© CiM-IMPRS

14th Interdisciplinary Graduate School Meeting

Breaking the Frontiers: Modern Perspectives in Life Science
30 September to 2 October, 2020
  • Conference programme

    Wednesday 30.09.2020

    14:00-14:30 Welcome

    14:30-19:00 Session 1 – Biology

    Time Topics and speakers
    14:30-15:30 Keynote: Molecular Mechanism of Cytokinesis
    Prof. Thomas D. Pollard, Department of Molecular Cellular and Developmental Biology, Yale University, USA
    15:30-16:00 Blastoids – Blastocyst-like Structures Generated Solely From Stem Cells
    Dr. Nicolas Rivron, Austrian Academy of Sciences, IMBA - Institute of Molecular Biotechnology, Austria
    16:00-16:30 Q&A Session & Coffee Break
    16:30-17:00 Dynamizing Nuclear Actin Filaments in Cell Division
    Prof. Robert Grosse, Experimental and clinical pharmacology and toxicology, Freiburg University, Germany
    17:00-17:30 Young Investigator Talk: Excluding Oct4 From Yamanaka Cocktail Unleashes the Developmental Potential of iPSCs
    Sergiy Velychko from Professor Dr. Hans R. Schöler's lab, Max Planck Institute for Molecular Biomedicine, Germany
    17:30-18:00 Identifying Chromatin Regulators at Specific Genomic Loci
    Prof. Sylvia Erhardt, Center for Molecular Biology, Heidelberg University, Germany
    18:00-18:30 Q&A Session
    18:30-19:00 Closing Remarks for the Day

    Thursday 01.10.2020

    09:00-13:00 Session 2 – Biology

    Time Topics and speakers
    09:00-10:00 Keynote: The Vascular Barrier – What We Know and Why It’s Important
    Prof. Lena Claesson-Welsh, Vascular Biology, Uppsala University, Sweden
    10:00-10:30 Quantifying Material Properties of Living Matter and How These Relate to Biological Function
    Prof. Lene B Oddershede, Optical Tweezers Group, Niels Bohr Institute, University of Copenhagen, Denmark
    10:30-11:00 Q&A Session & Coffee Break
    11:00-11:30 Young Investigator Talk: Master Mitotic Kinases Regulate HPV16 Nuclear Delivery During Mitosis
    Matteo Rizzato from Prof. Dr. Mario Schelhaas's lab, Institute for Cellular Virology, Münster University, Germany
    11:00-11:30 Young Investigator Talk: Master Mitotic Kinases Regulate HPV16 Nuclear Delivery During Mitosis
    Matteo Rizzato from Prof. Dr. Mario Schelhaas's lab, Institute for Cellular Virology, Münster University, Germany
    11:30-12:00 Young Investigator Talk: PECAM-1 Mediates Leukocyte Diapedesis by Triggering Dephosphorylation of VE-Cadherin-Y731
    Nida Arif from Prof. Dr. Dietmar Vestweber's lab, Max Planck Institute for Molecular Biomedicine, Germany
    12:00-12:30 Tolerance to Aneuploidy
    Prof. René Medema, Cell division and Cancer, Netherlands Cancer Institute, Netherlands
    12:30-13:00 Q&A Session

    13:00-14:00 Lunch Break

    14:00-19:00 Session 3 – Biophysics

    Time Topics and speakers
    14:00-15:00 Keynote: Engineering 3D Cultures of Physiology and Disease – How Simple is Complex Enough?
    Prof. Christopher Chen, Tissue Microfabrication Lab, Boston University & Harvard University, USA
    15:00-15:30 Young Investigator Talk: Synthetic Extracellular Matrices With Tailored Properties Support Lumen Formation During Angiogenic Sprouting
    Jifeng Liu from Dr. Britta Trappmann's lab, Max Planck Institute for Molecular Biomedicine, Germany
    15:30-16:00 Active Cell Deformation Through Actin Assembly, and How We May Infer Nucleus Deformation
    Dr. Cécile Sykes, Institute Curie PSL Paris, Sorbonne University, France
    16:00-17:00 Coffee Break & Poster Session
    17:00-17:30 Intravascular Tracking of Tumor Metastasis
    Dr. Jacky Goetz, Lab for Tumor Biomechanics, INSERM Institut d’Hématologie et d’Immunologie Strasbourg, France
    17:30-18:00 Deep Learning-Based Point-Scanning Super-Resolution Microscopy
    Prof. Uri Manor, Biophotonics Core Facility, Salk Institute for Biological Studies, USA
    18:00-18:30 Q&A Session
    18:30-19:00 Closing Remarks for the Day

    Friday 02.10.2020

    10:00-13:00 Session 4 – Biochemistry

    Time Topics and speakers
    10:00-11:00 Keynote: Synthetic Protobiology – The Chemistry of Life-like Objects
    Prof. Stephen Mann, Bristol Centre for Functional Nanomaterials, University of Bristol, UK
    11:00-11:30 Spatiotemporal Control Over Adhesions in Synthetic Cells Using Light
    Prof. Seraphine Wegner, Institute for Physiological Chemistry and Pathobiochemistry, Münster University, Germany
    11:30-12:00 Phthalocyanine-Based Photosensitizers and Their (Soft) Nanostructures for Photo-Antimicrobial Applications
    Dr. Anzhela Galstyan, Center for Soft Nanoscience, Münster University, Germany
    12:00-12:30 Molecularly Engineered Nanobiomaterials to Understand and Control Biology
    Dr. Helena Azevedo, School of Engineering and Materials Science and Institute of Bioengineering, Queen Mary University of London, UK
    12:30-13:00 Q&A Session

    13:00-14:00 Lunch Break

    14:00-16:30 Session 5 – Bioinformatics/Mathematics

    Time Topics and speakers
    14:00-14:30 Prediction and Design of Biological Sequences with Neural Machines
    Prof. Debora Marks, Department of Systems Biology, Harvard Medical School, USA
    14:30-15:00 Modeling Cellular Response in Time and Space
    Prof. Fabian Theis, Institute of Computational Biology, Helmholtz Zentrum München, Germany
    15:00-15:30 Suggestions From Mathematics for the Functioning of Flatworm Regeneration
    Prof. Angela Stevens, Institute for Applied Mathematics: Analysis and Numerics, Münster University, Germany
    15:30-16:00 Q&A Session
    16:00-16:30 Final Closing Remarks

  • Speakers

    • Prof. Thomas D. Pollard’s research focuses on understanding cell motility through the study of actin filaments and myosin motors. His lab uses a combination of biochemistry, biophysics, microscopy and fission yeast genetics to investigate the molecular basis of cellular motility and cytokinesis.
    • Dr. Nicolas Rivron’s lab is seeking to understand the general principles underlying the organization of stem cells in the early developmental phase of organisms. To study these principles, they use model organisms (Blastoids) that were created by harnessing the intrinsic potential of stem cells to self-organize which allows to systematically modulate and analyse their behavior. Their main focus is to generate more such embryo models for drug and genetic screens, biochemistry and genomic analysis.
    • Prof. Robert Grosse investigates the role of cytoskeletal proteins such as formin in cell motility, tumor progression and metastasis. His lab is also interested in discovering how actin network formation and organization drives cellular behaviors, such as polarization, invasion, mitotic spindle formation, chromosome congression and the effect of intracellular signaling on cellular morphology and dynamics.
    • Prof. Sylvia Erhardt’s research focuses on understanding the epigenetic mechanisms specifying centromere identity and aims to elucidate how these mechanisms are linked to chromosome segregation and cell cycle progression.
    • Prof. Lena Claesson-Welsh’s research focus lies in the molecular mechanisms of endothelial cell biology, particularly angiogenesis and its link to cancer metastasis, VEGF signal transduction, vessel permeability and tissue homeostasis.
    • Prof. Lene B Oddershede’s lab investigates physical properties of biological systems at levels ranging from the single molecule to the whole cell with a particular interest in stem cells. Her lab uses single particle tracking, fluorescence, sub-diffraction techniques and their state-of-the-art force-scope optical tweezers to study nanoparticle plasmonics.
    • Dr. Alex Bird’s group investigates the function and regulation of microtubule networks in context to mitosis, migration and neuritogenesis. One of the major aims of his research is to uncover the regulatory mechanisms and pathways that guide the formation function of the mitotic spindle to ensure genome stability.
    • Prof. René Medema studies the molecular mechanisms of cell division. His lab works on understanding cell recovery from DNA damage and aims to use this knowledge in designing efficient anti-cancer drugs. They are also interested in studying the role of establishment of the correct balance of forces during bipolar spindle assembly, which is required to segregate chromosomes during cell division.
    • Prof. Christopher Chen is interested in cellular interactions, especially the cooperation between mechanical and biochemical signaling in the regulation of angiogenesis and stem cell biology. His lab studies tissue vascularization, connective tissues and cancer using micro- and nanofabrication tools.
    • Prof. Cécile Sykes studies Biomimetism of cell movement and approaches the biological problems using the principles of soft matter physics. Her team focuses mainly on the underlying mechanisms of cell division and motility that would expand the knowledge about cancer invasion and metastasis. With a combination of in-vitro biomimetic systems and in-vivo cellular and animal models ranging from nematode worms to mouse oocytes, her research provides answers to many physical and biochemical mechanisms governing cell shape change and movement.
    • Having developed the unique intravital CLEM (Correlative Light and Electron Microscopy) technology, Dr. Jacky Goetz’s lab tracks intravascular tumor metastasis and are keen on understanding the molecular and cellular mechanisms driving metastasis formation. They are also examining the role of mechanical forces in tumor invasion and the fate and function of tumor exosomes on local and distant microenvironment during the priming of metastatic niches.
    • The primary focus of Prof. Uri Manor is the integration and application of optical and charged particle detection technologies to investigate problems of critical biological significance. He is focused on developing deep learning-based computational approaches to increase the resolution, sensitivity and speed of next generation microscopes, as well as designing nanoprobes for high spatiotemporal resolution imaging of subcellular dynamics. His main biological interests are organelle-organelle contacts, cytoskeletal dynamics, mitochondria, sensorineural hearing loss and neurodegeneration.
    • Prof. Stephen Mann is the founder of biomimetic chemistry and is distinguished for his contributions to biomineralization, bioinspired materials chemistry, self-assembly of functional nanostructures and hybrid nanoscale objects. His current research focus includes, the chemical synthesis, characterization and emergence of complex organized matter, including models of protocell assembly.
    • Prof. Seraphine Wegner is interested in light-controlled systems, especially the spatiotemporal control of cell-material and cell-cell interactions and associated processes in natural and synthetic minimal cells by using visible light. Her lab focuses on addressing questions in cell biology to better engineer new synthetic minimal cells, which reduces the complexity despite retaining the key features of a cell, allowing to quantify and correlate cell behavior with their molecular information.
    • Dr. Helena Azevedo engineers molecules for biomedical application. She uses supramolecular chemistry to program macromolecules to self-assemble into biologically active structures to understand the energy pathways required for this self-assembly.
    • Prof. Debora Marks and her lab develop computational methods for interpreting genetic variation with a focus on biomedical applications. To this end they have developed tools to predict 3D structures of RNAs, RNA-protein complexes and proteins from genomic sequence data. The current focus of her lab lies in developing methods in deep learning to address a wide range of biological challenges including the prediction of the effects of genetic variation and sequence design for biosynthetic applications.
    • The research focus of Prof. Fabian Theis’s lab includes using computational methods for analyzing and modelling single cell heterogeneities with a focus on machine learning approaches and predictive algorithms applied to biological and biomedical questions. This includes the development of tools for scRNA-Seq Analysis, predicting perturbation effects in scRNA-Seq data and analysing and interpreting RNA Velocity.
    • Prof. Angela Stevens is particularly interested in mathematical modelling in biology and medicine, where she analyses developmental processes and cell motility. Her work combines rigorous mathematical research with challenging problems in the life sciences.
© CiM-IMPRS

13th Interdisciplinary Graduate School Meeting

Horizons in biology: beyond the biological borders
Münster, 24–26 April 2019

  • Conference programme

    Wednesday, 24.04.2019

    09:00 Registration
    11:30 Lunch
    12:15 Opening remarks

    Morphogenesis session

    12:30 Keynote: Phase segregation of ooplasm and yolk granules in zebrafish oocytes is mediated
    by periodic bulk actin polymerization waves
    Carl-Philipp Heisenberg, Klosterneuburg/Austria
    13:30 Imaging How Cells Choose their Fate, Shape and Position to Form the
    Mammalian Embryo
    Nicolas Plachta, Singapore
    14:10 Coffee break

    Morphogenesis session

    14:40 Connections for vision
    Iris Salecker, London/UK
    15:20 Investigating neuronal cell fate in vivo in the developing vertebrate retina
    Leanne Godinho, Munich/Germany

    Poster session

    16:00 Students will present their projects in form of posters.

    Chemistry session

    17:00 DNA origami tools to explore biological processes
    Barbara Sacca, Essen/Germany

    Evening Program

    18:45 Dinner and city tour

    Thursday, 25.04.2019

    Cell biology session

    9:00 Frank Edenhofer, Innsbruck/Austria
    9:40 Binding of surface-associated antigen causes plasma membrane wounding
    and repair in B lymphocytes, a process that promotes BCR activation
    Norma Andrews, College Park/USA
    10:20 The Impact of organelle size control on a physiological function: Weibel-Palade Bodies and
    Haemostasis
    Daniel Cutler, London/UK
    11:00 Coffee break

    Cell biology session

    11:30 Information content of intracellular patterns
    Wu Min, Singapore
    12:10 Molecular control of actomyosin contractility and morphogenesis in epithelia
    Andreas Wodarz, Cologne/Germany
    12:50 Lunch

    Cell dynamics session

    13:50 The conserved Myosin 1D controls multiscale chirality in Drosophila
    Stephane Noselli, Nice/France
    14:30 Leukocyte transendothelial migration: the endothelium in control
    Jaap van Buul, Amsterdam/Netherlands
    15:10 Dynamics and mechanics of collective cancer cell migration
    Andrew Clark, Paris/France
    15:50 Coffee break

    Cell dynamics & biophysics session

    16:20 Keynote: Mechanosensing Depletion Drives Regeneration and Cancer
    Michael Sheetz, Singapore
    17:20 Mechanosensitivity and microtubule-dependent regulation of integrin-mediated adhesions
    Alexander D. Bershadsky, Singapore
    18:00 Reconstitution of the steady state of dynamic actin networks
    Laurent Blanchoin, Grenoble/France
    18:40 Physics of epithelial flows and folds
    Guillaume Salbreux, London/UK

    Evening Program

    20:15 Social event

    Friday, 26.04.2019

    Chemistry session

    8:20 Regulation of lipid droplet - endoplasmic reticulum membrane contacts by seipin
    Elina Ikonen, Helsinki/Finland

    Genomics session

    9:00 Mass spectrometry for cell signaling: from global maps to new biological insights
    Chuna Ram Choudhary, Copenhagen/Denmark
    9:40 Christoph Lippert, Berlin/Germany
    10:20 Keynote: Tracing genomic regulatory programs at single-cell resolution
    Stein Aerts, Leuven/Belgium

    Poster session

    11:20 Students will present their projects in form of posters.

    Young investigator's session

    12:20 Simulating the binding of Pioneer Transcription Factors to the nucleosome
    Jan Huertas, University of Münster/Max-Planck Institute for Molecular Biomedicine
    12:40 Cell surface functionality is triggered by endolysosomal calcium release
    Nicole Heitzig, University of Münster/Institute of Medical Biochemistry
    13:00 Endothelial Basement Membrane Laminins Affect Shear Response in Resistance Arteries by Modulating Communication between Endothelium and Smooth Muscle
    Anna-Liisa Luik, University of Münster/Institute for Physiological Chemistry and Pathobiochemistry
    13:20 Novel routes to holey (carbon) support films
    Philipp Selenschik, University of Münster/Institute of Medical Physics and Biophysics

    Closing ceremony

    13:40 Closing remarks and poster awards
    13:50 Lunch

© CiM

12th Interdisciplinary Graduate School Meeting

From molecules to life: a multiscale perspective of cell cynamics
Münster, 25–27 April 2018

  • Conference programme

    Wednesday, 25.04.2018

    09:00 Registration
    13:00 Opening

    Session 1: Cytoskeleton

    13:15 Reconstitution of (parts of) cell division
    Andrea Musacchio, Dortmund - Germany
    13:55 Comparative approach to understanding mitotic division
    Snezhana Oliferenko, London - UK
    14:35 Coffee break

    Session 2: Cell trafficking

    15:05 T-/B-cell interaction promoting CNS autoimmunity
    Alexander Flügel, Göttingen - Germany
    15:45 VE-cadherin endocytosis regulates cell polarity, collective cell migration, and angiogenesis during development
    Andrew P. Kowalczyk, Atlanta - USA

    Poster Session

    16:25 Students will present their projects in form of posters.

    Session 3: Ion channels

    17:25 Open Sesame...Close Sesame: Ion Channels - Key to stomatal gating
    Kavitha Sankaranarayanan, Chennai - India
    18:05 Structure and Biology of NMDA receptors
    Hiro Furukawa, New York - USA

    Evening Program

    18:45 Dinner and social event

    Thursday, 26.04.2018

    Session 4: Biomechanics

    09:20  Cell mechanoadaptation and tissue stiffening in health and disease
    Miguel Ángel del Pozo, Madrid - Spain
    10:00  Structural organisation, liquid disorder, jamming, and glassy dynamics in king penguin colonies
    Ben Fabry, Erlangen - Germany
    10:40  Real-time deformability cytometry: Mechanical phenotyping for translational applications
    Fabian Czerwinski, Greifswald - Germany
    11:20  Coffee break

    Session 5: Biochemistry

    11:50  Protein TAILS Tell Remarkable Tales: Proteomic Untangling of the Protease Web in Immunity
    Christopher Overall, Vancouver - Canada
    12:30 Circadian rhythms in immune cell trafficking and function
    Christoph Scheiermann, Munich - Germany

    Session 6: Chemistry

    14:10 Allosteric inhibitors of flaviviral NS3/NS2B proteases
    Tanja Schirmeister, Mainz - Germany
    14:50 The molecular dynamics of potassium channel permeation, selectivity and gating
    Bert de Groot, Göttingen - Germany
    15:30 Young investigator talk
    Imtiaz Ali

    Poster Session

    15:50 Students will present their projects in form of posters.

    Session 7: RNA and DNA biology

    16:50 Simulating chromatin
    Modesto Orozco, Barcelona - Spain
    17:30 Sensing the environment through tRNA modifications: T. brucei dynamically alters Queuosine levels in response to nutrient changes
    Juan Alfonzo, Columbus - USA
    18:10 Young investigator talk
    Sergiy Velychko

    Evening Program

    18:30 City tour and dinner (for speakers only)

    Friday, 27.04.2018

    Session 8: Imaging

    09:00 Collective cancer cell invasion: plasticity and interconversions
    Peter Friedl, Nijmegen - The Netherlands
    10:00 Endocytic control of mechanics, collective motion and cancer progression
    Giorgio Scita, Milan - Italy
    10:40 Coffee break

    Session 9: Imaging

    11:10 Actin regulation in healthy and diseased brain
    Pirta Hotulainen, Helsinki - Finland

    Closing Ceremony

    11:50 Closing remarks and poster awards

    Career Talks & Workshop

    13:20 Career talk
    14:30 Workshop: Huygens post-processing: the fastest road to TRUE analysis of your microscopic data
    16:30 End

© CiM-IMPRS

11th Interdisciplinary Graduate School Meeting

From cells to organisms: insights into biomolecular mechanisms
Münster, 26–28 April 2017

  • Conference programme

    Wednesday, 26.04.2017

    10:00 Registration
    12:00 Lunch (for speakers only)
    12:45 Opening remarks

    Session 1: Vasculature

    13:00  Endothelial cells in motion
    Holger Gerhardt, Berlin - Germany
    13:40  Vascular malformations: From human genetic mosaicism towards clinical trials
    Miikka Vikkula, Brussels - Belgium
    14:20  Cell mechanoadaptation: Caveolae mechanobiology and tissue biomechanics
    Miguel Ángel del Pozo Barriuso, Madrid - Spain
    15:00 Coffee break

    Session 2: Physiology

    15:30 How to use atomic-scale manipulations to study function & pharmacology of ion channels
    Stephan Pless, Copenhagen - Denmark
    16:10  The Quantum Robin: Magnetoreception in migratory birds
    Henrik Mouritsen, Oldenburg - Germany
    16:50  Optical control of synaptic signaling proteins: Photoswitchable ligands to study the function of glutamate receptors
    Andreas Reiner, Bochum - Germany

    Evening Program

    18:45 City tour and dinner (for speakers only)

    Thursday, 27.04.2017

    Session 3: Imaging and Detection Tools

    09:00  Labeling proteins on-demand with fl uorogenic probes
    Arnaud Gautier, Paris - France
    09:40  Bioelectronics: Building connections between DNA, proteins, neurons and electronics
    Andreas Offenhäusser, Jülich - Germany
    10:20  Molecular tracers for neuroinfl ammation: From synthesis to animal imaging
    Andrew Sutherland, Glasgow - UK
    11:00  Coffee break

    Session 4: Cell Migration

    11:30  Dynamic interplay between mitochondria, ER and actin filaments during mitochondrial fission
    Henry Higgs, Dartmouth - USA
    12:10 Rho GTPases: signalling in cell adhesion and migration
    Anne Ridley, London - UK
    12:50 Studying the mechanics and molecules underlying in vivo tissue invasion
    Daria Siekhaus, Klosterneuburg - Austria
    13:30 Lunch (for speakers only)

    Session 5: Biophysics

    14:30 Synthetic morphogenesis in naïve embryonic tissues
    Stefano De Renzis, Heidelberg - Germany
    15:10 A new perspective on nanoscale structure and dynamics with ultrasensitive optical microscopy
    Philipp Kukura, Oxford - UK
    15:50 From ancient lipids to synthetic life
    James Sáenz, Dresden - Germany

    Poster Session

    16:45 Students present their projects in a form of poster.

    Evening Program

    18:30 Dinner
    19:30 Social event

    Friday, 28.04.2017

    Session 6: Dynamics of the Cytoskeleton

    09:30 Forces controlling endothelial adhesion dynamics within the vasculature
    Stephan Huveneers, Amsterdam - Netherlands
    10:10 Cellular level chemotaxis and haptotaxis
    Nikolaos Sfakianakis, Mainz - Germany
    10:50 Molecular mechanisms for making tubes: anisotropies and cytoskeletal crosstalk
    Katja Röper, Cambridge - UK
    11:30 Lunch (for speakers only)

    Career Talks

    12:30 The industrial path: Insights into industrial careers
    13:00 The academical path: overview of grant application procedures and the career path

    Closing Remarks

    13:30 Closing remarks and poster awards

10th Interdisciplinary Graduate School Meeting

Insights into molecular and cellular dynamics
Münster, 11-13 May 2016

  • Conference programme

    Wednesday, 11.05.2016

    9:00 Registration
    10:45 Welcome Remarks

    Session 1: Immunology

    11:00  NETs - the second function of chromatin
    Arturo Zychlinsky (Max Planck Institute for Infection Biology)
    11:30  Retroviruses, envelopes, receptors and metabolic markers
    Marc Sitbon (The Institute of Molecular Genetics of Montpellier)
    12:00  Mammalian sterile 20-like kinase 1: an important player for neutrophil transmigration
    Markus Sperandio (Ludwig-Maximilians-Universität Munich)
    12:30 Lunch

    Session 2: Cell Biology

    14:00 Establishing new tools for manipulating alternative model organisms in the study of the evolution of developmental processes
    Cassandra G. Extavour (Department of Molecular and Cellular Biology, Harvard University)
    14:30  Extracellular matrix and its role in biomedical research
    Katja Schenke-Layland (Fraunhofer Institute for Interfacial Engineering and Biotechnology)
    15:00  Deconstructing cell migration
    Matthieu Piel (Institut Curie)
    15:30  Innate immune cell dynamics at sites of inflammation and infection
    Tim Lämmermann (Max Planck Institute of Immunobiology and Epigenetics)
    16:00 Coffee break

    Session 3: Young Scientist Talks

    16:30 Wound-induced signals and positional cues cooperate to initiate regeneration in the planarian s. mediterranea
    Suthira Owlarn (Münster, Germany)
    16:50 Regulation of bone vascularization and osteogenesis during mouse development
    Urs H. Langen (Münster, Germany)
    17:10 A nanotechnological approach reveals the role of alpha 2 beta 1 integrin in collagen-induced platelet aggregation
    Augusto Martins Lima (Münster, Germany)
    17:30 Plasma membrane organization in zebrafish primordial germ cells (PGCs) bleb
    Mohammad Goudarzi (Münster, Germany)

    Evening Program

    18:30 Guided City Tour
    19:30 Dinner

    Thursday, 12.05.2016

    Session 4: Developmental Biology

    09:00  Regeneration of hematopoietic stem cells from endothelial cells
    Dhvanit Shah (Harvard Medical School)
    09:30  Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6
    Victoria L. Bautch (University of North Carolina at Chapel Hill)
    10:00  Molecular regulation of endothelial barrier properties in the central nervous system
    Stefan Liebner (Goethe University Frankfurt)
    10:30  CNS neuronal progenitors regulate vascular patterning in adjacent mesodermal tissues
    Didier Stainier (Max Planck Institute for Heart and Lung Research)
    11:00 Coffee break

    Keynote lecture

    11:30  The development of colour patterns in fishes - Towards an understanding of the evolution of beauty
    Christiane Nüsslein-Volhard (Max Planck Institute for Developmental Biology)
    12:30 Lunch

    Session 5: Applied Mathematics

    14:00 Aspects of cell swimming motility
    Eamonn Gaffney (University of Oxford)
    14:30 Mathematical modeling of mechano-chemical pattern formation
    Anna Marciniak-Czochra (University of Heidelberg)
    15:00 Identification of mammary stem cells and their dynamics during branching morphogenesis
    Edouard Hannezo (University of Cambridge)
    15:30 Coffee break

    Poster Session

    16:00 to 18:00

    Evening Program

    18:30 Dinner
    19:30 Party

    Friday, 13.05.2016

    Session 6: Genomics and Systems Biology

    09:00 Towards a true isoform biology: deep long read sequencing reveals molecular co-association of distant splicing events in the human brain
    Hagen Tilgner (Stanford University)
    09:30 Epigenomic establishment of macrophage tolerance and trained immunity
    Henk Stunnenberg (Radboud Institute for Molecular Life Sciences)
    10:00 Establishment and maintenance of mammalian heterochromatin
    Thomas Jenuwein (Max Planck Institute of Immunobiology and Epigenetics)
    10:30 Coffee break

    Session 7: Drug Design

    11:00 Controlling biological activity with photopharmacology
    Dirk Trauner (Ludwig-Maximilians-Universität Munich)
    11:30 Tools to probe the epigenetic code
    Manfred Jung (University of Freiburg)
    12:00 Highly selective JAK3-inhibitors with a covalent-reversible binding mode targeting a nitrile induced arginine pocket
    Stefan Laufer (University of Tübingen)
    12:30 Lunch

    Session 8: Neuroscience

    14:00 Large protein and nanoparticle transport across the blood-brain barrier (BBB),with implications for drug delivery
    N. Joan Abbott (King's College London)
    14:30 Glial glycogen and brain energy metabolism: new insights
    Bruce R. Ransom (University of Washington)
    15:00 The interaction of genes and epigenes – A chromatin loop conferring an increased risk to develop Alzheimer’s disease
    Johannes Gräff (École polytechnique fédérale de Lausanne)

    Fare-Well

    15:30 Closing remarks and poster prize