Academics at the Department of Biology

Molekulare Pflanzenphysiologie (Molekularbiologie, Zellbiologie, Pflanzenstoffwechsel, Biochemie).

Molekulare Physiologie Höherer Pflanzen, Rolle komplexer N-Glykane im Sekretorischen System von Pflanzen, Reduktion des Allergiepotenzials in pflanzlichen Lebensmitteln.

Ausgewählte Projekte


  • Nagashima Y, von Schaewen A, Koiwa H. . ‘Function of N-glycosylation in plants.’ Plant Science 274, No. September: 70-79. doi: 10.1016/j.plantsci.2018.05.007.
  • Jeong IS, Lee S, Bonkhofer F, Tolley J, Fukudome A, Nagashima Y, May K, Rips S, Lee SY, Gallois P, Russell W, Hyun Suk J, von Schaewen A, Koiwa H. . ‘Purification and characterization of Arabidopsis thaliana oligosaccharyltransferase complexes from the native host: a protein super-expression system for structural studies.The Plant Journal 94, No. 1: 131-145. doi: 10.1111/tpj.13847.
  • Thyssen GM, Holtkamp M, Kaulfürst-Soboll H, Wehe CA, Sperling M, von Schaewen A, Karst U. . ‘Elemental bioimaging by means of LA-ICP-OES: investigation of the calcium, sodium and potassium distribution in tobacco plant stems and leaf petioles.’ Metallomics 9, No. 6: 676-684. doi: 10.1039/c7mt00003k.
  • Rips S, Frank M, Elting A, Offenborn JN, von Schaewen A. . ‘Golgi (alpha)1,4-fucosyltransferase of Arabidopsis thaliana partially localizes at the nuclear envelope.’ TRAFFIC 18, No. 10: 646-657. doi: 10.1111/tra.12506.
  • Lutterbey MC, von Schaewen A. . ‘Analysis of homo- and hetero-dimerization among the three 6-phosphogluconate dehydrogenase isoforms of Arabidopsis.Plant Signaling & Behavior 11, No. 10: e1207034. doi: 10.1080/15592324.2016.1207034.
  • Hölscher C, Lutterbey M-C, Lansing H, Meyer T, Fischer K, von Schaewen A. . ‘Defects in peroxisomal 6-phosphogluconate dehydrogenase isoform PGD2 prevent gametophytic interaction in Arabidopsis thaliana.’ Plant Physiology not yet available. doi: doi: http:/​/​dx.​doi.​org/​10.​1104/​pp.​15.​01301.
  • von Schaewen A, Rips S, Jeong IS, Koiwa H. . ‘Arabidopsis thaliana KORRIGAN1 protein: N-glycan modification, localization, and function in cellulose biosynthesis and osmotic stress responses.’ Plant Signaling & Behavior 10:, No. 5: e1024397. doi: DOI: 10.1080/15592324.2015.1024397.
  • Rips S, Bentley N, Jeong I, Welch JL, von Schaewen A, Koiwa H. . ‘Multiple N-glycans cooperate in the subcellular targeting and functioning of Arabidopsis KORRIGAN1.’ The Plant Cell 26, No. 9: 3792-3808. doi: 10.1105/tpc.114.129718.
  • Hölscher C, Meyer T, von Schaewen A. . ‘Dual-Targeting of Arabidopsis 6-Phosphogluconolactonase 3 (PGL3) to Chloroplasts and Peroxisomes Involves Interaction with Trx m2 in the Cytosol.’ Molecular Plant 7, No. 1: 252-255.
  • Kaulfürst-Soboll H, Mertens M, Brehler R, von Schaewen A. . ‘Reduction of cross-reactive carbohydrate determinants in plant foodstuff: elucidation of clinical relevance and implications for allergy diagnosis.PLoS ONE 6, No. 3: e17800. doi: 10.1371/journal.pone.0017800.
  • Trotta A, Wrzaczek M, Scharte J, Tikkanen M, Konert G, Rahikainen M, Holmström M, Hiltunen HM, Rips S, Sipari N, Mulo P, Weis E, von Schaewen A, Aro EM, Kangasjärvi S. . ‘Regulatory subunit B'gamma of protein phosphatase 2A prevents unnecessary defense reactions under low light in Arabidopsis.Plant Physiology 156, No. 3: 1464-80. doi: 10.1104/pp.111.178442.
  • Kaulfürst-Soboll H, Rips S, Koiwa H, Kajiura H, Fujiyama K, von Schaewen A. . ‘Reduced immunogenicity of Arabidopsis hgl1 mutant N-glycans caused by altered accessibility of xylose and core fucose epitopes.The Journal of Biological Chemistry 286, No. 26: 22955-64. doi: 10.1074/jbc.M110.196097.
  • Meyer T, Hölscher C, Schwöppe C, von Schaewen A. . ‘Alternative targeting of Arabidopsis plastidic glucose-6-phosphate dehydrogenase G6PD1 involves cysteine-dependent interaction with G6PD4 in the cytosol.The Plant Journal : for cell and molecular biology 66, No. 5: 745-58. doi: 10.1111/j.1365-313X.2011.04535.x.
  • Häweker H, Rips S, Koiwa H, Salomon S, Saijo Y, Chinchilla D, Robatzek S, von Schaewen A. . ‘Pattern Recognition Receptors Require N-Glycosylation to Mediate Plant Immunity.’ JOURNAL OF BIOLOGICAL CHEMISTRY 285, No. 7: 4629-4636. doi: 10.1074/jbc.M109.063073.
  • Scharte J, Schoen H, Tjaden Z, Weis E, von Schaewen A. . ‘Isoenzyme replacement of glucose-6-phosphate dehydrogenase in the cytosol improves stress tolerance in plants.’ Proceedings of the National Academy of Sciences of the United States of America 106, No. 19: 6. doi: 10.1073/pnas.0812902106.
  • Frank J, Kaulfürst-Soboll H, Rips S, Koiwa H, von Schaewen A. . ‘Comparative analyses of Arabidopsis complex glycan1 mutants and genetic inter­action with staurosporin and temperature-sensitive3a.’ Plant Physiology 2008, No. 148: 14. doi: 10.1104/pp.108.127027.
  • von Schaewen A, Frank J, Koiwa H. . ‘Role of complex N-glycans in plant stress tolerance.Plant Signaling & Behavior 3, No. 10: 10.
  • Kang JS, Frank J, Kang CH, Kajiura H, Vikram M, Ueda A, Kim S, Bahk JD, Triplett B, Fujiyama K, Lee SY, von Schaewen A, Koiwa H. . ‘Salt tolerance of Arabidopsis thaliana requires maturation of N‑glycosylated proteins in the Golgi apparatus.’ PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105, No. 15: 6. doi: 10.1073/pnas.0800237105.
  • Holtgrefe S, Bader KP, Horton P, Scheibe R, von Schaewen A, Backhausen JE. . ‘Decreased content of leaf ferredoxin changes electron distribution and limits photosynthesis in transgenic potato plants.’ PLANT PHYSIOLOGY 2003, No. 133: 10. doi: 10.1104/pp.103.026013.
  • Hauschild R, von Schaewen A. . ‘Differential regulation of glucose-6-phosphate dehydrogenase isoenzyme activities in potato.’ Plant Physiology 2003, No. 133: 16. doi: 10.1104/pp.103.025676.
  • Kruger N, von Schaewen A. . ‘The oxidative pentose phosphate pathway: structure and organisation.’ Current Opinion in Plant Biology 2003, No. 6: 10. doi: 10.1016/S1369-5266(03)00039-6.
  • Wendt U, Wenderoth I, Tegeler A, von Schaewen A. . ‘Molecular characterization of a novel glucose-6-phosphate dehydrogenase from potato (Solanum tuberosum L.).’ PLANT JOURNAL 23, No. 6: 10. doi: 10.1046/j.1365-313x.2000.00840.x.
  • Wenderoth I, von Schaewen A. . ‘Isolation and characterization of plant N-acetyl glucosaminyltransferase I (GntI) cDNA sequences. Functional analyses in the Arabidopsis cgl mutant and in antisense plants.’ PLANT PHYSIOLOGY 123, No. 3: 11. doi: 10.1104/pp.123.3.1097.
  • Wendt UK, Hauschild R, Lange C, Pietersma M, Wenderoth I, von Schaewen A. . ‘Evidence for functional convergence of redox regulation in G6PDH isoforms of cyanobacteria and higher plants.’ PLANT MOLECULAR BIOLOGY 40, No. 3: 7. doi: 10.1023/A:1006257230779.
  • Wingler A, von Schaewen A, Leegood RC, Lea PJ, Quick P. . ‘Regulation of leaf senescence by cytokinin, sugars and light: Effects on NADH-dependent hydroxylpyruvate reductase.’ Plant Physiology 1998, No. 116: 7. doi: 10.1104/pp.116.1.329.
  • Wenderoth I, Scheibe R, von Schaewen A. . ‘Identification of the cysteine residues involved in redox modification of plant plastidic glucose-6-phosphate dehydrogenase.’ JOURNAL OF BIOLOGICAL CHEMISTRY 272, No. 43: 6. doi: 10.1074/jbc.272.43.26985.
  • Faske M, Backhausen JE, Sendker M, Singer-Bayrle M, Scheibe R, von Schaewen A. . ‘Transgenic tobacco plants expressing pea chloroplast Nmdh cDNA in sense and antisense orientation: Effects on NADP-MDH level, stability of transformants, and plant growth.’ Plant Physiology 1997, No. 115: 10.
  • von Schaewen A, Langenkämper G, Graeve K, Wenderoth I, Scheibe R. . ‘Molecular characterization of the plastidic glucose-6-phosphate dehydrogenase from potato in comparison to its cytosolic counterpart.’ Plant Physiology 109, No. 4: 18. doi: 10.1104/pp.109.4.1327.
  • Falkenstein E, von Schaewen A, Scheibe R. . ‘Full-length cDNA sequences for both ferredoxin-thioredoxin reductase subunits from spinach (Spinacia oleracea L.).’ Biochimica et Biophysica Acta (BBA) - Bioenergetics 1185, No. 2: 3. doi: 10.1016/0005-2728(94)90218-6.
  • Graeve K, von Schaewen A, Scheibe R. . ‘Purification, characterization, and cDNA sequence of glucose-6-phosphate dehydrogenase from potato (Solatium tuberosum L.).’ The Plant Journal : for cell and molecular biology 5, No. 3: 9. doi: 10.1111/j.1365-313X.1994.00353.x.
  • von Schaewen A, Sturm A, O'Neill J, Chrispeels MJ. . ‘Isolation of a mutant Arabidopsis plant that lacks N-acetyl glucosaminyl transferase I and is unable to synthesize Golgi-modified complex N-linked glycans.’ Plant Physiology 102, No. 4: 10.
  • Chrispeels MJ, von Schaewen A. . ‘Identification of vacuolar sorting information in phytohemagglutinin, an unprocessed vacuolar protein.’ Journal of Experimental Botany 44: 4.
  • Chrispeels MJ, von Schaewen A. . ‘Sorting of proteins in the secretory system of plant cells.’ Antonie van Leeuwenhoek 61, No. 2: 5. doi: 10.1007/BF00580624.
  • Sonnewald U, Brauer M, von Schaewen A, Stitt M, Willmitzer L. . ‘Transgenic tobacco plants expressing yeast-derived invertase in either the cytosol, vacuole or apoplast: A powerful tool for studying sucrose metabolism and sink/source interactions.’ Plant Journal 1, No. 1: 12. doi: 10.1111/j.1365-313X.1991.00095.x.
  • von Schaewen A, Stitt M, Schmidt R, Willmitzer L. . ‘Expression of a yeast-derived invertase in the cell wall of tobacco and Arabidopsis plants leads to accumulation of carbohydrate and inhibition of photosynthesis and strongly influences growth and phenotype of transgenic tobacco plants.’ EMBO Journal 9, No. 10: 11.
  • Sonnewald U, von Schaewen A, Willmitzer L. . ‘Expression of mutant patatin protein in transgenic tobacco plants: Role of glycans and intracellular location.The Plant Cell 2, No. 4: 11. doi: 10.1105/tpc.2.4.345.
  • Stitt M, von Schaewen A, Willmitzer L. . ‘“Sink” regulation of photosynthetic metabolism in transgenic tobacco plants expressing yeast invertase in their cell wall involves a decrease of the Calvin-cycle enzymes and an increase of glycolytic enzymes.’ Planta 183: 11. doi: 10.1007/BF00197565.
  • Stochaj U, Fritz HJ, Heibach C, Markgraf M, von Schaewen A, Sonnewald U, Ehring R. . ‘Truncated forms of Escherichia coli lactose permease: models for study of biosynthesis and membrane insertion.’ Journal of Bacteriology 170, No. 6: 7.