Participation in “Cells in Motion”

  • Supervisor in the CiM-IMPRS Graduate Programme
  • Project FF-2014-15: Global analysis of shear stress regulated enhancer elements in endothelial cells (Hans-Joachim Schnittler, Arndt Siekmann, project time: 07/2014 - 06/2016)
© CiM - Peter Grewer

“Sport for endothelial cells“ – an interview

The question Prof Hans-Joachim Schnittler asks himself is: are trained endothelial cells the more resistant cells? It is a question which he is investigating with his team of international researchers – and with the help of his dedicated Flow System.

  • Papers in the research focus “cell dynamics and imaging”


    Bondareva O, Tsaryk R, Bojovic V, Odenthal-Schnittler M, Siekmann AF, Schnittler H-J. Identification of atheroprone shear stress responsive regulatory elements in endothelial cells. Cardiovasc Res 2019;115: 1487-1499. Abstract
    Cao J, Schnittler H. Putting VE-cadherin into JAIL for junction remodeling. J Cell Sci 2019;132: epub. Abstract
    Ghimire K, Zaric J, Alday-Parejo B, Seebach J, Bousquenaud M, Stalin J, Bieler G, Schnittler H-J, Ruegg C. MAGI1 Mediates eNOS Activation and NO Production in Endothelial Cells in Response to Fluid Shear Stress. Cells 2019;8: epub. Abstract
    Klusmeier N, Schnittler H-J, Seebach J. A Novel Microscopic Assay Reveals Heterogeneous Regulation of Local Endothelial Barrier Function. Biophys J 2019;116: 1547-1559. Abstract
    Schmitz B, Breulmann FL, Jubran B, Rolfes F, Thorwesten L, Kruger M, Klose A, Schnittler H-J, Brand S-M. A three-step approach identifies novel shear stress-sensitive endothelial microRNAs involved in vasculoprotective effects of high-intensity interval training (HIIT). Oncotarget 2019;10: 3625-3640. Abstract
    Schnittler H, Ortmann U, Washausen S, Knabe W, Wesemann F, Triphaus S, Schone-Seifert B. Holding donated human bodies in conservation: A novel interactive safe-keeping system meeting high ethical and safety standards. Ann Anat 2019;225: 11-16. Abstract
    Taha M, Aldirawi M, März S, Seebach J, Odenthal-Schnittler M, Bondareva O, Bojovic V, Schmandra T, Wirth B, Mietkowska M, Rottner K, Schnittler H. EPLIN-α and -β Isoforms Modulate Endothelial Cell Dynamics through a Spatiotemporally Differentiated Interaction with Actin. Cell Rep. 2019;29: 1010-1026.e6. Abstract
    Waschke J, Bergmann M, Brauer L, Brenner E, Buchhorn A, Deutsch A, Dokter M, Egu DT, Ergun S, Fassnacht U, Fietz D, Gundlach S, Heermann S, Hirt B, Kugelmann D, Muller-Gerbl M, Neiss W, Nimtschke U, Plendl J, Pretterklieber M, Redies C, Scaal M, Schmidt MHH, Schmiedl A, Schnittler H-J, Schomerus C, Sebesteny T, Spittau B, Steiniger B, Tschernig T, Unverzagt A, Viebahn C, Voigt E, Weigner J, Weyers I, Winkelmann A, Winkler M, Paulsen F. Recommendations of the working group of the Anatomische Gesellschaft on reduction of formaldehyde exposure in anatomical curricula and institutes. Ann Anat 2019;221: 179-185. Abstract


    Hofer I, Schimp C, Taha M, Seebach J, Aldirawi M, Cao J, Leidl Q, Ahle A, Schnittler H. Advanced Methods for the Investigation of Cell Contact Dynamics in Endothelial Cells Using Florescence-Based Live Cell Imaging. J Vasc Res 2018;55: 350-364. Abstract
    Rezaei M, Cao J, Friedrich K, Kemper B, Brendel O, Grosser M, Adrian M, Baretton G, Breier G, Schnittler H-J. The expression of VE-cadherin in breast cancer cells modulates cell dynamics as a function of tumor differentiation and promotes tumor-endothelial cell interactions. Histochem Cell Biol 2018;149: 15-30. Abstract


    Bulk E, Kramko N, Liashkovich I, Glaser F, Schillers H, Schnittler HJ, Oberleithner H, Schwab A. KCa31 channel inhibition leads to an ICAM-1 dependent increase of cell-cell adhesion between A549 lung cancer and HMEC-1 endothelial cells. Oncotarget 2017;8: 112268-112282. Abstract
    Cao J, Ehling M, März S, Seebach J, Tarbashevich K, Sixta T, Pitulescu ME, Werner A-C, Flach B, Montanez E, Raz E, Adams RH, Schnittler H. Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis. Nat Commun 2017;8Abstract
    Hasan SS, Tsaryk R, Lange M, Wisniewski L, Moore JC, Lawson ND, Wojciechowska K, Schnittler H, Siekmann AF. Endothelial Notch signalling limits angiogenesis via control of artery formation. Nat Cell Biol 2017;19: 928-940. Abstract
    Kage F, Winterhoff M, Dimchev V, Mueller J, Thalheim T, Freise A, Bruhmann S, Kollasser J, Block J, Dimchev G, Geyer M, Schnittler H-J, Brakebusch C, Stradal TEB, Carlier M-F, Sixt M, Kas J, Faix J, Rottner K. FMNL formins boost lamellipodial force generation. Nat Commun 2017;8: 14832. Abstract


    Schnittler H. Contraction of endothelial cells: 40 years of research, but the debate still lives. Histochem Cell Biol 2016;146: 651-656. Abstract
    Seebach J, Cao J, Schnittler HJ. Quantitative dynamics of VE-cadherin at endothelial cell junctions at a glance: basic requirements and current concepts. Discoveries 2016;4: e63. Abstract
    Strobel M, Pfortner H, Tuchscherr L, Volker U, Schmidt F, Kramko N, Schnittler H-J, Fraunholz MJ, Loffler B, Peters G, Niemann S. Post-invasion events after infection with Staphylococcus aureus are strongly dependent on both the host cell type and the infecting S aureus strain. Clin Microbiol Infect 2016;22: 799-809. Abstract


    Seebach J, Taha AA, Lenk J, Lindemann N, Jiang X, Brinkmann K, Bogdan S, Schnittler H-J. The CellBorderTracker, a novel tool to quantitatively analyze spatiotemporal endothelial junction dynamics at the subcellular level. Histochem Cell Biol 2015;144: 517-532. Abstract


    Abu Taha A, Schnittler H-J. Dynamics between actin and the VE-cadherin/catenin complex: novel aspects of the ARP2/3 complex in regulation of endothelial junctions. Cell Adh Migr 2014;8: 125-135. Abstract
    Abu Taha A, Taha M, Seebach J, Schnittler H-J. ARP2/3-mediated junction-associated lamellipodia control VE-cadherin-based cell junction dynamics and maintain monolayer integrity. Mol Biol Cell 2014;25: 245-256. Abstract
    Schnittler H. Between sealing and leakiness: molecular dynamics of the endothelium to maintain and regulate barrier function. Cell Tissue Res 2014;355: 481-483. Abstract
    Schnittler H, Taha M, Schnittler MO, Taha AA, Lindemann N, Seebach J. Actin filament dynamics and endothelial cell junctions: the Ying and Yang between stabilization and motion. Cell Tissue Res 2014;355: 529-543. Abstract


    Dietrich A, Stewart J, Huether M, Helm M, Schuetze C, Schnittler H-J, Jaffray DA, Kunz-Schughart LA. Macromolecule extravasation-xenograft size matters: a systematic study using probe-based confocal laser endomicroscopy (pCLE). Mol Imaging Biol 2013;15: 693-702. Abstract
    Korten S, Brunssen C, Poitz DM, Grossklaus S, Brux M, Schnittler H-J, Strasser RH, Bornstein SR, Morawietz H, Goettsch W. Impact of Hey2 and COUP-TFII on genes involved in arteriovenous differentiation in primary human arterial and venous endothelial cells. Basic Res Cardiol 2013;108: 362. Abstract
    Kramko N, Sinitski D, Seebach J, Loffler B, Dieterich P, Heilmann C, Peters G, Schnittler H-J. Early Staphylococcus aureus-induced changes in endothelial barrier function are strain-specific and unrelated to bacterial translocation. Int J Med Microbiol 2013;303: 635-644. Abstract
    Laugsch M, Seebach J, Schnittler H, Jessberger R. Imbalance of SMC1 and SMC3 cohesins causes specific and distinct effects. PLoS One 2013;8: e65149. Abstract


    Rezaei M, Friedrich K, Wielockx B, Kuzmanov A, Kettelhake A, Labelle M, Schnittler H, Baretton G, Breier G. Interplay between neural-cadherin and vascular endothelial-cadherin in breast cancer progression. Breast Cancer Res 2012;14: R154. Abstract