Participation in the Cluster of Excellence

CiM Group Leader

  • Research Area C.1: Angiogenic Blood Vessel Growth and Vessel Wall Assembly
  • Project FF-2017-21 – Analysis of the cytoskeleton in controlling endoglin-dependent endothelial cell shape changes in response to mechanical forces (Arndt Siekmann, Britta Trappmann; project time: 11/2017 - 12/2018)
  • Project FF-2014-15: Global analysis of shear stress regulated enhancer elements in endothelial cells (Hans-Joachim Schnittler, Arndt Siekmann, project time: 07/2014 - 06/2016)

CiM Papers


Sugden WW, Siekmann AF. Endothelial cell biology of Endoglin in hereditary hemorrhagic telangiectasia. Curr Opin Hematol 2018;25: 237-244. Abstract


Hasan SS, Tsaryk R, Lange M, Wisniewski L, Moore JC, Lawson ND, Wojciechowska K, Schnittler H, Siekmann AF. Endothelial Notch signalling limits angiogenesis via control of artery formation. Nat Cell Biol 2017;19: 928-940. Abstract
Sugden WW, Leonardo-Mendonca RC, Acuna-Castroviejo D, Siekmann AF. Genetic dissection of endothelial transcriptional activity of zebrafish aryl hydrocarbon receptors (AHRs). PLoS One 2017;12: e0183433. Abstract
Sugden WW, Meissner R, Aegerter-Wilmsen T, Tsaryk R, Leonard EV, Bussmann J, Hamm MJ, Herzog W, Jin Y, Jakobsson L, Denz C, Siekmann AF. Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Nat Cell Biol 2017;19: 653-665. Abstract


Papangeli I, Kim J, Maier I, Park S, Lee A, Kang Y, Tanaka K, Khan OF, Ju H, Kojima Y, Red-Horse K, Anderson DG, Siekmann AF, Chun HJ. MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation. Nat Commun 2016;7: 11268. Abstract


Harrison MRM, Bussmann J, Huang Y, Zhao L, Osorio A, Burns CG, Burns CE, Sucov HM, Siekmann AF, Lien C-L. Chemokine-guided angiogenesis directs coronary vasculature formation in zebrafish. Dev Cell 2015;33: 442-454. Abstract
Hasan SS, Siekmann AF. The same but different: signaling pathways in control of endothelial cell migration. Curr Opin Cell Biol 2015;36: 86-92. Abstract
Xu C, Volkery S, Siekmann AF. Intubation-based anesthesia for long-term time-lapse imaging of adult zebrafish. Nat Protoc 2015;10: 2064-2073. Abstract


Xu C, Hasan SS, Schmidt I, Rocha SF, Pitulescu ME, Bussmann J, Meyen D, Raz E, Adams RH, Siekmann AF. Arteries are formed by vein-derived endothelial tip cells. Nat Commun 2014;5: 5758. Abstract


Kochhan E, Lenard A, Ellertsdottir E, Herwig L, Affolter M, Belting H-G, Siekmann AF. Blood flow changes coincide with cellular rearrangements during blood vessel pruning in zebrafish embryos. PLoS One 2013;8: e75060. Abstract
Kochhan E, Siekmann AF. Zebrafish as a model to study chemokine function. Methods Mol Biol 2013;1013: 145-159. Abstract
Siekmann AF, Affolter M, Belting H-G. The tip cell concept 10 years after: New players tune in for a common theme. Exp Cell Res 2013;319: 1255-1263. Abstract