Die klinische Reviews-Datenbank UpToDate wurde aktualisiert und steht nun in der Version 20.4 mit über 9.000 Reviews unter http://www.uptodate.com/online zur Verfügung. UpToDate wird ab sofort wöchentlich aktualisiert.

In den Practice changing UpDates werden neue Empfehlungen und Updates besprochen, die sehr wahrscheinlich die bisher übliche klinische Praxis ändern werden, darunter

• Treatment for constipation — In patients over the age of 70 years being treated with enemas for constipation, we suggest that patients receive warm water enemas rather than sodium phosphate enemas
• Repeat screening for bone mineral density — In women 65 years of age and older with normal or slightly low bone mass (T-score -1.01 to -1.49) at baseline measurement and no risk factors for accelerated bone loss, we suggest follow-up dual-energy x-ray absorptiometry (DXA) in 10 to 15 years
• Treatment for latent tuberculosis – For treatment of latent tuberculosis infection (LTBI) in HIV-negative adults we suggest three months of weekly isoniazid and rifapentine (given by direct observation)
• Ivacaftor for cystic fibrosis – For all patients with cystic fibrosis who carry at least one copy of the G551D mutation and are six years of age or older, we recommend treatment with ivacaftor.
• Monitoring liver function tests for statin therapy – We suggest checking baseline aminotransferase levels prior to initiating statin therapy; routine monitoring of these levels is not necessary for patients on statins.

40% aller Übersichtsarbeiten werden alle vier Monate aktualisiert, eine Auswahl finden Sie im Bereich What’s new.

Jeder Review trägt nun am Ende eine fortlaufende Nummer, die das Update angibt:

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