Blutgefäße bilden eine Barriere zwischen Blutbahn und Gewebe. Sie bestehen aus einer Endothelzellschicht (grüne Zellkontakte) und einer Basalmembran. Um Entzündungen im Gewebe zu bekämpfen, durchqueren Immunzellen (rot) diese Barriere. Konfokale Laser Scanning Mikroskopie.
© Stefan Butz, Hang Li, Dietmar Vestweber

Forschungsgebiet B: Zellen in Barrieren

Wie Zellen Barrieren bilden und überwinden

Zellen finden sich zusammen und bilden Barrieren. So grenzen sie Gewebe und Organe voneinander ab, regulieren Stoffwechselprozesse und schützen den Organismus. Die CiM-Wissenschaftler untersuchen, wie solche Barrieren aufgebaut sind und funktionieren. Dazu gehört insbesondere, wie Immunzellen, also Zellen des körpereigenen Abwehrsystems, und krankmachende Keime Barrieren überwinden können.

Das wissenschaftliche Konzept

Alle höheren Organismen zeichnen sich durch eine Kompartimentierung durch zelluläre oder extrazelluläre Barrieren aus. Diese Barrieren definieren zum einen die Grenzen zwischen Innen und Außen aber auch die Grenzen zwischen den verschiedenen Organen des Körpers. An diesen Grenzen wird der metabolische Austausch reguliert und gleichermaßen die Integrität und Form der Gewebe oder des Organismus definiert. Die meisten zellulären Barrieren werden von endothelialen oder epithelialen Zellen aufgebaut, die in der Regel mit einer Basalmembran (BM) assoziiert sind. Im Forschungsbereich B wollen wir untersuchen wie diese wichtigen Barrieren gebildet werden und wie sie im Gewebe funktionieren (B.1). Ein wesentlicher Punkt in diesen Arbeiten ist zu verstehen, wie Immunzellen (B.2/B.3/B.4) und pathogene (B.5) Keime die Körperbarrieren überwinden können. Dieses Wissen hilft, therapeutische Strategien für die Bekämpfung von entzündlichen Erkrankungen zu entwickeln. Im Forschungsbereich B dominieren mikroskopische Nachweismethoden, die es erlauben, die zelluläre Dynamik in sehr hoher Auflösung darzustellen. Hierbei kommen sowohl die Raster-Kraft-Mikroskopie als auch Laserpinzetten zum Einsatz, um die Kräfte adhäsiver Wechselwirkungen darzustellen und zu messen. Um die Dynamik zellulärer Barrieren im intakten Tier zu verfolgen, werden mathematische Bildanalyse-Verfahren eingesetzt. Diese erlauben dann weitere Anwendungen der Positronen-Emissions-Tomographie (PET) oder Magnet-Resonanz-Tomographie (MRT) und stellen eine translationale Verbindung in die Klink dar.

Wissenschaftliche Publikationen

2019

Hannocks M-J, Zhang X, Gerwien H, Chashchina A, Burmeister M, Korpos E, Song J, Sorokin L. The gelatinases, MMP-2 and MMP-9, as fine tuners of neuroinflammatory processes. Matrix Biol 2019;75-76: 102-113. Abstract

2018

Axer A, Hermann S, Kehr G, Clases D, Karst U, Fischer-Riepe L, Roth J, Fobker M, Schafers M, Gilmour R, Faust A. Harnessing the Maltodextrin Transport Mechanism for Targeted Bacterial Imaging: Structural Requirements for Improved in vivo Stability in Tracer Design. ChemMedChem 2018;13: 241-250. Abstract
Baumann D, Salia H, Greune L, Norkowski S, Korner B, Uckeley ZM, Frankel G, Guenot M, Ruter C, Schmidt MA. Multitalented EspB of enteropathogenic Escherichia coli (EPEC) enters cells autonomously and induces programmed cell death in human monocytic THP-1 cells. Int J Med Microbiol 2018;308: 387-404. Abstract
Becker M, Greune L, Schmidt MA, Schelhaas M. Extracellular conformational changes in the capsid of human papillomaviruses contribute to asynchronous uptake into host cells. J Virol 2018;92: e02106-17. Abstract
Beutel B, Song J, Konken CP, Korpos E, Schinor B, Gerwien H, Vidyadharan R, Burmeister M, Li L, Haufe G, Sorokin L. New in Vivo Compatible Matrix Metalloproteinase (MMP)-2 and MMP-9 Inhibitors. Bioconjug Chem 2018;29: 3715-3725. Abstract
Burger M, Dirks H, Schönlieb C-B. A Variational Model for Joint Motion Estimation and Image Reconstruction. SIAM J. Imaging Sci. 2018;11: 94-128. Abstract
de Vega RG, Sanchez MLF, Eiro N, Vizoso FJ, Sperling M, Karst U, Medel AS. Multimodal laser ablation/desorption imaging analysis of Zn and MMP-11 in breast tissues. Anal Bioanal Chem 2018;410: 913-922. Abstract
Gran S, Honold L, Fehler O, Zenker S, Eligehausen S, Kuhlmann MT, Geven E, den Bosch M van, van Lent P, Spiekermann C, Hermann S, Vogl T, Schäfers M, Roth J. Imaging, myeloid precursor immortalization, and genome editing for defining mechanisms of leukocyte recruitment_in vivo_. Theranostics 2018;8: 2407-2423. Abstract
Hägerling R, Hoppe E, Dierkes C, Stehling M, Makinen T, Butz S, Vestweber D, Kiefer F. Distinct roles of VE‐cadherin for development and maintenance of specific lymph vessel beds. EMBO J 2018: e98271. Abstract
Hannocks M-J, Pizzo ME, Huppert J, Deshpande T, Abbott NJ, Thorne RG, Sorokin L. Molecular characterization of perivascular drainage pathways in the murine brain. J Cereb Blood Flow Metab 2018;38: 669-686. Abstract
Heming M, Gran S, Jauch S-L, Fischer-Riepe L, Russo A, Klotz L, Hermann S, Schafers M, Roth J, Barczyk-Kahlert K. Peroxisome Proliferator-Activated Receptor-γ Modulates the Response of Macrophages to Lipopolysaccharide and Glucocorticoids. Front Immunol 2018;9: 893. Abstract
Masemann D, Köther K, Kuhlencord M, Varga G, Roth J, Lichty BD, Rapp UR, Wixler V, Ludwig S. Oncolytic influenza virus infection restores immunocompetence of lung tumor-associated alveolar macrophages. OncoImmunology 2018: e1423171. Abstract
Masthoff M, Gran S, Zhang X, Wachsmuth L, Bietenbeck M, Helfen A, Heindel W, Sorokin L, Roth J, Eisenblatter M, Wildgruber M, Faber C. Temporal window for detection of inflammatory disease using dynamic cell tracking with time-lapse MRI. Sci Rep 2018;8: 9563. Abstract
Meissner R, Oliver N, Denz C. Optical Force Sensing with Cylindrical Microcontainers. Part. Part. Syst. Charact. 2018;35: 1800062. Abstract
Nascimento MA, Sorokin L, Coelho-Sampaio T. Fractone Bulbs Derive from Ependymal Cells and Their Laminin Composition Influence the Stem Cell Niche in the Subventricular Zone. J Neurosci 2018;38: 3880-3889. Abstract
Norkowski S, Korner B, Greune L, Stolle A-S, Lubos M-L, Hardwidge PR, Schmidt MA, Ruter C. Bacterial LPX motif-harboring virulence factors constitute a species-spanning family of cell-penetrating effectors. Cell Mol Life Sci 2018;75: 2273-2289. Abstract
Orlich M, Kiefer F. A qualitative comparison of ten tissue clearing techniques. Histol Histopathol 2018;33: 181-199. Abstract
Pizzo ME, Wolak DJ, Kumar NN, Brunette E, Brunnquell CL, Hannocks M-J, Abbott NJ, Meyerand ME, Sorokin L, Stanimirovic DB, Thorne RG. Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery. J Physiol 2018;596: 445-475. Abstract
Rezaei M, Cao J, Friedrich K, Kemper B, Brendel O, Grosser M, Adrian M, Baretton G, Breier G, Schnittler H-J. The expression of VE-cadherin in breast cancer cells modulates cell dynamics as a function of tumor differentiation and promotes tumor-endothelial cell interactions. Histochem Cell Biol 2018;149: 15-30. Abstract
Samus M, Seelige R, Schafer K, Sorokin L, Vestweber D. CD99L2 deficiency inhibits leukocyte entry into the central nervous system and ameliorates neuroinflammation. J Leukoc Biol 2018;104: 787-797. Abstract
Schräder T, Dudek SE, Schreiber A, Ehrhardt C, Planz O, Ludwig S. The clinically approved MEK inhibitor Trametinib efficiently blocks influenza A virus propagation and cytokine expression. Antiviral Res 2018;157: 80-92. Abstract
Tuchscherr L, Korpos E, van de Vyver H, Findeisen C, Kherkheulidze S, Siegmund A, Deinhardt-Emmer S, Bach O, Rindert M, Mellmann A, Sunderkotter C, Peters G, Sorokin L, Loffler B. Staphylococcus aureus requires less virulence to establish an infection in diabetic hosts. Int J Med Microbiol 2018;308: 761-769. Abstract
Voeller T, Faust A, Roth J, Schafers M, Vogl T, Hermann S. A Non-Peptidic S100A9 Specific Ligand for Optical Imaging of Phagocyte Activity In Vivo. Mol Imaging Biol 2018;20: 407-416. Abstract
Vogl T, Stratis A, Wixler V, Voller T, Thurainayagam S, Jorch SK, Zenker S, Dreiling A, Chakraborty D, Frohling M, Paruzel P, Wehmeyer C, Hermann S, Papantonopoulou O, Geyer C, Loser K, Schafers M, Ludwig S, Stoll M, Leanderson T, Schultze JL, Konig S, Pap T, Roth J. Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation. J Clin Invest 2018;128: 1852-1866. Abstract

2017

Abdurrachim D, Nabben M, Hoerr V, Kuhlmann MT, Bovenkamp P, Ciapaite J, Geraets IME, Coumans W, Luiken JJFP, Glatz JFC, Schafers M, Nicolay K, Faber C, Hermann S, Prompers JJ. Diabetic db/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations. Cardiovasc Res 2017;113: 1148-1160. Abstract
Aschner M, Palinski C, Sperling M, Karst U, Schwerdtle T, Bornhorst J. Imaging metals in Caenorhabditis elegans. Metallomics 2017;9: 357-364. Abstract
Aydin I, Villalonga-Planells R, Greune L, Bronnimann MP, Calton CM, Becker M, Lai K-Y, Campos SK, Schmidt MA, Schelhaas M. A central region in the minor capsid protein of papillomaviruses facilitates viral genome tethering and membrane penetration for mitotic nuclear entry. PLoS Pathog 2017;13: e1006308. Abstract
Bruna M, Burger M, Ranetbauer H, Wolfram M-T. Cross-Diffusion Systems with Excluded-Volume Effects and Asymptotic Gradient Flow Structures. J Nonlinear Sci 2017;27: 687-719. Abstract
Clases D, Birka M, Sperling M, Faust A, Karst U. Isobaric dilution analysis as a calibration tool for long lived radionuclides in ICP-MS. J Trace Elem Med Biol 2017;40: 97-103. Abstract
Di Russo J, Hannocks M-J, Luik A-L, Song J, Zhang X, Yousif L, Aspite G, Hallmann R, Sorokin L. Vascular laminins in physiology and pathology. Matrix Biol 2017;57-58: 140-148. Abstract
Di Russo J, Luik A-L, Yousif L, Budny S, Oberleithner H, Hofschröer V, Klingauf J, van Bavel E, Bakker E NTP, Hellstrand P, Bhattachariya A, Albinsson S, Pincet F, Hallmann R, Sorokin L. Endothelial basement membrane laminin 511 is essential for shear stress response. EMBO J 2017;36: 183-201. Abstract
Hachmoeller O, Aichler M, Schwamborn K, Lutz L, Werner M, Sperling M, Walch A, Karst U. Investigating the influence of standard staining procedures on the copper distribution and concentration in Wilson's disease liver samples by laser ablation-inductively coupled plasma-mass spectrometry. J Trace Elem Med Biol 2017;44: 71-75. Abstract
Hachmoeller O, Zibert A, Zischka H, Sperling M, Groba SR, Grunewald I, Wardelmann E, Schmidt HH-J, Karst U. Spatial investigation of the elemental distribution in Wilson's disease liver after d-penicillamine treatment by LA-ICP-MS. J Trace Elem Med Biol 2017;44: 26-31. Abstract
Hagerling R, Drees D, Scherzinger A, Dierkes C, Martin-Almedina S, Butz S, Gordon K, Schafers M, Hinrichs K, Ostergaard P, Vestweber D, Goerge T, Mansour S, Jiang X, Mortimer PS, Kiefer F. VIPAR, a quantitative approach to 3D histopathology applied to lymphatic malformations. JCI Insight 2017;2Abstract
Höltke C, Faust A. Molecular imaging of integrins in oncology. Rmi 2017;Volume 10: 17-30. Abstract
Kage F, Winterhoff M, Dimchev V, Mueller J, Thalheim T, Freise A, Bruhmann S, Kollasser J, Block J, Dimchev G, Geyer M, Schnittler H-J, Brakebusch C, Stradal TEB, Carlier M-F, Sixt M, Kas J, Faix J, Rottner K. FMNL formins boost lamellipodial force generation. Nat Commun 2017;8: 14832. Abstract
Klemm C, Bruchhagen C, van Kruchten A, Niemann S, Loffler B, Peters G, Ludwig S, Ehrhardt C. Mitogen-activated protein kinases (MAPKs) regulate IL-6 over-production during concomitant influenza virus and Staphylococcus aureus infection. Sci Rep 2017;7: 42473. Abstract
Langen UH, Pitulescu ME, Kim JM, Enriquez-Gasca R, Sivaraj KK, Kusumbe AP, Singh A, Di Russo J, Bixel MG, Zhou B, Sorokin L, Vaquerizas JM, Adams RH. Cell-matrix signals specify bone endothelial cells during developmental osteogenesis. Nat Cell Biol 2017;19: 189-201. Abstract
Latasiewicz J, Artz A, Jing D, Blanco MP, Currie SM, Avila MV, Schnoor M, Vestweber D. HS1 deficiency impairs neutrophil recruitment in vivo and activation of the small GTPases Rac1 and Rap1. J Leukoc Biol 2017;101: 1133-1142. Abstract
Nacken W, Wixler V, Ehrhardt C, Ludwig S. Influenza A virus NS1 protein-induced JNK activation and apoptosis are not functionally linked. Cell Microbiol 2017;19: e12721. Abstract
Polisetti N, Sorokin L, Okumura N, Koizumi N, Kinoshita S, Kruse FE, Schlotzer-Schrehardt U. Laminin-511 and -521-based matrices for efficient ex vivo-expansion of human limbal epithelial progenitor cells. Sci Rep 2017;7: 5152. Abstract
Risse B, Otto N, Berh D, Jiang X, Kiel M, Klambt C. FIM2c : A Multi-Colour, Multi-Purpose Imaging System to Manipulate and Analyse Animal Behaviour. IEEE Trans Biomed Eng 2017;64: 610-620. Abstract
Ruter C, Schmidt MA. Cell-Penetrating Bacterial Effector Proteins: Better Tools than Targets. Trends Biotechnol 2017;35: 109-120. Abstract
Song J, Zhang X, Buscher K, Wang Y, Wang H, Di Russo J, Li L, Lutke-Enking S, Zarbock A, Stadtmann A, Striewski P, Wirth B, Kuzmanov I, Wiendl H, Schulte D, Vestweber D, Sorokin L. Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration. Cell Rep 2017;18: 1256-1269. Abstract
Stocks T, Hillen T, Gong J, Burger M. A stochastic model for the normal tissue complication probability (NTCP) and applicationss. Math Med Biol 2017;34: 469-492. Abstract
Thyssen GM, Holtkamp M, Kaulfurst-Soboll H, Wehe CA, Sperling M, von Schaewen A, Karst U. Elemental bioimaging by means of LA-ICP-OES: investigation of the calcium, sodium and potassium distribution in tobacco plant stems and leaf petioles. Metallomics 2017;9: 676-684. Abstract
Van de Vyver H, Bovenkamp PR, Hoerr V, Schwegmann K, Tuchscherr L, Niemann S, Kursawe L, Grosse C, Moter A, Hansen U, Neugebauer U, Kuhlmann MT, Peters G, Hermann S, Loffler B. A Novel Mouse Model of Staphylococcus aureus Vascular Graft Infection: Noninvasive Imaging of Biofilm Development in Vivo. Am J Pathol 2017;187: 268-279. Abstract

2016

Artz A, Butz S, Vestweber D. GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-betaRII heterodimer. Blood 2016;128: 529-541. Abstract
Brinkmann BF, Steinbacher T, Hartmann C, Kummer D, Pajonczyk D, Mirzapourshafiyi F, Nakayama M, Weide T, Gerke V, Ebnet K. VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation. Mol Biol Cell 2016;27: 2811-2821. Abstract
Burger M, Dirks H, Frerking L. On Optical Flow Models for Variational Motion Estimation. In: G.Peyre, C.Schnörr, J.Caillau, T.Haberkorn, eds., Variational Methods, RICAM Series on Computati 2016;RICAM: 226-252. Abstract
Buscher K, Wang H, Zhang X, Striewski P, Wirth B, Saggu G, Lutke-Enking S, Mayadas TN, Ley K, Sorokin L, Song J. Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules. Nat Commun 2016;7: 10828. Abstract
Dudek SE, Nitzsche K, Ludwig S, Ehrhardt C. Influenza A viruses suppress cyclooxygenase-2 expression by affecting its mRNA stability. Sci Rep 2016;6: 27275. Abstract
Erapaneedi R, Belousov VV, Schafers M, Kiefer F. A novel family of fluorescent hypoxia sensors reveal strong heterogeneity in tumor hypoxia at the cellular level. Embo J 2016;35: 102-113. Abstract
Fleger-Weckmann A, Ustun Y, Kloepper J, Paus R, Bloch W, Chen Z-L, Wegner J, Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T, Nischt R. Deletion of the epidermis derived laminin gamma1 chain leads to defects in the regulation of late hair morphogenesis. Matrix Biol 2016;56: 42-56. Abstract
Galstyan A, Block D, Niemann S, Gruner MC, Abbruzzetti S, Oneto M, Daniliuc CG, Hermann S, Viappiani C, Schafers M, Loffler B, Strassert CA, Faust A. Labeling and Selective Inactivation of Gram-Positive Bacteria Employing Bimodal Photoprobes with Dual Readouts. Chemistry 2016;22: 5243-5252. Abstract
Galstyan A, Riehemann K, Schäfers M, Faust A. A combined experimental and computational study of the substituent effect on the photodynamic efficacy of amphiphilic Zn(ii)phthalocyanines. J. Mater. Chem. B 2016;4: 5683-5691. Abstract
Gerwien H, Hermann S, Zhang X, Korpos E, Song J, Kopka K, Faust A, Wenning C, Gross CC, Honold L, Melzer N, Opdenakker G, Wiendl H, Schafers M, Sorokin L. Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier. Sci Transl Med 2016;8: 364ra152. Abstract
Gobel K, Pankratz S, Asaridou C-M, Herrmann AM, Bittner S, Merker M, Ruck T, Glumm S, Langhauser F, Kraft P, Krug TF, Breuer J, Herold M, Gross CC, Beckmann D, Korb-Pap A, Schuhmann MK, Kuerten S, Mitroulis I, Ruppert C, Nolte MW, Panousis C, Klotz L, Kehrel B, Korn T, Langer HF, Pap T, Nieswandt B, Wiendl H, Chavakis T, Kleinschnitz C, Meuth SG. Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells. Nat Commun 2016;7: 11626. Abstract
Grabner A, Kentrup D, Muhlmeister M, Pawelski H, Biermann C, Bettinger T, Pavenstadt H, Schlatter E, Tiemann K, Reuter S. Noninvasive Imaging of Acute Renal Allograft Rejection by Ultrasound Detection of Microbubbles Targeted to T-lymphocytes in Rats. Ultraschall Med 2016;37: 82-91. Abstract
Hachmoeller O, Aichler M, Schwamborn K, Lutz L, Werner M, Sperling M, Walch A, Karst U. Element bioimaging of liver needle biopsy specimens from patients with Wilson's disease by laser ablation-inductively coupled plasma-mass spectrometry. J Trace Elem Med Biol 2016;35: 97-102. Abstract
Hachmoller O, Buzanich AG, Aichler M, Radtke M, Dietrich D, Schwamborn K, Lutz L, Werner M, Sperling M, Walch A, Karst U. Elemental bioimaging and speciation analysis for the investigation of Wilson's disease using muXRF and XANES. Metallomics 2016;8: 648-653. Abstract
Mykicki N, Herrmann AM, Schwab N, Deenen R, Sparwasser T, Limmer A, Wachsmuth L, Klotz L, Kohrer K, Faber C, Wiendl H, Luger TA, Meuth SG, Loser K. Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease. Sci Transl Med 2016;8: 362ra146. Abstract
Niehoff A-C, Grunebaum J, Moosmann A, Mulac D, Sobbing J, Niehaus R, Buchholz R, Kroger S, Wiehe A, Wagner S, Sperling M, von Briesen H, Langer K, Karst U. Quantitative bioimaging of platinum group elements in tumor spheroids. Anal Chim Acta 2016;938: 106-113. Abstract
Niehoff A-C, Schulz J, Soltwisch J, Meyer S, Kettling H, Sperling M, Jeibmann A, Dreisewerd K, Francesconi KA, Schwerdtle T, Karst U. Imaging by Elemental and Molecular Mass Spectrometry Reveals the Uptake of an Arsenolipid in the Brain of Drosophila melanogaster. Anal Chem 2016;88: 5258-5263. Abstract
Niehoff  A-C, Wachsmuth L, Schmid F, Sperling M, Faber C, Karst U. Quantification of Manganese Enhanced Magnetic Resonance Imaging based on Spatially Resolved Elemental Mass Spectrometry. ChemistrySelect 2016;1: 264-266. Abstract
Paksa A, Bandemer J, Hoeckendorf B, Razin N, Tarbashevich K, Minina S, Meyen D, Biundo A, Leidel SA, Peyrieras N, Gov NS, Keller PJ, Raz E. Repulsive cues combined with physical barriers and cell-cell adhesion determine progenitor cell positioning during organogenesis. Nat Commun 2016;7: 11288. Abstract
Rossaint J, Kuhne K, Skupski J, Van Aken H, Looney MR, Hidalgo A, Zarbock A. Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response. Nat Commun 2016;7: 13464. Abstract
Rossaint J, Oehmichen J, Van Aken H, Reuter S, Pavenstadt H, Meersch M, Unruh M, Zarbock A. FGF23 signaling impairs neutrophil recruitment and host defense during CKD. J Clin Invest 2016;126: 962-974. Abstract
Schnittler H. Contraction of endothelial cells: 40 years of research, but the debate still lives. Histochem Cell Biol 2016;146: 651-656. Abstract
Seebach J, Cao J, Schnittler HJ. Quantitative dynamics of VE-cadherin at endothelial cell junctions at a glance: basic requirements and current concepts. Discoveries 2016;4: e63. Abstract
Starost LJ, Karassek S, Sano Y, Kanda T, Kim KS, Dobrindt U, Ruter C, Schmidt MA. Pertussis Toxin Exploits Host Cell Signaling Pathways Induced by Meningitis-Causing E coli K1-RS218 and Enhances Adherence of Monocytic THP-1 Cells to Human Cerebral Endothelial Cells. Toxins (Basel) 2016;8Abstract
Strobel M, Pfortner H, Tuchscherr L, Volker U, Schmidt F, Kramko N, Schnittler H-J, Fraunholz MJ, Loffler B, Peters G, Niemann S. Post-invasion events after infection with Staphylococcus aureus are strongly dependent on both the host cell type and the infecting S aureus strain. Clin Microbiol Infect 2016;22: 799-809. Abstract
Volmering S, Block H, Boras M, Lowell CA, Zarbock A. The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation. Immunity 2016;44: 73-87. Abstract
Wales P, Schuberth CE, Aufschnaiter R, Fels J, Garcia-Aguilar I, Janning A, Dlugos CP, Schafer-Herte M, Klingner C, Walte M, Kuhlmann J, Menis E, Hockaday Kang L, Maier KC, Hou W, Russo A, Higgs HN, Pavenstadt H, Vogl T, Roth J, Qualmann B, Kessels MM, Martin DE, Mulder B, Wedlich-Soldner R. Calcium-mediated actin reset (CaAR) mediates acute cell adaptations. Elife 2016;5: e19850. Abstract
Wegner J, Loser K, Apsite G, Nischt R, Eckes B, Krieg T, Werner S, Sorokin L. Laminin alpha5 in the keratinocyte basement membrane is required for epidermal-dermal intercommunication. Matrix Biol 2016;56: 24-41. Abstract

2015

Birka M, Wentker KS, Lusmoller E, Arheilger B, Wehe CA, Sperling M, Stadler R, Karst U. Diagnosis of nephrogenic systemic fibrosis by means of elemental bioimaging and speciation analysis. Anal Chem 2015;87: 3321-3328. Abstract
Boergeling Y, Rozhdestvensky TS, Schmolke M, Resa-Infante P, Robeck T, Randau G, Wolff T, Gabriel G, Brosius J, Ludwig S. Evidence for a Novel Mechanism of Influenza Virus-Induced Type I Interferon Expression by a Defective RNA-Encoded Protein. PLoS Pathog 2015;11: e1004924. Abstract
Byri S, Misra T, Syed ZA, Batz T, Shah J, Boril L, Glashauser J, Aegerter-Wilmsen T, Matzat T, Moussian B, Uv A, Luschnig S. The Triple-Repeat Protein Anakonda Controls Epithelial Tricellular Junction Formation in Drosophila. Dev Cell 2015;33: 535-548. Abstract
Cerqueira C, Samperio Ventayol P, Vogeley C, Schelhaas M. Kallikrein-8 Proteolytically Processes Human Papillomaviruses in the Extracellular Space To Facilitate Entry into Host Cells. J Virol 2015;89: 7038-7052. Abstract
Frye M, Dierkes M, Kuppers V, Vockel M, Tomm J, Zeuschner D, Rossaint J, Zarbock A, Koh GY, Peters K, Nottebaum AF, Vestweber D. Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin. J Exp Med 2015;212: 2267-2287. Abstract
Hallmann R, Zhang X, Di Russo J, Li L, Song J, Hannocks M-J, Sorokin L. The regulation of immune cell trafficking by the extracellular matrix. Curr Opin Cell Biol 2015;36: 54-61. Abstract
Hillgruber C, Poppelmann B, Weishaupt C, Steingraber AK, Wessel F, Berdel WE, Gessner JE, Ho-Tin-Noe B, Vestweber D, Goerge T. Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopenia. J Exp Med 2015;212: 1255-1266. Abstract
Karassek S, Starost L, Solbach J, Greune L, Sano Y, Kanda T, Kim KS, Schmidt MA. Pertussis Toxin Exploits Specific Host Cell Signaling Pathways for Promoting Invasion and Translocation of Escherichia coli K1 RS218 in Human Brain-derived Microvascular Endothelial Cells. J Biol Chem 2015;290: 24835-24843. Abstract
Klenner L, Hafezi W, Clausen BE, Lorentzen EU, Luger TA, Beissert S, Kuhn JE, Loser K. Cutaneous RANK-RANKL Signaling Upregulates CD8-Mediated Antiviral Immunity during Herpes simplex Virus Infection by Preventing Virus-Induced Langerhans Cell Apoptosis. J Invest Dermatol 2015;135: 2676-2687. Abstract
Kliche K, Gerth U, Pavenstadt H, Oberleithner H. Recharging red blood cell surface by hemodialysis. Cell Physiol Biochem 2015;35: 1107-1115. Abstract
Koeppen C, Reifschneider O, Castanheira I, Sperling M, Karst U, Ciarimboli G. Quantitative imaging of platinum based on laser ablation-inductively coupled plasma-mass spectrometry to investigate toxic side effects of cisplatin. Metallomics 2015;7: 1595-1603. Abstract
Kronlage C, Schafer-Herte M, Boning D, Oberleithner H, Fels J. Feeling for Filaments: Quantification of the Cortical Actin Web in Live Vascular Endothelium. Biophys J 2015;109: 687-698. Abstract
Liu Z, Xu Y, Zhang X, Song J, Sorokin L, Bahler M. The motorized RhoGAP myosin IXb (Myo9b) in leukocytes regulates experimental autoimmune encephalomyelitis induction and recovery. J Neuroimmunol 2015;282: 25-32. Abstract
Niehaus R, Sperling M, Karst U. Study on aerosol characteristics and fractionation effects of organic standard materials for bioimaging by means of LA-ICP-MS. J. Anal. At. Spectrom. 2015;30: 2056-2065. Abstract
Niehoff A-C, Bauer OB, Kroger S, Fingerhut S, Schulz J, Meyer S, Sperling M, Jeibmann A, Schwerdtle T, Karst U. Quantitative Bioimaging to Investigate the Uptake of Mercury Species in Drosophila melanogaster. Anal Chem 2015;87: 10392-10396. Abstract
Oberleithner H. Sodium selective erythrocyte glycocalyx and salt sensitivity in man. Pflugers Arch 2015;467: 1319-1325. Abstract
Oberleithner H, Wilhelmi M. Vascular Glycocalyx Sodium Store - Determinant of Salt Sensitivity. Blood Purif 2015;39: 7-10. Abstract
Reifschneider O, Schutz CL, Brochhausen C, Hampel G, Ross T, Sperling M, Karst U. Quantitative bioimaging of p-boronophenylalanine in thin liver tissue sections as a tool for treatment planning in boron neutron capture therapy. Anal Bioanal Chem 2015;407: 2365-2371. Abstract
Santschi N, Wagner S, Daniliuc C, Hermann S, Schafers M, Gilmour R. Synthesis of 2-[(18) F]Fluoro-2-deoxyisosorbide 5-mononitrate and Assessment of Its in vivo Biodistribution as Determined by Dynamic Positron Emission Tomography (PET). ChemMedChem 2015;10: 1724-1732. Abstract
Schirmeier S, Klambt C. The Drosophila blood-brain barrier as interface between neurons and hemolymph. Mech Dev 2015;138 Pt 1: 50-55. Abstract
Schwab N, Schneider-Hohendorf T, Wiendl H. Therapeutic uses of anti-alpha4-integrin (anti-VLA-4) antibodies in multiple sclerosis. Int Immunol 2015;27: 47-53. Abstract
Seebach J, Taha AA, Lenk J, Lindemann N, Jiang X, Brinkmann K, Bogdan S, Schnittler H-J. The CellBorderTracker, a novel tool to quantitatively analyze spatiotemporal endothelial junction dynamics at the subcellular level. Histochem Cell Biol 2015;144: 517-532. Abstract
Shaikh RS, Keul P, Schäfers M, Levkau B, Haufe G. New fluorinated agonists for targeting the sphingosin-1-phosphate receptor 1 (S1P1). Bioorganic & Medicinal Chemistry Letters 2015;25: 5048-5051. Abstract
Silva IT, Carvalho A, Lang KL, Dudek SE, Masemann D, Duran FJ, Caro MSB, Rapp UR, Wixler V, Schenkel EP, Simoes CMO, Ludwig S. In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B. PLoS One 2015;10: e0117794. Abstract
Song J, Wu C, Korpos E, Zhang X, Agrawal SM, Wang Y, Faber C, Schafers M, Korner H, Opdenakker G, Hallmann R, Sorokin L. Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration. Cell Rep 2015;10: 1040-1054. Abstract
Tuncay H, Brinkmann BF, Steinbacher T, Schurmann A, Gerke V, Iden S, Ebnet K. JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Nat Commun 2015;6: 8128. Abstract
Vestweber D. How leukocytes cross the vascular endothelium. Nat Rev Immunol 2015;15: 692-704. Abstract
Wehe CA, Thyssen GM, Herdering C, Raj I, Ciarimboli G, Sperling M, Karst U. Elemental Bioimaging by Means of Fast Scanning Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry. J Am Soc Mass Spectrom 2015;26: 1274-1282. Abstract

2014

Abu Taha A, Schnittler H-J. Dynamics between actin and the VE-cadherin/catenin complex: novel aspects of the ARP2/3 complex in regulation of endothelial junctions. Cell Adh Migr 2014;8: 125-135. Abstract
Abu Taha A, Taha M, Seebach J, Schnittler H-J. ARP2/3-mediated junction-associated lamellipodia control VE-cadherin-based cell junction dynamics and maintain monolayer integrity. Mol Biol Cell 2014;25: 245-256. Abstract
Aydin I, Weber S, Snijder B, Samperio Ventayol P, Kuhbacher A, Becker M, Day PM, Schiller JT, Kann M, Pelkmans L, Helenius A, Schelhaas M. Large Scale RNAi Reveals the Requirement of Nuclear Envelope Breakdown for Nuclear Import of Human Papillomaviruses. PLoS Pathog 2014;10: e1004162. Abstract
Azzoni E, Conti V, Campana L, Dellavalle A, Adams RH, Cossu G, Brunelli S. Hemogenic endothelium generates mesoangioblasts that contribute to several mesodermal lineages in vivo. Development 2014;141: 1821-1834. Abstract
Bentley K, Franco CA, Philippides A, Blanco R, Dierkes M, Gebala V, Stanchi F, Jones M, Aspalter IM, Cagna G, Westrom S, Claesson-Welsh L, Vestweber D, Gerhardt H. The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis. Nat Cell Biol 2014;16: 309-321. Abstract
Bogdani M, Korpos E, Simeonovic CJ, Parish CR, Sorokin L, Wight TN. Extracellular matrix components in the pathogenesis of type 1 diabetes. Curr Diab Rep 2014;14: 552. Abstract
Borgeling Y, Schmolke M, Viemann D, Nordhoff C, Roth J, Ludwig S. Inhibition of p38 mitogen-activated protein kinase impairs influenza virus-induced primary and secondary host gene responses and protects mice from lethal H5N1 infection. J Biol Chem 2014;289: 13-27. Abstract
Breuer J, Schwab N, Schneider-Hohendorf T, Marziniak M, Mohan H, Bhatia U, Gross CC, Clausen BE, Weishaupt C, Luger TA, Meuth SG, Loser K, Wiendl H. Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity. Ann Neurol 2014;75: 739-758. Abstract
Cichon C, Sabharwal H, Rüter C, Schmidt MA. MicroRNAs regulate tight junction proteins and modulate epithelial/endothelial barrier functions. Tissue Barriers 2014;2: e944446.
Dartsch N, Schulte D, Hagerling R, Kiefer F, Vestweber D. Fusing VE-Cadherin to alpha-Catenin Impairs Fetal Liver Hematopoiesis and Lymph but Not Blood Vessel Formation. Mol Cell Biol 2014;34: 1634-1648. Abstract
Day PM, Schelhaas M. Concepts of papillomavirus entry into host cells. Curr Opin Virol 2014;4: 24-31. Abstract
Fels J, Jeggle P, Liashkovich I, Peters W, Oberleithner H. Nanomechanics of vascular endothelium. Cell Tissue Res 2014;355: 727-737. Abstract
Gorina R, Lyck R, Vestweber D, Engelhardt B. beta2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier. J Immunol 2014;192: 324-337. Abstract
Grimm KB, Oberleithner H, Fels J. Fixed endothelial cells exhibit physiologically relevant nanomechanics of the cortical actin web. Nanotechnology 2014;25: 215101. Abstract
Hillgruber C, Steingraber AK, Poppelmann B, Denis CV, Ware J, Vestweber D, Nieswandt B, Schneider SW, Goerge T. Blocking von Willebrand factor for treatment of cutaneous inflammation. J Invest Dermatol 2014;134: 77-86. Abstract
Hinkel R, Trenkwalder T, Petersen B, Husada W, Gesenhues F, Lee S, Hannappel E, Bock-Marquette I, Theisen D, Leitner L, Boekstegers P, Cierniewski C, Muller OJ, le Noble F, Adams RH, Weinl C, Nordheim A, Reichart B, Weber C, Olson E, Posern G, Deindl E, Niemann H, Kupatt C. MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2. Nat Commun 2014;5: 3970. Abstract
Hoerr V, Faber C. Magnetic resonance imaging characterization of microbial infections. J Pharm Biomed Anal 2014;93: 136-146. Abstract
Kim C, Yang H, Fukushima Y, Saw PE, Lee J, Park J-S, Park I, Jung J, Kataoka H, Lee D, Heo WD, Kim I, Jon S, Adams RH, Nishikawa S-I, Uemura A, Koh GY. Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption. Cancer Cell 2014;25: 102-117. Abstract
Klingner C, Cherian AV, Fels J, Diesinger PM, Aufschnaiter R, Maghelli N, Keil T, Beck G, Tolic-Norrelykke IM, Bathe M, Wedlich-Soldner R. Isotropic actomyosin dynamics promote organization of the apical cell cortex in epithelial cells. J Cell Biol 2014;207: 107-121. Abstract
Korn C, Scholz B, Hu J, Srivastava K, Wojtarowicz J, Arnsperger T, Adams RH, Boutros M, Augustin HG, Augustin I. Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis. Development 2014;141: 1757-1766. Abstract
Korte S, Strater AS, Druppel V, Oberleithner H, Jeggle P, Grossmann C, Fobker M, Nofer J-R, Brand E, Kusche-Vihrog K. Feedforward activation of endothelial ENaC by high sodium. Faseb J 2014;28: 4015-4025. Abstract
Kraus H, Kaiser S, Aumann K, Bonelt P, Salzer U, Vestweber D, Erlacher M, Kunze M, Burger, Pieper K, Sic H, Rolink A, Eibel H, Rizzi M. A feeder-free differentiation system identifies autonomously proliferating B cell precursors in human bone marrow. J Immunol 2014;192: 1044-1054. Abstract
Kusche-Vihrog K, Jeggle P, Oberleithner H. The role of ENaC in vascular endothelium. Pflugers Arch 2014;466: 851-859. Abstract
Liedmann S, Hrincius ER, Anhlan D, McCullers JA, Ludwig S, Ehrhardt C. New virulence determinants contribute to the enhanced immune response and reduced virulence of an influenza A virus A/PR8/34 variant. J Infect Dis 2014;209: 532-541. Abstract
Liedmann S, Hrincius ER, Guy C, Anhlan D, Dierkes R, Carter R, Wu G, Staeheli P, Green DR, Wolff T, McCullers JA, Ludwig S, Ehrhardt C. Viral suppressors of the RIG-I-mediated interferon response are pre-packaged in influenza virions. Nat Commun 2014;5: 5645. Abstract
Nacken W, Anhlan D, Hrincius ER, Mostafa A, Wolff T, Sadewasser A, Pleschka S, Ehrhardt C, Ludwig S. Activation of c-jun N-terminal kinase upon influenza A virus (IAV) infection is independent of pathogen-related receptors but dependent on amino acid sequence variations of IAV NS1. J Virol 2014;88: 8843-8852. Abstract
Noels H, Zhou B, Tilstam PV, Theelen W, Li X, Pawig L, Schmitz C, Akhtar S, Simsekyilmaz S, Shagdarsuren E, Schober A, Adams RH, Bernhagen J, Liehn EA, Doring Y, Weber C. Deficiency of endothelial CXCR4 reduces reendothelialization and enhances neointimal hyperplasia after vascular injury in atherosclerosis-prone mice. Arterioscler Thromb Vasc Biol 2014;34: 1209-1220. Abstract
Paar M, Pavenstadt H, Kusche-Vihrog K, Druppel V, Oberleithner H, Kliche K. Endothelial sodium channels trigger endothelial salt sensitivity with aging. Hypertension 2014;64: 391-396. Abstract
Padberg J-S, Wiesinger A, di Marco GS, Reuter S, Grabner A, Kentrup D, Lukasz A, Oberleithner H, Pavenstadt H, Brand M, Kumpers P. Damage of the endothelial glycocalyx in chronic kidney disease. Atherosclerosis 2014;234: 335-343. Abstract
Reichman-Fried M, Raz E. Small proteins, big roles: The signaling protein Apela extends the complexity of developmental pathways in the early zebrafish embryo. Bioessays 2014;36: 741-745. Abstract
Riese SB, Kuehne C, Tedder TF, Hallmann R, Hohenester E, Buscher K. Heterotropic modulation of selectin affinity by allosteric antibodies affects leukocyte rolling. J Immunol 2014;192: 1862-1869. Abstract
Ring J, Hoerr V, Tuchscherr L, Kuhlmann MT, Loffler B, Faber C. MRI Visualization of Staphyloccocus aureus-Induced Infective Endocarditis in Mice. PLoS One 2014;9: e107179. Abstract
Rossaint J, Herter JM, Van Aken H, Napirei M, Doring Y, Weber C, Soehnlein O, Zarbock A. Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation. Blood 2014;123: 2573-2584. Abstract
Ruter C, Silva MR, Grabowski B, Lubos M-L, Scharnert J, Poceva M, von Tils D, Flieger A, Heesemann J, Bliska JB, Schmidt MA. Rabbit monoclonal antibodies directed at the T3SS effector protein YopM identify human pathogenic Yersinia isolates. Int J Med Microbiol 2014;304: 444-451. Abstract
Schneider-Hohendorf T, Rossaint J, Mohan H, Boning D, Breuer J, Kuhlmann T, Gross CC, Flanagan K, Sorokin L, Vestweber D, Zarbock A, Schwab N, Wiendl H. VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells. J Exp Med 2014;211: 1833-1846. Abstract
Schnittler H. Between sealing and leakiness: molecular dynamics of the endothelium to maintain and regulate barrier function. Cell Tissue Res 2014;355: 481-483. Abstract
Schnittler H, Taha M, Schnittler MO, Taha AA, Lindemann N, Seebach J. Actin filament dynamics and endothelial cell junctions: the Ying and Yang between stabilization and motion. Cell Tissue Res 2014;355: 529-543. Abstract
Schulze U, Vollenbroker B, Braun DA, Van Le T, Granado D, Kremerskothen J, Franzel B, Klosowski R, Barth J, Fufezan C, Wolters DA, Pavenstadt H, Weide T. The Vac14-interaction Network Is Linked to Regulators of the Endolysosomal and Autophagic Pathway. Mol Cell Proteomics 2014;13: 1397-1411. Abstract
Spenle C, Lefebvre O, Lacroute J, Mechine-Neuville A, Barreau F, Blottiere HM, Duclos B, Arnold C, Hussenet T, Hemmerle J, Gullberg D, Kedinger M, Sorokin L, Orend G, Simon-Assmann P. The laminin response in inflammatory bowel disease: protection or malignancy?. PLoS One 2014;9: e111336. Abstract
Vogl T, Eisenblatter M, Voller T, Zenker S, Hermann S, van Lent P, Faust A, Geyer C, Petersen B, Roebrock K, Schafers M, Bremer C, Roth J. Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity. Nat Commun 2014;5: 4593. Abstract
Warnock DG, Kusche-Vihrog K, Tarjus A, Sheng S, Oberleithner H, Kleyman TR, Jaisser F. Blood pressure and amiloride-sensitive sodium channels in vascular and renal cells. Nat Rev Nephrol 2014;10: 146-157. Abstract
Weiss N, Stegemann A, Elsayed MAT, Schallreuter KU, Luger TA, Loser K, Metze D, Weishaupt C, Bohm M. Inhibition of the prohormone convertase subtilisin-kexin isoenzyme-1 induces apoptosis in human melanoma cells. J Invest Dermatol 2014;134: 168-175. Abstract
Wennmann DO, Schmitz J, Wehr MC, Krahn MP, Koschmal N, Gromnitza S, Schulze U, Weide T, Chekuri A, Skryabin BV, Gerke V, Pavenstadt H, Duning K, Kremerskothen J. Evolutionary and Molecular Facts Link the WWC Protein Family to Hippo Signaling. Mol Biol Evol 2014;31: 1710-1723. Abstract
Wessel F, Winderlich M, Holm M, Frye M, Rivera-Galdos R, Vockel M, Linnepe R, Ipe U, Stadtmann A, Zarbock A, Nottebaum AF, Vestweber D. Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin. Nat Immunol 2014;15: 223-230. Abstract
Woerdemann M, Hörner F, Denz C. Structured attachment of bacterial molecular motors for defined micro flow induction. Optofluidics, Microfluidics, and Nanofluidics 2014;1: 19-26. Abstract
You W-K, Yotsumoto F, Sakimura K, Adams RH, Stallcup WB. NG2 proteoglycan promotes tumor vascularization via integrin-dependent effects on pericyte function. Angiogenesis 2014;17: 61-76. Abstract

2013

Bittner S, Ruck T, Schuhmann MK, Herrmann AM, Moha ou Maati H, Bobak N, Gobel K, Langhauser F, Stegner D, Ehling P, Borsotto M, Pape H-C, Nieswandt B, Kleinschnitz C, Heurteaux C, Galla H-J, Budde T, Wiendl H, Meuth SG. Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS. Nat Med 2013;19: 1161-1165. Abstract
Brandherm I, Disse J, Zeuschner D, Gerke V. cAMP-induced secretion of endothelial von Willebrand factor is regulated by a phosphorylation/dephosphorylation switch in annexin A2. Blood 2013;122: 1042-1051. Abstract
Cerqueira C, Liu Y, Kuhling L, Chai W, Hafezi W, van Kuppevelt TH, Kuhn JE, Feizi T, Schelhaas M. Heparin increases the infectivity of Human Papillomavirus type 16 independent of cell surface proteoglycans and induces L1 epitope exposure. Cell Microbiol 2013;15: 1818-1836. Abstract
Chen Z, Barbi J, Bu S, Yang H-Y, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z, Wang H, Luo W, Li L, Semenza GL, Zheng S-G, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F, Li B. The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. Immunity 2013;39: 272-285. Abstract
Dietrich A, Stewart J, Huether M, Helm M, Schuetze C, Schnittler H-J, Jaffray DA, Kunz-Schughart LA. Macromolecule extravasation-xenograft size matters: a systematic study using probe-based confocal laser endomicroscopy (pCLE). Mol Imaging Biol 2013;15: 693-702. Abstract
Druppel V, Kusche-Vihrog K, Grossmann C, Gekle M, Kasprzak B, Brand E, Pavenstadt H, Oberleithner H, Kliche K. Long-term application of the aldosterone antagonist spironolactone prevents stiff endothelial cell syndrome. Faseb J 2013;27: 3652-3659. Abstract
Enzmann G, Mysiorek C, Gorina R, Cheng Y-J, Ghavampour S, Hannocks M-J, Prinz V, Dirnagl U, Endres M, Prinz M, Beschorner R, Harter PN, Mittelbronn M, Engelhardt B, Sorokin L. The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury. Acta Neuropathol 2013;125: 395-412. Abstract
Friesenhagen J, Viemann D, Borgeling Y, Schmolke M, Spiekermann C, Kirschnek S, Ludwig S, Roth J. Highly Pathogenic Influenza Viruses Inhibit Inflammatory Response in Monocytes via Activation of Rar-Related Orphan Receptor RORalpha. J Innate Immun 2013;5: 505-518. Abstract
Ghavampour S, Lange C, Bottino C, Gerke V. Transcriptional profiling of human monocytes identifies the inhibitory receptor CD300a as regulator of transendothelial migration. PLoS One 2013;8: e73981. Abstract
Hoerr V, Tuchscherr L, Huve J, Nippe N, Loser K, Glyvuk N, Tsytsyura Y, Holtkamp M, Sunderkotter C, Karst U, Klingauf J, Peters G, Loffler B, Faber C. Bacteria tracking by in vivo magnetic resonance imaging. BMC Biol 2013;11: 63. Abstract
Jeggle P, Callies C, Tarjus A, Fassot C, Fels J, Oberleithner H, Jaisser F, Kusche-Vihrog K. Epithelial sodium channel stiffens the vascular endothelium in vitro and in Liddle mice. Hypertension 2013;61: 1053-1059. Abstract
Khoufache K, Berri F, Nacken W, Vogel AB, Delenne M, Camerer E, Coughlin SR, Carmeliet P, Lina B, Rimmelzwaan GF, Planz O, Ludwig S, Riteau B. PAR1 contributes to influenza A virus pathogenicity in mice. J Clin Invest 2013;123: 206-214. Abstract
Kleinschnitz C, Kraft P, Dreykluft A, Hagedorn I, Gobel K, Schuhmann MK, Langhauser F, Helluy X, Schwarz T, Bittner S, Mayer CT, Brede M, Varallyay C, Pham M, Bendszus M, Jakob P, Magnus T, Meuth SG, Iwakura Y, Zernecke A, Sparwasser T, Nieswandt B, Stoll G, Wiendl H. Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood 2013;121: 679-691. Abstract
Kluger MS, Clark PR, Tellides G, Gerke V, Pober JS. Claudin-5 controls intercellular barriers of human dermal microvascular but not human umbilical vein endothelial cells. Arterioscler Thromb Vasc Biol 2013;33: 489-500. Abstract
Korpos E, Kadri N, Kappelhoff R, Wegner J, Overall CM, Weber E, Holmberg D, Cardell S, Sorokin L. The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human. Diabetes 2013;62: 531-542. Abstract
Korten S, Brunssen C, Poitz DM, Grossklaus S, Brux M, Schnittler H-J, Strasser RH, Bornstein SR, Morawietz H, Goettsch W. Impact of Hey2 and COUP-TFII on genes involved in arteriovenous differentiation in primary human arterial and venous endothelial cells. Basic Res Cardiol 2013;108: 362. Abstract
Koyama T, Ochoa-Callejero L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Arai T, Yoshizawa T, Iesato Y, Lei Y, Uetake R, Okimura A, Yamauchi A, Tanaka M, Igarashi K, Toriyama Y, Kawate H, Adams RH, Kawakami H, Mochizuki N, Martinez A, Shindo T. Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis. Circulation 2013;127: 842-853. Abstract
Kramko N, Sinitski D, Seebach J, Loffler B, Dieterich P, Heilmann C, Peters G, Schnittler H-J. Early Staphylococcus aureus-induced changes in endothelial barrier function are strain-specific and unrelated to bacterial translocation. Int J Med Microbiol 2013;303: 635-644. Abstract
Laugsch M, Seebach J, Schnittler H, Jessberger R. Imbalance of SMC1 and SMC3 cohesins causes specific and distinct effects. PLoS One 2013;8: e65149. Abstract
Musiol A, Gran S, Ehrhardt C, Ludwig S, Grewal T, Gerke V, Rescher U. Annexin A6-balanced late endosomal cholesterol controls influenza a replication and propagation. MBio 2013;4: e00608-13. Abstract
Nakayama M, Nakayama A, van Lessen M, Yamamoto H, Hoffmann S, Drexler HCA, Itoh N, Hirose T, Breier G, Vestweber D, Cooper JA, Ohno S, Kaibuchi K, Adams RH. Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol 2013;15: 249-260. Abstract
Oberleithner H. Vascular endothelium leaves fingerprints on the surface of erythrocytes. Pflugers Arch 2013;465: 1451-1458. Abstract
Peddibhotla SSD, Brinkmann BF, Kummer D, Tuncay H, Nakayama M, Adams RH, Gerke V, Ebnet K. Tetraspanin CD9 links junctional adhesion molecule-A to alphavbeta3 integrin to mediate basic fibroblast growth factor-specific angiogenic signaling. Mol Biol Cell 2013;24: 933-944. Abstract
Petersen B, Wolf M, Austermann J, van Lent P, Föll D, Ahlmann M, Kupas V, Loser K, Sorg C, Roth J, Vogl T. The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis. EMBO J 2013;32: 100-111. Abstract
Retser E, Schied T, Skryabin BV, Vogl T, Kanczler JM, Hamann N, Niehoff A, Hermann S, Eisenblätter M, Wachsmuth L, Pap T, van Lent PLEM, Loser K, Roth J, Zaucke F, Ludwig S, Wixler V. Doxycycline-induced expression of transgenic human tumor necrosis factor alpha in adult mice results in psoriasis-like arthritis. Arthritis Rheum 2013;65: 2290-2300. Abstract
Scharnert J, Greune L, Zeuschner D, Lubos M-L, Alexander Schmidt M, Ruter C. Autonomous translocation and intracellular trafficking of the cell-penetrating and immune-suppressive effector protein YopM. Cell Mol Life Sci 2013;70: 4809-4823. Abstract
Sehnert B, Burkhardt H, Wessels JT, Schroder A, May MJ, Vestweber D, Zwerina J, Warnatz K, Nimmerjahn F, Schett G, Dubel S, Voll RE. NF-kappaB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-kappaB in immune-mediated diseases. Proc Natl Acad Sci USA 2013;110: 16556-16561. Abstract
Song J, Wu C, Zhang X, Sorokin LM. In Vivo Processing of CXCL5 (LIX) by Matrix Metalloproteinase (MMP)-2 and MMP-9 Promotes Early Neutrophil Recruitment in IL-1beta-Induced Peritonitis. J Immunol 2013;190: 401-410. Abstract
Spoden G, Kuhling L, Cordes N, Frenzel B, Sapp M, Boller K, Florin L, Schelhaas M. Human papillomavirus types 16, 18, and 31 share similar endocytic requirements for entry. J Virol 2013;87: 7765-7773. Abstract
Visekruna A, Ritter J, Scholz T, Campos L, Guralnik A, Poncette L, Raifer H, Hagner S, Garn H, Staudt V, Bopp T, Reuter S, Taube C, Loser K, Huber M. Tc9 cells, a new subset of CD8(+) T cells, support Th2-mediated airway inflammation. Eur J Immunol 2013;43: 606-618. Abstract
Vockel M, Vestweber D. How T cells trigger the dissociation of the endothelial receptor phosphatase VE-PTP from VE-cadherin. Blood 2013;122: 2512-2522. Abstract
Weinl C, Riehle H, Park D, Stritt C, Beck S, Huber G, Wolburg H, Olson EN, Seeliger MW, Adams RH, Nordheim A. Endothelial SRF/MRTF ablation causes vascular disease phenotypes in murine retinae. J Clin Invest 2013;123: 2193-2206. Abstract
Woerdemann M, Alpmann C, Esseling M, Denz C. Advanced optical trapping by complex beam shaping. Laser Photonics Rev 2013;7: 839–854. Abstract
Yang H, Lee S, Lee S, Kim K, Yang Y, Kim JH, Adams RH, Wells JM, Morrison SJ, Koh GY, Kim I. Sox17 promotes tumor angiogenesis and destabilizes tumor vessels in mice. J Clin Invest 2013;123: 418-431. Abstract
Zhang X, Wu C, Song J, Gotte M, Sorokin L. Syndecan-1, a Cell Surface Proteoglycan, Negatively Regulates Initial Leukocyte Recruitment to the Brain across the Choroid Plexus in Murine Experimental Autoimmune Encephalomyelitis. J Immunol 2013;191: 4551-4561. Abstract

2012

Alpmann C, Esseling M, Rose P, Denz C. Dynamic Light Cages: Putting Absorbing Matter Behind Bars. Opt Photon News 2012;23: 48. Abstract
Iden S, Misselwitz S, Peddibhotla SSD, Tuncay H, Rehder D, Gerke V, Robenek H, Suzuki A, Ebnet K. aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation. J Cell Biol 2012;196: 623-639. Abstract
Joseph J, Bittner S, Kaiser FMP, Wiendl H, Kissler S. IL-17 Silencing Does Not Protect Nonobese Diabetic Mice from Autoimmune Diabetes. J Immunol 2012;188: 216-221. Abstract
Rezaei M, Friedrich K, Wielockx B, Kuzmanov A, Kettelhake A, Labelle M, Schnittler H, Baretton G, Breier G. Interplay between neural-cadherin and vascular endothelial-cadherin in breast cancer progression. Breast Cancer Res 2012;14: R154. Abstract
Woerdemann M, Veiga-Gutiérrez M, De Cola L, Denz C. Creating Functional Microstructures with an Optical-Tweezers Assembly-Line. Opt Photon News 2012;23: 47. Abstract