Dr. Matthias Lechtenberg

Lebenslauf

1985- 1990 Studium der Lebensmittelchemie an der Westfälischen Wilhelms-Universität, Münster

1990 1. Staatsexamen Lebensmittelchemie; 1990-1991 Praktisches Jahr im ChLUA, Münster

1991 2. Staatsexamen Lebensmittelchemie

Feb. 1992 - Feb. 1996 Promotion (bei Prof. A. Nahrstedt), Universität Münster, Institut für Pharmazeutische Biologie und Phytochemie: Cyanogene Glykoside in Rosaceae

März - Mai 1996 Sertürner Arzneimittel, Gütersloh

seit Juni 1996 akademischer Rat am Institut für Pharmazeutische Biologie und Phytochemie

seit 2002 akadem. Oberrat am Institut für Pharmazeutische Biologie und Phytochemie.

Forschung

Naturstoffanalytik (DC, CE, (U)HPLC, GC, FCPC...)

Extraktion, Fraktionierung, Isolierung, Strukturaufklärung

speziell: Cyanogene Glykoside und nicht-cyanogene Nitrilglykoside

Lehre

M.Sc. Modul "Biologie der Nutzpflanzen und Bioaktivität" für Lebensmittelchemiker

Praktikum Pharmazeutische Biologie III (Biologische und Phytochemische Untersuchungen) für Pharmazeuten

Betreuung von Bachelor- und Masterarbeiten für Lebensmittelchemiker und M.Sc. Arzneimitelwissenschaften

weitere Aufgaben und Gremien

IVV4-Expertenrunde, IT-Administrator, Content-Management-System "Imperia", Institutsvorstand

Publikationen

  • Sarshar S, Brandt S, Asadi Karamb MR, Habibib H, Bouzarib S, Lechtenberg M, Dobrindt U, Qind X, Goycoolea FM, Hensel A. . ‘Aqueous extract from Orthosiphon stamineus leaves prevents bladder and kidney infection in mice.’ Phytomedicine 28. doi: 10.1016/j.phymed.2017.02.009.
  • Lechtenberg M, Hensel A, Steinhoff B. . „Hepatotoxisch und karzinogen - Pyrrolizidinalkaloide in Arznei- und Lebensmitteln sorgen für Probleme.“ Deutsche Apotheker Zeitung 31, Nr. 157: 32-40.
  • de Oliveira Caleare A., Hensel A., Mello J., Pinha A., Panizzon G., Lechtenberg M., Petereit F., Nakamura C. . ‘Flavan-3-ols and proanthocyanidins from Limonium brasiliense inhibit the adhesion of Porphyromonas gingivalis to epithelial host cells by interaction with gingipains.’ Fitoterapia 118, Nr. null: 87-93. doi: 10.1016/j.fitote.2017.03.002.

  • Hielscher J, Lemmes AS, von Holtum B, Hasse A, Sendker J, Petereit F, Hensel A, Lechtenberg M. . „Nachweis und quantitative Bestimmung von Piperin in Cayennepfeffer, Chillipulver und Rosenpaprika – Sind Verunreinigungen mit echtem Pfeffer technisch unvermeidbar?Lebensmittelchemie 70: 81-112. doi: 10.1002/lemi.201690028.
  • Rafsanjany N, Sendker J, Lechtenberg M, Petereit F, Scharf B, Hensel A. . „Unkomplizierte Harnwegsinfektionen: Extrakte aus Maisgriffeln (Zea mays L.) wirken gegen uropathogene E. coli.“ Zeitschrift für Phytotherapie 37: 9-12.
  • Rafsanjany N., Sendker J., Lechtenberg M., Petereit F., Scharf B., Hensel A. . „Uncomplicated urinary tract infections: The efficacy of extracts from corn silk (Zea mays L.) against uropathogenic E. coli.“ Zeitschrift fur Phytotherapie 37, Nr. 1: 9-15. doi: 10.1055/s-0042-102715.
  • Kisseih E., Agyare C., Lechtenberg M., Petereit F., Sendker J., Brandt S., Hensel A. . „Von der Ethnopharmakologie zur rationalen Phytotherapie: Phytochemische Charakterisierung und präklinische Untersuchungen zur potenziellen Wundheilungsaktivität von Extrakten aus Combretum mucronatum Schum& Thonn.Zeitschrift fur Phytotherapie 37, Nr. 2: 59-65. doi: 10.1055/s-0042-104378.
  • Lechtenberg M., Hensel A. . „Safran gegen Depressionen.“ Deutsche Apotheker Zeitung 156, Nr. 25.

  • Hensel A, Kisseih E, Lechtenberg M, Petereit F, Agyare C, Asase A. . ‘From Ethnopharmacological Field Study to Phytochemistry and Preclinical Research: The Example of Ghanaian Medicinal Plants for Improved Wound Healing.’ In Ethnopharmacology, edited by Heinrich Michael, Jäger Anna K., 179-196. Chichester: John Wiley & Sons.
  • Rafsanjany N, Sendker J, Lechtenberg M, Petereit F, Scharf B, Hensel A. . ‘Traditionally used medicinal plants against uncomplicated urinary tract infections: Are unusual, flavan-4-ol- and derhamnosylmaysin derivatives responsible for the antiadhesive activity of extracts obtained from stigmata of Zea mays L. against uropathogenic E. coli and Benzethonium chloride as frequent contaminant faking potential antibacterial activities?Fitoterapia 105, Nr. null: 246-253. doi: 10.1016/j.fitote.2015.07.014.
  • Hellenbrand N., Lechtenberg M., Petereit F., Sendker J., Hensel A. . ‘Isolation and Quantification of Oligomeric and Polymeric Procyanidins in the Aerial Parts of St John' Wort (Hypericum perforatum).’ Planta Medica 81, Nr. null: 1175-1181. doi: 10.1055/s-0035-1545916.
  • Kisseih E, Lechtenberg M, Petereit F, Sendker J, Zacharski D, Brandt S, Agyare C, Hensel A. . ‘Phytochemical characterization and in vitro wound healing activity of leaf extracts from Combretum mucronatum Schum. & Thonn.: Oligomeric procyanidins as strong inductors of cellular differentiation.’ Journal of Ethnopharmacology 174: 628-636. doi: 10.1016/j.jep.2015.06.008.
  • Hellenbrand N, Sendker J, Lechtenberg M, Petereit F, Hensel A. . ‘Isolation and quantification of oligomeric and polymeric procyanidins in leaves and flowers of Hawthorn (Crataegus spp.).’ Fitoterapia 104, Nr. null: 14-22. doi: 10.1016/j.fitote.2015.04.010.

  • Pillukat MH, Bester C, Hensel A, Lechtenberg M, Petereit F, Beckebaum S, Müller KM, Schmidt HH. . ‘Concentrated green tea extract induces severe acute hepatitis in a 63-year-old woman--a case report with pharmaceutical analysis.Journal of ethnopharmacology 155, Nr. 1: 165-70. doi: 10.1016/j.jep.2014.05.015.
  • Pillukat MH*, Bester C*, Hensel A, Lechtenberg M, Petereit F, Beckebaum S, Müller KM, Schmidt HH. . ‘Concentrated green tea extract induces severe acute hepatitis in a 63-year-old woman--a case report with pharmaceutical Analysis.’ Journal of Ethnopharmacology 155, Nr. 1.
  • Lautenschläger M, Lechtenberg M, Sendker J, Hensel A. . ‘Effective isolation protocol for secondary metabolites from Saffron: Semi-preparative scale preparation of crocin-1 and trans-crocetin.’ Fitoterapia 92: 290 - 295. doi: 10.1016/j.fitote.2013.11.014.
  • Bueno F., Panizzon G., Mello E., Lechtenberg M., Petereit F., Mello J., Hensel A. . ‘Hydrolyzable tannins from hydroalcoholic extract from Poincianella pluviosa stem bark and its wound-healing properties: Phytochemical investigations and influence on in vitro cell physiology of human keratinocytes and dermal fibroblasts.’ Fitoterapia 99, Nr. null: 252-260. doi: 10.1016/j.fitote.2014.10.007.
  • Lechtenberg M, Dierks F, Sendker J, Louis A, Schepker H, Hensel A. . ‘Extracts from Rhododendron ferrugineum Do Not Exhibit Grayanotoxin I: An Analytical Survey on Grayanotoxin I within the Genus Rhododendron.’ Planta Medica 80: 1321-1328. doi: http://dx.doi.org/ 10.1055/s-0034-1383039.

  • Hensel A, Schmidt TJ, Lechtenberg M. . ‘61st International Congress and Annual Meeting of the Society of Medicinal Plant and Natural Product Research - Book of abstracts (issue editors).’ Planta medica 79, Nr. 13: 1097-1288.
  • Hensel A., Heimink M., Lechtenberg M., Sendker J., Petereit F., Derksen A., Schmidt T.J., Kuhn J., Nauert C. . „Eupatorium perfoliatum L.: New findings about an old medicinal plant.“ Zeitschrift fur Phytotherapie 34, Nr. 2: 90-98. doi: 10.1055/s-0032-1331485.
  • Rafsanjany N., Lechtenberg M., Petereit F., Hensel A. . „Traditional herbal drugs against uncomplicated urinary tract infections. In vitro investigations of their anti-adhesive effects against uropathogenic Escherichia coli.“ Zeitschrift fur Phytotherapie 34, Nr. 5: 214-220. doi: 10.1055/s-0033-1349766.
  • Rafsanjany N., Lechtenberg M., Petereit F., Hensel A. . ‘Antiadhesion as a functional concept for protection against uropathogenic Escherichia coli: In vitro studies with traditionally used plants with antiadhesive activity against uropathognic Escherichia coli.’ Journal of Ethnopharmacology 145, Nr. 2: 591-597. doi: 10.1016/j.jep.2012.11.035.
  • Wang R, Lechtenberg M, Sendker J, Petereit F, Deters A, Hensel A. . ‘Wound-healing plants from TCM: in vitro investigations on selected TCM plants and their influence on human dermal fibroblasts and keratinocytes.Fitoterapia 84: 308-317. doi: 10.1016/j.fitote.2012.12.020.

  • Engelbertz J, Lechtenberg M, Studt L, Hensel A, Verspohl EJ. . ‘Bioassay-guided fractionation of a thymol-deprived hydrophilic thyme extract and its antispasmodic effect.Journal of Ethnopharmacology 141, Nr. 3: 848-53. doi: 10.1016/j.jep.2012.03.025.
  • Herrmann A, König S, Lechtenberg M, Sehlbach M, Vakhrushev SY, Peter-Katalinic J, Hensel A. . ‘Proteoglycans from Boswellia serrata Roxb. and B. carteri Birdw. and identification of a proteolytic plant basic secretory protein.Glycobiology 22, Nr. 11: 1424-39. doi: 10.1093/glycob/cws107.
  • Lechtenberg M, Henschel K, Liefländer-Wulf U, Quandt B, Hensel A. . ‘Fast determination of N-phenylpropenoyl-L-amino acids (NPA) in cocoa samples from different origins by ultra-performance liquid chromatography and capillary electrophoresis.’ Food Chemistry 135: 1676-1964. doi: 10.1016/j.foodchem.2012.06.006.

  • Hensel A, Maas M, Sendker J, Lechtenberg M, Petereit F, Deters A, Schmidt T, Stark T. . ‘Eupatorium perfoliatum L.: phytochemistry, traditional use and current applications.Journal of Ethnopharmacology 138, Nr. 3: 641-51. doi: 10.1016/j.jep.2011.10.002.
  • Agyare C., Lechtenberg M., Deters A., Petereit F., Hensel A. . ‘Ellagitannins from Phyllanthus muellerianus (Kuntze) Exell.: Geraniin and furosin stimulate cellular activity, differentiation and collagen synthesis of human skin keratinocytes and dermal fibroblasts.’ Phytomedicine 18, Nr. 7: 617-624. doi: 10.1016/j.phymed.2010.08.020.
  • Lechtenberg, Matthias. . ‘Cyanogenesis in Higher Plants and Animals.In Encyclopedia of Life Sciences (ELS).: John Wiley & Sons, Ltd.

  • Agyare C, Deters A, Lechtenberg M, Petereit F, Hensel A. . ‘Ellagitannins from Phyllanthus muellerianus: geraniin stimulates keratinocytes differentiation and collagen synthesis of skin dermal fibroblasts - new concept for improved wound-healing.’ PLANTA MEDICA 76, Nr. 12: 1165-1166. doi: 10.1055/s-0030-1264188.
  • Hensel A, Schmidt TJ, Engelshowe R, Lechtenberg M, Petereit F, Sendker J, Krüger L. . Arzneipflanzen entdecken. (2. erweiterte Auflage). 2. Aufl. Münster: Eigenverlag.
  • Louis A, Petereit F, Lechtenberg M, Deters A, Hensel A. . ‘Phytochemical characterization of Rhododendron ferrugineum and in vitro assessment of an aqueous extract on cell toxicity.’ Planta Medica 76, Nr. 14: 1550-1557. doi: 10.1055/s-0029-1241016.

  • Agyare C, Asase A, Lechtenberg M, Niehues M, Deters A, Hensel A. . ‘An ethnopharmacological survey and in vitro confirmation of ethnopharmacological use of medicinal plants used for wound healing in Bosomtwi-Atwima-Kwanwoma area, Ghana.’ Journal of Ethnopharmacology 125, Nr. 3: 393-403. doi: 10.1016/j.jep.2009.07.024.
  • Hungeling M, Lechtenberg M, Fronczek FR, Nahrstedt A. . ‘Cyanogenic and non-cyanogenic pyridone glucosides from Acalypha indica (Euphorbiaceae).’ Phytochemistry 70, Nr. 2: 270-277. doi: 10.1016/j.phytochem.2008.12.011.

  • Lechtenberg M, Schepmann D, Niehues M, Hellenbrand N, Wünsch B, Hensel A. . ‘Quality and Functionality of Saffron: Quality Control, Species Assortment and Affinity of Extract and Isolated Saffron Compounds to NMDA and Sigma-1 Receptors.’ PLANTA MEDICA 74, Nr. 7: 764-772. doi: 10.1055/s-2008-1074535.
  • Lechtenberg M, Quandt B, Nahrstedt A, Hensel A. . „Internet trade with kava preparations (Kava-Präparate im Internethandel).“ Deutsche Apotheker Zeitung 148, Nr. 16: 1709-1710.
  • Lechtenberg M., Quandt B., Schmidt M., Nahrstedt A. . ‘Is the alkaloid pipermethystine connected with the claimed liver toxicity of Kava products?Pharmazie 63, Nr. 1: 71-74. doi: 10.1691/ph.2008.7638.

  • Lechtenberg M, Zumdick S, Gerhards C, Schmidt TJ, Hensel A. . ‘Evaluation of analytical markers characterising different drying methods of parsley leaves (Petroselinum crispum L.).’ PHARMAZIE 62, Nr. 12: 949-954. doi: 10.1691/ph.2007.12.7543.
  • Lechtenberg M. . ‘Cyanogenesis in higher plants and animals.In Handbook of Plant Science Section Title: Plant Biochemistry, edited by Roberts Keith, 1033-1035.: Wiley.

  • Qa'dan F, Petereit F, Lechtenberg M, Nahrstedt A. . ‘Qualitative determination of proanthocyanidin cleavage products after acid-catalyzed degradation in the presence of excess phloroglucinol by cyclodextrin-modified micellar electrokinetic chromatography.’ Pharmaceutical Biology 44, Nr. 4: 309-314. doi: 10.1080/13880200600716090.

  • Lechtenberg M, Quandt B, Nahrstedt A. . ‘Quantitative determination of curcuminoids in Curcuma rhizomes and rapid differentiation of Curcuma domestica Val. and Curcuma xanthorrhiza Roxb. by capillary electrophoresis.’ Phytochemical Analysis 15, Nr. 3: 152-158. doi: 10.1002/pca.759.

  • Boje K, Lechtenberg M, Nahrstedt A. . ‘New and Known Iridoid- and Phenylethanoid Glycosides from Harpagophytum procumbens and their in vitro Inhibition of Human Leukocyte Elastase.’ Planta Medica 69, Nr. 9: 820-825. doi: 10.1055/s-2003-43225.

  • Andersen L, Clausen V, Oketch-Rabah HA, Lechtenberg M, Adsersen A, Nahrstedt A, Jaroszewski JW. . ‘Gynocardin and cyclopentenylglycine in Rawsonia lucida.’ Biochemical systematics and ecology 29, Nr. 2: 219-222. doi: 10.1016/S0305-1978(00)00048-X.

  • Lechtenberg M, Nahrstedt A. . ‘Cyanogenic Glycosides.’ In Naturally Occurring Glycosides, edited by Ikan R, 147-191. Chichester: Wiley.
  • Lechtenberg M, Quandt B, Kohlenberg F-J, Nahrstedt A. . ‘Qualitative and quantitative micellar electrokinetic chromatography of kavalactones from dry extracts of Piper methysticum Forst. and commercial drugs.’ Journal of Chromatography A 848, Nr. 1-2: 457-464. doi: 10.1016/S0021-9673(99)00425-2.
  • Lechtenberg M., Nahrstedt A., Brinker A., Seigler D., Readel K. . ‘Prunasin 6'-malonate from Lotononis fruticoides and Lotononis aft. falcata (Fabaceae).’ Biochemical Systematics and Ecology 27, Nr. 6: 607-612. doi: 10.1016/S0305-1978(98)00121-5.

  • Goonasekera CD, Ratnatunga N, Seneviratne CA, Nahrstedt A, Lechtenberg M. . ‘Nai habarala (Alocasia cucullata) fruits; analysed for potential hydrogen cyanide.The Ceylon medical journal 42, Nr. 2: 110-111.

  • Lechtenberg M, Nahrstedt A, Fronczek FR. . ‘Leucine-derived nitrile glucosides in the Rosaceae and their systematic significance.’ Phytochemistry 41, Nr. 3: 779-785. doi: 10.1016/0031-9422(95)00661-3.

  • Lechtenberg, M. . Untersuchungen zur Cyanogenese höherer Pflanzen Dissertation, Universität Münster.

  • Lechtenberg M, Nahrstedt A, Wray V, Fronczek FR. . ‘Cyanoglucosides from Osmaronia cerasiformis (Rosaceae).’ Phytochemistry 37, Nr. 4: 1039-1043. doi: 10.1016/S0031-9422(00)89525-4.

  • Nahrstedt A, Lechtenberg M, Brinker A, Seigler DS, Hegnauer R. . ‘4-Hydroxymandelonitrile glucosides, dhurrin in Suckleya suckleyana and taxiphyllin in Girgensohnia oppositiflora (Chenopodiaceae).’ Phytochemistry 33, Nr. 4: 847-850. doi: 10.1016/0031-9422(93)85288-3.
  • Lechtenberg M., Nahrstedt A. . ‘Cyanoglucosides from Osmaronia cerasiformis.’Contributed to the Gesellschaft für Arzneipflanzenforschung (GA) 31.8.1993 bis zum 4.9.1993, Düsseldorf.