Prof. Dr. Dr. Sven G. Meuth
NO POSITIONS VIA CiM-IMPRS IN 2021
TRESK ion channels in autoimmune neuroinflammation
Blood-brain barrier
Neuroimmunology
Ion channels
Multiple sclerosis is a chronic inflammatory autoimmune disorder of the central nervous system with heterogeneous clinical presentation. Autoreactive T lymphocytes are thought to play a central role and ion channels function as regulators of fundamental processes of the immune system. The principal aim of this study is to investigate the role of the K2P channel TRESK in pathophysiological T cell migration from thymus via peripheral blood to the central nervous system. Generally, TRESK displays unique biological and biophysical properties different from “classical” potassium channels on T lymphocytes predicting not only a key role for T lymphocyte effector functions but also for thymic T lymphocyte differentiation. Different genetically modified mice will be used to dissect the exact functional role of TRESK channels both in vivo and in vitro. Molecular biological and immunological tools, animal models of autoimmune neuroinflammation and human samples will be used to obtain knowledge about the implications of TRESK channels and to address the following objectives:
1) Influence for T lymphocyte effector functions and migration
2) Impact on thymic regulatory T cell development and regulatory T cell functions
3) Relevance of TRESK function in animal models of autoimmune neuroinflammation
4) Role in the human immune system
Vita
- 1997 – 2004: Medicine, University of Magdeburg, Germany
- 2000 – 2004: Neurobiology, University of Magdeburg, Germany
- April 2004: Dr. med. Degree. (Supervisor: Prof. Thomas Budde)
- 2004 – 2005: Stay abroad at UT Southwestern Medical Center, Dallas, Texas, USA
- March 2007: Dr. rer. nat. Degree (Supervisor: Prof. Hans-Christian Pape)
- 2004 - 2010: Postdoctoral Fellow and Resident, Department of Neurology, University of Würzburg (Prof. Klaus Viktor Toyka / Prof. Heinz Wiendl)
- 2009 – 2011: Open University Degree “Master of Health Business Administration”
- 2013 - 2016: Full Professor, Institute of Physiology – Neuropathophysiology, WWU Münster
- Since 2013: Full Professor, Department of Neurology, University Clinic Münster
- Since 2016: Director of the Institute for Translational Neurology, University Clinic Münster
- 2017 – 2019: Vice Dean, Medical Faculty, WWU Münster
- March 2019- November 2019: Dean, Medical Faculty, WWU Münster
Selected references
Mykicki N, Herrmann AM, Schwab N, Deenen R, Sparwasser T, Limmer A, Wachsmuth L, Klotz L, Kohrer K, Faber C, Wiendl H, Luger TA, Meuth SG and Loser K. (2016). Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease. Sci Transl Med, 8, 362ra146.
Gobel K, Pankratz S, Asaridou CM., Herrmann AM., Bittner S, Merker M, Ruck T, Glumm S, Langhauser F, Kraft P, Krug TF, Breuer J, Herold M, Gross CC, Beckmann D, Korb-Pap A, Schuhmann MK, Kuerten S, Mitroulis I, Ruppert C, Nolte MW, Panousis C, Klotz L, Kehrel B, Korn T, Langer HF, Pap T, Nieswandt B, Wiendl H, Chavakis T, Kleinschnitz C and Meuth SG. (2016). Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells. Nat Commun, 7, 11626.
Bittner S, Ruck T, Schuhmann MK, Herrmann AM, Moha ou Maati H, Bobak N, Gobel K, Langhauser F, Stegner D, Ehling P, Borsotto M, Pape HC, Nieswandt B, Kleinschnitz C, Heurteaux C, Galla HJ, Budde T, Wiendl H and Meuth SG. (2013). Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS. Nat Med, 19, 1161-1165.
Meuth SG, Budde T, Kanyshkova T, Broicher T, Munsch T and Pape HC. (2003). Contribution of TWIK-related acid-sensitive K+ channel 1 (TASK1) and TASK3 channels to the control of activity modes in thalamocortical neurons. J Neurosci, 23, 6460-6469.
Budde T, Meuth S and Pape HC. (2002). Calcium-dependent inactivation of neuronal calcium channels. Nat Rev Neurosci, 3, 873-883.