Beteiligung am Exzellenzcluster

CiM-Gruppenleiter
Mitglied der CiM-IMPRS Graduiertenschule

  • Forschungsgebiet B.1: Ausbildung und Eigenschaften von epithelialen und endothelialen Zellbarrieren
  • Forschungsgebiet B.2: Kontrolle der vaskulären Permeabilität und der Einwanderung von Leukozyten in Gewebe
  • Forschungsgebiet B.5: Pathogene an Endo- und Epithel-Barrieren
  • Projekt FF-2014-15: Genomweite Analyse von schubspannungsinduzierten "enhancer" Elementen in Endothelzellen (Hans-Joachim Schnittler, Arndt Siekmann, Projektlaufzeit: 07/2014 - 06/2016)

© CiM - Peter Grewer

"Sport für Endothelzellen"

Prof. Dr. Hans-Joachim Schnittler fragt sich: Sind trainierte Endothelzellen die resistenteren Zellen? Dieser Frage geht er mit einem internationalen Forschungsteam nach – und mithilfe seines eigens entwickelten Flow-Systems. Zum Interview

CiM-Publikationen

2018

Rezaei M, Cao J, Friedrich K, Kemper B, Brendel O, Grosser M, Adrian M, Baretton G, Breier G, Schnittler H-J. The expression of VE-cadherin in breast cancer cells modulates cell dynamics as a function of tumor differentiation and promotes tumor-endothelial cell interactions. Histochem Cell Biol 2018;149: 15-30. Abstract

2017

Bulk E, Kramko N, Liashkovich I, Glaser F, Schillers H, Schnittler HJ, Oberleithner H, Schwab A. KCa31 channel inhibition leads to an ICAM-1 dependent increase of cell-cell adhesion between A549 lung cancer and HMEC-1 endothelial cells. Oncotarget 2017;8: 112268-112282. Abstract
Cao J, Ehling M, März S, Seebach J, Tarbashevich K, Sixta T, Pitulescu ME, Werner A-C, Flach B, Montanez E, Raz E, Adams RH, Schnittler H. Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis. Nat Commun 2017;8Abstract
Hasan SS, Tsaryk R, Lange M, Wisniewski L, Moore JC, Lawson ND, Wojciechowska K, Schnittler H, Siekmann AF. Endothelial Notch signalling limits angiogenesis via control of artery formation. Nat Cell Biol 2017;19: 928-940. Abstract
Kage F, Winterhoff M, Dimchev V, Mueller J, Thalheim T, Freise A, Bruhmann S, Kollasser J, Block J, Dimchev G, Geyer M, Schnittler H-J, Brakebusch C, Stradal TEB, Carlier M-F, Sixt M, Kas J, Faix J, Rottner K. FMNL formins boost lamellipodial force generation. Nat Commun 2017;8: 14832. Abstract

2016

Schnittler H. Contraction of endothelial cells: 40 years of research, but the debate still lives. Histochem Cell Biol 2016;146: 651-656. Abstract
Seebach J, Cao J, Schnittler HJ. Quantitative dynamics of VE-cadherin at endothelial cell junctions at a glance: basic requirements and current concepts. Discoveries 2016;4: e63. Abstract
Strobel M, Pfortner H, Tuchscherr L, Volker U, Schmidt F, Kramko N, Schnittler H-J, Fraunholz MJ, Loffler B, Peters G, Niemann S. Post-invasion events after infection with Staphylococcus aureus are strongly dependent on both the host cell type and the infecting S aureus strain. Clin Microbiol Infect 2016;22: 799-809. Abstract

2015

Seebach J, Taha AA, Lenk J, Lindemann N, Jiang X, Brinkmann K, Bogdan S, Schnittler H-J. The CellBorderTracker, a novel tool to quantitatively analyze spatiotemporal endothelial junction dynamics at the subcellular level. Histochem Cell Biol 2015;144: 517-532. Abstract

2014

Abu Taha A, Schnittler H-J. Dynamics between actin and the VE-cadherin/catenin complex: novel aspects of the ARP2/3 complex in regulation of endothelial junctions. Cell Adh Migr 2014;8: 125-135. Abstract
Abu Taha A, Taha M, Seebach J, Schnittler H-J. ARP2/3-mediated junction-associated lamellipodia control VE-cadherin-based cell junction dynamics and maintain monolayer integrity. Mol Biol Cell 2014;25: 245-256. Abstract
Schnittler H. Between sealing and leakiness: molecular dynamics of the endothelium to maintain and regulate barrier function. Cell Tissue Res 2014;355: 481-483. Abstract
Schnittler H, Taha M, Schnittler MO, Taha AA, Lindemann N, Seebach J. Actin filament dynamics and endothelial cell junctions: the Ying and Yang between stabilization and motion. Cell Tissue Res 2014;355: 529-543. Abstract

2013

Dietrich A, Stewart J, Huether M, Helm M, Schuetze C, Schnittler H-J, Jaffray DA, Kunz-Schughart LA. Macromolecule extravasation-xenograft size matters: a systematic study using probe-based confocal laser endomicroscopy (pCLE). Mol Imaging Biol 2013;15: 693-702. Abstract
Korten S, Brunssen C, Poitz DM, Grossklaus S, Brux M, Schnittler H-J, Strasser RH, Bornstein SR, Morawietz H, Goettsch W. Impact of Hey2 and COUP-TFII on genes involved in arteriovenous differentiation in primary human arterial and venous endothelial cells. Basic Res Cardiol 2013;108: 362. Abstract
Kramko N, Sinitski D, Seebach J, Loffler B, Dieterich P, Heilmann C, Peters G, Schnittler H-J. Early Staphylococcus aureus-induced changes in endothelial barrier function are strain-specific and unrelated to bacterial translocation. Int J Med Microbiol 2013;303: 635-644. Abstract
Laugsch M, Seebach J, Schnittler H, Jessberger R. Imbalance of SMC1 and SMC3 cohesins causes specific and distinct effects. PLoS One 2013;8: e65149. Abstract

2012

Rezaei M, Friedrich K, Wielockx B, Kuzmanov A, Kettelhake A, Labelle M, Schnittler H, Baretton G, Breier G. Interplay between neural-cadherin and vascular endothelial-cadherin in breast cancer progression. Breast Cancer Res 2012;14: R154. Abstract