I will first introduce scalar-valued and operator-valued Schur multipliers and their partially defined versions, and will provide a Grothendieck-type characterisation of operator-valued Schur multipliers. After a brief introduction to the matrix setting, I will talk about the positive extension problem of Schur multipliers and characterise its affirmative solution in terms of structures on an operator system associated with the domain of the multipliers. This talk will be based on joint papers with R. Levene and I. G. Todorov.