“Multiscale imaging” – an example: Our interdisciplinary team of researchers has discovered in mice with MS-like disease that specific enzymes (microscopy left, green) enable immune cells (red) to cross the blood-brain barrier (white, cross-section). The team made the active enzymes visible in mice using a fluorescent tracer (FRI, centre) – and in MS patients using a radioactively labelled variant of the tracer (PET-MRI, right).
© Korpos (left) / Gerwien, Faust, Sorokin, Schäfers (centre) / Sci. Transl. Med. 8 (2016), Gerwien & Hermann et al. (right)

Multiscale Imaging lecture

Imaging has become a central instrument for the investigation of cellular processes in organisms. Using a variety of imaging modalities, ranging from optical microscopy to whole-body imaging, we investigate the organ specific mechanisms and consequences of inflammation. Our approach – multiscale imaging – refers to the strategy to examine inflammatory processes through the integration of different imaging methods. Together, these cover the spatial dimensions from individual cells to the organism and follow pathologies over time, thereby improving our understanding of the “big picture”. Such an integral view requires the development of chemical and mathematical methods that bridge the different imaging modalities. This strategy holds the promise of a future transfer of methodological developments applied to disease models to clinical diagnostic imaging in patients.

  • Topics and dates

    On Wednesdays, 4:00 to 5:00 p.m. at the University Hospital Münster (level 05 East, conference room 403)

    March 2020

    04.03.2020

    Heterogeneity of macrophage´s functions in inflammation and development
    Noelia Alonso Gonzalez (Institute of Immunology)

    Dynamic PET-MRI for integrated quantification of molecular immune responses and their vascular consequence
    Philipp Backhaus (EIMI) & Florian Büther (Department of Nuclear Medicine)

    import to own diary

    11.03.2020

    New coordination chemical strategies in multimodal imaging
    Cristian A. Strassert (Center for Nanotechnology (CeNTech))

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    18.03.2020

    Research data management and infrastructures for visualization, analysis and sustainable software development
    Raimund Vogl & Markus Blank-Burian (both: Zentrum für Informationsverarbeitung (ZIV))

    Talk 2 – to be announced

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    25.03.2020 Talk 1 – to be announced
    Talk 2 – to be announced

    April 2020

    01.04.2020 Talk 1 – to be announced
    Talk 2 – to be announced
    22.04.2020 Talk 1 – to be announced
    Talk 2 – to be announced
    29.04.2020

    Quantitative assessment of endothelial permeability by novel scalable BODIPY nanostructures
    Gustavo Fernandez Huertas (Institute of Organic Chemistry) & Max Masthoff (Translational Radiology)

    Talk 2 – to be announced

    import to own diary

    May 2020

    06.05.2020

    Verena Hörr (Institute of Clinical Radiology) & Stefan Reuter (Dept. of Nephrology and Rheumatology)

    Talk 2 – to be announced

    import to own diary

    20.05.2020 Talk 1 – to be announced
    Talk 2 – to be announced
    27.05.2020 Talk 1 – to be announced
    Talk 2 – to be announced

    June 2020

    10.06.2020 Talk 1 – to be announced
    Talk 2 – to be announced
    17.06.2020 to be announced
    24.06.2020 Talk 1 – to be announced
    Talk 2 – to be announced

  • Previous topics and dates

    26.02.2020 Dynamics and molecular mechanisms of myeloid cell infiltration into the inflamed peritoneum
    Lydia Sorokin (Institute of Physiological Chemistry and Pathobiochemistry)

    Computational analysis of large multiscale imaging data
    Xiaoyi Jiang (Institute of Computer Science)

    19.02.2020 Imaging of inflammatory and regulatory mechanisms in rheumatoid arthritis
    Sven Hermann (EIMI) & Thomas Vogl (Institute of Immunology)

    Targeting S100A9 – SAR studies and their consequences for radiotracer development
    Andreas Faust (EIMI) & Günter Fritz (University of Hohenheim)

    12.02.2020 Interactive analysis of large multiscale imaging data
    Lars Linsen (Institute of Computer Science)
    05.02.2020 Imaging of bacterial infection processes during acute and chronic infections
    Petra Dersch (Institute of Infectiology) & Jan Rossaint (Department of Anaesthesiology and Intensive Care Medicine)

    18F-fluorinated complex carbohydrates – a chance for bacteria specific imaging?
    Andreas Faust (EIMI), Ryan Gilmour (Institute of Organic Chemistry) & Silke Niemann (Institute of Medical Microbiology)

    29.01.2020 Platelet-leukocyte interactions in inflammatory diseases
    Helena Block & Alexander Zarbock (both: Department of Anaesthesiology and Intensive Care Medicine)

    Cell tracking by combined MRI and mass spectrometric imaging
    Cornelius Faber (Institute of Clinical Radiology) & Uwe Karst (Institute of Inorganic and Analytical Chemistry)

    22.01.2020 Nanocapsules for imaging, sensing, targeting and delivering of drugs
    Katharina Landfester (Max Planck Institute for Polymer Research, Mainz)

    Functional analysis of myeloid cells in autoimmune diseases
    Kerstin Steinbrink (Department of Dermatology)

    15.01.2020 Selective and bioorthogonal modification of reporter proteins for the imaging of immune cells
    Henning Mootz (Institute of Biochemistry) & Andrea Rentmeister (Institute of Biochemistry)
    08.01.2020 Endothelial cells as regulators of vascular permeability and leukocyte extravasation
    Dietmar Vestweber (Max Planck Institute for Molecular Biomedicine)
    11.12.2019 Deep learning for partial differential equations
    Arnulf Jentzen (Applied Mathematics Münster)
    28.11.2019 Molecular imaging of monocyte/macrophage dynamics
    Johannes Roth (Institut für Immunologie) & Michael Schäfers (EIMI)
    20.11.2019 Predictive mathematical algorithms enable real-time control of motion artifact correction in microscopy
    Thomas Huser (University Bielefeld) & Benedikt Wirth (Institute for Applied Mathematics: Analysis and Numerics)

    PET and the mathematical theory of optimal transport
    Klaus Schäfers (EIMI) & Benedikt Wirth

    06.11.2019 Introduction
    Michael Schäfers, European Institute for Molecular Imaging (EIMI)

    Intravital visualization of hypoxia
    Friedemann Kiefer, European Institute for Molecular Imaging (EIMI)