Dr. Simone Scintilla
Postdoctoral Researcher
Place of Birth: Bari, Italy
Date of birth: August 13, 1980
Physikalisches Institut, Westfälische Wilhlems-Universität Münster c/o ICB
Heisenbergstrasse 11
D-48149 Münster
Germany
Phone: +49 (0)251-5340-6902
E-mail: s.scintilla(at)uni-muenster.de
Current position:
I am currently employed as a postdoctoral fellow in Prof. L. De Cola’s group, at Physikalisches Institut, Westfälisches-Wilhelms Universität, Münster (Germany), working on the project ONE-P (Organic Nanomaterials for Electronics and Photonics), funded by the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 212311, working on design, synthesis and characterization of novel Cu(I)-based materials for application in Organic Light-Emitting Devices (OLEDs).
Education and research interests:
12 March 2009 I defended my PhD thesis in "Applied chemical and enzymatic synthesis" at the Pharmaceutical Chemistry Department of the University of Bari (supervisor: Prof. G. Natile) entitled "Copper and platinum in biological systems: some toxic and beneficial effects" in which new biophysical and biostructural studies both on the role of copper in the unfolding of the protein ubiquitin and its effect on neurodegenerative diseases and on the cellular uptake of platinum-based antitumor drugs mediated by copper transport proteins have been discussed.
21 July 2005 I received the degree in Chemistry at University of Bari, full mark (110/110) cum laude, with a thesis on "Reactivity between platinum complexes bearing secondary phosphanes and oxygenated bases" (supervisors: Prof. C. F. Nobile, Prof. P. Mastrorilli and Prof. M. Castagnolo), in which the synthesis of new platinum dinuclear complexes with bridging phosphido ligands, with platinum-platinum, bonding was presented.
Research products:
1) Arnesano F., Scintilla S., Natile G. (2007).
Interaction between Platinum Complexes and a Methionine Motif Found in Copper Transport Proteins.
ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 2007; 46(47): 9062-4.
VIP paper. Cover picture.
2) Milardi D., Arnesano F., Grasso G., Magrì A., Tabbì G., Scintilla S., Natile G., Rizzarelli E. (2007).
Ubiquitin stability and the Lys63-linked polyubiquitination site are compromised on copper binding.
ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 2007; 46(42):7993-5.
3) Arnesano F., Scintilla S., Calò V., Bonfrate E., Ingrosso C., Losacco M., Pellegrino T., Rizzarelli E., Natile G. (2009).
Copper-triggered aggregation of ubiquitin.
PLoS ONE. 2009; 16;4(9):e7052.
4) Kubícek K., Monnet J., Scintilla S., Kopecná J., Arnesano F., Trantírek L., Chopard C., Natile G., Kozelka J. (2010)
Unusual interstrand Pt(S,S-diaminocyclohexane)-GG crosslink formed by rearrangement of a classical intrastrand crosslink within a DNA duplex.
CHEMISTRY, AN ASIAN JOURNAL. 2010; 1;5(2):244-7.
References:
Prof. Piero Mastrorilli
Department of water engeneering and of chemistry (DIAC)
Polytechnic of Bari, Bari, ITALY
Phone +39 080 5963605
Fax +39 080 5963611
e-mail: p.mastrorilli@poliba.it
Prof. Giovanni Natile
Department of Pharmaceutical Chemistry
University of Bari “A. Moro”, Bari, ITALY
Phone +39 080 5442734
Fax +39 080 5442230
e-mail: natile@farmchim.uniba.it
Dr. Jiri Kozelka
Directeur de Recherche Université Paris Descartes
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Paris FRANCE
Phone +331 40 20 96 33
Professor of Chemistry
Masaryk University of Brno
Department of Condensed Matter Physics, Faculty of Science, Brno, CZECH REPUBLIC
Phone +420 549 49 4048
e-mail: kozelka.jiri@gmail.com
