Guentner, Willet and Yu defined a notion of dynamic asymptotic dimension for an etale groupoid that can be used to bound the nuclear dimension of its groupoid C*-algebra. To have finite dynamic asymptotic dimension, the isotropy subgroups of the groupoid must be locally finite. I will discuss 1) how to use similar ideas to bound the nuclear dimension of the C*-algebra of a groupoid with `large' isotropy subgroups and 2) the limitations of that approach. In an application to the C*-algebra of a directed graph, if the C*-algebra is stably finite, then its nuclear dimension is at most 1. This is joint work with Dana Williams.