Blood flow in the large arteries. The streamlines display the shape of the blood vessels, and their colour coding (red-orange) depicts the temporal and spatial dynamics of blood flow. 4D phase magnetic resonance imaging
© Philiipp Bovenkamp, Florian Lindemann, Tobias Brix, Verena Hörr

Research Area C: Cells in Complex Systems

When Cells Step Out of Line

In order for tissues and organs to function correctly, cells must be interconnected with each other and act collectively in highly complex processes. When even one cell dysfunctions in such a complex system, it can have serious consequences. CiM scientists analyse how complex cellular systems, in particular the vascular and central nervous systems, can develop into diseased states.

Scientific Concept

Cells in complex systems are engaged in multiple and highly dynamic interactions that form the basis of all tissues. Despite the high degree of specialization of different tissues, they rely on a similar set of self-organization principles such as decision-making (alterations in cellular behaviour in response to signals and stimuli), supramolecular organization (the assembly of molecules into functional complexes), cellular interactions (functionally adaptive crosstalk between cells) and time scaling (correlation of timing between input and output). The dysregulation of such complex interaction networks frequently results in pathologies. Research Area C will study cell dynamics in tissue organization focusing on the vascular and neural systems and their interplay with immune cells. Aspects of vascular development and functional integrity (C.1) will be extrapolated to important pathological scenarios such as tumour angiogenesis (C.2) and immune-vessel interactions in atherosclerosis (C.3). Here, the knowledge of vascular pathologies will be exploited for ligand- and nanoparticle-based in vivo imaging and targeted delivery of therapeutic drugs. Moreover, molecular biomarkers like MMPs, indicative of the remodelling of the atherosclerotic vessel wall, will be used in PET-based imaging of the pathological events. Neurovascular interactions are disrupted in neuroinflammation which represents a direct link between the vascular and the nervous systems (C.4). Such disruptions are manifested in functional impairment, which will be analysed by electrophysiology and in vivo imaging modalities such as magnetoencephalography (MEG). Since cellular behaviour is heavily influenced by anaesthetics, typically applied in whole-body imaging of model organisms, mathematical approaches for tracking and compensating the movement of awake animals in order to unbiasedly visualize cellular behaviour in freely moving animals will be developed in C.5.

Scientific Publications


Angenendt L, Mikesch J-H, Gorlich D, Busch A, Arnhold I, Rudack C, Hartmann W, Wardelmann E, Berdel WE, Stenner M, Schliemann C, Grunewald I. Stromal collagen type VI associates with features of malignancy and predicts poor prognosis in salivary gland cancer. Cell Oncol (Dordr) 2018;41: 517-525. Abstract
Bäumer N, Rehkamper J, Appel N, Terheyden L, Hartmann W, Wardelmann E, Buchholz F, Muller-Tidow C, Berdel WE, Baumer S. Downregulation of PIK3CA via antibody-esiRNA-complexes suppresses human xenograft tumor growth. PLoS One 2018;13: e0200163. Abstract
Bolwin K, Czekalla B, Frohwein LJ, Buther F, Schafers KP. Anthropomorphic thorax phantom for cardio-respiratory motion simulation in tomographic imaging. Phys Med Biol 2018;63: 035009. Abstract
Delcanale P, Galstyan A, Daniliuc CG, Grecco HE, Abbruzzetti S, Faust A, Viappiani C, Strassert CA. Oxygen-Insensitive Aggregates of Pt(II) Complexes as Phosphorescent Labels of Proteins with Luminescence Lifetime-Based Readouts. ACS Appl Mater Interfaces 2018;10: 24361-24369. Abstract
Eichinger P, Herrmann AM, Ruck T, Herty M, Gola L, Kovac S, Budde T, Meuth SG, Hundehege P. Human T cells in silico: Modelling dynamic intracellular calcium and its influence on cellular electrophysiology. J Immunol Methods 2018;461: 78-84. Abstract
Frohwein LJ, Hess M, Schlicher D, Bolwin K, Buther F, Jiang X, Schafers KP. PET attenuation correction for flexible MRI surface coils in hybrid PET/MRI using a 3D depth camera. Phys Med Biol 2018;63: 025033. Abstract
Gran S, Honold L, Fehler O, Zenker S, Eligehausen S, Kuhlmann MT, Geven E, den Bosch M van, van Lent P, Spiekermann C, Hermann S, Vogl T, Schäfers M, Roth J. Imaging, myeloid precursor immortalization, and genome editing for defining mechanisms of leukocyte recruitment_in vivo_. Theranostics 2018;8: 2407-2423. Abstract
Grosche J, Meissner J, Eble JA. More than a syllable in fib-ROS-is: The role of ROS on the fibrotic extracellular matrix and on cellular contacts. Mol Aspects Med 2018;63: 30-46. Abstract
Heming M, Gran S, Jauch S-L, Fischer-Riepe L, Russo A, Klotz L, Hermann S, Schafers M, Roth J, Barczyk-Kahlert K. Peroxisome Proliferator-Activated Receptor-γ Modulates the Response of Macrophages to Lipopolysaccharide and Glucocorticoids. Front Immunol 2018;9: 893. Abstract
Kato K, Dieguez-Hurtado R, Park DY, Hong SP, Kato-Azuma S, Adams S, Stehling M, Trappmann B, Wrana JL, Koh GY, Adams RH. Pulmonary pericytes regulate lung morphogenesis. Nat Commun 2018;9: 2448. Abstract
Kessler T, Baumeier A, Brand C, Grau M, Angenendt L, Harrach S, Stalmann U, Schmidt LH, Gosheger G, Hardes J, Andreou D, Dreischaluck J, Lenz G, Wardelmann E, Mesters RM, Schwoppe C, Berdel WE, Hartmann W, Schliemann C. Aminopeptidase N (CD13): Expression, Prognostic Impact, and Use as Therapeutic Target for Tissue Factor Induced Tumor Vascular Infarction in Soft Tissue Sarcoma. Transl Oncol 2018;11: 1271-1282. Abstract
Lima AM, Wegner SV, Martins Cavaco AC, Estevao-Costa MI, Sanz-Soler R, Niland S, Nosov G, Klingauf J, Spatz JP, Eble JA. The spatial molecular pattern of integrin recognition sites and their immobilization to colloidal nanobeads determine alpha2beta1 integrin-dependent platelet activation. Biomaterials 2018;167: 107-120. Abstract
Lleras Forero L, Narayanan R, Huitema LFA, VanBergen M, Apschner A, Peterson-Maduro J, Logister I, Valentin G, Morelli LG, Oates A, Schulte-Merker S. Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock. Elife 2018;7: epub. Abstract
Lopez-Baez JC, Simpson DJ, LLeras Forero L, Zeng Z, Brunsdon H, Salzano A, Brombin A, Wyatt C, Rybski W, Huitema LFA, Dale RM, Kawakami K, Englert C, Chandra T, Schulte-Merker S, Hastie ND, Patton EE. Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair. Elife 2018;7Abstract
Masthoff M, Helfen A, Claussen J, Roll W, Karlas A, Becker H, Gabriels G, Riess J, Heindel W, Schafers M, Ntziachristos V, Eisenblatter M, Gerth U, Wildgruber M. Multispectral optoacoustic tomography of systemic sclerosis. J Biophotonics 2018: e201800155. Abstract
Mauri C, Wang G, Schulte-Merker S. From fish embryos to human patients: lymphangiogenesis in development and disease. Curr Opin Immunol 2018;53: 167-172. Abstract
Michels T, Berh D, Jiang X. An RJMCMC-based method for tracking and resolving collisions of Drosophila Larvae. IEEE/ACM Transactions on Computational Biology and Bioinformatics 2018: epub. Abstract
Mikesch J-H, Hartmann W, Angenendt L, Huber O, Schliemann C, Arteaga MF, Wardelmann E, Rudack C, Berdel WE, Stenner M, Grunewald I. AAA+ ATPases Reptin and Pontin as potential diagnostic and prognostic biomarkers in salivary gland cancer - a short report. Cell Oncol (Dordr) 2018;41: 455–462. Abstract
Mikesch J-H, Schwammbach D, Hartmann W, Schmidt LH, Schliemann C, Angenendt L, Wiewrodt R, Marra A, Thoennissen NH, Wardelmann E, Kohler G, Lenz G, Muller-Tidow C, Berdel WE, Arteaga M-F. Reptin drives tumour progression and resistance to chemotherapy in nonsmall cell lung cancer. Eur Respir J 2018;52: 1701637. Abstract
Nadarajah N, Schulte D, McConnell V, Martin-Almedina S, Karapouliou C, Mortimer PS, Jeffery S, Schulte-Merker S, Gordon K, Mansour S, Ostergaard P. A Novel Splice-Site Mutation in VEGFC Is Associated with Congenital Primary Lymphoedema of Gordon. Int J Mol Sci 2018;19: 2259. Abstract
Reips L, Burger M, Engbers R. Towards dynamic PET reconstruction under flow conditions: Parameter identification in a PDE model. Journal of Inverse and Ill-posed Problems 2018;26: 185-200. Abstract
Rossig C, Kailayangiri S, Jamitzky S, Altvater B. Carbohydrate Targets for CAR T Cells in Solid Childhood Cancers. Front. Oncol. 2018;8: epub. Abstract
Schelhaas S, Heinzmann K, Honess DJ, Smith D-M, Keen H, Heskamp S, Witney TH, Besret L, Doblas S, Griffiths JR, Aboagye EO, Jacobs AH. 3'-Deoxy-3'-[(18)F]Fluorothymidine Uptake Is Related to Thymidine Phosphorylase Expression in Various Experimental Tumor Models. Mol Imaging Biol 2018;20: 194-199. Abstract
Schelhaas S, Wachsmuth L, Hermann S, Rieder N, Heller A, Heinzmann K, Honess DJ, Smith D-M, Fricke IB, Just N, Doblas S, Sinkus R, Doring C, Schafers KP, Griffiths JR, Faber C, Schneider R, Aboagye EO, Jacobs AH. Thymidine Metabolism as a Confounding Factor for 3'-Deoxy-3'-(18)F-Fluorothymidine Uptake After Therapy in a Colorectal Cancer Model. J Nucl Med 2018;59: 1063-1069. Abstract
Seifert R, Kuhlmann MT, Eligehausen S, Kiefer F, Hermann S, Schafers M. Molecular imaging of MMP activity discriminates unstable from stable plaque phenotypes in shear-stress induced murine atherosclerosis. PLoS One 2018;13: e0204305. Abstract
Spukti EU, Schmidt LH, Schulze A, Schliemann C, Gorlich D, Wardelmann E, Hartmann W, Lenz G, Berdel WE, Kerkhoff A. (90) Y-ibritumomab-tiuxetan as a therapeutic alternative for follicular lymphoma (FL): A single-center experience. Eur J Haematol 2018;101: 514-521. Abstract
Spurny C, Kailayangiri S, Altvater B, Jamitzky S, Hartmann W, Wardelmann E, Ranft A, Dirksen U, Amler S, Hardes J, Fluegge M, Meltzer J, Farwick N, Greune L, Rossig C. T cell infiltration into Ewing sarcomas is associated with local expression of immune-inhibitory HLA-G. Oncotarget 2018;9: 6536-6549. Abstract
Spurny C, Kailayangiri S, Jamitzky S, Altvater B, Wardelmann E, Dirksen U, Hardes J, Hartmann W, Rossig C. Programmed cell death ligand 1 (PD-L1) expression is not a predominant feature in Ewing sarcomas. Pediatr Blood Cancer 2018;65: e26719. Abstract
Sugden WW, Siekmann AF. Endothelial cell biology of Endoglin in hereditary hemorrhagic telangiectasia. Curr Opin Hematol 2018;25: 237-244. Abstract
Wiesmann M, Timmer NM, Zinnhardt B, Reinhard D, Eligehausen S, Konigs A, Ben Jeddi H, Dederen PJ, Jacobs AH, Kiliaan AJ. Effect of a multinutrient intervention after ischemic stroke in female C57Bl/6 mice. J Neurochem 2018;144: 549-564. Abstract
Wopat S, Bagwell J, Sumigray KD, Dickson AL, Huitema LFA, Poss KD, Schulte-Merker S, Bagnat M. Spine Patterning Is Guided by Segmentation of the Notochord Sheath. Cell Reports 2018;22: 2026-2038. Abstract
Zinnhardt B, Wiesmann M, Honold L, Barca C, Schäfers M, Kiliaan A, Jacobs AH. In vivo imaging biomarkers of neuroinflammation in the development and assessment of stroke therapies - towards clinical translation. Theranostics 2018;8: 2603-2620. Abstract


Baumer N, Berdel WE, Baumer S. Immunoprotein-Mediated siRNA Delivery. Mol Pharm 2017;14: 1339-1351. Abstract
Berh D, Risse B, Michels T, Otto N, Jiang X, Klambt C. An FIM-Based Long-Term In-Vial Monitoring System for Drosophila Larvae. IEEE Trans. Biomed. Eng. 2017;64: 1862-1874. Abstract
Bixel MG, Kusumbe AP, Ramasamy SK, Sivaraj KK, Butz S, Vestweber D, Adams RH. Flow Dynamics and HSPC Homing in Bone Marrow Microvessels. Cell Rep 2017;18: 1804-1816. Abstract
Brabetz O, Alla V, Angenendt L, Schliemann C, Berdel WE, Arteaga M-F, Mikesch J-H. RNA-Guided CRISPR-Cas9 System-Mediated Engineering of Acute Myeloid Leukemia Mutations. Mol Ther Nucleic Acids 2017;6: 243-248. Abstract
Brinkmann E-M, Burger M, Rasch J, Sutour C. Bias Reduction in Variational Regularization. J Math Imaging Vis 2017;59: 534-566. Abstract
Dunaeva M, Waltenberger J. Hh signaling in regeneration of the ischemic heart. Cell Mol Life Sci 2017;74: 3481-3490. Abstract
Eilken HM, Dieguez-Hurtado R, Schmidt I, Nakayama M, Jeong H-W, Arf H, Adams S, Ferrara N, Adams RH. Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1. Nat Commun 2017;8: 1574. Abstract
Gollner S, Oellerich T, Agrawal-Singh S, Schenk T, Klein H-U, Rohde C, Pabst C, Sauer T, Lerdrup M, Tavor S, Stolzel F, Herold S, Ehninger G, Kohler G, Pan K-T, Urlaub H, Serve H, Dugas M, Spiekermann K, Vick B, Jeremias I, Berdel WE, Hansen K, Zelent A, Wickenhauser C, Muller LP, Thiede C, Muller-Tidow C. Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia. Nat Med 2017;23: 69-78. Abstract
Hagerling R, Drees D, Scherzinger A, Dierkes C, Martin-Almedina S, Butz S, Gordon K, Schafers M, Hinrichs K, Ostergaard P, Vestweber D, Goerge T, Mansour S, Jiang X, Mortimer PS, Kiefer F. VIPAR, a quantitative approach to 3D histopathology applied to lymphatic malformations. JCI Insight 2017;2Abstract
Hasan SS, Tsaryk R, Lange M, Wisniewski L, Moore JC, Lawson ND, Wojciechowska K, Schnittler H, Siekmann AF. Endothelial Notch signalling limits angiogenesis via control of artery formation. Nat Cell Biol 2017;19: 928-940. Abstract
Hess M, Buther F, Schafers KP. Data-Driven Methods for the Determination of Anterior-Posterior Motion in PET. IEEE Trans Med Imaging 2017;36: 422-432. Abstract
Hogan BM, Schulte-Merker S. How to Plumb a Pisces: Understanding Vascular Development and Disease Using Zebrafish Embryos. Dev Cell 2017;42: 567-583. Abstract
Hübner K, Grassme KS, Rao J, Wenke NK, Zimmer CL, Korte L, Müller K, Sumanas S, Greber B, Herzog W. Wnt signaling positively regulates endothelial cell fate specification in the Fli1a-positive progenitor population via Lef1. Dev Biol 2017;430: 142-155. Abstract
Hugenberg V, Wagner S, Kopka K, Schafers M, Schuit RC, Windhorst AD, Hermann S. Radiolabeled Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitors: (Radio)Syntheses and in Vitro and First in Vivo Evaluation. J Med Chem 2017;60: 307-321. Abstract
Jeong H-W, Hernandez-Rodriguez B, Kim JM, Kim K-P, Enriquez-Gasca R, Yoon J, Adams S, Scholer HR, Vaquerizas JM, Adams RH. Transcriptional regulation of endothelial cell behavior during sprouting angiogenesis. Nat Commun 2017;8: 726. Abstract
Karpanen T, Padberg Y, van de Pavert SA, Dierkes C, Morooka N, Peterson-Maduro J, van de Hoek G, Adrian M, Mochizuki N, Sekiguchi K, Kiefer F, Schulte D, Schulte-Merker S. An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation. Circ Res 2017;120: 1263-1275. Abstract
Leist M, Rinne S, Datunashvili M, Aissaoui A, Pape H-C, Decher N, Meuth SG, Budde T. Acetylcholine-dependent upregulation of TASK-1 channels in thalamic interneurons by a smooth muscle-like signalling pathway. J Physiol 2017;595: 5875-5893. Abstract
Li L, Heiduschka P, Alex AF, Niekamper D, Eter N. Behaviour of CD11b-Positive Cells in an Animal Model of Laser-Induced Choroidal Neovascularisation. Ophthalmologica 2017;237: 29-41. Abstract
Lutz M, Schulze AB, Rebber E, Wiebe S, Zoubi T, Grauer OM, Kessler T, Kerkhoff A, Lenz G, Berdel WE. Progressive Multifocal Leukoencephalopathy after Ibrutinib Therapy for Chronic Lymphocytic Leukemia. Cancer Res Treat 2017;49: 548-552. Abstract
Meissner T, Mark A, Williams C, Berdel WE, Wiebe S, Kerkhoff A, Wardelmann E, Gaiser T, Muller-Tidow C, Rosenstiel P, Arnold N, Leyland-Jones B, Franke A, Stanulla M, Forster M. Metastatic triple-negative breast cancer patient with TP53 tumor mutation experienced 11 months progression-free survival on bortezomib monotherapy without adverse events after ending standard treatments with grade 3 adverse events. Cold Spring Harb Mol Case Stud 2017;3Abstract
Misra T, Baccino-Calace M, Meyenhofer F, Rodriguez-Crespo D, Akarsu H, Armenta-Calderon R, Gorr TA, Frei C, Cantera R, Egger B, Luschnig S. A genetically encoded biosensor for visualising hypoxia responses in vivo. Biol Open 2017;6: 296-304. Abstract
Orlich M, Kiefer F. A qualitative comparison of ten tissue clearing techniques. Histol Histopathol 2017: 11903. Abstract
Padberg Y, Schulte-Merker S, van Impel A. The lymphatic vasculature revisited-new developments in the zebrafish. Methods Cell Biol 2017;138: 221-238. Abstract
Pitulescu ME, Schmidt I, Giaimo BD, Antoine T, Berkenfeld F, Ferrante F, Park H, Ehling M, Biljes D, Rocha SF, Langen UH, Stehling M, Nagasawa T, Ferrara N, Borggrefe T, Adams RH. Dll4 and Notch signalling couples sprouting angiogenesis and artery formation. Nat Cell Biol 2017;19: 915-927. Abstract
Risse B, Berh D, Otto N, Klambt C, Jiang X. FIMTrack: An open source tracking and locomotion analysis software for small animals. PLoS Comput Biol 2017;13: e1005530. Abstract
Scherzinger A, Klemm S, Berh D, Jiang X. CNN-based background subtraction for long-term in-vial FIM imaging. In: Felsberg et al. (Eds.): Computer Analysis of Images and Patterns. CAIP 2017. LNCS 10424 2017;Springer, Cham: 359–371. Abstract
Schierke F, Wyrwoll MJ, Wisdorf M, Niedzielski L, Maase M, Ruck T, Meuth SG, Kusche-Vihrog K. Nanomechanics of the endothelial glycocalyx contribute to Na(+)-induced vascular inflammation. Sci Rep 2017;7: 46476. Abstract
Schmidt LH, Brand C, Stucke-Ring J, Schliemann C, Kessler T, Harrach S, Mohr M, Gorlich D, Marra A, Hillejan L, Muller-Tidow C, Lenz G, Wardelmann E, Wiewrodt R, Berdel WE, Schwoppe C, Hartmann W. Potential therapeutic impact of CD13 expression in non-small cell lung cancer. PLoS One 2017;12: e0177146. Abstract
Schmidt LH, Stucke-Ring J, Brand C, Schliemann C, Harrach S, Muley T, Herpel E, Kessler T, Mohr M, Görlich D, Kreuter M, Lenz G, Wardelmann E, Thomas M, Berdel WE, Schwöppe C, Hartmann W. CD13 as target for tissue factor induced tumor vascular infarction in small cell lung cancer. Lung Cancer 2017;113: 121-127. Abstract
Schneider C, Oellerich T, Baldauf H-M, Schwarz S-M, Thomas D, Flick R, Bohnenberger H, Kaderali L, Stegmann L, Cremer A, Martin M, Lohmeyer J, Michaelis M, Hornung V, Schliemann C, Berdel WE, Hartmann W, Wardelmann E, Comoglio F, Hansmann M-L, Yakunin AF, Geisslinger G, Strobel P, Ferreiros N, Serve H, Keppler OT, Cinatl JJ. SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia. Nat Med 2017;23: 250-255. Abstract
Schwab N, Schneider-Hohendorf T, Hoyt T, Gross CC, Meuth SG, Klotz L, Foley JF, Wiendl H. Anti-JCV serology during natalizumab treatment: Review and meta-analysis of 17 independent patient cohorts analyzing anti-John Cunningham polyoma virus sero-conversion rates under natalizumab treatment and differences between technical and biological sero-converters. Mult Scler 2017: 1352458517728814. Abstract
Seifert R, Scherzinger A, Kiefer F, Hermann S, Jiang X, Schafers MA. Statistical Permutation-based Artery Mapping (SPAM): a novel approach to evaluate imaging signals in the vessel wall. BMC Med Imaging 2017;17: 36. Abstract
Stocks T, Hillen T, Gong J, Burger M. A stochastic model for the normal tissue complication probability (NTCP) and applicationss. Math Med Biol 2017;34: 469-492. Abstract
Straub L, Gonzalez-Abradelo D, Strassert CA. Oxygen-insensitive phosphorescence in water from a Pt-doped supramolecular array. Chem Commun (Camb) 2017;53: 11806-11809. Abstract
Sugden WW, Leonardo-Mendonca RC, Acuna-Castroviejo D, Siekmann AF. Genetic dissection of endothelial transcriptional activity of zebrafish aryl hydrocarbon receptors (AHRs). PLoS One 2017;12: e0183433. Abstract
Sugden WW, Meissner R, Aegerter-Wilmsen T, Tsaryk R, Leonard EV, Bussmann J, Hamm MJ, Herzog W, Jin Y, Jakobsson L, Denz C, Siekmann AF. Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Nat Cell Biol 2017;19: 653-665. Abstract
van Lessen M, Shibata-Germanos S, van Impel A, Hawkins TA, Rihel J, Schulte-Merker S. Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development. Elife 2017;6: e25932. Abstract
Wild R, Klems A, Takamiya M, Hayashi Y, Strahle U, Ando K, Mochizuki N, van Impel A, Schulte-Merker S, Krueger J, Preau L, le Noble F. Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization. Nat Commun 2017;8: 13991. Abstract
Zhou F, Liu Y, Rohde C, Pauli C, Gerloff D, Kohn M, Misiak D, Baumer N, Cui C, Gollner S, Oellerich T, Serve H, Garcia-Cuellar M-P, Slany R, Maciejewski JP, Przychodzen B, Seliger B, Klein H-U, Bartenhagen C, Berdel WE, Dugas M, Taketo MM, Farouq D, Schwartz S, Regev A, Hebert J, Sauvageau G, Pabst C, Huttelmaier S, Muller-Tidow C. AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia. Nat Cell Biol 2017;19: 844-855. Abstract
Zinnhardt B, Pigeon H, Theze B, Viel T, Wachsmuth L, Fricke IB, Schelhaas S, Honold L, Schwegmann K, Wagner S, Faust A, Faber C, Kuhlmann MT, Hermann S, Schafers M, Winkeler A, Jacobs AH. Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake. Cancer Res 2017;77: 1831-1841. Abstract


Baumer N, Appel N, Terheyden L, Buchholz F, Rossig C, Muller-Tidow C, Berdel WE, Baumer S. Antibody-coupled siRNA as an efficient method for in vivo mRNA knockdown. Nat Protoc 2016;11: 22-36. Abstract
Bettenworth D, Mucke MM, Schwegmann K, Faust A, Poremba C, Schafers M, Domagk D, Lenz P. Endoscopy-guided orthotopic implantation of colorectal cancer cells results in metastatic colorectal cancer in mice. Clin Exp Metastasis 2016;33: 551-562. Abstract
Brand C, Schliemann C, Ring J, Kessler T, Baumer S, Angenendt L, Mantke V, Ross R, Hintelmann H, Spieker T, Wardelmann E, Mesters RM, Berdel WE, Schwoppe C. NG2 proteoglycan as a pericyte target for anticancer therapy by tumor vessel infarction with retargeted tissue factor. Oncotarget 2016;7: 6774-6789. Abstract
Burger M. Bregman Distances in Inverse Problems and Partial Differential Equations. In: Hiriart-Urruty JB., Korytowski A., eds., Advances in Mathematical Modeling, Optimization and Opt 2016;Springer, Cham: 3-33. Abstract
Burger M, Papafitsoros K, Papoutsellis E, Schonlieb C-B. Infimal Convolution Regularisation Functionals of BV and [Formula: see text] Spaces: Part I: The Finite [Formula: see text] Case. J Math Imaging Vis 2016;55: 343-369. Abstract
Buther F, Vehren T, Schafers KP, Schafers M. Impact of Data-driven Respiratory Gating in Clinical PET. Radiology 2016: 152067. Abstract
Caviglia S, Brankatschk M, Fischer EJ, Eaton S, Luschnig S. Staccato/Unc-13-4 controls secretory lysosome-mediated lumen fusion during epithelial tube anastomosis. Nat Cell Biol 2016;18: 727-739. Abstract
Chen Q, Zhang H, Liu Y, Adams S, Eilken H, Stehling M, Corada M, Dejana E, Zhou B, Adams RH. Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells. Nat Commun 2016;7: 12422. Abstract
de Bruin A, A Cornelissen PW, Kirchmaier BC, Mokry M, Iich E, Nirmala E, Liang K-H, D Vegh AM, Scholman KT, Groot Koerkamp MJ, Holstege FC, Cuppen E, Schulte-Merker S, Bakker WJ. Genome-wide analysis reveals NRP1 as a direct HIF1alpha-E2F7 target in the regulation of motorneuron guidance in vivo. Nucleic Acids Res 2016;44: 3549-3566. Abstract
De Lella Ezcurra AL, Bertolin AP, Kim K, Katz MJ, Gandara L, Misra T, Luschnig S, Perrimon N, Melani M, Wappner P. miR-190 Enhances HIF-Dependent Responses to Hypoxia in Drosophila by Inhibiting the Prolyl-4-hydroxylase Fatiga. PLoS Genet 2016;12: e1006073. Abstract
Erapaneedi R, Belousov VV, Schafers M, Kiefer F. A novel family of fluorescent hypoxia sensors reveal strong heterogeneity in tumor hypoxia at the cellular level. Embo J 2016;35: 102-113. Abstract
Fricke IB, Viel T, Worlitzer MM, Collmann FM, Vrachimis A, Faust A, Wachsmuth L, Faber C, Dolle F, Kuhlmann MT, Schafers K, Hermann S, Schwamborn JC, Jacobs AH. 6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging-detectable alteration in adult neurogenesis. Eur J Neurosci 2016;43: 1352-1365. Abstract
Galstyan A, Kauscher U, Block D, Ravoo BJ, Strassert CA. Silicon(IV) Phthalocyanine-Decorated Cyclodextrin Vesicles as a Self-Assembled Phototherapeutic Agent against MRSA. ACS Appl Mater Interfaces 2016;8: 12631-12637. Abstract
Grainger S, Richter J, Palazón RE, Pouget C, Lonquich B, Wirth S, Grassme KS, Herzog W, Swift MR, Weinstein BM, Traver D, Willert K. Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells. Cell Rep 2016;17: 1595-1606. Abstract
Gross CC, Ahmetspahic D, Ruck T, Schulte-Mecklenbeck A, Schwarte K, Jorgens S, Scheu S, Windhagen S, Graefe B, Melzer N, Klotz L, Arolt V, Wiendl H, Meuth SG, Alferink J. Alemtuzumab treatment alters circulating innate immune cells in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 2016;3: e289. Abstract
Gross CC, Schulte-Mecklenbeck A, Runzi A, Kuhlmann T, Posevitz-Fejfar A, Schwab N, Schneider-Hohendorf T, Herich S, Held K, Konjevic M, Hartwig M, Dornmair K, Hohlfeld R, Ziemssen T, Klotz L, Meuth SG, Wiendl H. Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation. Proc Natl Acad Sci U S A 2016;113: E2973-82. Abstract
Hamm MJ, Kirchmaier BC, Herzog W. Sema3d controls collective endothelial cell migration by distinct mechanisms via Nrp1 and PlxnD1. J Cell Biol 2016;215: 415-430. Abstract
Hermann S, Kuhlmann MT, Starsichova A, Eligehausen S, Schafers K, Stypmann J, Tiemann K, Levkau B, Schafers M. Imaging Reveals the Connection Between Spontaneous Coronary Plaque Ruptures, Atherothrombosis, and Myocardial Infarctions in HypoE/SRBI-/- Mice. J Nucl Med 2016;57: 1420-1427. Abstract
Hucke S, Herold M, Liebmann M, Freise N, Lindner M, Fleck A-K, Zenker S, Thiebes S, Fernandez-Orth J, Buck D, Luessi F, Meuth SG, Zipp F, Hemmer B, Engel DR, Roth J, Kuhlmann T, Wiendl H, Klotz L. The farnesoid-X-receptor in myeloid cells controls CNS autoimmunity in an IL-10-dependent fashion. Acta Neuropathol 2016;132: 413-431. Abstract
Kailayangiri S, Altvater B, Spurny C, Jamitzky S, Schelhaas S, Jacobs AH, Wiek C, Roellecke K, Hanenberg H, Hartmann W, Wiendl H, Pankratz S, Meltzer J, Farwick N, Greune L, Fluegge M, Rossig C. Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G. OncoImmunology 2016: e1250050. Abstract
Kalinin DV, Wagner S, Riemann B, Hermann S, Schmidt F, Becker-Pauly C, Rose-John S, Schafers M, Holl R. Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography. J Med Chem 2016;59: 9541-9559. Abstract
Kusumbe AP, Ramasamy SK, Itkin T, Mae MA, Langen UH, Betsholtz C, Lapidot T, Adams RH. Age-dependent modulation of vascular niches for haematopoietic stem cells. Nature 2016;532: 380-384. Abstract
Matsuoka RL, Marass M, Avdesh A, Helker CS, Maischein HM, Grosse AS, Kaur H, Lawson ND, Herzog W, Stainier DY. Radial glia regulate vascular patterning around the developing spinal cord. eLife 2016;5: e20253. Abstract
Otto N, Risse B, Berh D, Bittern J, Jiang X, Klambt C. Interactions among Drosophila larvae before and during collision. Sci Rep 2016;6: 31564. Abstract
Pankratz S, Ruck T, Meuth SG, Wiendl H. CD4(+)HLA-G(+) regulatory T cells: Molecular signature and pathophysiological relevance. Hum Immunol 2016;77: 727-733. Abstract
Papangeli I, Kim J, Maier I, Park S, Lee A, Kang Y, Tanaka K, Khan OF, Ju H, Kojima Y, Red-Horse K, Anderson DG, Siekmann AF, Chun HJ. MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation. Nat Commun 2016;7: 11268. Abstract
Pardali E, Schmitz T, Borgscheiper A, Iking J, Stegger L, Waltenberger J. Cryopreservation of primary human monocytes does not negatively affect their functionality or their ability to be labelled with radionuclides: basis for molecular imaging and cell therapy. EJNMMI Res 2016;6: 77. Abstract
Pohlen M, Groth C, Sauer T, Gorlich D, Mesters R, Schliemann C, Lenz G, Muller-Tidow C, Buchner T, Berdel WE, Stelljes M. Outcome of allogeneic stem cell transplantation for AML and myelodysplastic syndrome in elderly patients (60 years). Bone Marrow Transplant 2016;51: 1441-1448. Abstract
Pohlen M, Marx J, Mellmann A, Becker K, Mesters RM, Mikesch J-H, Schliemann C, Lenz G, Muller-Tidow C, Buchner T, Krug U, Stelljes M, Karch H, Peters G, Gerth HU, Gorlich D, Berdel WE. Ciprofloxacin versus colistin prophylaxis during neutropenia in acute myeloid leukemia: two parallel patient cohorts treated in a single center. Haematologica 2016;101: 1208-1215. Abstract
Ramasamy SK, Kusumbe AP, Itkin T, Gur-Cohen S, Lapidot T, Adams RH. Regulation of Hematopoiesis and Osteogenesis by Blood Vessel-Derived Signals. Annu Rev Cell Dev Biol 2016;32: 649-675. Abstract
Ramasamy SK, Kusumbe AP, Schiller M, Zeuschner D, Bixel MG, Milia C, Gamrekelashvili J, Limbourg A, Medvinsky A, Santoro MM, Limbourg FP, Adams RH. Blood flow controls bone vascular function and osteogenesis. Nat Commun 2016;7: 13601. Abstract
Reinartz G, Haverkamp U, Wullenkord R, Lehrich P, Kriz J, Buther F, Schafers K, Schafers M, Eich HT. 4D-Listmode-PET-CT and 4D-CT for optimizing PTV margins in gastric lymphoma : Determination of intra- and interfractional gastric motion. Strahlenther Onkol 2016;192: 322-332. Abstract
Schelhaas S, Held A, Wachsmuth L, Hermann S, Honess DJ, Heinzmann K, Smith D-M, Griffiths JR, Faber C, Jacobs AH. Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3'-Deoxy-3'-[18F]Fluorothymidine in Preclinical Models of Lung Cancer. Cancer Res 2016;76: 7096-7105. Abstract
Schmidt LH, Kuemmel A, Schliemann C, Schulze A, Humberg J, Mohr M, Gorlich D, Hartmann W, Brockling S, Marra A, Hillejan L, Goletz S, Karsten U, Berdel WE, Spieker T, Wiewrodt R. Blood group antigen A type 3 expression is a favorable prognostic factor in advanced NSCLC. Lung Cancer 2016;92: 8-14. Abstract
Schmidt LH, Vietmeier B, Kaleschke G, Schulke C, Gorlich D, Schliemann C, Kessler T, Schulze AB, Buerke B, Kuemmel A, Thrull M, Wiewrodt R, Baumgartner H, Berdel WE, Mohr M. Thoracic Malignancies and Pulmonary Nodules in Patients under Evaluation for Transcatheter Aortic Valve Implantation (TAVI): Incidence, Follow Up and Possible Impact on Treatment Decision. PLoS One 2016;11: e0155398. Abstract
Schulze I, Rohde C, Scheller-Wendorff M, Baumer N, Krause A, Herbst F, Riemke P, Hebestreit K, Tschanter P, Lin Q, Linhart H, Godley LA, Glimm H, Dugas M, Wagner W, Berdel WE, Rosenbauer F, Muller-Tidow C. Increased DNA methylation of Dnmt3b targets impairs leukemogenesis. Blood 2016;127: 1575-1586. Abstract
Sivaraj KK, Adams RH. Blood vessel formation and function in bone. Development 2016;143: 2706-2715. Abstract
Spiegler S, Kirchmaier B, Rath M, Korenke GC, Tetzlaff F, van de Vorst M, Neveling K, Acker-Palmer A, Kuss AW, Gilissen C, Fischer A, Schulte-Merker S, Felbor U. FAM222B Is Not a Likely Novel Candidate Gene for Cerebral Cavernous Malformations. Mol Syndromol 2016;7: 144-152. Abstract
Stucke-Ring J, Ronnacker J, Brand C, Holtke C, Schliemann C, Kessler T, Schmidt LH, Harrach S, Mantke V, Hintelmann H, Hartmann W, Wardelmann E, Lenz G, Wunsch B, Muller-Tidow C, Mesters RM, Schwoppe C, Berdel WE. Combinatorial effects of doxorubicin and retargeted tissue factor by intratumoral entrapment of doxorubicin and proapoptotic increase of tumor vascular infarction. Oncotarget 2016;7: 82458-82472. Abstract
Uttarkar S, Piontek T, Dukare S, Schomburg C, Schlenke P, Berdel WE, Muller-Tidow C, Schmidt TJ, Klempnauer K-H. Small-Molecule Disruption of the Myb/p300 Cooperation Targets Acute Myeloid Leukemia Cells. Mol Cancer Ther 2016;15: 2905-2915. Abstract
Vahle A-K, Hermann S, Schafers M, Wildner M, Kerem A, Ozturk E, Jure-Kunkel M, Franklin C, Lang S, Brandau S. Multimodal imaging analysis of an orthotopic head and neck cancer mouse model and application of anti-CD137 tumor immune therapy. Head Neck 2016;38: 542-549. Abstract
Vrachimis A, Honold L, Faust A, Hermann S, Schafers M. New molecular probes of vascular inflammation. Q J Nucl Med Mol Imaging 2016;60: 194-204. Abstract
Vrachimis A, Weckesser M, Schafers M, Stegger L. Imaging of differentiated thyroid carcinoma: (124)I-PET/MRI may not be superior to (124)I-PET/CT. Eur J Nucl Med Mol Imaging 2016;43: 1183-1184. Abstract
Wagner S, Burger M, Wolters CH. An Optimization Approach for Well-Targeted Transcranial Direct Current Stimulation. SIAM J. Appl. Math. 2016;76: 2154-2174. Abstract
Wagner S, Lucka F, Vorwerk J, Herrmann CS, Nolte G, Burger M, Wolters CH. Using reciprocity for relating the simulation of transcranial current stimulation to the EEG forward problem. Neuroimage 2016;140: 163-173. Abstract


Agelopoulos K, Richter GHS, Schmidt E, Dirksen U, von Heyking K, Moser B, Klein H-U, Kontny U, Dugas M, Poos K, Korsching E, Buch T, Weckesser M, Schulze I, Besoke R, Witten A, Stoll M, Kohler G, Hartmann W, Wardelmann E, Rossig C, Baumhoer D, Jurgens H, Burdach S, Berdel WE, Muller-Tidow C. Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma. Clin Cancer Res 2015;21: 4935-4946. Abstract
Bălan M, Kiefer F. A novel model for ectopic, chronic, intravital multiphoton imaging of bone marrow vasculature and architecture in split femurs. IntraVital 2015;4: e1066949. Abstract
Baumer S, Baumer N, Appel N, Terheyden L, Fremerey J, Schelhaas S, Wardelmann E, Buchholz F, Berdel WE, Muller-Tidow C. Antibody-Mediated Delivery of Anti-KRAS-siRNA In Vivo Overcomes Therapy Resistance in Colon Cancer. Clin Cancer Res 2015;21: 1383-1394. Abstract
Bista P, Pawlowski M, Cerina M, Ehling P, Leist M, Meuth P, Aissaoui A, Borsotto M, Heurteaux C, Decher N, Pape H-C, Oliver D, Meuth SG, Budde T. Differential phospholipase C-dependent modulation of TASK and TREK two-pore domain K+ channels in rat thalamocortical relay neurons. J Physiol 2015;593: 127-144. Abstract
Borschel N, Schwoppe C, Zerbst C, Angenendt L, Kessler T, Klapper W, Giovannoni L, Elia G, Neri D, Berdel WE, Mesters RM, Schliemann C. Potentiating the activity of rituximab against mantle cell lymphoma in mice by targeting interleukin-2 to the neovasculature. Leuk Res 2015;39: 739-748. Abstract
Brand C, Dencks S, Schmitz G, Muhlmeister M, Stypmann J, Ross R, Hintelmann H, Schliemann C, Muller-Tidow C, Mesters RM, Berdel WE, Schwoppe C. Low-Energy Ultrasound Treatment Improves Regional Tumor Vessel Infarction by Retargeted Tissue Factor. J Ultrasound Med 2015;34: 1227-1236. Abstract
Brand C, Frohlich M, Ring J, Schliemann C, Kessler T, Mantke V, Konig S, Lucke M, Mesters RM, Berdel WE, Schwoppe C. Tumor Growth Inhibition via Occlusion of Tumor Vasculature Induced by N-Terminally PEGylated Retargeted Tissue Factor tTF-NGR. Mol Pharm 2015;12: 3749-3758. Abstract
Bulk E, Ay A-S, Hammadi M, Ouadid-Ahidouch H, Schelhaas S, Hascher A, Rohde C, Thoennissen NH, Wiewrodt R, Schmidt E, Marra A, Hillejan L, Jacobs AH, Klein H-U, Dugas M, Berdel WE, Muller-Tidow C, Schwab A. Epigenetic dysregulation of KCa 31 channels induces poor prognosis in lung cancer. Int J Cancer 2015;137: 1306-1317. Abstract
Burger M, Modersitzki J, Suhr S. A Nonlinear Variational Approach to Motion-Corrected Reconstruction of Density Images. arXiv 2015: epub. Abstract
Ehling P, Cerina M, Budde T, Meuth SG, Bittner S. The CNS under pathophysiologic attack--examining the role of K(2)p channels. Pflugers Arch 2015;467: 959-972. Abstract
Ehling P, Melzer N, Budde T, Meuth SG. CD8(+) T Cell-Mediated Neuronal Dysfunction and Degeneration in Limbic Encephalitis. Front Neurol 2015;6: 163. Abstract
Ersepke T, Buther F, Hess M, Schafers KP. A contactless approach for respiratory gating in PET using continuous-wave radar. Med Phys 2015;42: 4911. Abstract
Frisch H, Besenius P. pH-Switchable Self-Assembled Materials. Macromol Rapid Commun 2015;36: 346-363. Abstract
Harrison MRM, Bussmann J, Huang Y, Zhao L, Osorio A, Burns CG, Burns CE, Sucov HM, Siekmann AF, Lien C-L. Chemokine-guided angiogenesis directs coronary vasculature formation in zebrafish. Dev Cell 2015;33: 442-454. Abstract
Hasan SS, Siekmann AF. The same but different: signaling pathways in control of endothelial cell migration. Curr Opin Cell Biol 2015;36: 86-92. Abstract
Helin T, Burger M. Maximum_a posteriori_probability estimates in infinite-dimensional Bayesian inverse problems. Inverse Problems 2015;31: 085009. Abstract
Helker CSM, Schuermann A, Pollmann C, Chng SC, Kiefer F, Reversade B, Herzog W. The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis. Elife 2015;4: epub. Abstract
Hermkens DMA, van Impel A, Urasaki A, Bussmann J, Duckers HJ, Schulte-Merker S. Sox7 controls arterial specification in conjunction with hey2 and efnb2 function. Development 2015;142: 1695-1704. Abstract
Kok FO, Shin M, Ni C-W, Gupta A, Grosse AS, van Impel A, Kirchmaier BC, Peterson-Maduro J, Kourkoulis G, Male I, DeSantis DF, Sheppard-Tindell S, Ebarasi L, Betsholtz C, Schulte-Merker S, Wolfe SA, Lawson ND. Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Dev Cell 2015;32: 97-108. Abstract
Kusumbe AP, Ramasamy SK, Starsichova A, Adams RH. Sample preparation for high-resolution 3D confocal imaging of mouse skeletal tissue. Nat Protoc 2015;10: 1904-1914. Abstract
Mackay EW, Apschner A, Schulte-Merker S. Vitamin K reduces hypermineralisation in zebrafish models of PXE and GACI. Development 2015;142: 1095-1101. Abstract
Nunan R, Campbell J, Mori R, Pitulescu ME, Jiang WG, Harding KG, Adams RH, Nobes CD, Martin P. Ephrin-Bs Drive Junctional Downregulation and Actin Stress Fiber Disassembly to Enable Wound Re-epithelialization. Cell Rep 2015;13: 1380-1395. Abstract
Oelmann E, Stein H, Berdel WE, Herbst H. Expression of Interleukin-1 and Interleukin-1 Receptors Type 1 and Type 2 in Hodgkin Lymphoma. PLoS One 2015;10: e0138747. Abstract
Ortmann C, Pickhinke U, Exner S, Ohlig S, Lawrence R, Jboor H, Dreier R, Grobe K. Sonic hedgehog processing and release are regulated by glypican heparan sulfate proteoglycans. J Cell Sci 2015;128: 2374-2385. Abstract
Polprasert C, Schulze I, Sekeres MA, Makishima H, Przychodzen B, Hosono N, Singh J, Padgett RA, Gu X, Phillips JG, Clemente M, Parker Y, Lindner D, Dienes B, Jankowsky E, Saunthararajah Y, Du Y, Oakley K, Nguyen N, Mukherjee S, Pabst C, Godley LA, Churpek JE, Pollyea DA, Krug U, Berdel WE, Klein H-U, Dugas M, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Yoshida K, Ogawa S, Muller-Tidow C, Maciejewski JP. Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms. Cancer Cell 2015;27: 658-670. Abstract
Ramasamy SK, Kusumbe AP, Adams RH. Regulation of tissue morphogenesis by endothelial cell-derived signals. Trends Cell Biol 2015;25: 148-157. Abstract
Reilmann R, Lippross V, Holzner E, Gigengack F, Bohlen S, Kugel H, Deppe M, Osada N, Lucke M, Riess O, Nguyen HP, Von Horsten S, Schafers K, Schafers M, Jacobs AH, Hermann S. FDG muPET Fails to Detect a Disease-Specific Phenotype in Rats Transgenic for Huntington's Disease - A 15 Months Follow-up Study. J Huntingtons Dis 2015;4: 37-47. Abstract
Roukens MG, Peterson-Maduro J, Padberg Y, Jeltsch M, Leppanen V-M, Bos FL, Alitalo K, Schulte-Merker S, Schulte D. Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain. Circ Res 2015;116: 1660-1669. Abstract
Ruck T, Bittner S, Wiendl H, Meuth SG. Alemtuzumab in Multiple Sclerosis: Mechanism of Action and Beyond. Int J Mol Sci 2015;16: 16414-16439. Abstract
Schliemann C, Gutbrodt KL, Kerkhoff A, Pohlen M, Wiebe S, Silling G, Angenendt L, Kessler T, Mesters RM, Giovannoni L, Schafers M, Altvater B, Rossig C, Grunewald I, Wardelmann E, Kohler G, Neri D, Stelljes M, Berdel WE. Targeting interleukin-2 to the bone marrow stroma for therapy of acute myeloid leukemia relapsing after allogeneic hematopoietic stem cell transplantation. Cancer Immunol Res 2015;3: 547-556. Abstract
Schmid S, Jiang X, Schafers K. Puzzle Approach to Pose Tracking of a Rigid Object in a Multi Camera System. Lect Notes Comput Sc 2015;9256: 337-349. Abstract
Schmidt C, Wagner S, Burger M, Rienen U van, Wolters CH. Impact of uncertain head tissue conductivity in the optimization of transcranial direct current stimulation for an auditory target. J Neural Eng 2015;12: 046028. Abstract
Schmidt LH, Kummel A, Gorlich D, Mohr M, Brockling S, Mikesch JH, Grunewald I, Marra A, Schultheis AM, Wardelmann E, Muller-Tidow C, Spieker T, Schliemann C, Berdel WE, Wiewrodt R, Hartmann W. PD-1 and PD-L1 Expression in NSCLC Indicate a Favorable Prognosis in Defined Subgroups. PLoS One 2015;10: e0136023. Abstract
Schuermann A, Helker CSM, Herzog W. Metallothionein 2 regulates endothelial cell migration through transcriptional regulation of vegfc expression. Angiogenesis 2015;18: 463-475. Abstract
Tchaikovski V, Tchaikovski S, Olieslagers S, Waltenberger J. Monocyte dysfunction as a previously unrecognized pathophysiological mechanism in ApoE−/− mice contributing to impaired arteriogenesis. Int. J. Cardiol. 2015;190: 214-216. Abstract
Tjaden K, Pardali E, Waltenberger J. Hypercholesterolemia Induces Vascular Cell Dysfunction: Molecular Basis for Atherosclerosis. Austin J Vasc Med 2015;2(1): 1011. Abstract
van Lessen M, Nakayama M, Kato K, Kim JM, Kaibuchi K, Adams RH. Regulation of Vascular Endothelial Growth Factor Receptor Function in Angiogenesis by Numb and Numb-Like. Arterioscler Thromb Vasc Biol 2015;35: 1815-1825. Abstract
Wenge DV, Felipe-Fumero E, Angenendt L, Schliemann C, Schmidt E, Schmidt LH, Thiede C, Ehninger G, Berdel WE, Arteaga M-F, Mikesch J-H. MN1-Fli1 oncofusion transforms murine hematopoietic progenitor cells into acute megakaryoblastic leukemia cells. Oncogenesis 2015;4: e179. Abstract
Wenning C, Vrachimis A, Dell Aquila A, Penning A, Stypmann J, Schafers M. Inhomogeneous myocardial stress perfusion in SPECT studies predicts future allograft dysfunction in heart transplant recipients. EJNMMI Res 2015;5: 51. Abstract
Xu C, Volkery S, Siekmann AF. Intubation-based anesthesia for long-term time-lapse imaging of adult zebrafish. Nat Protoc 2015;10: 2064-2073. Abstract
Yamamoto H, Ehling M, Kato K, Kanai K, van Lessen M, Frye M, Zeuschner D, Nakayama M, Vestweber D, Adams RH. Integrin beta1 controls VE-cadherin localization and blood vessel stability. Nat Commun 2015;6: 6429. Abstract
Zinnhardt B, Viel T, Wachsmuth L, Vrachimis A, Wagner S, Breyholz H-J, Faust A, Hermann S, Kopka K, Faber C, Dolle F, Pappata S, Planas AM, Tavitian B, Schafers M, Sorokin LM, Kuhlmann MT, Jacobs AH. Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke. J Cereb Blood Flow Metab 2015;35: 1711-1721. Abstract


Ahlers P, Frisch H, Spitzer D, Vobecka Z, Vilela F, Besenius P. The Synthesis of Dendritic EDOT-Peptide Conjugates and their Multistimuli-Responsive Self-Assembly into Supramolecular Nanorods and Fibers in Water. Chem Asian J 2014;9: 2052-2057. Abstract
Altvater B, Kailayangiri S, Theimann N, Ahlmann M, Farwick N, Chen C, Pscherer S, Neumann I, Mrachatz G, Hansmeier A, Hardes J, Gosheger G, Juergens H, Rossig C. Common Ewing sarcoma-associated antigens fail to induce natural T cell responses in both patients and healthy individuals. Cancer Immunol Immunother 2014;63: 1047-1060. Abstract
Azzoni E, Conti V, Campana L, Dellavalle A, Adams RH, Cossu G, Brunelli S. Hemogenic endothelium generates mesoangioblasts that contribute to several mesodermal lineages in vivo. Development 2014;141: 1821-1834. Abstract
Baumer N, Baumer S, Berkenfeld F, Stehling M, Kohler G, Berdel WE, Muller-Tidow C, Tschanter P. Maintenance of leukemia-initiating cells is regulated by the CDK inhibitor Inca1. PLoS One 2014;9: e115578. Abstract
Baumer N, Krause A, Kohler G, Lettermann S, Evers G, Hascher A, Baumer S, Berdel WE, Muller-Tidow C, Tickenbrock L. Proteinase-Activated Receptor 1 (PAR1) regulates leukemic stem cell functions. PLoS One 2014;9: e94993. Abstract
Bentley K, Franco CA, Philippides A, Blanco R, Dierkes M, Gebala V, Stanchi F, Jones M, Aspalter IM, Cagna G, Westrom S, Claesson-Welsh L, Vestweber D, Gerhardt H. The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis. Nat Cell Biol 2014;16: 309-321. Abstract
Bettenworth D, Nowacki TM, Ross M, Kyme P, Schwammbach D, Kerstiens L, Thoennissen GB, Bokemeyer C, Hengst K, Berdel WE, Heidemann J, Thoennissen NH. Nicotinamide treatment ameliorates the course of experimental colitis mediated by enhanced neutrophil-specific antibacterial clearance. Mol Nutr Food Res 2014;58: 1474-1490. Abstract
Blaske F, Reifschneider O, Gosheger G, Wehe CA, Sperling M, Karst U, Hauschild G, Holl S. Elemental bioimaging of nanosilver-coated prostheses using X-ray fluorescence spectroscopy and laser ablation-inductively coupled plasma-mass spectrometry. Anal Chem 2014;86: 615-620. Abstract
Bogdani M, Korpos E, Simeonovic CJ, Parish CR, Sorokin L, Wight TN. Extracellular matrix components in the pathogenesis of type 1 diabetes. Curr Diab Rep 2014;14: 552. Abstract
Burger M, Lucka F. Maximum_a posteriori_estimates in linear inverse problems with log-concave priors are proper Bayes estimators. Inverse Problems 2014;30: 114004. Abstract
Burger M, Müller J, Papoutsellis E, Schönlieb CB. Total variation regularization in measurement and image space for PET reconstruction. Inverse Probl 2014;30: 105003. Abstract
Chamakuri N, Engwer C, Kunisch K. Boundary control of bidomain equations with state-dependent switching source functions in the ionic model. J Comp Phys 2014;15: 227-242. Abstract
D'Amico G, Korhonen EA, Anisimov A, Zarkada G, Holopainen T, Hagerling R, Kiefer F, Eklund L, Sormunen R, Elamaa H, Brekken RA, Adams RH, Koh GY, Saharinen P, Alitalo K. Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. J Clin Invest 2014;124: 824-834. Abstract
Dartsch N, Schulte D, Hagerling R, Kiefer F, Vestweber D. Fusing VE-Cadherin to alpha-Catenin Impairs Fetal Liver Hematopoiesis and Lymph but Not Blood Vessel Formation. Mol Cell Biol 2014;34: 1634-1648. Abstract
Gobel K, Schuhmann MK, Pankratz S, Stegner D, Herrmann AM, Braun A, Breuer J, Bittner S, Ruck T, Wiendl H, Kleinschnitz C, Nieswandt B, Meuth SG. Phospholipase D1 mediates lymphocyte adhesion and migration in experimental autoimmune encephalomyelitis. Eur J Immunol 2014;44: 2295-2305. Abstract
Gorina R, Lyck R, Vestweber D, Engelhardt B. beta2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier. J Immunol 2014;192: 324-337. Abstract
Grosse Brinkhaus S, Bornhorst J, Chakraborty S, Wehe CA, Niehaus R, Reifschneider O, Aschner M, Karst U. Elemental bioimaging of manganese uptake in C elegans. Metallomics 2014;6: 617-621. Abstract
Hascher A, Haase A-K, Hebestreit K, Rohde C, Klein H-U, Rius M, Jungen D, Witten A, Stoll M, Schulze I, Ogawa S, Wiewrodt R, Tickenbrock L, Berdel WE, Dugas M, Thoennissen NH, Muller-Tidow C. DNA methyltransferase inhibition reverses epigenetically embedded phenotypes in lung cancer preferentially affecting polycomb target genes. Clin Cancer Res 2014;20: 814-826. Abstract
Hillgruber C, Steingraber AK, Poppelmann B, Denis CV, Ware J, Vestweber D, Nieswandt B, Schneider SW, Goerge T. Blocking von Willebrand factor for treatment of cutaneous inflammation. J Invest Dermatol 2014;134: 77-86. Abstract
Himpe C, Ohlberger M. Cross-Gramian-Based Combined State and Parameter Reduction for Large-Scale Control Systems. Mathematical Problems in Engineering 2014;2014: 1-13. Abstract
Hinkel R, Trenkwalder T, Petersen B, Husada W, Gesenhues F, Lee S, Hannappel E, Bock-Marquette I, Theisen D, Leitner L, Boekstegers P, Cierniewski C, Muller OJ, le Noble F, Adams RH, Weinl C, Nordheim A, Reichart B, Weber C, Olson E, Posern G, Deindl E, Niemann H, Kupatt C. MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2. Nat Commun 2014;5: 3970. Abstract
Hu J, Popp R, Fromel T, Ehling M, Awwad K, Adams RH, Hammes H-P, Fleming I. Muller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid. J Exp Med 2014;211: 281-295. Abstract
Hultin S, Zheng Y, Mojallal M, Vertuani S, Gentili C, Balland M, Milloud R, Belting H-G, Affolter M, Helker CSM, Adams RH, Herzog W, Uhlen P, Majumdar A, Holmgren L. AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion. Nat Commun 2014;5: Article number: 3743. Abstract
Hupe M, Li MX, Gertow Gillner K, Adams RH, Stenman JM. Evaluation of TRAP-sequencing technology with a versatile conditional mouse model. Nucleic Acids Res 2014;42: e14. Abstract
Junker A, Kokornaczyk AK, Strunz AK, Wünsch B. Selective and Dual Targeting of CCR2 and CCR5 Receptors: A Current Overview. Chemokines 2014: 1-55. Abstract
Kanyshkova T, Ehling P, Cerina M, Meuth P, Zobeiri M, Meuth SG, Pape H-C, Budde T. Regionally specific expression of high-voltage-activated calcium channels in thalamic nuclei of epileptic and non-epileptic rats. Mol Cell Neurosci 2014;61: 110-122. Abstract
Kim C, Yang H, Fukushima Y, Saw PE, Lee J, Park J-S, Park I, Jung J, Kataoka H, Lee D, Heo WD, Kim I, Jon S, Adams RH, Nishikawa S-I, Uemura A, Koh GY. Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption. Cancer Cell 2014;25: 102-117. Abstract
Korn C, Scholz B, Hu J, Srivastava K, Wojtarowicz J, Arnsperger T, Adams RH, Boutros M, Augustin HG, Augustin I. Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis. Development 2014;141: 1757-1766. Abstract
Kraus H, Kaiser S, Aumann K, Bonelt P, Salzer U, Vestweber D, Erlacher M, Kunze M, Burger, Pieper K, Sic H, Rolink A, Eibel H, Rizzi M. A feeder-free differentiation system identifies autonomously proliferating B cell precursors in human bone marrow. J Immunol 2014;192: 1044-1054. Abstract
Krause TA, Alex AF, Engel DR, Kurts C, Eter N. VEGF-production by CCR2-dependent macrophages contributes to laser-induced choroidal neovascularization. PLoS One 2014;9: e94313. Abstract
Kusumbe AP, Ramasamy SK, Adams RH. Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature 2014;507: 323-328. Abstract
Liersch R, Muller-Tidow C, Berdel WE, Krug U. Prognostic factors for acute myeloid leukaemia in adults--biological significance and clinical use. Br J Haematol 2014;165: 17-38. Abstract
Niehoff A-C, Moosmann A, Sobbing J, Wiehe A, Mulac D, Wehe CA, Reifschneider O, Blaske F, Wagner S, Sperling M, von Briesen H, Langer K, Karst U. A palladium label to monitor nanoparticle-assisted drug delivery of a photosensitizer into tumor spheroids by elemental bioimaging. Metallomics 2014;6: 77-81. Abstract
Nielsen N, Lindemann O, Schwab A. TRP channels and STIM/ORAI proteins: sensors and effectors of cancer and stroma cell migration. Br J Pharmacol 2014;171: 5524-5540. Abstract
Noels H, Zhou B, Tilstam PV, Theelen W, Li X, Pawig L, Schmitz C, Akhtar S, Simsekyilmaz S, Shagdarsuren E, Schober A, Adams RH, Bernhagen J, Liehn EA, Doring Y, Weber C. Deficiency of endothelial CXCR4 reduces reendothelialization and enhances neointimal hyperplasia after vascular injury in atherosclerosis-prone mice. Arterioscler Thromb Vasc Biol 2014;34: 1209-1220. Abstract
Pankratz S, Bittner S, Herrmann AM, Schuhmann MK, Ruck T, Meuth SG, Wiendl H. Human CD4+HLA-G+ regulatory T cells are potent suppressors of graft-versus-host disease in vivo. Faseb J 2014;28: 3435-3445. Abstract
Persigehl T, Ring J, Bremer C, Heindel W, Holtmeier R, Stypmann J, Claesener M, Hermann S, Schafers M, Zerbst C, Schliemann C, Mesters RM, Berdel WE, Schwoppe C. Non-invasive monitoring of tumor-vessel infarction by retargeted truncated tissue factor tTF-NGR using multi-modal imaging. Angiogenesis 2014;17: 235-246. Abstract
Pitulescu ME, Adams RH. Regulation of signaling interactions and receptor endocytosis in growing blood vessels. Cell Adh Migr 2014;8: 366-377. Abstract
Prasad VP, Wagner S, Keul P, Hermann S, Levkau B, Schafers M, Haufe G. Synthesis of fluorinated analogues of sphingosine-1-phosphate antagonists as potential radiotracers for molecular imaging using positron emission tomography. Bioorg Med Chem 2014;22: 5168-5181. Abstract
Ramasamy SK, Kusumbe AP, Wang L, Adams RH. Endothelial Notch activity promotes angiogenesis and osteogenesis in bone. Nature 2014;507: 376-380. Abstract
Reichman-Fried M, Raz E. Small proteins, big roles: The signaling protein Apela extends the complexity of developmental pathways in the early zebrafish embryo. Bioessays 2014;36: 741-745. Abstract
Reinhardt B, Godfrey R, Fellbrich G, Frank H, Luske A, Olieslagers S, Mertens T, Waltenberger J. Human cytomegalovirus infection impairs endothelial cell chemotaxis by disturbing VEGF signalling and actin polymerization. Cardiovasc Res 2014;104: 315-325. Abstract
Risse B, Otto N, Berh D, Jiang X, Klambt C. FIM imaging and FIMtrack: two new tools allowing high-throughput and cost effective locomotion analysis. J Vis Exp 2014: e52207. Abstract
Schäfers KP, Bolwin K, Büther F, Hermann S, Jacobs AH, Kösters T, Kuhlmann M, Schäfers M, Viel T. High-Resolution Small Animal Imaging. In: Comprehensive Biomedical Physics 2014;Elsevier, Oxford: 181-211. Abstract
Schelhaas S, Wachsmuth L, Viel T, Honess DJ, Heinzmann K, Smith D-M, Hermann S, Wagner S, Kuhlmann MT, Muller-Tidow C, Kopka K, Schober O, Schafers M, Schneider R, Aboagye EO, Griffiths J, Faber C, Jacobs AH. Variability of Proliferation and Diffusion in Different Lung Cancer Models as Measured by 3'-Deoxy-3'-18F-Fluorothymidine PET and Diffusion-Weighted MR Imaging. J Nucl Med 2014;55: 983-988. Abstract
Schmidt R, Nippe N, Strobel K, Masthoff M, Reifschneider O, Castelli DD, Holtke C, Aime S, Karst U, Sunderkotter C, Bremer C, Faber C. Highly Shifted Proton MR Imaging: Cell Tracking by Using Direct Detection of Paramagnetic Compounds. Radiology 2014;272: 785-795. Abstract
Schoofs T, Berdel WE, Muller-Tidow C. Origins of aberrant DNA methylation in acute myeloid leukemia. Leukemia 2014;28: 1-14. Abstract
Schuermann A, Helker CSM, Herzog W. Angiogenesis in zebrafish. Semin Cell Dev Biol 2014;31c: 106-114. Abstract
Spenle C, Lefebvre O, Lacroute J, Mechine-Neuville A, Barreau F, Blottiere HM, Duclos B, Arnold C, Hussenet T, Hemmerle J, Gullberg D, Kedinger M, Sorokin L, Orend G, Simon-Assmann P. The laminin response in inflammatory bowel disease: protection or malignancy?. PLoS One 2014;9: e111336. Abstract
Tessneer KL, Pasula S, Cai X, Dong Y, McManus J, Liu X, Yu L, Hahn S, Chang B, Chen Y, Griffin C, Xia L, Adams RH, Chen H. Genetic reduction of vascular endothelial growth factor receptor 2 rescues aberrant angiogenesis caused by epsin deficiency. Arterioscler Thromb Vasc Biol 2014;34: 331-337. Abstract
Wehe CA, Beyer G, Sperling M, Ciarimboli G, Karst U. Assessing the intracellular concentration of platinum in medulloblastoma cell lines after Cisplatin incubation. J Trace Elem Med Biol 2014;28: 166-172. Abstract
Wenning C, Kloth C, Kuhlmann MT, Jacobs AH, Schober O, Hermann S, Schafers MA. Serial F-18-FDG PET/CT distinguishes inflamed from stable plaque phenotypes in shear-stress induced murine atherosclerosis. Atherosclerosis 2014;234: 276-282. Abstract
Wessel F, Winderlich M, Holm M, Frye M, Rivera-Galdos R, Vockel M, Linnepe R, Ipe U, Stadtmann A, Zarbock A, Nottebaum AF, Vestweber D. Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin. Nat Immunol 2014;15: 223-230. Abstract
Xu C, Hasan SS, Schmidt I, Rocha SF, Pitulescu ME, Bussmann J, Meyen D, Raz E, Adams RH, Siekmann AF. Arteries are formed by vein-derived endothelial tip cells. Nat Commun 2014;5: 5758. Abstract
You W-K, Yotsumoto F, Sakimura K, Adams RH, Stallcup WB. NG2 proteoglycan promotes tumor vascularization via integrin-dependent effects on pericyte function. Angiogenesis 2014;17: 61-76. Abstract


Bettenworth D, Reuter S, Hermann S, Weckesser M, Kerstiens L, Stratis A, Nowacki TM, Ross M, Lenze F, Edemir B, Maaser C, Pap T, Koschmieder S, Heidemann J, Schäfers M, Lugering A. Translational 18F-FDG PET/CT Imaging to Monitor Lesion Activity in Intestinal Inflammation. J Nucl Med 2013;54: 748-755. Abstract
Bittner S, Ruck T, Schuhmann MK, Herrmann AM, Moha ou Maati H, Bobak N, Gobel K, Langhauser F, Stegner D, Ehling P, Borsotto M, Pape H-C, Nieswandt B, Kleinschnitz C, Heurteaux C, Galla H-J, Budde T, Wiendl H, Meuth SG. Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS. Nat Med 2013;19: 1161-1165. Abstract
Buther F, Ernst I, Hamill J, Eich HT, Schober O, Schafers M, Schafers KP. External radioactive markers for PET data-driven respiratory gating in positron emission tomography. Eur J Nucl Med Mol Imaging 2013;40: 602-614. Abstract
Corada M, Orsenigo F, Morini MF, Pitulescu ME, Bhat G, Nyqvist D, Breviario F, Conti V, Briot A, Iruela-Arispe ML, Adams RH, Dejana E. Sox17 is indispensable for acquisition and maintenance of arterial identity. Nat Commun 2013;4: 2609. Abstract
Corroyer-Dulmont A, Peres EA, Petit E, Guillamo J-S, Varoqueaux N, Roussel S, Toutain J, Divoux D, Mackenzie ET, Delamare J, Ibazizene M, Lecocq M, Jacobs AH, Barre L, Bernaudin M, Valable S. Detection of glioblastoma response to temozolomide combined with bevacizumab based on muMRI and muPET imaging reveals [18F]-fluoro-L-thymidine as an early and robust predictive marker for treatment efficacy. Neuro Oncol 2013;15: 41-56. Abstract
Dawood M, Gigengack F, Jiang X, Schäfers KP. A mass conservation-based optical flow method for cardiac motion correction in 3D-PET. Med Phys 2013;40: 012505. Abstract
Dimidschstein J, Passante L, Dufour A, van den Ameele J, Tiberi L, Hrechdakian T, Adams R, Klein R, Lie DC, Jossin Y, Vanderhaeghen P. Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration. Neuron 2013;79: 1123-1135. Abstract
Ehling M, Adams S, Benedito R, Adams RH. Notch controls retinal blood vessel maturation and quiescence. Development 2013;140: 3051-3061. Abstract
Ehling P, Cerina M, Meuth P, Kanyshkova T, Bista P, Coulon P, Meuth SG, Pape H-C, Budde T. Ca(2+)-dependent large conductance K(+) currents in thalamocortical relay neurons of different rat strains. Pflugers Arch 2013;465: 469-480. Abstract
Ehling P, Gob E, Bittner S, Budde T, Ludwig A, Kleinschnitz C, Meuth SG. Ischemia-induced cell depolarization: does the hyperpolarization-activated cation channel HCN2 affect the outcome after stroke in mice?. Exp Transl Stroke Med 2013;5: 16. Abstract
Enzmann G, Mysiorek C, Gorina R, Cheng Y-J, Ghavampour S, Hannocks M-J, Prinz V, Dirnagl U, Endres M, Prinz M, Beschorner R, Harter PN, Mittelbronn M, Engelhardt B, Sorokin L. The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury. Acta Neuropathol 2013;125: 395-412. Abstract
Fieseler M, Kugel H, Gigengack F, Kösters T, Büther F, Quick HH, Faber C, Jiang X, Schäfers KP. A dynamic thorax phantom for the assessment of cardiac and respiratory motion correction in PET/MRI: A preliminary evaluation. Nucl Instrum Methods Phys Res A 2013;702: 59-63. Abstract
Gigengack F, Ruthotto L, Jiang X, Modersitzki J, Burger M, Hermann S, Schäfers KP. Atlas-Based Whole-Body PET-CT Segmentation using a Passive Contour Distance. Lect Notes Comput Sc 2013;7766: 82-92. Abstract
Gobel K, Wedell J-H, Herrmann AM, Wachsmuth L, Pankratz S, Bittner S, Budde T, Kleinschnitz C, Faber C, Wiendl H, Meuth SG. 4-Aminopyridine ameliorates mobility but not disease course in an animal model of multiple sclerosis. Exp Neurol 2013;248: 62-71. Abstract
Gottschlag H, Kösters T, Vernekohl D, Reygers K, Schäfers KP, Wübbeling F, Wessels JP. Towards Quantitative Image Reconstruction Using Monte-Carlo Simulations in Multi-Wire Proportional Chamber-Based Small Animal PET. IEEE Trans Nucl Sci 2013;60: 3343-3354. Abstract
Grabner A, Kentrup D, Edemir B, Sirin Y, Pavenstadt H, Schlatter E, Schober O, Schafers M, Schnockel U, Reuter S. PET with 18F-FDG-labeled T lymphocytes for diagnosis of acute rat renal allograft rejection. J Nucl Med 2013;54: 1147-1153. Abstract
Gutbrodt KL, Schliemann C, Giovannoni L, Frey K, Pabst T, Klapper W, Berdel WE, Neri D. Antibody-based delivery of interleukin-2 to neovasculature has potent activity against acute myeloid leukemia. Sci Transl Med 2013;5: 201ra118. Abstract
Hägerling R, Pollmann C, Andreas M, Schmidt C, Nurmi H, Adams RH, Alitalo K, Andresen V, Schulte-Merker S, Kiefer F. A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy. EMBO J 2013;32: 629-644. Abstract
Hahnenkamp A, Schäfers M, Bremer C, Höltke C. Design and Synthesis of Small-Molecule Fluorescent Photoprobes Targeted to Aminopeptdase N (APN/CD13) for Optical Imaging of Angiogenesis. Bioconjug Chem 2013;24: 1027-1038. Abstract
Helker CSM, Schuermann A, Karpanen T, Zeuschner D, Belting H-G, Affolter M, Schulte-Merker S, Herzog W. The zebrafish common cardinal veins develop by a novel mechanism: lumen ensheathment. Development 2013;140: 2776-2786. Abstract
Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. Targeting of alphav integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med 2013;19: 1617-1624. Abstract
Herdering C, Reifschneider O, Wehe CA, Sperling M, Karst U. Ambient molecular imaging by laser ablation atmospheric pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom 2013;27: 2595-2600. Abstract
Herdering C, Wehe CA, Reifschneider O, Raj I, Ciarimboli G, Diebold K, Becker C, Sperling M, Karst U. Laser ablation based bioimaging with simultaneous elemental and molecular mass spectrometry: towards spatially resolved speciation analysis. Rapid Commun Mass Spectrom 2013;27: 2588-2594. Abstract
Hermann S, Pichler B, Kotzerke J. [Preclinical research Seal of approval translational medicine]. Nuklearmedizin 2013;52: N53-4. Abstract
Hoerr V, Nagelmann N, Nauerth A, Kuhlmann MT, Stypmann J, Faber C. Cardiac-respiratory self-gated cine ultra-short echo time (UTE) cardiovascular magnetic resonance for assessment of functional cardiac parameters at high magnetic fields. J Cardiovasc Magn Reson 2013;15: 59. Abstract
Hutterer M, Nowosielski M, Putzer D, Jansen NL, Seiz M, Schocke M, McCoy M, Gobel G, la Fougere C, Virgolini IJ, Trinka E, Jacobs AH, Stockhammer G. [18F]-fluoro-ethyl-L-tyrosine PET: a valuable diagnostic tool in neuro-oncology, but not all that glitters is glioma. Neuro Oncol 2013;15: 341-351. Abstract
Jiang Q, Lagos-Quintana M, Liu D, Shi Y, Helker C, Herzog W, le Noble F. miR-30a regulates endothelial tip cell formation and arteriolar branching. Hypertension 2013;62: 592-598. Abstract
Jiang X, Dawood M, Gigengack F, Risse B, Schmid S, Tenbrinck D, Schäfers K. Biomedical imaging: A computer vision perspective. Lect Notes Comput Sc 2013;8047: 1-19. Abstract
Kleinschnitz C, Kraft P, Dreykluft A, Hagedorn I, Gobel K, Schuhmann MK, Langhauser F, Helluy X, Schwarz T, Bittner S, Mayer CT, Brede M, Varallyay C, Pham M, Bendszus M, Jakob P, Magnus T, Meuth SG, Iwakura Y, Zernecke A, Sparwasser T, Nieswandt B, Stoll G, Wiendl H. Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood 2013;121: 679-691. Abstract
Kochhan E, Lenard A, Ellertsdottir E, Herwig L, Affolter M, Belting H-G, Siekmann AF. Blood flow changes coincide with cellular rearrangements during blood vessel pruning in zebrafish embryos. PLoS One 2013;8: e75060. Abstract
Kochhan E, Siekmann AF. Zebrafish as a model to study chemokine function. Methods Mol Biol 2013;1013: 145-159. Abstract
Koyama T, Ochoa-Callejero L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Arai T, Yoshizawa T, Iesato Y, Lei Y, Uetake R, Okimura A, Yamauchi A, Tanaka M, Igarashi K, Toriyama Y, Kawate H, Adams RH, Kawakami H, Mochizuki N, Martinez A, Shindo T. Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis. Circulation 2013;127: 842-853. Abstract
Liebsch L, Kailayangiri S, Beck L, Altvater B, Koch R, Dierkes C, Hotfilder M, Nagelmann N, Faber C, Kooijman H, Ring J, Vieth V, Rossig C. Ewing sarcoma dissemination and response to T-cell therapy in mice assessed by whole-body magnetic resonance imaging. Br J Cancer 2013;109: 658-666. Abstract
Lustfeld I, Altvater B, Ahlmann M, Ligges S, Brinkrolf P, Rosemann A, Moericke A, Rossig C. High Proportions of CD4+ T Cells among Residual Bone Marrow T Cells in Childhood Acute Lymphoblastic Leukemia Are Associated with Favorable Early Responses. Acta Haematol 2013;131: 28-36. Abstract
Mueller S-K, Altvater B, Chen C, Kailayangiri S, Ahlmann M, Dirksen U, Juergens H, Rossig C. Zoledronic acid negatively affects the expansion of in vitro activated human NK cells and their cytolytic interactions with Ewing sarcoma cells. Oncol Rep 2013;29: 2348-2354. Abstract
Nakayama A, Nakayama M, Turner CJ, Hoing S, Lepore JJ, Adams RH. Ephrin-B2 controls PDGFRbeta internalization and signaling. Genes Dev 2013;27: 2576-2589. Abstract
Nakayama M, Nakayama A, van Lessen M, Yamamoto H, Hoffmann S, Drexler HCA, Itoh N, Hirose T, Breier G, Vestweber D, Cooper JA, Ohno S, Kaibuchi K, Adams RH. Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol 2013;15: 249-260. Abstract
Palm T, Hemmer K, Winter J, Fricke IB, Tarbashevich K, Sadeghi Shakib F, Rudolph I-M, Hillje A-L, De Luca P, Bahnassawy L'a, Madel R, Viel T, De Siervi A, Jacobs AH, Diederichs S, Schwamborn JC. A systemic transcriptome analysis reveals the regulation of neural stem cell maintenance by an E2F1-miRNA feedback loop. Nucleic Acids Res 2013;41: 3699-3712. Abstract
Peddibhotla SSD, Brinkmann BF, Kummer D, Tuncay H, Nakayama M, Adams RH, Gerke V, Ebnet K. Tetraspanin CD9 links junctional adhesion molecule-A to alphavbeta3 integrin to mediate basic fibroblast growth factor-specific angiogenic signaling. Mol Biol Cell 2013;24: 933-944. Abstract
Rapic S, Backes H, Viel T, Kummer MP, Monfared P, Neumaier B, Vollmar S, Hoehn M, Van der Linden A, Heneka MT, Jacobs AH. Imaging microglial activation and glucose consumption in a mouse model of Alzheimer's disease. Neurobiol Aging 2013;34: 351-354. Abstract
Rettinger E, Bonig H, Wehner S, Lucchini G, Willasch A, Jarisch A, Soerensen J, Esser R, Rossig C, Klingebiel T, Bader P. Feasibility of IL-15-activated cytokine-induced killer cell infusions after haploidentical stem cell transplantation. Bone Marrow Transplant 2013;48: 1141-1143. Abstract
Risse B, Thomas S, Otto N, Lopmeier T, Valkov D, Jiang X, Klambt C. FIM, a novel FTIR-based imaging method for high throughput locomotion analysis. PLoS One 2013;8: e53963. Abstract
Ruck T, Bittner S, Gross CC, Breuer J, Albrecht S, Korr S, Gobel K, Pankratz S, Henschel CM, Schwab N, Staszewski O, Prinz M, Kuhlmann T, Meuth SG, Wiendl H. CD4+NKG2D+ T cells exhibit enhanced migratory and encephalitogenic properties in neuroinflammation. PLoS One 2013;8: e81455. Abstract
Schmid S, Jiang X, Schäfers K. High-precision lens distortion correction using smoothed thin plate splines. Lect Notes Comput Sc 2013;8048: 432-439. Abstract
Schoofs T, Rohde C, Hebestreit K, Klein H-U, Gollner S, Schulze I, Lerdrup M, Dietrich N, Agrawal-Singh S, Witten A, Stoll M, Lengfelder E, Hofmann W-K, Schlenke P, Buchner T, Hansen K, Berdel WE, Rosenbauer F, Dugas M, Muller-Tidow C. DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding. Blood 2013;121: 178-187. Abstract
Schwab N, Schneider-Hohendorf T, Posevitz V, Breuer J, Gobel K, Windhagen S, Brochet B, Vermersch P, Lebrun-Frenay C, Posevitz-Fejfar A, Capra R, Imberti L, Straeten V, Haas J, Wildemann B, Havla J, Kumpfel T, Meinl I, Niessen K, Goelz S, Kleinschnitz C, Warnke C, Buck D, Gold R, Kieseier BC, Meuth SG, Foley J, Chan A, Brassat D, Wiendl H. L-selectin is a possible biomarker for individual PML risk in natalizumab-treated MS patients. Neurology 2013;81: 865-871. Abstract
Schwöppe C, Zerbst C, Fröhlich M, Schliemann C, Kessler T, Liersch R, Overkamp L, Holtmeier R, Stypmann J, Dreiling A, König S, Höltke C, Lücke M, Müller-Tidow C, Mesters RM, Berdel WE. Anticancer therapy by tumor vessel infarction with polyethylene glycol conjugated retargeted tissue factor. J Med Chem 2013;56: 2337-2347. Abstract
Sehnert B, Burkhardt H, Wessels JT, Schroder A, May MJ, Vestweber D, Zwerina J, Warnatz K, Nimmerjahn F, Schett G, Dubel S, Voll RE. NF-kappaB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-kappaB in immune-mediated diseases. Proc Natl Acad Sci USA 2013;110: 16556-16561. Abstract
Siekmann AF, Affolter M, Belting H-G. The tip cell concept 10 years after: New players tune in for a common theme. Exp Cell Res 2013;319: 1255-1263. Abstract
Sivaraj KK, Takefuji M, Schmidt I, Adams RH, Offermanns S, Wettschureck N. G13 Controls Angiogenesis through Regulation of VEGFR-2 Expression. Dev Cell 2013;25: 427-434. Abstract
Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell 2013;152: 1065-1076. Abstract
Song J, Lokmic Z, Lämmermann T, Rolf J, Wu C, Zhang X, Hallmann R, Hannocks M-J, Horn N, Ruegg MA, Sonnenberg A, Georges-Labouesse E, Winkler TH, Kearney JF, Cardell S, Sorokin L. Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival. Proc Natl Acad Sci USA 2013;110: E2915-24. Abstract
Stegger L, Schülke C, Wenning C, Rahbar K, Kies P, Schober O, Schäfers M. Cardiac PET/MRI. Curr Cardiovasc Imaging Rep 2013: 1-10. Abstract
Steingräber AK, Schelhaas S, Faust A, Jacobs AH, Schäfers M, Goerge T. Molecular imaging reveals time course of MMP activity in acute cutaneous vasculitis in vivo. Exp Dermatol 2013;22: 730-735. Abstract
Tenbrinck D, Schmid S, Jiang X, Schäfers K, Stypmann J. Histogram-based Optical Flow for Motion Estimation in Ultrasound Imaging. J Math Imaging Vision 2013;47(1): 138-150.
Viel T, Boehm-Sturm P, Rapic S, Monfared P, Neumaier B, Hoehn M, Jacobs AH. Non-invasive imaging of glioma vessel size and densities in correlation with tumour cell proliferation by small animal PET and MRI. Eur J Nucl Med Mol Imaging 2013;40: 1595-1606. Abstract
Viel T, Monfared P, Schelhaas S, Fricke IB, Kuhlmann MT, Fraefel C, Jacobs AH. Optimizing glioblastoma temozolomide chemotherapy employing lentiviral-based anti-MGMT shRNA technology. Mol Ther 2013;21: 570-579. Abstract
Viel T, Schelhaas S, Wagner S, Wachsmuth L, Schwegmann K, Kuhlmann M, Faber C, Kopka K, Schafers M, Jacobs AH. Early assessment of the efficacy of temozolomide chemotherapy in experimental glioblastoma using [18F]FLT-PET imaging. PLoS One 2013;8: e67911. Abstract
Vockel M, Vestweber D. How T cells trigger the dissociation of the endothelial receptor phosphatase VE-PTP from VE-cadherin. Blood 2013;122: 2512-2522. Abstract
Wang L, Benedito R, Bixel MG, Zeuschner D, Stehling M, Savendahl L, Haigh JJ, Snippert H, Clevers H, Breier G, Kiefer F, Adams RH. Identification of a clonally expanding haematopoietic compartment in bone marrow. EMBO J 2013;32: 219-230. Abstract
Weinl C, Riehle H, Park D, Stritt C, Beck S, Huber G, Wolburg H, Olson EN, Seeliger MW, Adams RH, Nordheim A. Endothelial SRF/MRTF ablation causes vascular disease phenotypes in murine retinae. J Clin Invest 2013;123: 2193-2206. Abstract
Wenning C, Rahbar K, Vrachimis A, Schober O, Schäfers M, Stegger L. Myocardial perfusion imaging and coronary calcium scoring with a two-slice SPECT/CT system: can the attenuation map be calculated from the calcium scoring CT scan?. Eur J Nucl Med Mol Imaging 2013;40: 1069-1076. Abstract
Worlitzer MMA, Viel T, Jacobs AH, Schwamborn JC. The majority of newly generated cells in the adult mouse substantia nigra express low levels of Doublecortin, but their proliferation is unaffected by 6-OHDA-induced nigral lesion or Minocycline-mediated inhibition of neuroinflammation. Eur J Neurosci 2013;38: 2684-2692. Abstract
Yang H, Lee S, Lee S, Kim K, Yang Y, Kim JH, Adams RH, Wells JM, Morrison SJ, Koh GY, Kim I. Sox17 promotes tumor angiogenesis and destabilizes tumor vessels in mice. J Clin Invest 2013;123: 418-431. Abstract
Yousif L, Di Russo J, Sorokin L. Laminin isoforms in endothelial and perivascular basement membranes. Cell Adh Migr 2013;7: 101-110. Abstract


Bulk E, Yu J, Hascher A, Koschmieder S, Wiewrodt R, Krug U, Timmermann B, Marra A, Hillejan L, Wiebe K, Berdel WE, Schwab A, Muller-Tidow C. Mutations of the EPHB6 receptor tyrosine kinase induce a pro-metastatic phenotype in non-small cell lung cancer. PLoS One 2012;7: e44591. Abstract
Joseph J, Bittner S, Kaiser FMP, Wiendl H, Kissler S. IL-17 Silencing Does Not Protect Nonobese Diabetic Mice from Autoimmune Diabetes. J Immunol 2012;188: 216-221. Abstract
Steiner E, Enzmann GU, Lin S, Ghavampour S, Hannocks M-J, Zuber B, Ruegg MA, Sorokin L, Engelhardt B. Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation. Glia 2012;60: 1646-1659. Abstract