Dr. Michael Sperling (Dipl. Chem.)
© Michael Sperling
Dr. Michael Sperling (Dipl. Chem.)
European Virtual Institute for Speciation Analysis (EVISA)
T: +49 176 183 002 68
michael.sperling@uni-muenster.de

Personal

Chief Managing Director of the European Virtual Institute for Speciation Analysis (EVISA) at the University of Muenster

Research interests

Development of robust methods for speciation analysis

Development of binary speciation techniques for species screening

Hyphenated techniques using atomic spectrometric detection

Automation of analytical methods by the use of flow techniques

Development of plasma sources for atomic and mass spectrometry

Bioimaging by mass spectrometry

Imaging by µXRF (instrumental and synchrotron-based)

Publications

  • Sommer K; Becker T; von Bremen-Kühne M; Gotters M; Quarles CD; Sperling M; Kudla J; Karst U. . ‘Analysis of the elemental species-dependent uptake of lanthanide complexes in Arabidopsis thaliana plants by LA-ICP-MS.’ Chemosphere 338: 139534. doi: 10.1016/j.chemosphere.2023.139534.

  • Bücker P, Funke SKI, Factor C, Rasschaert M, Robert P, Sperling M, Karst U. . ‘Combined speciation analysis and elemental bioimaging provide new insight into gadolinium retention in kidney.’ Metallomics 14, No. 3: mfac004. doi: 10.1093/mtomcs/mfac004.
  • Buchholz R, Krossa S, Andersen MK, Holtkamp M, Sperling M, Karst U, Tessem MB. . ‘A simple preparation protocol for shipping and storage of tissue sections for laser ablation-inductively coupled plasma-mass spectrometry imaging.’ Metallomics 14, No. 3: mfac013. doi: 10.1093/mtomcs/mfac013.
  • Reifschneider O, Blaske F, Vennemann A, Köppen C, Sperling M, Karst U, Wiemann M. . ‘Quantitative elemental bioimaging: an antibody-based double-labelling method to quantify the cell-specific distribution of silver nanoparticles in lung tissue sections.’ Journal of Analytical Atomic Spectrometry 37: 1084–1089. doi: 10.1039/d1ja00466b.
  • von Bremen-Kühne, Maximilian; Ahmadi, Hassan; Sperling, Michael; Krämer, Ute; Karst, Uwe. . ‘Elemental bioimaging of Zn and Cd in leaves of hyperaccumulator Arabidopsis halleri using laser ablation-inductively coupled plasma-mass spectrometry and referencing strategies.’ Chemosphere 305: 135267. doi: 10.1016/j.chemosphere.2022.135267.
  • Sommer, Karolin; Sperling, Michael; Karst, Uwe. . ‘Species-dependent interaction of Gd-based contrast agents with humic substances.’ Chemosphere 300: 134528. doi: 10.1016/j.chemosphere.2022.134528.
  • Fingerhut, Stefanie; Buchholz Rebecca; Bücker, Patrick; Clasen, Wolfgang; Sperling, Michael; Müller, Klaus-Michael; Rehkämper, Jan; Radbruch, Alexander; Richter, Henning; Jeibmann, Astrid; Karst, Uwe. . ‘Gadolinium retention in the tunica media of arterial walls—a complementary study using elemental bioimaging and immunogold staining.’ Metallomics 14, No. 6: mfac029. doi: 10.1093/mtomcs/mfac029.
  • Funke, SKI; Factor, C;Rasschaert, M; Lezius, L; Sperling, M, Karst, U; Robert, P. . ‘Long-term Gadolinium Retention in the Healthy Rat Brain: Comparison between Gadopiclenol, Gadobutrol, and Gadodiamide.’ Radiology 305, No. 1: 179–189. doi: 10.1148/radiol.212600.
  • Bücker, P; Buzzi, RM; Akeret, K; Mosberger, L; Richter, H; Sperling, M; Hugeslhofer, M; Schaer, DJ; Karst, U. . ‘A model to visualize the fate of iron after intracranial hemorrhage using isotopic tracers and elemental bioimaging.’ Metallomics 14, No. 8: mfac057. doi: 10.1093/mtomcs/mfac057.

  • Erbacher C, Flothkötter N, Macke M, Quarles Jr. CD, Sperling M, Müller J, Karst U. . ‘A fast and automated separation and quantification method for bromine speciation analyzing bromide and 5-bromo-2’-deoxyuridine in enzymatically digested DNA samples via IC-ICP-MS.’ Journal of Chromatography A 1652: 462370. doi: 10.1016/j.chroma.2021.462370.
  • Bücker P, Richter H, Radbruch A, Sperling M, Brand M, Holling M, Van Marck V, Paulus W, Jeibman A, Karst U. . ‘Deposition patterns of iatrogenic lanthanum and gadolinium in the human body depend on delivered chemical binding forms.’ Journal of Trace Elements in Medicine and Biology 63, No. 126665. doi: 10.1016/j.jtemb.2020.126665.
  • Richter H, Bücker P, Martin LF, Dunker C, Fingerhut S, Xia AN, Karol A, Sperling M, Karst U, Radbruch A, Jeibmann A. . ‘Gadolinium Tissue Distribution in a Large-Animal Model after a Single Dose of Gadolinium-based Contrast Agents.’ Radiology 301, No. 3: 637–642. doi: 10.1148/radiol.2021210553.
  • Funke SKI, Sperling M, Karst U. . ‘Weighted Linear Regression Improves Accuracy of Quantitative Elemental Bioimaging by Means of LA-ICP-MS.’ Analytical Chemistry 93, No. 47: 15720–15727. doi: 10.1021/acs.analchem.1c03630.
  • Macke M, Quarles CD, Sperling M, Karst U. . ‘Fast and Automated Monitoringh of Gadolinium-based Contrast Agents in Surface Waters.’ Water Research 207, No. 117836. doi: 10.1016/j.watres.2021.117836.
  • Nordhorn I., Dietrich D., Verlemann C., Vennemann A., Schmid R., Elinkmann M., Fuchs J., Sperling M., Wiemann M., Karst U. . ‘Spatially and size-resolved analysis of gold nanoparticles in rat spleen after intratracheal instillation by laser ablation-inductively coupled plasma-mass spectrometry.’ Metallomics 13, No. 6. doi: 10.1093/mtomcs/mfab028.
  • Schlatt L., Köhrer A., Factor C., Robert P., Rasschaert M., Sperling M., Karst U. . ‘Mild Dissolution/Recomplexation Strategy for Speciation Analysis of Gadolinium from MR Contrast Agents in Bone Tissues by Means of HPLC-ICP-MS.’ Analytical Chemistry 93, No. 33: 11398–11405. doi: 10.1021/acs.analchem.1c01100.

  • El-Hamrani D, Vives V, Buchholz R, Meme W, Factor C, Fingerhut S, Sperling M, Karst U, Robert P, Meme S. . ‘Effect of Long-Term Retention of Gadolinium on Metabolism of Deep Cerebellar Nuclei After Repeated Injection of Gadolinium in Rats.’ Investigative Radiology 55, No. 2: 120–128. doi: 10.1097/RLI.0000000000000621.
  • Lützen E, Holtkamp M, Stamme I, Schmid R, Sperling M, Pütz M, Karst U. . ‘Multimodal imaging of hallucinogens 25C- and 25I-NBOMe on blotter papers.’ Drug Testing and Analysis 12: 465–471. doi: 10.1002/dta.2751.
  • Sperling M, von Bremen-Kühne M, Funke S, Schlatt L, Karst U. . ‘Analysis of rare-earth metals and their species.’ In Rare Earth Chemistry, edited by Pöttgen Rainer, Jüstel Thomas, Strassert Cristian A., 225–234. Berlin/Munich/Boston: De Gruyter. doi: 10.1515/9783110654929-016.
  • Will JM, Erbacher C, Sperling M, Karst U. . ‘A mass spectrometry-based approach gives new insight into organotin–protein interactions.’ Metallomics 12, No. 11: 1701–1712. doi: 10.1039/d0mt00171f.
  • Richter-Brockmann S, Garbert K, von Bremen-Kühne M, Wehe CA, Reifschneider O, Sperling M, Wallrad L, Schmitz-Thom I, Kudla J, Karst U. . ‘Elemental bioimaging of Na distribution in roots of Arabidopsis thaliana using laser ablation-ICP-MS under cold plasma conditions.’ Journal of Analytical Atomic Spectrometry 35, No. 9: 2057–2063. doi: 10.1039/D0JA00151A.
  • Vosse C, Thyssen G, Sperling M, Karst U, Hayen H. . ‘Complementary approach for analysis of phospholipids by liquid chromatography hyphenated to elemental and molecular mass spectrometry.’ Analytical Science Advances 1: 46–55. doi: 10.1002/ansa.20190009.
  • Reifschneider O, Vennemann A, Buzanich G, Radtke M, Reinholz U, Riesemeier H, Hogeback J, Köppen C, Grossgarten M, Sperling M, Wiemann M, Karst U. . ‘Revealing Silver Nanoparticle Uptake by Macrophages using SR-µXRF and LA-ICP-MS.’ Chemical Research in Toxicology 33, No. 5: 1250–1255. doi: 10.1021/acs.chemrestox.9b00507.

  • van der Bent SAS, Berg T, Karst U, Sperling M, Rustemeyer T. . ‘Allergic reaction to a green tattoo with nickel as a possible allergen.’ Contact Dermatitis 81, No. 1: 64–66. doi: 10.1111/cod.13226.
  • Radbruch A, Richter H, Fingerhut S, Martin LF, Xia A, Henze N, Paulus W, Sperling M, Karst U, Jeibmann A,. . ‘Gadolinium Deposition in the Brain in a Large Animal Model: Comparison of Linear and Macrocyclic Gadolinium-Based Contrast Agents .’ Investigative Radiology 54, No. 9: 531–536. doi: 10.1097/RLI.0000000000000575.
  • Hucke A, Rinschen MM, Bauer OB, Sperling M, Karst U, Koppen C, Sommer K, Schroter R, Ceresa C, Chiorazzi A, Canta A, Semperboni S, Marmiroli P, Cavaletti G, Schlatt S, Schlatter E, Pavenstadt H, Heitplatz B, Van Marck V, Sparreboom A, Barz V, Knief A, Deuster D, Zehnhoff-Dinnesen AA, Ciarimboli G. . ‘An integrative approach to cisplatin chronic toxicities in mice reveals importance of organic cation-transporter-dependent protein networks for renoprotection.’ Archives of Toxicology 93, No. 10: 2835–2848. doi: 10.1007/s00204-019-02557-9.
  • Crone B, Schlatt L, Nadar RA, van Dijk NWM, Margiotta N, Sperling M, Leeuwenburghg S, Karst U. . ‘Quantitative imaging of platinum-based antitumor complexes in bone tissue samples using LA-ICP-MS.’ Journal of Trace Elements in Medicine and Biology 54: 98–102. doi: 10.1016/j.jtemb.2019.04.011.
  • Clases D, Fingerhut S, Jeibmann A, Sperling M, Doble P, Karst U. . ‘LA-ICP-MS/MS improves limits of detection in elemental bioimaging of gadolinium deposition originating from MRI contrast agents in skin and brain tissues.’ Journal of Trace Elements in Medicine and Biology 51: 212–218. doi: 10.1016/j.jtemb.2018.10.021.
  • Kroeger S, Sperling M, Karst U. . ‘Quantitative dried blood spot analysis for metallodrugs by laser ablation inductively coupled plasma-mass spectrometry.’ Journal of Trace Elements in Medicine and Biology 51: 50–56. doi: 10.1016/j.jtemb.2018.09.009.
  • Bauer OB, Hachmoeller O, Borovinskaya O, Sperling M, Schurek H, Ciarimboli G, Karst U. . ‘LA-ICP-TOF-MS for rapid, all-elemental and quantitative bioimaging, isotopic analysis and the investigation of plasma processes.’ Journal of Analytical Atomic Spectrometry 34, No. 4: 694–701. doi: 10.1039/c8ja00288f.

  • Thyssen G., Keil C., Wolff M., Sperling M., Kadow D., Haase H., Karst U. . ‘Bioimaging of the elemental distribution in cocoa beans by means of LA-ICP-TQMS.’ Journal of Analytical Atomic Spectrometry 33, No. 2: 187–194. doi: 10.1039/c7ja00354d.
  • Fingerhut S., Niehoff A., Sperling M., Jeibmann A., Paulus W., Niederstadt T., Allkemper T., Heindel W., Holling M., Karst U. . ‘Spatially resolved quantification of gadolinium deposited in the brain of a patient treated with gadolinium-based contrast agents.’ Journal of Trace Elements in Medicine and Biology 45, No. null: 125–130. doi: 10.1016/j.jtemb.2017.10.004.
  • Clases D., Sperling M., Karst U. . ‘Analysis of metal-based contrast agents in medicine and the environment.’ TrAC - Trends in Analytical Chemistry null, No. null. doi: 10.1016/j.trac.2017.12.011. [online first]
  • Vega R, Fernandez Sanchez ML, Eiro N, Vizoso FJ, Sperling M, Karst U, Sanz Medel A. . ‘Multimodal laser ablation/desorption imaging analysis of Zn and MMP-11 in breast tissues.’ Analytical and Bioanalytical Chemistry 410, No. 3: 913–922. doi: 10.1007/s00216-017-0537-x.
  • Mueller J, Lichtmannegger J, Zischka H, Sperling M, Karst U. . ‘High spatial resolution LA-ICP-MS demonstrates massive liver copper depletion in Wilson disease rats upon Methanobactin treatment.’ Journal of Trace Elements in Medicine and Biology 49: 119–127. doi: 10.1016/j.jtemb.2018.05.009.
  • Strohmidel P, Sperling M, Karst U. . ‘Investigations on the binding of ethylmercury from thiomersal to proteins in influenza vaccines.’ Journal of Trace Elements in Medicine and Biology 50: 100–104. doi: 10.1016/j.jtemb.2018.06.011.
  • Bishop DP, Grossgarten M, Dietrich D, Vennemann A, Cole N, Sperling M, Wiemann M, Doble PA, Karst U. . ‘Quantitative imaging of translocated silver following nanoparticle exposure by laser ablation-inductively coupled plasma-mass spectrometry (vol 10, pg 836, 2018).’ Analytical Methods 10, No. 8: 926. doi: 10.1039/c8ay90014k.
  • Bishop DP, Grossgarten M, Dietrich D, Vennemann A, Cole N, Sperling M, Wiemann M, Doble PA, Karst U. . ‘Quantitative imaging of translocated silver following nanoparticle exposure by laser ablation-inductively coupled plasma-mass spectrometry.’ Analytical Methods 10, No. 8: 836–840. doi: 10.1039/c7ay02294h.
  • Veith L, Dietrich D, Vennemann A, Breitenstein D, Engelhard C, Karst U, Sperling M, Wiemann M, Hagenhoff B. . ‘Combination of micro X-ray fluorescence spectroscopy and time-of-flight secondary ion mass spectrometry imaging for the marker-free detection of CeO2 nanoparticles in tissue sections.’ Journal of Analytical Atomic Spectrometry 33, No. 3: 491–501. doi: 10.1039/c7ja00325k.
  • Hucke A, Park GY, Bauer OB, Beyer G, Koeppen C, Zeeh D, Wehe CA, Sperling M, Schroeter R, Kantauskaite M, Hagos Y, Karst U, Lippard SJ, Ciarimboli G. . ‘Interaction of the New Monofunctional Anticancer Agent Phenanthriplatin With Transporters for Organic Cations.’ Frontiers in Chemistry 6. doi: 10.3389/fchem.2018.00180.
  • Bauer OB, Koeppen C, Sperling M, Schurek H, Ciarimboli G, Karst U. . ‘Quantitative Bioimaging of Platinum via Online Isotope Dilution Laser Ablation-Inductively Coupled Plasma Mass Spectrometry.’ Analytical Chemistry 90, No. 11: 7033–7039. doi: 10.1021/acs.analchem.8b01429.
  • Fingerhut S, Sperling M, Holling M, Niederstadt T, Allkemper T, Radbruch A, Heindel W, Paulus W, Jeibmann A, Karst U. . ‘Gadolinium-based contrast agents induce gadolinium deposits in cerebral vessel walls, while the neuropil is not affected: an autopsy study.’ Acta Neuropathologica 136, No. 1: 127–138. doi: 10.1007/s00401-018-1857-4.
  • Sperling M, Karst U. . ‘Advances in speciation techniques and methodology.’ TrAC - Trends in Analytical Chemistry 104, No. SI: 1–3. doi: 10.1016/j.trac.2018.04.006.
  • Grossgarten M, Holzlechner M, Vennemann A, Balbekova A, Wieland K, Sperling M, Lendl B, Marchetti-Deschmann M, Karst U, Wiemann M. . ‘Phosphonate coating of SiO2 nanoparticles abrogates inflammatory effects and local changes of the lipid composition in the rat lung: a complementary bioimaging study.’ Particle and Fibre Toxicology 15. doi: 10.1186/s12989-018-0267-z.
  • Robert P, Fingerhut S, Factor C, Vives V, Letien J, Sperling M, Rasschaert M, Santus R, Ballet S, Idee J, Corot C, Karst U. . ‘One-year Retention of Gadolinium in the Brain: Comparison of Gadodiamide and Gadoterate Meglumine in a Rodent Model.’ Radiology 288, No. 2: 424–433. doi: 10.1148/radiol.2018172746.
  • Fuchs J, Aghaei M, Schachel TD, Sperling M, Bogaerts A, Karst U. . ‘Impact of the Particle Diameter on Ion Cloud Formation from Gold Nanoparticles in ICPMS.’ Analytical Chemistry 90, No. 17: 10271–10278. doi: 10.1021/acs.analchem.8b02007.
  • Kroger S, Niehoff A, Jeibmann A, Sperling M, Paulus W, Stummer W, Karst U. . ‘Complementary Molecular and Elemental Mass-Spectrometric Imaging of Human Brain Tumors Resected by Fluorescence-Guided Surgery.’ Analytical Chemistry 90, No. 20: 12253–12260. doi: 10.1021/acs.analchem.8b03516.
  • Mueller-Bomke S, Sperling M, Hayen H, Karst U. . ‘Biolabeling with cobaltocinium tags.’ Zeitschrift für Naturforschung B - A Journal of Chemical Sciences 73, No. 11, SI: 781–791. doi: 10.1515/znb-2018-0093.

  • Thyssen, GM; Holtkamp, M; Kaulfürst-Soboll, H; Wehe, CA; Sperling, M; von Schaewen, A; Karst, U. . ‘Elemental bioimaging by means of LA-ICP-OES: investigation of the calcium, sodium and potassium distribution in tobacco plant stems and leaf petioles.’ Metallomics 9, No. 6: 587–804. doi: 10.1039/c7mt00003k.
  • Hachmöller O., Aichler M., Schwamborn K., Lutz L., Werner M., Sperling M., Walch A., Karst U. . ‘Investigating the influence of standard staining procedures on the copper distribution and concentration in Wilson's disease liver samples by laser ablation-inductively coupled plasma-mass spectrometry.’ Journal of Trace Elements in Medicine and Biology 44, No. null: 71–75. doi: 10.1016/j.jtemb.2017.06.002.
  • Hachmöller O., Zibert A., Zischka H., Sperling M., Groba S., Grünewald I., Wardelmann E., Schmidt H., Hartmut H. . ‘Spatial investigation of the elemental distribution in Wilson's disease liver after D-penicillamine treatment by LA-ICP-MS.’ Journal of Trace Elements in Medicine and Biology 44, No. null: 26–31. doi: 10.1016/j.jtemb.2017.05.008.
  • Aschner M., Palinski C., Sperling M., Karst U., Schwerdtle T., Bornhorst J. . ‘Imaging metals in: Caenorhabditis elegans.’ Metallomics 9, No. 4: 357–364. doi: 10.1039/c6mt00265j.
  • Clases D., Birka M., Sperling M., Faust A., Karst U. . ‘Isobaric dilution analysis as a calibration tool for long lived radionuclides in ICP-MS.’ Journal of Trace Elements in Medicine and Biology 40, No. null: 97–103. doi: 10.1016/j.jtemb.2017.01.002.
  • Wiemann M., Vennemann A., Blaske F., Sperling M., Karst U. . ‘Silver nanoparticles in the lung: Toxic effects and focal accumulation of silver in remote organs.’ Nanomaterials 7, No. 12. doi: 10.3390/nano7120441.

  • Niehoff A., Schulz J., Soltwisch J., Meyer S., Kettling H., Sperling M., Jeibmann A., Dreisewerd K., Francesconi K., Schwerdtle T., Karst U. . ‘Imaging by Elemental and Molecular Mass Spectrometry Reveals the Uptake of an Arsenolipid in the Brain of Drosophila melanogaster.’ Analytical Chemistry 88, No. 10: 5258–5263. doi: 10.1021/acs.analchem.6b00333.
  • Niehoff AC , Wachsmuth L , Schmid F , Sperling M, Faber C , Karst U. . ‘Quantification of Manganese Enhanced Magnetic Resonance Imaging based on Spatially Resolved Elemental Mass Spectrometry.’ Chemistryselect 1, No. 2: 264–266. doi: 10.1002/slct.201600058.
  • Hogeback J, Schwarzer M , Wehe CA , Sperling M, Karst U. . ‘Investigating the adduct formation of organic mercury species with carbonic anhydrase and hemoglobin from human red blood cell hemolysate by means of LC/ESI-TOF-MS and LC/ICP-MS.’ Metallomics 8, No. 1: 101–107. doi: 10.1039/c5mt00186b.
  • Hachmöller O, Aichler M, Schwamborn K , Lutz L, Werner M, Sperling M , Walch A , Karst U. . ‘Element bioimaging of liver needle biopsy specimens from patients with Wilson's disease by laser ablation-inductively coupled plasma-mass spectrometry.’ Journal of Trace Elements in Medicine and Biology 35: 97–102. doi: 10.1016/j.jtemb.2016.02.001.
  • Niehoff A., Grünebaum J., Moosmann A., Mulac D., Söbbing J., Niehaus R., Buchholz R., Kröger S., Wiehe A., Wagner S., Sperling M., von Briesen H., Langer K., Karst U. . ‘Quantitative bioimaging of platinum group elements in tumor spheroids.’ Analytica Chimica Acta 938, No. null: 106–113. doi: 10.1016/j.aca.2016.07.021.
  • Birka M., Wehe C., Hachmöller O., Sperling M., Karst U. . ‘Tracing gadolinium-based contrast agents from surface water to drinking water by means of speciation analysis.’ Journal of Chromatography A 1440, No. null: 105–111. doi: 10.1016/j.chroma.2016.02.050.
  • Birka M., Roscher J., Holtkamp M., Sperling M., Karst U. . ‘Investigating the stability of gadolinium based contrast agents towards UV radiation.’ Water Research 91, No. null: 244–250. doi: 10.1016/j.watres.2016.01.012.
  • Hogeback J., Schwarzer M., Wehe C., Sperling M., Karst U. . ‘Investigating the adduct formation of organic mercury species with carbonic anhydrase and hemoglobin from human red blood cell hemolysate by means of LC/ESI-TOF-MS and LC/ICP-MS.’ Metallomics 8, No. 1: 101–107. doi: 10.1039/c5mt00186b.
  • Birka M., Wehe C., Telgmann L., Sperling M., Karst U. . ‘ICPMS for environmental and bioimaging research.’ Spectroscopy (Santa Monica) 31, No. 1: 36–37.
  • Hachmöller O., Aichler M., Schwamborn K., Lutz L., Werner M., Sperling M., Walch A., Karst U. . ‘Element bioimaging of liver needle biopsy specimens from patients with Wilson's disease by laser ablation-inductively coupled plasma-mass spectrometry.’ Journal of Trace Elements in Medicine and Biology 35, No. null: 97–102. doi: 10.1016/j.jtemb.2016.02.001.
  • Hachmöller O., Buzanich A., Aichler M., Radtke M., Dietrich D., Schwamborn K., Lutz L., Werner M., Sperling M., Walch A., Karst U. . ‘Elemental bioimaging and speciation analysis for the investigation of Wilson's disease using μxRF and XANES.’ Metallomics 8, No. 7: 648–653. doi: 10.1039/c6mt00001k.

  • Köppen C., Reifschneider O., Castanheira I., Sperling M., Karst U., Ciarimboli G. . ‘Quantitative imaging of platinum based on laser ablation-inductively coupled plasma-mass spectrometry to investigate toxic side effects of cisplatin.’ Metallomics 7, No. 12: 1595–1603. doi: 10.1039/c5mt00226e.
  • Niehoff A., Bauer O., Kröger S., Fingerhut S., Schulz J., Meyer S., Sperling M., Jeibmann A., Schwerdtle T., Karst U. . ‘Quantitative Bioimaging to Investigate the Uptake of Mercury Species in Drosophila melanogaster.’ Analytical Chemistry 87, No. 20: 10392–10396. doi: 10.1021/acs.analchem.5b02500.
  • Mak C., Wehe C., Sperling M., Karst U. . ‘Identification and quantification of electrochemically generated metabolites of thyroxine by means of liquid chromatography/electrospray-mass spectrometry and countergradient liquid chromatography/inductively coupled plasma-mass spectrometry.’ Journal of Chromatography A 1419, No. null: 81–88. doi: 10.1016/j.chroma.2015.09.076.
  • Wehe C., Thyssen G., Herdering C., Raj I., Ciarimboli G., Sperling M., Karst U. . ‘Elemental Bioimaging by Means of Fast Scanning Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry.’ Journal of The American Society for Mass Spectrometry 26, No. 8: 1274–1282. doi: 10.1007/s13361-015-1141-y.
  • Birka M., Wentker K., Lusmöller E., Arheilger B., Wehe C., Sperling M., Stadler R., Karst U. . ‘Diagnosis of Nephrogenic Systemic Fibrosis by means of Elemental Bioimaging and Speciation Analysis.’ Analytical Chemistry 87, No. 6: 3321–3328. doi: 10.1021/ac504488k.
  • Karst U., Sperling M. . ‘2015 European Winter Conference on Plasma Spectrochemistry.’ Journal of Analytical Atomic Spectrometry 30, No. 10: 2035–2037. doi: 10.1039/c5ja90044a.
  • Niehaus R, Sperling M, Karst U. . ‘Study on aerosol characteristics and fractionation effects of organic standard materials for bioimaging by means of LA-ICP-MS.’ Journal of Analytical Atomic Spectrometry 30, No. 10: 2056–2065. doi: 10.1039/C5JA00221D.

  • Wehe CA, Pieper I, Holtkamp M, Thyssen GM, Sperling M, Schwerdtle T, Karst U. . ‘On-line species-unspecific isotope dilution analysis in the picomolar range reveals the time- and species-depending mercury uptake in human astrocytes.’ Analytical and Bioanalytical Chemistry 406, No. 7: 1909. doi: 10.1007/s00216-013-7608-4.
  • Reifschneider O., Schutz C.L., Brochhausen C., Hampel G., Ross T., Sperling M., Karst U. . ‘Quantitative bioimaging of p-boronophenylalanine in thin liver tissue sections as a tool for treatment planning in boron neutron capture therapy.’ Analytical and Bioanalytical Chemistry null, No. null. doi: 10.1007/s00216-014-8012-4. [online first]
  • Blaske F., Reifschneider O., Gosheger G., Wehe C.A., Sperling M., Karst U., Hauschild G., Holl S. . ‘Elemental bioimaging of nanosilver-coated prostheses using X-ray fluorescence spectroscopy and laser ablation-inductively coupled plasma-mass spectrometry.’ Analytical Chemistry 86, No. 1: 615–620. doi: 10.1021/ac4028577.
  • Wehe C.A., Beyer G., Sperling M., Ciarimboli G., Karst U. . ‘Assessing the intracellular concentration of platinum in medulloblastoma cell lines after Cisplatin incubation.’ Journal of Trace Elements in Medicine and Biology 28, No. 2: 166–172. doi: 10.1016/j.jtemb.2014.01.001.
  • Nowak S, Gesell M, Holtkamp M, Sperling M, Karst U, Buscher W. . ‘Low Gas Flow Inductively Coupled Plasma Optical Emission Spectrometry for the Analysis of Food Samples after Microwave Digestion.’ Talanta 129: 575–578. doi: 10.1016/j.talanta.2014.06.045.
  • Niehoff A.-C., Moosmann A., Söbbing J., Wiehe A., Mulac D., Wehe C.A., Reifschneider O., Blaske F., Wagner S., Sperling M., von Briesen H., Langer K., Karst U. . ‘A palladium label to monitor nanoparticle-assisted drug delivery of a photosensitizer into tumor spheroids by elemental bioimaging.’ Metallomics 6, No. 1: 77–81. doi: 10.1039/c3mt00223c.
  • Wehe C., Niehoff A., Thyssen G., Sperling M., Karst U. . ‘Rapid cell mode switching and dual laser ablation inductively coupled plasma mass spectrometry for elemental bioimaging.’ Rapid Communications in Mass Spectrometry 28, No. 23: 2627–2635. doi: 10.1002/rcm.7054.

  • Birka M, Wehe CA, Telgmann L, Sperling M, Karst U. . ‘Sensitive quantification of gadolinium-based magnetic resonance imaging contrast agents in surface waters using hydrophilic interaction liquid chromatography and inductively coupled plasma sector field mass spectrometry.’ Journal of Chromatography A 1308: 125. doi: 10.1016/j.chroma.2013.08.017.
  • Telgmann L, Sperling M, Karst U. . ‘Determination of gadolinium-based MRI contrast agents in biological and environmental samples: a review.’ Analytica Chimica Acta 764: 1–16. doi: 10.1016/j.aca.2012.12.007.
  • Sperling M., Karst U. . ‘Metallomics: An emerging interdisciplinary science.’ Analytical and Bioanalytical Chemistry 405, No. 6: 1289–1290. doi: 10.1007/s00216-012-6619-x.
  • Reifschneider O., Wehe C.A., Diebold K., Becker C., Sperling M., Karst U. . ‘Elemental bioimaging of haematoxylin and eosin-stained tissues by laser ablation ICP-MS.’ Journal of Analytical Atomic Spectrometry 28, No. 7: 989–993. doi: 10.1039/c3ja50046b.
  • Blaske F., Stork L., Sperling M., Karst U. . ‘Adduct formation of ionic and nanoparticular silver with amino acids and glutathione.’ Journal of Nanoparticle Research 15, No. 9. doi: 10.1007/s11051-013-1928-3.
  • Reifschneider O., Wehe C.A., Raj I., Ehmcke J., Ciarimboli G., Sperling M., Karst U. . ‘Quantitative bioimaging of platinum in polymer embedded mouse organs using laser ablation ICP-MS.’ Metallomics 5, No. 10: 1440–1447. doi: 10.1039/c3mt00147d.
  • Herdering C., Wehe C.A., Reifschneider O., Raj I., Ciarimboli G., Diebold K., Becker C., Sperling M., Karst U. . ‘Laser ablation based bioimaging with simultaneous elemental and molecular mass spectrometry: Towards spatially resolved speciation analysis.’ Rapid Communications in Mass Spectrometry 27, No. 23: 2588–2594. doi: 10.1002/rcm.6726.
  • Herdering C., Reifschneider O., Wehe C.A., Sperling M., Karst U. . ‘Ambient molecular imaging by laser ablation atmospheric pressure chemical ionization mass spectrometry.’ Rapid Communications in Mass Spectrometry 27, No. 23: 2595–2600. doi: 10.1002/rcm.6727.
  • Brauckmann C, Wehe CA, Kieshauer M, Lanvers-Kaminsky C, Sperling M, Karst U. . ‘The interaction of platinum-based drugs with native biologically relevant proteins.’ Analytical and Bioanalytical Chemistry 405, No. 6: 1855–64. doi: 10.1007/s00216-012-6410-z.

  • Meermann B, Sperling M. . ‘Hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals: developments and applications.’ Analytical and Bioanalytical Chemistry 403, No. 6: 1501–1522. doi: 10.1007/s00216-012-5915-9.
  • Telgmann L, Wehe CA, Birka M, Kunnemeyer J, Nowak S, Sperling M, Karst U. . ‘Speciation and isotope dilution analysis of gadolinium-based contrast agents in wastewater.’ Environmental Science and Technology 46, No. 21: 11929–11936. doi: 10.1021/es301981z.
  • Holtkamp M, Wehe CA, Blaske F, Holtschulte C, Sperling M, Karst U. . ‘Nitrogen purged TXRF for the quantification of silver and palladium.’ Journal of Analytical Atomic Spectrometry 27: 1799–1802. doi: 10.1039/c2ja30117b.
  • Pfeifer T, Janzen R, Steingrobe T, Sperling M, Franze B, Engelhard C, Buscher W. . ‘Development of a novel low-flow ion source/sampling cone geometry for inductively coupled plasma mass spectrometry and application in hyphenated techniques.’ Spectrochimica Acta - Part B: Atomic Spectroscopy 76: 48–55. doi: 10.1016/j.sab.2012.06.053.

  • Wehe CA, Bornhorst J, Holtkamp M, Sperling M, Galla H-J, Schwerdtle T, Karst U. . ‘Fast and low sample consuming quantification of manganese in cell nutrient solutions by flow injection ICP-QMS.’ Metallomics 3, No. 12: 1291–1296. doi: 10.1039/c1mt00170a.
  • Janzen R, Schwarzer M, Sperling M, Vogel M, Schwerdtle T, Karst U. . ‘Adduct formation of Thimerosal with human and rat hemoglobin: a study using liquid chromatography coupled to electrospray time-of-flight mass spectrometry (LC/ESI-TOF-MS).’ Metallomics 3, No. 8: 847. doi: 10.1039/c1mt00043h.
  • Sperling M., Szpunar J. . ‘Editorial: Speciation issue.’ Journal of Analytical Atomic Spectrometry 26, No. 1: 22. doi: 10.1039/c0ja90031a.
  • Telgmann L.; Holtkamp M.; Künnemeyer J.; Gelhard C.; Hartmann M.; Klose A.; Sperling M.; Karst U. . ‘Simple and rapid quantification of gadolinium in urine and blood plasma samples by means of total reflection X-ray fluorescence (TXRF).’ Metallomics 3, No. 10: 1035–1040. doi: 10.1039/c1mt00054c.

  • Bomke S, Sperling M, Karst U. . ‘Organometallic derivatizing agents in bioanalysis.’ Analytical and Bioanalytical Chemistry 397, No. 8: 3483. doi: 10.1007/s00216-010-3611-1.
  • Ciarimboli G, Deuster D, Knief A, Sperling M, Holtkamp M, Edemir B, Pavenstädt H, Lanvers-Kaminsky C, am Zehnhoff-Dinnesen A, Schinkel AH, Koepsell H, Jürgens H, Schlatter E. . ‘Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions.’ American Journal of Pathology 176, No. 3: 1169–1180. doi: 10.2353/ajpath.2010.090610.
  • Wilken A, Janzen R, Holtkamp M, Nowak S, Sperling M, Vogel M, Karst U. . ‘Investigation of the interaction of Mercurochrome® constituents with proteins using liquid chromatography/mass spectrometry.’ Analytical and Bioanalytical Chemistry 397, No. 8: 3525–3532. doi: 10.1007/s00216-010-3842-1.

  • Trumpler S, Lohmann W, Meermann B, Buscher W, Sperling M, Karst U. . ‘Interaction of thimerosal with proteins-ethylmercury adduct formation of human serum albumin and beta-lactoglobulin A.’ Metallomics 1, No. 1: 87–91.
  • Nowak S, Trümpler S, Meermann B, Wiesmüller GA, Buscher W, Sperling M, Karst U. ‘Investigations of mercury interaction with human blood components by means of Static High Sensitivity ICP (SHIP).’ contributed to the TraceSpec, Mainz, .
  • Trumpler S, Nowak S, Meermann B, Wiesmuller GA, Buscher W, Sperling M, Karst U. . ‘Detoxification of mercury species-an in vitro study with antidotes in human whole blood.’ Analytical and Bioanalytical Chemistry 395, No. 6: 1929–1935. doi: 10.1007/s00216-009-3105-1.

  • Scheffer A, Engelhard C, Sperling M, Buscher W. . ‘ICP-MS as a new tool for the determination of gold nanoparticles in bioanalytical applications.’ Analytical and Bioanalytical Chemistry 390, No. 1: 249. doi: 10.1007/s00216-007-1576-5.

  • Scheffer A, Engelhard C, Sperling M, Buscher W. . ‘Introducing wet aerosols into the static high sensitivity ICP (SHIP).’ Analytical and Bioanalytical Chemistry 388, No. 8: 1605. doi: 10.1007/s00216-007-1378-9.

  • Proust N., Buscher W., Sperling M. . ‘Speciation and the Emerging Legislation.’ In Handbook of Elemental Speciation II - Species in the Environment, Food, Medicine and Occupational Health, edited by Cornesis R, Caruso J, Crews H, Heumann K, 737–744. John Wiley & Sons. doi: 10.1002/0470856009.ch4.
  • Francesconi K.A., Sperling M. . ‘Speciation analysis with HPLC-mass spectrometry: Time to take stock.’ Analyst 130, No. 7: 998–1001. doi: 10.1039/b504485p.
  • Buscher W., Sperling M. . ‘Introduction.’ In Handbook of Elemental Speciation II - Species in the Environment, Food, Medicine and Occupational Health, edited by Cornelis Rita, Caruso Joe, Crews Helen, Heumann Klaus, 1–4. John Wiley & Sons. doi: 10.1002/0470856009.ch1.

  • Cornelis R., Buscher W., Sperling M., Donard O.F.X., Proust N., Rosenberg E., Milacic R. . ‘The EC networking on elemental speciation revisited.’ Accreditation and Quality Assurance 9, No. 4-5: 268–271. doi: 10.1007/s00769-004-0761-x.