PET imaging of freely moving mice

Camera perspective of a freely moving mouse inside the quadHIDAC PET scanner (left) and simultaneously acquired PET projection data (right).
© Xiaoyi Jiang, Frank Wübbeling, Klaus Schäfers

Principal investigators: Xiaoyi Jiang, Frank Wübbeling, Klaus Schäfers
Project time: 07/2013 - 06/2016
Project code: FF-2013-16

Positron Emission Tomography (PET) is a most sensitive imaging tool to study molecular metabolism in vivo. Due to the long acquisition time (minutes) of PET, anesthesia is widely used in small animal studies to avoid motion. However, impact of anesthesia on organ function depicted by PET studies was found to be significant. Therefore, the application of PET as a quantitative method to analyze spontaneous “natural” metabolism becomes critical or even impossible in anesthetized animal subjects. In this project we develop techniques and realize a system for freely moving mouse PET imaging based on the high-resolution small animal PET scanner quadHIDAC.