Chemistry, null(11), pp. 2260–2265. doi: 10.1002/ejic.200300799.2003Ünaldi, ., Aumann, . and Fröhlich, ., 2003. C-Cα insertion: Insertion of an alkyne into the C-C single bond between the carbene-carbon atom and the α-carbon atom of a fischer carbene complex by an unprecedented metalla(di-π-methane) skeletal rearrangement: Chemistry - A European Journal, 9(14), pp. 3300–3309. doi: 10.1002/chem.200304767.2002Altundas, ., Dastan, ., Ünaldi, ., Güven, ., Uzun, . and Balci, ., 2002. The di-π-methane photorearrangement of 2,3-disubstituted benzobarrelenes and benzonorbornadiene - Substituent effects in regioselectivity: European Journal of Organic Chemistry, null(3), pp. 526–533.2001Ünaldi, N.S. and Balci, M., 2001. Substituent effect on regioselectivity in the di-π-methane rearrangement: synthesis of disubstituted benzobarrelene derivatives and their photochemistry: Tetrahedron Letters, 42, pp. 8365–8367. doi: 10.1016/S0040-4039(01)01770-1.