PET imaging of freely moving mice
Positron Emission Tomography (PET) is a most sensitive imaging tool to study molecular metabolism in vivo. Due to the long acquisition time (minutes) of PET, anesthesia is widely used in small animal studies to avoid motion. However, impact of anesthesia on organ function depicted by PET studies was found to be significant. Therefore, the application of PET as a quantitative method to analyze spontaneous “natural” metabolism becomes critical or even impossible in anesthetized animal subjects. In this project we develop techniques and realize a system for freely moving mouse PET imaging based on the high-resolution small animal PET scanner quadHIDAC.