Dr. Mariano Malamud Guillan
Myeloid inhibitory receptors as central regulators of chronic inflammation
Immunology
Inflammation
Innate immunity
Inhibitory receptors
Regulation of inflammatory responses is essential for maintaining homeostasis, and its disruption is a key driver of chronic inflammatory and autoimmune diseases. Innate inhibitory receptors play a central role in restraining excessive immune activation by modulating the signalling and function of myeloid cells. Genetic loss or functional impairment of these germline-encoded receptors is often linked with uncontrolled inflammation, tissue damage, and exacerbated disease pathology.
Our research aims to elucidate the role of a recently discovered inhibitory receptor in controlling immune responses under conditions of metabolic dysregulation. Metabolic stress, as observed in obesity and cardiovascular disease, profoundly alters immune cell function and promotes chronic low-grade inflammation. We study how inhibitory receptor signalling modulates myeloid cell activation and inflammatory reprogramming in these settings. By integrating in vivo disease models with cellular and molecular approaches, we seek to define how inhibitory pathways maintain immune balance during cardiometabolic inflammation. Ultimately, this research will provide fundamental insights into immune regulation and may identify novel therapeutic strategies to limit inflammation-driven disease.
Vita
- 2009-2014 Studies in Biochemistry, Universidad Nacional de La Plata, Argentina
- 2015-2019 PhD in Biological Sciences: Universidad Nacional de La Plata, Argentina
- 2020-2021 Postdoctoral Research Fellow, Universidad Nacional de La Plata, Argentina
- 2021-2025 Postdoctoral Research Fellow, MRC Centre for Medical Mycology,
University of Exeter, UK - Since 2025 Group Leader, Institute of Experimental Pathology, University of Münster
Selected references
Malamud M*, Brown GD. The Dectin-1 and Dectin-2 clusters: C-type lectin receptors with fundamental roles in immunity. EMBO Rep. (2024). doi: 10.1038/s44319-024-00296-2. PMID: 39482490
Malamud M, Whitehead L, McIntosh A, Colella F, Roelofs AJ, Kusakabe T, Dambuza IM, Phillips-Brookes A, Salazar F, Perez F, Shoesmith R, Zakrzewski P, Sey EA, Rodrigues C, Morvay PL, Redelinghuys P, Bedekovic T, Fernandes MJG, Almizraq R, Branch DR, Amulic B, Harvey J, Stewart D, Yuecel R, Reid DM, McConnachie A, Pickering MC, Botto M, Iliev ID, McInnes IB, De Bari C, Willment JA and Brown GD. Recognition and control of neutrophil extracellular trap formation by MICL. Nature (2024). https://doi.org/10.1038/s41586-024-07820-3
Malamud M, Cavallero GJ, Casabuono AC, Lepenies B, Serradell MLÁ, Couto AS. Immunostimulation by Lactobacillus kefiri S-layer proteins with distinct glycosylation patterns requires different lectin partners. J Biol Chem. 2020 Oct 16;295(42):14430-14444. doi: 10.1074/jbc.RA120.013934
Malamud M, Carasi P, Assandri MH, Freire T, Lepenies B, Serradell MLÁ. S-Layer Glycoprotein From Lactobacillus kefiri Exerts Its Immunostimulatory Activity Through Glycan Recognition by Mincle. Front Immunol. 2019 Jun 26;10:1422. doi: 10.3389/fimmu.2019.01422