• © Evonik Stiftung

    Research Project

    Water-soluble biodegradable polymers

    Polyphosphoester (PPE) polymers represent a new class of polymers that have attracted a lot of attention due to their water-soluble and biodegradable properties, which makes them the perfect candidates for nanotechnologies, in particular in the field of biomedicine. PPEs are synthesized by anionic ring-opening polymerization (AROP), which leads to a great control over molecular weights and dispersity. Further, it allows versatile modification of the polymer chains, in order to achieve different polymer architectures. The pentavalent phosphorus atom enables a high level of structural and chemical versatility. In addition, it is possible to fundamentally control the chemical and physical properties of the polymer, whereby properties such as water solubility and degradability can be adjusted as required.

  • Research Interests

    • Polymer synthesis
    • Self-Assembly
    • Analysis of nanostructures
    • Biodegradable polymers

  • Skills

    • Transmission Electron Microscopy (TEM),
    • Energy-Dispersive X-ray Spectroscopy (EDX STEM),
    • Scanning Slectron Microscopy (SEM),
    • Dynamic Light Scattering (DLS)
    • Atomic Force Microscopy (AFM),
    • Ultra-Microtomy
  • © Evonik Stiftung

    Scientific Career

    12.​2020 -                     Evonik Scholarship

    12.​2020 -                     PhD student – Westfälische Wilhelms-Universität Münster

    10.​2018 - 11.​2020   Master of Chemistry – University of Duisburg-Essen

    08.​2019 - 12.​2019   Lab course – Bio-Photonics Group Prof. Vignolini – University Cambridge

    02.​2019 - 11.​2019   research assistent – AK Gröschel – University of Duisburg-Essen

    03.​2018 - 09.​2018   studend research assistent – AK Gröschel – University of Duisburg-Essen

    10.​2014 - 09.​2018   Bachelor of Chemistry – University of Duisburg-Essen

  • Awards

    2021     Evonik scholarship - Evonik Stiftung

    2019     Deutschland Stipendium - Studienstiftung des deutschen Volkes

  • Presentations and Confrence Appearences

    07/2022     Talk at Macro, World Polymer Congress, Winnipeg, Canada

    06/2022     Talk at European Polymer Congress, Prague, Czech Republic

    06/2022     Poster at Bordeaux Polymers Conference, Bordeaux, France

    04/2022     Talk at Zsigmondy Colloquium, Aachen, German

    04/2020    Girl´s Day, "Structural Color in Nature and Science", WWU

    02/2019    Delegate at the Macromolecular Colloquium Freiburg, Germany

  •  

    Publications

    • Adick A.; Hoheisel W.; Schneid S.; Mulac D.; Azhdari S.; Langer K. . ‘Challenges of nanoparticle albumin bound (nab™) technology: Comparative study of Abraxane® with a newly developed albumin-stabilized itraconazole nanosuspension.’ European journal of pharmaceutics and biopharmaceutics 193: 129–143. doi: 10.1016/j.ejpb.2023.10.022.
    • Hester S.; B. Ferenz K.; Adick A.; Kakalias C.; Mulac D.; Azhdari S.; Langer K. . ‘Triglyceride-filled albumin-based nanocapsules: A promising new system to avoid discarding poorly water-soluble drug candidates.’ International Journal of Pharmaceutics 646. doi: 10.1016/j.ijpharm.2023.123454.
    • Azhdari S, Herrmann F, Coban D, Linders J, Gröschel AH. . ‘Confinement-Assembly of Terpolymer-based Janus Nanoparticles.’ Macromolecular Rapid Communications 43, No. 14: 2100932. doi: 10.1002/marc.202100932.
    • Janoszka N, Azhdari S, Hüls C, Coban D, Schmalz H, Gröschel AH. . ‘Morphology and Degradation of Multicompartment Microparticles Based on Semi-Crystalline Polystyrene-block-Polybutadiene-block-Poly(L-lactide) Triblock Terpolymers.’ Polymers 13: 4358. doi: 10.3390/polym13244358.
    • S. Azhdari, M. Trömer, D. Coban and André H. Gröschel. ‘Homogenous and Monodisperse Janus Cups Tuneable in Curvature and Size.’ präsentiert auf der Macrosymposium 2021, Online, .
    • Pottanam Chali S, Azhdari S, Galstyan A, Gröschel AH, Ravoo BJ. . ‘Biodegradable supramolecular micelles via host–guest interaction of cyclodextrin-terminated polypeptides and adamantane-terminated polycaprolactones.’ Chemical communications 57: 9446–9449. doi: 10.1039/D1CC03372G.