The role of GABA-ergic inhibitory interneurons in medial prefrontal cortex (mPFC) networking and oscillation
Multiple studies have been conducted to investigate the role of GABA-ergic interneurons in hippocampus which is a relatively simple cortical structure. These studies suggest that GABA-ergic transmission contribute to modulation of neuronal excitability, controlling the spike timing and inhibition of pyramidal neurons.
Different types of hippocampal inhibitory interneurons control spike initiation and synaptic integration within pyramidal neurons and modulate local network activity, providing proper pathways of information processing. Therefore it has been proposed that in hippocampus, GABA-ergic inhibitory interneurons represent crucial regulating elements for information processing and network activity. Given the essential role of GABA-ergic interneurons in hippocampus by regulating the neuronal activity, an important question will be raised with concerning the involvement of these neurons in modulation of the network in another cortical regions distinctively m-PFC.
The aims of my PhD project: To investigate the expression rate of different subclasses of GABA-ergic interneurons in m-PFC in different layers I-VI and also to Study the intrinsic properties of the dominant subtypes of GABA-ergic interneurons in m-PFC and their role in controlling the pyramidal cell firing pattern.
Prof. Dr. Weiqi Zhang
Prof. Dr. Sylvia Kaiser
Prof. Dr. Thomas Budde
Saffari, R., Teng, Z., Zhang, M., Kravchenko, M., Hohoff, C., Ambrée, O., & Zhang, W. (2016). NPY+-, but not PV+-GABAergic neurons mediated long-range inhibition from infra-to prelimbic cortex. Translational psychiatry, 6(2), e736.
Mykola Kravchenko, Mingyue Zhang, Lisa Reinhardt, Roja Saffari, Weiqi Zhang. (2014). Spironolactone normalized inhibitory-excitatory synaptic balance in brain of mice model for schizophrenia.International Conference of the German neuroscience. Neuro Visionen 10. Jülich, Germany. September 2014
|1998-2002||B.Sc. in Cellular and Molecular Biology (Microbiology)/ Tehran-Iran|
|2003-2009||Employee as a Microbiologist in Pharmaceutical Company (Tehran-Iran)|
|2009-2012||Master of Science (Immunology) at Uppsala University/ Uppsala-Sweden|
|2012-2013||Research assistant (Neuroscience department) At Uppsala University/Uppsala-Sweden|
|2013||Beginning of PhD research project, Institute of Psychiatry, University of Münster-Germany|