Dr. Dominik Grotegerd
Department of Psychiatry and Psychotherapy
Research Group "Translational Psychiatry"

Albert-Schweitzer-Campus 1 A9
48149 Münster

T: +49 (0)251 83-56422
F: +49 (0)251 83-56612
dominik.grotegerd@uni-muenster.de

PhD in 2016

Research Project

Multivariate analysis of functional MRI data of psychiatric patients by using soft-computing approaches

Functional Resonance Magnetic Imaging (fMRI) has become in the recent years one of the most important imaging approaches in congitive neuroscience. The analysis of fMRI data is based mainly  on mass-univariate analysis. However, univariate analysis have some limitations, as for instance activities in neighbouring voxels are treated as independend events.
In the last years, different pattern recognition techniques have been applied in the field of neuroimaging. Such soft-computing methods have the potential to circumvent the problems of conventional methods and could be intended as a useful supplement for analysis of fMRI data.
My research project focuses on the development and application of fmri pattern classification methods, which aim to recognize psychiatric disorders and can identify underlying processes.

PhD Committee

PD Dr. Dr. Udo Dannlowski
Prof. Dr. Volker Arolt
Prof. Dr. Norbert Sachser

Publications

R. Redlich, JJ Almeida, D. Grotegerd, N. Opel, H. Kugel, W. Heindel, V. Arolt, M.L. Phillips, and U. Dannlowski. Brain morphomet- ric biomarkers distinguishing unipolar and bipolar depression: a voxel- based morphometry-pattern classification approach. JAMA Psychiatry, 71(11):1222–30, 2014.

D. Stacey, R. Redlich, N. Opel, D. Grotegerd, V. Arolt, H. Kugel, W. Heindel, B.T. Baune BT, and U. Dannlowski. No evidence of DISC1- associated morphological changes in the hippocampus, anterior cingulate cortex, or striatum in major depressive disorder cases and healthy con- trols. Journal of Affective Disorders, 166:103–7, 2014.

N. Opel, R. Redlich, P. Zwanzger, D. Grotegerd, V. Arolt, W. Heindel, C. Konrad, H. Kugel, and U. Dannlowski. Hippocampal atrophy in major depression: a function of childhood maltreatment rather than diagnosis? Neuropsychopharmacology, 39(12):2723–31, 2014.

U. Dannlowski, H. Kugel, R. Redlich, A. Halik, I. Schneider, N. Opel, D. Grotegerd, K. Schwarte, C. Schettler, O. Ambrée, S. Rust, K. Domschke, V. Arolt, W. Heindel, T.B. Baune, T. Suslow, W. Zhang W, and C. Hohoff. Serotonin transporter gene methylation is associated with hippocampal gray matter volume. Human Brain Mapping, 35(11):5356– 67, 2014.

U. Dannlowski, H.J. Grabe, K. Wittfeld, J. Klaus, C. Konrad, D. Grotegerd, R. Redlich, T. Suslow, N. Opel, P. Ohrmann, J. Bauer, P. Zwanzger, I. Laeger, C. Hohoff, V. Arolt, W. Heindel, M. Deppe, K. Domschke, K. Hegenscheid, H. Völzke, D. Stacey, H. Meyer Zu Schwabedissen, H. Kugel, and B.T. Baune. Multimodal imaging of a tescalcin (TESC)- regulating polymorphism (rs7294919)-specific effects on hippocampal gray matter structure. Molecular Psychiatry, (in press) 2014.

R. Redlich, D. Grotegerd, N. Opel, C. Kaufmann, P. Zwitserlood, H. Kugel, W. Heindel, U. S. Donges, T. Suslow, V. Arolt, and U. Dannlowski. Are you gonna leave me? Separation anxiety is associated with increased amygdala responsiveness and volume. Social Cognitive and Affective Neuroscience, (in press) 2014.

D. Grotegerd, R. Redlich, J.R. Almeida, M. Riemenschneider, H. Kugel, V. Arolt, and U. Dannlowski. MANIA - a pattern classification toolbox for neuroimaging data.Neuroinformatics, 12(3):471–86, 2014.

D. Grotegerd, A. Stuhrmann, H. Kugel, S. Schmidt, R. Redlich, P. Zwanzger, A. Rauch, W. H. Heindel, P. Zwitserlood, V. Arolt, T. Suslow, and U. Dannlowski. Amygdala excitability to subliminally presented emotional faces distinguishes unipolar and bipolar depression - an fmri and pattern classification study. Human Brain Mapping, 35(7):2995– 3007, 2014.

A. Stuhrmann, K. Dohm, H. Kugel, P. Zwanzger, R. Redlich, D. Grotegerd, A. V. Rauch, V. Arolt, W. Heindel, T. Suslow, and others. Mood- congruent amygdala responses to subliminally presented facial expres- sions in major depression: associations with anhedonia. Journal of psy- chiatry & neuroscience: JPN, 38(4):249–58, 2013.

T. Suslow, H. Kugel, P. Ohrmann, A. Stuhrmann, D. Grotegerd, R. Redlich, J. Bauer, and U. Dannlowski. Neural correlates of affective priming ef- fects based on masked facial emotion: An fmri study. Psychiatry Re- search: Neuroimaging, 211:239–45, 2013.

K. Ihme, U. Dannlowski, V. Lichev, A. Stuhrmann, D. Grotegerd, N. Rosenberg, H. Kugel, W. Heindel, V. Arolt, A. Kersting, and others. Alexithymia is related to differences in gray matter volume: A voxel- based morphometry study. Brain research, 1491:60–7, 2013.

U.-S. Donges, H. Kugel, A. Stuhrmann, D. Grotegerd, R. Redlich, V. Lichev, N. Rosenberg, K. Ihme, T. Suslow, and U. Dannlowski. Adult attachment anxiety is associated with enhanced automatic neural re- sponse to positive facial expression. Neuroscience, 220:149–57, 2012.

U. Dannlowski, H. Kugel, F. Huber, A. Stuhrmann, R. Redlich, D. Grotegerd, K. Dohm, C. Sehlmeyer, C. Konrad, B. T. Baune, V. Arolt, W. Heindel, P. Zwitserlood, and T. Suslow. Childhood maltreatment is associated with an automatic negative emotion processing bias in the amygdala. Human Brain Mapping, 34(11):2899–909, 2013.

B. T. Baune, C. Konrad, D. Grotegerd, T. Suslow, E. Birosova, P. Ohrmann, J. Bauer, V. Arolt, W. Heindel, K. Domschke, S. Schöning, A. V. Rauch, C. Uhlmann, H. Kugel, and U. Dannlowski. Interleukin-6 gene (il-6): a possible role in brain morphology in the healthy adult brain. Journal of Neuroinflammation, 9(9):1–9, 2012.

I. Laeger, C. Dobel, U. Dannlowski, H. Kugel, D. Grotegerd, J. Kissler, K. Keuper, A. Eden, P. Zwitserlood, and P. Zwanzger. Amygdala re- sponsiveness to emotional words is modulated by subclinical anxiety and depression. Behavioural Brain Research, 15;261:369–70, 2014.

D. Grotegerd, T. Suslow, J. Bauer, P. Ohrmann, V. Arolt, A. Stuhrmann, W. Heindel, H. Kugel, and U. Dannlowski. Discriminating unipolar and bipolar depression by means of fmri and pattern classification: a pi- lot study. European Archives of Psychiatry and Clinical Neuroscience, 263(2):119–31, 2013.

B.T. Baune, C. Konrad, D. Grotegerd, T. Suslow, P. Ohrmann, J. Bauer, V. Arolt, W. Heindel, K. Domschke, S. Schöning, A. V. Rauch, C. Sehlmeyer, H. Kugel, and U. Dannlowski. Tumor necrosis factor gene variation predicts hippocampus volume in healthy individuals. D. Grotegerd, R. Redlich, J.R. Almeida, M. Riemenschneider, H. Kugel, V. Arolt, and U. Dannlowski. Biological Psychiatry, 12(3):471–86, 2012.

K. Domschke, B. T. Baune, L. Havlik, A. Stuhrmann, T. Suslow, H. Kugel, P. Zwanzger, D. Grotegerd, C. Sehlmeyer, V. Arolt, and U. Dannlowski. Catechol-o-methyltransferase gene variation: Impact on amygdala re- sponse to aversive stimuli. Neuroimage, 60(4):2222–2229, May 2012.

U. Dannlowski, A. Stuhrmann, V. Beutelmann, P. Zwanzger, T. Lenzen, D. Grotegerd, K. Domschke, C. Hohoff, P. Ohrmann, J. Bauer, C. Lind- ner, C. Postert, C. Konrad, V. Arolt, W. Heindel, T. Suslow, and H. Kugel. Limbic scars: long-term consequences of childhood maltreatment re- vealed by functional and structural magnetic resonance imaging. Biol Psychiatry, 71(4):286–293, Feb 2012.

U. Dannlowski, H. Kugel, F. Franke, A. Stuhrmann, C. Hohoff, P. Zwanzger, T. Lenzen, D. Grotegerd, T. Suslow, V. Arolt, W. Heindel, and K. Dom- schke. Neuropeptide-s (nps) receptor genotype modulates basolateral amygdala responsiveness to aversive stimuli. Neuropsychopharmacology, 36(9):1879–1885, Aug 2011.

Conference Contributions

Grotegerd, D., Suslow, T.,  Ohrmann, P., Bauer, J. Stuhrmann, A., Arolt, V., Kugel, H., Heindel, W. & Dannlowski, U. (2011). Diskrimination von unipolarer und bipolarer Depression mittels Mustererkennung auf fMRT-Daten – eine Pilotstudie. DGGPN conference, Berlin, Germany.

Grotegerd, D., Suslow, T., Bauer, J., Ohrmann, P., Arolt, V., Stuhrmann, A., Heindel, W., Kugel, H. & Dannlowski, U. (2011). Pattern Classification on fMRI-data:  A diagnostic approach on psychiatric disorders. Poster presented at the conference 'NeuroVisionen 7' Essen, Germany.

CV