Publikationen

 

Buchbeiträge und sonstige Veröffentlichungen

 

Originalarbeiten, Reviews

2024, 2023, 2022,  2021, 2020, 2019, 2018, 2017, 2016, 2015, 2014, 2013, 2012, 2011, 2010, 2009, 2008, 2007, 2006, 2005, 2004, 2003, 2002, 2001, 2000,

2024

  • Dombovski, A., Steigerwald, R., Ritter, N., Disse, P., Goerges, G., Osthues, J., Aymanns, I., Dilkaute, C., Schreiber, J., Düfer, M., Seebohm, G., Wünsch, B., Jose, J. (2024) A novel fluorescent labeling compound for GluN2A containing N-methyl-D-aspartate receptors identified by Autodisplay-based screening. J. Pharm. Anal., accepted

  • Todesca, L. M., Gerke, M., Bulk, E. E., Bachmann, M., Rudersdorf, A., Antonuzzo, L., Pillozzi, S., Düfer, M., Szabo, I., Schwab, A. (2024) Targeting KCa3.1 channels to overcome erlotinib resistance in non-small cell lung cancer cells. Cell Death Discov., 10(1):2. https://doi.org/10.1038/s41420-023-01776-5

2023

  • Noguera Hurtado, H. , Gresch, A., Düfer, M. (2023) NMDA receptors – regulatory function and pathophysiological significance for pancreatic beta cells. Biol. Chem., 404:311-324, https://doi.org/10.1515/hsz-2022-0236

2022

  • Soret, B., Hense, J., Lüdtke, S., Thale, I., Schwab, A., Düfer, M. (2022) Pancreatic KCa3.1 channels in health and disease. Biol. Chem., 404:339-353, https://doi.org/10.1515/hsz-2022-0232

  • Pajaziti, B., Yosy, K., Steinberg, O.V., Düfer, M. (2022) FGF-23 protects cell function and viability in murine pancreatic islets challenged by glucolipotoxicity. Pfügers Archiv - European Journal of Physiology, 475:309-322, https://doi.org/10.1007/s00424-022-02772-x

  • Schreiber, J.A., Düfer, M., Seebohm, G. (2022) The Special One: Architecture, Physiology and Pharmacology of the TRESK Channel. Cell. Physiol. Biochem., 56(6):663-684.  https://doi.org/10.33594/000000589

  • Hake, A., Begrow, F., Spiegler, V., Symma, N., Hensel, A., Düfer, M. (2022) Effects of extracts and flavonoids from Drosera rotundifolia L. on ciliary beat frequency and murine airway smooth muscle. Molecules., Oct 5;27(19):6622. https://doi.org/10.3390/molecules27196622

  • Hake, A., Symma, N., Esch, S., Hensel, A., Düfer, M. (2022) Alkaloids from lime flower (Tiliae flos) exert spasmodic activity on murine airway smooth muscle involving acetylcholinesterase. Planta Med., Jul;88(8):639-649. https://doi.org/10.1055/a-1534-3766

  • Schreiber, J.A., Möller, M., Zaydman, M., Zhao, L., Beller, Z., Becker, S., Ritter, N., Hou, P., Shi, J., Silva, J., Wrobel, E., Strutz-Seebohm, N., Decher, N., Schmitt, N., Meuth, S.G., Düfer, M., Wünsch, B., Cui, J., Seebohm, G. (2022) A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling. Commun. Biol. Apr 1;5(1):301. https://doi.org/10.1038/s42003-022-03229-8

  • Hüwel, J.D., Gresch, A., Berger, T., Düfer, M., Beecks, C. (2022) Analysis of Extracellular Potential Recordings by High-Density Micro-electrode Arrays of Pancreatic Islets. In: Strauss, C., Cuzzocrea, A., Kotsis, G., Tjoa, A.M., Khalil, I. (eds) Database and Expert Systems Applications. DEXA 2022. Lecture Notes in Computer Science, vol 13427. Springer, Cham. https://doi.org/10.1007/978-3-031-12426-6_23

2021

  • Gresch, A., Noguera Hurtado, H., Wörmeyer, L., De Luca, V., Wiggers, R., Seebom, G., Wünsch, B., Düfer, M. (2021) Selective Inhibition of NMDA receptors with GluN2B subunit protects beta cells against stress-induced apoptotic cell death. J. Pharmacol. Exp. Ther., https://doi.org/10.1124/jpet.121.000807
  • Guzmán, T., Düfer, M., Wiedemann, M., Olguín-Alor, R., Soldevila, G., Gurrola-Díaz, C. (2021) Lupin γ-conglutin protects against cell death induced by oxidative stress and lipotoxicity, but transiently inhibits in vitro insulin secretion by increasing KATP channel currents. Int. J. Biol. Macromol., 187:76-90, https://doi.org/10.1016/j.ijbiomac.2021.07.088
  • Symma, N., Bütegerds, M., Senker, J., Petereit, F., Hake, A., Düfer, M., Hensel, A. (2021) Novel piperidine and 3,4-dihydro-2H-pyrrole alkaloids from tilia platyphyllos and tilia cordata flowers. Planta Med., https://doi.org/10.1055/a-1340-0099

2020

  • Sikimic, J., Hoffmeister, T., Gresch, A., Kaiser, J., Barthlen, W., Wolke, C., Wieland, I., Lendeckel, U., Krippeit-Drews, P., Düfer, M., Drews, G. (2020) Possible new strategies for the treatment of congenital hyperinsulinism. Front. Endocrinol., 11:545638 https://dx.doi.org/10.3389/fendo.2020.545638
  • Gresch, A., Düfer, M. (2020) Dextromethorphan and dextrorphan influence insulin secretion by interacting with KATP and L-type Ca2+ channels in pancreatic β-cells. J. Pharmacol. Exp. Ther., 375:10-20 doi:10.1124/jpet.120.265835 https://dx.doi.org/10.1124/jpet.120.265835
  • Hoffmeister, T., Kaiser, J., Lüdtke, S., Drews, G., Düfer, M. (2020) Interactions between atorvastatin and the farnesoid X receptor impair insulinotropic effects of bile acids and modulate diabetogenic risk. Mol. Pharmacol., 97:202-211 https://dx.doi.org/10.1124/mol.119.118083
  • Schepmann, D., Neue, C., Westphälinger, S., Müller, C., Bracer, F., Lange, C., Bednarski, P., Almansa, C., Friedland, K., Räbiger, V., Düfer, M., Wünsch, B. (2020) Pharmacological characterization of high-affinity σ1 receptor ligands with spirocyclic thienopyran and thienofuran scaffold. J. Pharm. Pharmacol., 72:236-248 https://dx.doi.org/10.1111/jphp.13196

2019

  • Schultheis, J., Beckmann, D., Mulac, D., Müller, L., Esselen, M., Düfer, M. (2019) Nrf2 activation protects mouse beta cells from glucolipotoxicity by restoring mitochondrial function and physiological redox balance. Oxid. Med. Cell. Longev., 2019:7518510, https://dx.doi.org/10.1155/2019/7518510
  • Maczewsky, J., Kaiser, J., Gresch, A., Gerst, F., Düfer, M., Krippeit-Drews, P., Drews, G. (2019) TGR5 activation promotes stimulus-secretion coupling of pancreatic beta-cells via a PKA-dependent pathway. Diabetes, 68:324-336, https://dx.doi.org/10.2337/db18-0315
  • Bauer, C., Kaiser, J., Sikimic, J., Krippeit-Drews, P., Düfer, M., Drews, G. (2019) ATP mediates a negative autocrine signal on stimulus-secretion coupling in mouse pancreatic beta-cells. Endocrine, 63(2):270-283, https://dx.doi.org/10.1007/s12020-018-1731-0

2018

  • Brouwer, S., Hoffmeister, T., Gresch, A., Schönhoff, L., Düfer, M. (2018) Resveratrol influences pancreatic islets by opposing effects on electrical activity and insulin release. Mol. Nutr. Food Res., https://dx.doi.org/10.1002/mnfr.201700902

2017

  • Undank, S., Kaiser, J., Sikimic, J., Düfer, M., Krippeit-Drews, P., Drews, G. (2017) Atrial natriuretic peptide (ANP) affects stimulus-secretion coupling of pancreatic beta-cells. Diabetes, 66:2840-2848, https://dx.doi.org/10.2337/db17-0392

2016

  • Gonnissen, D., Qu, Y., Langer, K., Öztürk, C., Zhao, Y., Chen, C., Seeboom, G., Düfer, M., Fuchs, H., Galla, H.J., Riehemann, K. (2016) Comparison of cellular effects of starch-coated SPIONs and poly(lactic-co-glycolic acid) matrix nanoparticles on human monocytes. Int. J. Nanomedicine, 11:5221-5236, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072557

2015

  • Wiedemann, M., Gurrola-Díaz, C., Vargas-Guerrero, B., Wink, M., Garcia-Lopez, P. M., Düfer, M. (2015) Lupanine improves glucose homeostasis by influencing KATP channels and insuline gene expression. Molecules, 20:19085-19100, https://dx.doi.org/10.3390/molecules201019085
  • Drews, G., Bauer, C., Edalat, A., Düfer M., Krippeit-Drews, P. (2015) Evidence against a Ca2+-induced potentiation of dehydrogenase activity in pancreatic beta-cells. Pfügers Arch., 467:2389-2397, https://dx.doi.org/10.1007/s00424-015-1707-3
  • Edalat, A., Schulte-Mecklenbeck, P., Bauer, C., Undank, S., Krippeit-Drews, P., Drews, G., Düfer, M. (2015) Mitochondrial succinate dehydrogenase is involved in stimulus-secretion coupling and endogenous ROS formation in murine beta cells. Diabetologia, https://dx.doi.org/10.1007/s00125-015-3577-9
  • Schittenhelm, B., Wagner, R., Kähny, V., Peter, A., Krippeit-Drews, P., Düfer, M., Drews, G. (2015) Role of FXR in beta-cells of lean and obese mice. Endocrinology, 156:1263-1271, https://dx.doi.org/10.1210/en.2014-1751
  • Lautenschläger, M., Sendker, J., Hüwel, S., Galla, H.J., Brandt, S., Düfer, M., Riehemann, K., Hensel, A. (2015) Intestinal formation of trans-crocetin from saffron extract (Crocus Sativus L.) and in vitro permeation trough intestinal and blood brain barrier. Phytomedicine, 22:36-44, https://dx.doi.org/10.1016/j.phymed.2014.10.009

2014

  • Schönecker S, Kraushaar U, Düfer M, Sahr A, Härdtner C, Guenther E, Walther R, Lendeckel U, Barthlen W, Krippeit-Drews P, Drews G. (2014) Long-term culture and functionality of pancreatic islets monitored using microelectrode arrays. Integr Biol (Camb). Apr 22; 6: 540-544, https://dx.doi.org/10.1039/c3ib40261d

2013

  • Düfer, M., Noack, K., Edalat, A., Krippeit-Drews, P., Drews, G (2013) Glitazones exert multiple effects on beta-cell stimulus-secretion coupling. Mol Pharmacol. 83, 51-60, https://dx.doi.org/10.1124/mol.112.081638

2012

  • Düfer, M., Hörth K., Krippeit-Drews, P., Drews, G. (2012) The significance of the nuclear farnesoid X receptor (FXR) in beta-cell function. Islets, 4:334-338, https://dx.doi.org/10.4161/isl.22383
  • Drews, G, Düfer, M. (2012) Role of KATP channels in beta-cell resistance to oxidative stress, Diabetes Obes Metab. 14 Suppl 3, 120-128    Review, https://dx.doi.org/10.1111/j.1463-1326.2012.01644.x
  • Düfer, M., Hörth, K., Wagner, R., Prowald, S., Schittenhelm, B., Wagner, T., Oberwinkler, J., Lukowski, R., Krippeit-Drews, P., Drews, G. (2012)
    Bile acids acutely stimulate insulin secretion of mouse beta-cells via farnesoid X receptor activation and KATP channel inhibition. Diabetes 61, 1479-89, https://dx.doi.org/10.2337/db11-0815

2011

  • Pfeiffer, T., Kraushaar, U., Düfer, M., Schönecker, S., Haspel, D., Günther, E., Drews, G., Krippeit-Drews P. (2011)
    Rapid functional evaluation of beta-cells by extracellular recording of membrane potential oscillations with microelectrode arrays. Pflügers Arch. 462, 835-840, https://dx.doi.org/10.1007/s00424-011-1029-z
  • Düfer, M., Neye, Y., Hörth, K., Krippeit-Drews, P., Hennige, A., Widmer, H., McClafferty, H., Shipston, M.J., Häring, H.-U., Ruth, P., Drews, G.  (2011)
    BK channels affect glucose homeostasis and cell viability of murine pancreatic beta-cells. Diabetologia 54, 423-32, https://dx.doi.org/10.1007/s00125-010-1936-0

2010

  • Drews G., Krippeit-Drews P., Düfer M. (2010)
    Oxidative stress and beta-cell function. Pflügers Arch.  460, 703-718 Review, https://dx.doi.org/10.1007/s00424-010-0862-9
  • Düfer M., Noack K., Krippeit-Drews, P., Drews, G. (2010)
    Activation of the AMP-activated protein kinase enhances glucose-stimulated insulin secretion, Islets 2, 156-163, https://dx.doi.org/10.4161/isl.2.3.11412
  • Hennige, A. M., Ranta, F., Heinzelmann, I., Düfer, M., Michael, D., Braunmüller, H., Lutz, S., Lammers, R., Drews, G., Bosch, F., Häring, H.-U., Ullrich, S. (2010)
    Overexpression of kinase negative PKCdelta in pancreatic beta-cells protects from diet-induced glucose intolerance and beta-cell dysfunction. Diabetes 59, 119-127, https://dx.doi.org/10.2337/db09-0512

2009

  • Gier, B., Krippeit-Drews, P., Sheiko, T., Aguilar-Bryan, L., Bryan, J., Düfer, M., Drews, G. (2009)
    Suppression of KATP channel activity protects pancreatic beta cells against oxidative stress. J. Clin. Invest. 119, 3246-3256, https://dx.doi.org/10.1172/JCI38817
  • Düfer, M., Gier, B., Wolpers, D., Krippeit-Drews, P., Ruth, P., Drews, G. (2009)
    Enhanced glucose tolerance by SK4 channel inhibition in pancreatic beta-cells.
    Diabetes 58, 1835-1843, https://dx.doi.org/10.2337/db08-1324
  • Düfer, M., Haspel, D., Krippeit-Drews, P., Aguilar-Bryan, L., Bryan, J., Drews, G. (2009)
    Activation of the Na+/K+-ATPase by insulin and glucose as a putative negative feedback mechanism in pancreatic beta-cells. Pflügers Arch. 457, 1351-1360, https://dx.doi.org/10.1007/s00424-008-0592-4

2008

  • Wagner, T. F. J., Loch, S., Lambert, S., Straub, I., Mannebach, S., Mathar, I.,  Düfer, M., Lis, A., Flockerzi, V., Philipp, S. E., Oberwinkler, J. (2008)
    Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta-cells. Nature Cell Biology 10, 1421-1430, https://dx.doi.org/10.1038/ncb1801
  • Ranta, F., Düfer, M., Stork, B., Wesselborg, S., Drews, G., Häring, H.-U., Lang, F., Ullrich, S. (2008)
    Regulation of  calcineurin activity in insulin secreting cells: Stimulation by Hsp90 during glucocorticoid-induced apoptosis. Cell. Signal. 20, 1780-1786, https://dx.doi.org/10.1016/j.cellsig.2008.06.003

2007

  • Weigert, C., Düfer, M.,  Simon, P., Runge, H., Brodbeck, K., Häring, H. U., Schleicher, E. D. (2007)
    Upregulation of IL-6 mRNA by IL-6 via a Ca2+-dependent mechanism and IL-6 mRNA stabilization in skeletal muscle cells. Am. J. Physiol. Cell Physiol. 293, C1139-C1147, https://dx.doi.org/10.1152/ajpcell.00142.2007
  • Schulze, D U., Düfer, M., Krippeit-Drews, P., Drews, G. (2007)
    An adenylate kinase is involved in KATP channel regulation of mouse pancreatic beta cells. Diabetologia 50, 2126-2134, https://dx.doi.org/10.1007/s00125-007-0742-9
  • Düfer, M., Haspel, D., Krippeit-Drews, P., Kelm, M., Ranta, F., Nitschke, R., Ullrich, S., Aguilar-Bryan, L., Bryan, J., Drews, G. (2007)
    The KATP channel is critical for calcium sequestration into non-ER compartments in mouse pancreatic beta cells. Cell. Physiol. Biochem. 20, 65-74, https://dx.doi.org/10.1159/000104154
  • Bryan, J., Munoz, A., Zhang, X., Düfer, M., Drews, G., Krippeit-Drews, P., Aguilar-Bryan, L. (2007)
    ABCC8 and ABCC9: ABC transporter that regulate K+ channels. Pflügers Arch. - Eur. J. Physiol. 453, 703-718   Review, https://dx.doi.org/10.1007/s00424-006-0116-z

2006

  • Ranta, F., Avram, D., Berchtold, S., Düfer, M., Drews, G., Lang, F., Ullrich, S. (2006)
    Dexamethasone-induced cell death in insulin secreting cells, an effect reversed by exendin-4. Diabetes 55, 1380-1390, https://dx.doi.org/10.2337/db05-1220
  • Neye, Y., Düfer, M., Drews, G., Krippeit-Drews, P. (2006)
    HIV protease inhibitors: Suppression of insulin secretion by inhibition of voltage-dependent K+ currents and anion currents. J. Pharmacol. Exp. Ther. 316, 106-112, https://dx.doi.org/10.1124/jpet.105.090589

2005

  • Haspel, D., Krippeit-Drews, P., Aguilar-Bryan, L., Bryan, J., Drews, G., Düfer, M. (2005)
    Crosstalk between membrane potential and cytosolic Ca2+ concentration in beta cells from Sur1-/- mice. Diabetologia 48, 913-921, https://dx.doi.org/10.1007/s00125-005-1720-8

2004

  • Düfer, M., Neye, Y., Krippeit-Drews, P., Drews, G. (2004)
    Direct interference of HIV protease inhibitors with pancreatic ß-cell function. Naunyn-Schmiedeberg´s Arch. Pharmacol. 369, 583-590, https://dx.doi.org/10.1007/s00210-004-0933-6
  • Düfer, M., Haspel, D., Krippeit-Drews, P., Aguilar-Bryan, L., Bryan, J., Drews, G. (2004)
    Oscillations of membrane potential and cytosolic Ca2+ concentration in SUR1-/- beta cells. Diabetologia 47, 488-498, https://dx.doi.org/10.1007/s00125-004-1348-0

2003

  • Remizov, O., Jakubov, R., Düfer, M., Krippeit-Drews, P., Drews, G., Waring, M., Brabant, G., Wienbergen, A., Rustenbeck, I., Schöfl, C. (2003)
    Palmitate-induced Ca2+-signaling in pancreatic beta-cells. Mol. Cell. Endocrinol. 212, 1-9, https://dx.doi.org/10.1016/j.mce.2003.09.026
  • Krippeit-Drews, P., Bäcker, M., Düfer, M., Drews, G. (2003)
    Phosphocreatine as a determinant of KATP channel activity in pancreatic ß-cells. Pflügers Arch. - Eur. J. Physiol. 445, 556-562, https://dx.doi.org/10.1007/s00424-002-0975-x

2002

  • Düfer, M., Krippeit-Drews, P., Buntinas, L., Siemen, D., Drews, G. (2002)
    Methyl pyruvate stimulates pancreatic ß-cells by a direct effect on KATP channels and not as a mitochondrial substrate. Biochem. J. 368, 817-825, https://dx.doi.org/10.1042/BJ20020657
  • Düfer, M., Krippeit-Drews, P., Drews, G. (2002)
    Inhibition of mitochondrial function affects cellular Ca2+ handling in pancreatic B-cells. Pflügers Arch. - Eur. J. Physiol. 444, 236-243, https://dx.doi.org/10.1007/s00424-002-0799-8

2001

  • Düfer, M., Krippeit-Drews, P., Lembert, N., Idahl, L.- Å., Drews, G. (2001)
    Diabetogenic effect of cyclosporin A is mediated by interference with mitochondrial function of pancreatic B-cells. Mol. Pharmacol. 60, 873-879, https://pubmed.ncbi.nlm.nih.gov/11562451/
  • Boden, S.E., Schweizer, S., Bertsche, T., Düfer, M., Drews, G., Safayhi H. (2001)
    Stimulation of leukotriene synthesis in intact polymorphnuclear cells by the 5-lipoxygenase inhibitor 3-oxo-tirucallic acid. Mol. Pharmacol. 60, 267-273, https://dx.doi.org/10.1124/mol.60.2.267

2000

  • Drews, G., Krämer, C., Düfer, M., Krippeit-Drews, P. (2000)
    Contrasting effects of alloxan on islets and single mouse pancreatic ß-cells. Biochem. J. 352, 389-397, https://pubmed.ncbi.nlm.nih.gov/11085932/
  • Krippeit-Drews, P., Düfer, M., Drews, G. (2000)
    Parallel oscillations of intracellular calcium activity and mitochondrial membrane potential in mouse pancreatic B-cells. Biochem. Biophys. Res. Commun. 267, 179-183, https://dx.doi.org/10.1006/bbrc.1999.1921

 

 

 

 

Buchbeiträge und sonstige Veröffentlichungen:

Editorials

Düfer, M. (2018)
Gap junctional communication between beta- and delta-cells: another player for suppression of glucagon release. Perspectives. J. Physiol. 596:131-132

 

 
 

Düfer, M. (2011)
Strategies for protection of pancreatic beta-cells against oxidative stress. Editorial. Diabetologie und Stoffwechsel, 4, 213-215

 

Deutschsprachige Fachzeitschriften

Düfer, M., Maas, D. und Waltering, I. (2020) Medizin meets Pharmazie. Osteoporose: Basiswissen - Diagnostik - Therapie - Patientenfall. Med. Monatsschr. Pharm., 2020(03):83-101

Düfer, M. (2017) Gestörter Knochenstoffwechsel. Dt. Apotherker Zeitung, 2017/16

Düfer, M. (2016) Biologicals zur Behandlung der Osteoporose und anderer Knochenstoffwechselstörungen. Med. Monatsschr. Pharm., 39:247-253

Düfer, M. (2016) Die Gefäßneubildung unterdrücken: Angiogenesehemmung mit Biologicals. Dt. Apotheker Zeitung, 2016/42

Düfer, M. (2014) Benzodiazepine: Ein Angriffspunkt, viele Wirkungen, Dt. Apotheker Zeitung, 2014/16

Düfer, M., Düfer-Kinzinger A. (jährlich seit 2013) Insulintabelle & Kommentar zur Insulintabelle. Diab. Stoffw. Herz

 

Bücher

Bendas, G. und Düfer, M. (2016) Update Biologicals. Update-Buchreihe, Deutscher Apotheker Verlag

Düfer, M. (2012) Ion channel function in beta cells. In "Animal Models of Diabetes" Hrsg. Joost, H.-G., Schürmann, A., Al-Hasani, H., Humana Press, Springer, 933:203-217

 

Drews, G., Krippeit-Drews, P., Düfer, M. (2010, aktualisierte Auflage: 2013) Electrophysiology of islet cells. In “The Islets of Langerhans”,
Hrsg. Islam, S. et al., Adv. Exp. Biol. Med., 654:115-163

 

Arzneimittelinformation und –beratung (2009)
Hrsg. Ammon, Mutschler, Scholz, Wissenschaftliche Verlagsgesellschaft mbH Stuttgart; Antimykotika, COX-2 Inhibitoren, Kalium-sparende Diuretika

 

Kommentare zu pharmakologischen Eigenschaften folgender Arzneistoffe für die Ergänzungslieferungen 17 bis 22 zum Arzneibuch-Kommentar, Hrsg. Hartke et al., Wissenschaftliche Verlagsgesellschaft mbH Stuttgart: