Dr. N. Seda Kehr
Senior Scientists-Habilitandin im AK De Cola
Physikalisches Institut
Westfälische Wilhelms-Universität Münster
Heisenbergstrasse 11, D-48149 Münster - Deutschland
Tel.: +49(0)251-5340-6905
Fax +49(0)251-5340-6958
E-Mail: seda(at)uni-muenster.de
Research interest:
1- Spatial controlled functionalization of self-assembled monolayers of nano-objects:
Microcontact printing (mCP) is used as a method to functionalize self-assembled monolayers (SAMs) of zeolite L crystals in spatial controlled way. Chemically patterned surfaces of monolayers of zeolite L crystals are obtained by using patterned stamps with different ink solutions. Additionally, printing of functionalized nano-objects on SAMs of zeolite L crystals is possible by this technique.
2- Cell adhesion and cellular patterning on self-assembled monolayer of porous nano-objects: Chemically functionalized SAMs made by disk shaped zeolite L nanocrystals are used as model system for biocompatible surfaces to study cell-adhesion behaviour. Different chemical groups immobilized on zeolite surfaces lead to different cellular behaviour and fluorescent molecules loaded zeolites allow us to determine the position of the cells. Furthermore patterned monolayers of zeolite L are used for cellular patterning.
3- Cell adhesion behaviour on enantiomorphous zeolite L monolayer and separation of health cells from cancereogenic cells: D- and L-penicillamine functionalized zeolite L nanocrystals and their respective self-assembled monolayers (SAMs) have been used for the first time for the stereocontroled interaction of the obtained enantiomorphous SAMs of zeolites with different cell types (primary cells, cancereogenic cells lines). By using different cells we demonstrated that cells recognize and differentiate between the different enantiomorphous SAM of zeolite L surfaces. Finally we used our new biocompatible surface for the separation of primary endothelial cells from malignant C-6-Glioma cell lines. Our results showed the perfect separation of those cells from each other on these surfaces.
4- Structured inorganic-organic nanocomposite hydrogel film formation and their spatial interaction with cells: Structured organic hydrogel films with inorganic nanoparticles as hybrid surfaces are prepared by soft lithography. These new inorganic-organic hybrid surfaces are used for controlled cell adhesion and for cellular patterning. Jun. 2011 – Sep. 2011; Research stay at MIT (Department of Chemical Engineering, research group of Prof. Langer, Massachusetts Institute of Technology, USA), patent and paper about this respective collaboration work has been accepted.
5- Selective functionalization of external and internal surfaces of porous nanoparticles and their applications in biotechnologies: External and internal surfaces of inorganicorganic hybrid mesoporous nanoparticles (NPs) are functionalized selectively with bioactive molecules and fluorescent dye molecules respectively. Self-assembled non-patterned and patterned monolayers of bifunctional mesoporous hybrid nanoparticles are prepared and used as biocompatible surfaces for cell adhesions and for cellular patterning.
6- Nanocomposite hydrogels for tissue engineering: Nanocomposite (NC) hydrogels are synthesized through the cooperative interaction of polymers and porous nanoparticles. This new NC hydrogels are used as an artificial tissue for cell adhesion and growth.
7- Design of multifunctional nanomaterials (Janus particles): New multifunctional mesoporous nanoparticles and nanocomposites are synthesized by microcontact printing technique.
Collaboration partners:
AK Galla-Institute für Biochemie, AK Ravoo-Organisch-Chemisches Institut; AK Langer-MIT.
Teaching:
1. General Aspects of Nanoparticles (Since 2011, Responsible person, University of Münster, Germany).
2. Seminar Struktur der Materie (Since 2010, Assigned responsible person, University of Münster, Germany).
Projects: “Synthesis of new nanocomposite hydrogels through host-guest interaction of nanoparticles with polymers” associated investigator, SFB 858 "Synergetic Effects in Chemistry - From Additivity towards Cooperativity" (Since 2011, Universität Münster, Germany, Organisch- Chemisches Institut).
