Project Z02
Animal models and phenotyping
Michael Kuhlmann, Cornelius Faber
Project
Access to appropriate disease models, mimicking the pathology of cardiovascular human diseases is essential for progress in the field of molecular imaging and for the transfer of preclinical results into the clinical setting. Project Z2 provides highly standardized models for validation of imaging techniques and new ligands.
In addition, phenotyping, and morphological and functional imaging of the models will be provided and organized. Project Z2 will serve as an imaging platform providing established and tailored techniques in ultrasound (US), magnetic resonance imaging (MRI), positron emission tomography (PET) and fluorescence mediated tomography (FMT).
Papers resulting from project Z02
In press
| Currently none. |
2013
| Schmid F, Höltke C, Parker D, Faber C. Boosting (19) F MRI-SNR efficient detection of paramagnetic contrast agents using ultrafast sequences. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2013;69: 1056-1062. Abstract |
2012
| Hermann S, Starsichova A, Waschkau B, Kuhlmann M, Wenning C, Schober O, Schäfers M. Non-FDG imaging of atherosclerosis: Will imaging of MMPs assess plaque vulnerability?. Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology 2012;19: 609-617. Abstract |
| Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S, Schäfers M. Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice. Journal of Visualized Experiments : JoVE 2012: 3308. Abstract |
| Paulis LE, Geelen T, Kuhlmann MT, Coolen BF, Schäfers M, Nicolay K, Strijkers GJ. Distribution of lipid-based nanoparticles to infarcted myocardium with potential application for MRI-monitored drug delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society 2012;162: 276-285. Abstract |
| Strobel K, Hoerr V, Schmid F, Wachsmuth L, Löffler B, Faber C. Early detection of lung inflammation: Exploiting T1-effects of iron oxide particles using UTE MRI. Magn. Reson. Med. 2012;68: 1924-1931. Abstract |
2011
| Baumann A, Faust A, Law MP, Kuhlmann MT, Kopka K, Schäfers M, Karst U. Metabolite identification of a radiotracer by electrochemistry coupled to liquid chromatography with mass spectrometric and radioactivity detection. Analytical Chemistry 2011;83: 5415-5421. Abstract |
| Wenning C, Stegger D, Hermann S, Schober O, Schäfers M. F-18-FDG Imaging for Atherosclerotic Plaque Characterization. Current Cardiovascular Imaging Reports 2011;4: 190-198. Abstract |
2010
| Blana A, Kaese S, Fortmuller L, Laakmann S, Damke D, van Bragt K, Eckstein J, Piccini I, Kirchhefer U, Nattel S, Breithardt G, Carmeliet P, Carmeliet E, Schotten U, Verheule S, Kirchhof P, Fabritz L. Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability. Heart Rhythm : the Official Journal of the Heart Rhythm Society 2010;7: 1862-1869. Abstract |
| Bovens S, Schulze Elfringhoff A, Kaptur M, Reinhardt D, Schäfers M, Lehr M. 1-(5-Carboxyindol-1-yl)propan-2-one Inhibitors of Human Cytosolic Phospholipase A(2)alpha: Effect of Substituents in Position 3 of the Indole Scaffold on Inhibitory Potency, Metabolic Stability, Solubility, and Bioavailability. Journal of Medicinal Chemistry 2010;53: 8298–8308. Abstract |
| Buscher K, Judenhofer MS, Kuhlmann MT, Hermann S, Wehrl HF, Schäfers KP, Schäfers M, Pichler BJ, Stegger L. Isochronous assessment of cardiac metabolism and function in mice using hybrid PET/MRI. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 2010;51: 1277-1284. Abstract |
| Dreischaluck J, Schwöppe C, Spieker T, Kessler T, Tiemann K, Liersch R, Schliemann C, Kreuter M, Kolkmeyer A, Hintelmann H, Mesters RM, Berdel WE. Vascular infarction by subcutaneous application of tissue factor targeted to tumor vessels with NGR-peptides: activity and toxicity profile. International Journal of Oncology 2010;37: 1389-1397. Abstract |
| Drews A, Bovens S, Roebrock K, Sunderkotter C, Reinhardt D, Schäfers M, van der Velde A, Schulze Elfringhoff A, Fabian J, Lehr M. 1-(5-carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A(2)alpha with reduced lipophilicity: synthesis, biological activity, metabolic stability, solubility, bioavailability, and topical in vivo activity. Journal of Medicinal Chemistry 2010;53: 5165-5178. Abstract |
| Larmann J, Frenzel T, Hahnenkamp A, Herzog C, Lorenz A, Steinbicker AU, Calmer S, Harendza T, Schmitz M, Echtermeyer F, Hildebrand R, Bremer C, Theilmeier G. In vivo fluorescence-mediated tomography for quantification of urokinase receptor-dependent leukocyte trafficking in inflammation. Anesthesiology 2010;113: 610-618. Abstract |
| Schäfers M, Schober O, Hermann S. Matrix-metalloproteinases as imaging targets for inflammatory activity in atherosclerotic plaques. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 2010;51: 663-666. Abstract |
| Schnöckel U, Hermann S, Stegger L, Law M, Kuhlmann M, Schober O, Schäfers K, Schäfers M. Small-animal PET: a promising, non-invasive tool in pre-clinical research. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2010;74: 50-54. Abstract |
2009
| Höltke C, Waldeck J, Kopka K, Heindel W, Schober O, Schäfers M, Bremer C. Biodistribution of a nonpeptidic fluorescent endothelin A receptor imaging probe. Molecular Imaging : Official Journal of the Society for Molecular Imaging 2009;8: 27-34. Abstract |
| Stegger L, Heijman E, Schäfers KP, Nicolay K, Schäfers MA, Strijkers GJ. Quantification of left ventricular volumes and ejection fraction in mice using PET, compared with MRI. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 2009;50: 132-138. Abstract |
| Wagner S, Breyholz H-J, Höltke C, Faust A, Schober O, Schäfers M, Kopka K. A new 18F-labelled derivative of the MMP inhibitor CGS 27023A for PET: radiosynthesis and initial small-animal PET studies. Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for use in Agriculture, Industry and Medicine 2009;67: 606-610. Abstract |
2008
| Grote-Wessels S, Baba HA, Boknik P, El-Armouche A, Fabritz L, Gillmann H-J, Kucerova D, Matus M, Muller FU, Neumann J, Schmitz M, Stumpel F, Theilmeier G, Wohlschlaeger J, Schmitz W, Kirchhefer U. Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload. Cardiovascular Research 2008;79: 464-471. Abstract |
| Levkau B, Schäfers M, Wohlschlaeger J, von Wnuck Lipinski K, Keul P, Hermann S, Kawaguchi N, Kirchhof P, Fabritz L, Stypmann J, Stegger L, Flogel U, Schrader J, Fischer JW, Hsieh P, Ou YL, Mehrhof F, Tiemann K, Ghanem A, Matus M, Neumann J, Heusch G, Schmid KW, Conway EM, Baba HA. Survivin determines cardiac function by controlling total cardiomyocyte number. Circulation 2008;117: 1583-1593. Abstract |
| Waldeck J, Hager F, Höltke C, Lanckohr C, von Wallbrunn A, Torsello G, Heindel W, Theilmeier G, Schäfers M, Bremer C. Fluorescence reflectance imaging of macrophage-rich atherosclerotic plaques using an alphavbeta3 integrin-targeted fluorochrome. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 2008;49: 1845-1851. Abstract |
2006
| Stegger L, Hoffmeier A-N, Schäfers KP, Hermann S, Schober O, Schäfers MA, Theilmeier G. Accurate noninvasive measurement of infarct size in mice with high-resolution PET. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 2006;47: 1837-1844. Abstract |
| Theilmeier G, Schmidt C, Herrmann J, Keul P, Schäfers M, Herrgott I, Mersmann J, Larmann J, Hermann S, Stypmann J, Schober O, Hildebrand R, Schulz R, Heusch G, Haude M, von Wnuck Lipinski K, Herzog C, Schmitz M, Erbel R, Chun J, Levkau B. High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor. Circulation 2006;114: 1403-1409. Abstract |
Team
Principal investigators
Michael Kuhlmann, PhD
European Institute for Molecular Imaging (EIMI)
Tel.: +49 251 83-49312
kuhlmam@uni-muenster.de
Prof. Cornelius Faber, PhD
Department of Clinical Radiology
Tel.: +49 251 83-57608
faberc@uni-muenster.de
Scientific staff
Dipl.-Phys. Florian Schmid
Department of Clinical Radiology
Tel.: +49 251 83-44300
florian.schmid@uni-muenster.de
Jörg Stypmann, MD
Department of Cardiology and Angiology
Tel.: +49 251 83-44906
stypmann@ukmuenster.de
Non-scientific staff
Justina Mbah
Department of Cardiology and Angiology
Technical Assistant – Medicine
JustinaYelumaOngey.Mbah@ukmuenster.de
Contact
Michael Schäfers, MDSFB 656 MoBil
Mendelstraße 11
D-48149 Münster
Tel.: +49 251 83-49300
Fax: +49 251 83-49313
schafmi@uni-muenster.de
