“Multiscale imaging” – an example: Our interdisciplinary team of researchers has discovered in mice with MS-like disease that specific enzymes (microscopy left, green) enable immune cells (red) to cross the blood-brain barrier (white, cross-section). The team made the active enzymes visible in mice using a fluorescent tracer (FRI, centre) – and in MS patients using a radioactively labelled variant of the tracer (PET-MRI, right).
© Korpos (left) / Gerwien, Faust, Sorokin, Schäfers (centre) / Sci. Transl. Med. 8 (2016), Gerwien & Hermann et al. (right)

Multiscale Imaging lecture

Imaging has become a central instrument for the investigation of cellular processes in organisms. Using a variety of imaging modalities, ranging from optical microscopy to whole-body imaging, we investigate the organ specific mechanisms and consequences of inflammation. Our approach – multiscale imaging – refers to the strategy to examine inflammatory processes through the integration of different imaging methods. Together, these cover the spatial dimensions from individual cells to the organism and follow pathologies over time, thereby improving our understanding of the “big picture”. Such an integral view requires the development of chemical and mathematical methods that bridge the different imaging modalities. This strategy holds the promise of a future transfer of methodological developments applied to disease models to clinical diagnostic imaging in patients.

  • Topics and dates

    On Wednesdays, 4:00 to 5:00 p.m. at the University Hospital Münster (level 05 East, conference room 403)

    November 2019

    27.11.2019

    Molecular imaging of monocyte/macrophage dynamics
    Johannes Roth (Institute of Immunology) & Michael Schäfers (EIMI)

    Talk 2 – to be announced

    import to own diary

    December 2019

    04.12.2019 Talk 1 – to be announced
    Talk 2 – to be announced
    11.12.2019 Talk 1 – to be announced
    Talk 2 – to be announced
    18.12.2019 Talk 1 – to be announced
    Talk 2 – to be announced

    January 2020

    08.01.2020

    Henning Mootz (Institute of Biochemistry) & Andrea Rentmeister(Institute of Biochemistry)

    Talk 2 – to be announced

    import to own diary

    15.01.2020 Talk 1 – to be announced
    Talk 2 – to be announced
    22.01.2020 Talk 1 – to be announced
    Talk 2 – to be announced
    29.01.2020

    Platelet-leukocyte interactions in inflammatory diseases
    Jan Rossaint & Alexander Zarbock (both: Department of Anesthesiology and Intensive Care Medicine)

    Cell tracking by combined MRI and mass spectrometric imaging
    Cornelius Faber (Institute of Clinical Radiology) & Uwe Karst (Institute of Inorganic and Analytical Chemistry)

    import to own diary

    February 2020

    05.02.2020

    Imaging of bacerial infection processes during acute and chronic infections
    Petra Dersch ( Institute of Infectiology)

    18F-fluorinated complex carbohydrates – a chance for bacteria specific imaging?
    Andreas Faust (EIMI) & Ryan Gilmour (Institute of Organic Chemistry)

    import to own diary

    12.02.2020 Talk 1 – to be announced
    Talk 2 – to be announced
    19.02.2020

    Targeting S100A9 – SAR studies and their consequences for radiotracer development
    Andreas Faust (EIMI) & Günter Fritz (University of Hohenheim)

    Talk 2 – to be announced

    import to own diary

    26.02.2020

    Dynamics and molecular mechanisms of myeloid cell infiltration into the inflamed peritoneum
    Lydia Sorokin (Institute of Physiological Chemistry and Pathobiochemistry)

    Talk 2 – to be announced

    import to own diary

    March 2020

    04.03.2020

    Heterogeneity of macrophage´s functions in inflammation and development
    Noelia Alonso Gonzalez (Institute of Immunology)

    Talk 2 – to be announced

    import to own diary

    11.03.2020

    New coordination chemical strategies in multimodal imaging
    Cristian A. Strassert (Institute of Organic Chemistry)

    import to own diary

    18.03.2020 Talk 1 – to be announced
    Talk 2 – to be announced
    25.03.2020 Talk 1 – to be announced
    Talk 2 – to be announced

    April 2020

    01.04.2020 Talk 1 – to be announced
    Talk 2 – to be announced
    22.04.2020 Talk 1 – to be announced
    Talk 2 – to be announced
    29.04.2020 Talk 1 – to be announced
    Talk 2 – to be announced

    May 2020

    06.05.2020 Talk 1 – to be announced
    Talk 2 – to be announced
    20.05.2020 Talk 1 – to be announced
    Talk 2 – to be announced
    27.05.2020 Talk 1 – to be announced
    Talk 2 – to be announced

    June 2020

    10.06.2020 Talk 1 – to be announced
    Talk 2 – to be announced
    17.06.2020 to be announced
    24.06.2020 Talk 1 – to be announced
    Talk 2 – to be announced

  • Previous topics and dates

    20.11.2019 Predictive mathematical algorithms enable real-time control of motion artifact correction in microscopy
    Thomas Huser (University Bielefeld) & Benedikt Wirth (Institute for Applied Mathematics: Analysis and Numerics)

    PET and the mathematical theory of optimal transport
    Klaus Schäfers (EIMI) & Benedikt Wirth

    06.11.2019 Introduction
    Michael Schäfers, European Institute for Molecular Imaging (EIMI)

    Intravital visualization of hypoxia
    Friedemann Kiefer, European Institute for Molecular Imaging (EIMI)