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Arbeitsgruppe Prof. Dr. Hans-Ulrich Humpf
Corrensstr. 45 48149 Münster
Tel.: +49 251 83 33391
Fax: +49 251 83-33396
humpf@uni-muenster.de

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Publikationen

2013 2012 2011 2010 2009 2008 2007 2006 2005 2004

2003 2002 2001 2000 vor 2000

2013
Engemann A., Focke C., Humpf H.-U.
Intestinal Formation of N-Nitroso Compounds in the Pig Cecum-Model.
J Agric Food Chem. 2013, [Epub ahead of print]

Mulac D., Lepski S., Ebert F., Schwerdtle T., Humpf H.-U.
Cytotoxicity and fluorescence visualization of ergot alkaloids in human cell lines.
J Agric Food Chem. 2013, 61(2), 461-471

Lohrey L., Marschik S., Cramer B., Humpf H.-U.br /> Large-Scale Synthesis of Isotopically Labeled (13)C(2)-Tenuazonic Acid and Development of a Rapid HPLC-MS/MS Method for the Analysis of Tenuazonic Acid in Tomato and Pepper Products.
J Agric Food Chem. 2013, 60 (45), 11274-11281

2012
Harrer H., Laviad E.L., Humpf H.-U., Futerman A.H.
Identification of N-acyl-fumonisin B1 as new cytotoxic metabolites of fumonisin mycotoxins.
Mol Nutr Food Res. 2012, [Epub ahead of print]

Schmidt-Heydt M., Cramer B., Graf I., Lerch S., Humpf H.-U., Geisen R.
Wavelength-dependent degradation of ochratoxin and citrinin by light in vitro and in vivo and its implications on penicillium.
Toxins (Basel). 2012, 4(12), 1535-1551

De Santis Ferreira L., Callejon D.R., Engemann A., Cramer B., Humpf H.-U., de Barros V.P., Assis Md., da Silva D.B., de Albuquerque S., Okano L.T., Kato M.J., Lopes N.P.
In vitro Metabolism of Grandisin, a Lignan with Anti-chagasic Activity.
Planta Med. 2012, 78(18), 1939-1941

von Bargen C., Hübner F., Cramer B., Rzeppa S., Humpf H.-U.br /> Systematic approach for structure elucidation of polyphenolic compounds using a bottom-up approach combining ion trap experiments and accurate mass measurements.
J Agric Food Chem. 2012, 60 (45), 11274-11281

van Valen F., Harrer H., Hotfilder M., Dirksen U., Pap T., Gosheger G., Humpf H.-U., Jürgens H.
A Novel Role of IGF1 in Apo2L/TRAIL-Mediated Apoptosis of Ewing Tumor Cells.
Sarcoma. 2012, [Epub ahead of print]

Kuczius T., Hummel M., Böhler O., Humpf H.-U.
Development and applications of simultaneous immunochemical staining and serial detection of overlapping proteins in blotting procedures.
J Immunol Methods. 2012, 386 (1-2), 70-77

Welsch T., Humpf H.-U.
HT-2 Toxin 4-Glucuronide as New T-2 Toxin Metabolite: Enzymatic Synthesis, Analysis, and Species Specific Formation of T-2 and HT-2 Toxin Glucuronides by Rat, Mouse, Pig, and Human Liver Microsomes.
J Agric Food Chem. 2012, [Epub ahead of print]

Storck W., Meisen I., Gianmoena K., Pläger I., Kouzel I.U., Bielaszewska M., Haier J., Mormann M., Humpf H.-U., Karch H., Müthing J.
Shiga toxin glycosphingolipid receptor expression and toxin susceptibility of human pancreatic ductal adenocarcinomas of differing origin and differentiation.
Biol Chemi.2012, 393 (3), 785-799

Wu, Q.; Engemann, A.; Cramer, C.; Welsch, T.; Yuan, Z.; Humpf, H.-U.
Intestinal metabolism of T-2 toxin in the pig cecum model.
Mycotoxin Research 2012, 28, 191-198

Biedermann, L.; Mwinyi, J.; Scharl, M.; Frei, P.; Zeitz, J.; Kullak-Ublick, G. A.; Vavricka, S. R.; Fried, M.; Weber, A.; Humpf, H.-U.; Peschke, S.; Jetter, A.; Krammer, G.; Rogler, G.
Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis - An open pilot study.
J Crohns Colitis. 2012, [Epub ahead of print]

Kleigrewe, K.; Niehaus, E.M.; Wiemann, P.; Tudzynski, B.; Humpf, H.-U.
New Approach via Gene Knockout and Single-Step Chemical Reaction for the Synthesis of Isotopically Labeled Fusarin C as an Internal Standard for the Analysis of this Fusarium Mycotoxin in Food and Feed Samples.
J Agric Food Chem. 2012, [Epub ahead of print]

Hennemeier, I.; Humpf, H.-U.; Gekle, M., Schwerdt, G.
The food contaminant and nephrotoxin ochratoxin A enhances Wnt1 inducible signaling protein 1 and tumor necrosis factor-α expression in human primary proximal tubule cells.
Mol Nutr Food Res. 2012, [doi: 10.1002/mnfr.201200164.]

Betz, J.; Bauwens, A.; Kunsmann, L.; Bielaszewska, M.; Mormann, M.; Humpf, H.-U.; Karch, H.; Friedrich, A.W.; Müthing J.
Uncommon membrane distribution of Shiga toxin glycosphingolipid receptors in toxin-sensitive human glomerular microvascular endothelial cells.
Biol Chem. 2012, [doi: 10.1515/hsz-2011-0288.]

Wiemann, P.; Albermann, S.; Niehaus, E.M.; Studt, L.; von Bargen, K.W.; Brock, N.L.; Humpf, H.-U.; Dickschat, J.S.; Tudzynski, B.
The Sfp-Type 4'-Phosphopantetheinyl Transferase Ppt1 of Fusarium fujikuroi Controls Development, Secondary Metabolism and Pathogenicity.
PLoS One. 2012, [Epub 2012 May 25.]

Studt, L.; Troncoso, C.; Gong, F.; Hedden, P.; Toomajian, C.; Leslie, J.F.; Humpf, H.-U.; Rojas, M.C.; Tudzynski, B.
Segregation of secondary metabolite biosynthesis in hybrids of Fusarium fujikuroi and Fusarium proliferatum.
Fungal Genet Biol. 2012, [Epub ahead of print]

Weidner, M.; Welsch, T.; Hübner, F.; Schwerdt, G.; Gekle, M.; Humpf, H.-U.
Identification and apoptotic potential of T-2 toxin metabolites in human cells.
J Agric Food Chem. 2012, [Epub 2012 May 24]

Kleigrewe, K.; Aydin, F.; Hogrefe, K.; Piecuch, P.; Bergander, K.; Würthwein, E.-U.; Humpf, H.-U.
Structure elucidation of new fusarins revealing insights in the rearrangement mechanisms of the fusarium mycotoxin fusarin C.
J Agric Food Chem. 2012, 30;60(21)

Rzeppa, S.; Bittner, K.; Döll, S.; Dänicke, S; Humpf, H.-U.
Urinary excretion and metabolism of procyanidins in pigs.
Mol Nutr Food Res. 2012, [doi: 10.1002/mnfr.201100471]

Studt, L; Wiemann, P; Kleigrewe, K; Humpf, H.-U.; Tudzynski, B.
Biosynthesis of fusarubins accounts for pigmentation of Fusarium fujikuroi perithecia.
Appl Environ Microbiol. 2012, [Epub ahead of print]

von Bargen, K.W.; Lohrey, L; Cramer, B; Humpf, H.-U.
Analysis of the fusarium mycotoxin moniliformin in cereal samples using (13)c(2)-moniliformin and high-resolution mass spectrometry.
J Agric Food Chem. 2012, [Epub 2012 Mar 28]

Bornhorst, J.; Ebert, F.; Lohren, H.; Humpf, H.-U.; Karst, U.; Schwerdtle, T.
Effects of manganese and arsenic species on the level of energy related nucleotides in human cells.
Metallomics 2012, [Epub ahead of print]

Engemann, A.; Hübner, F.; Rzeppa, S.; Humpf, H.-U.
Intestinal Metabolism of Two A-type Procyanidins Using the Pig Cecum Model: Detailed Structure Elucidation of Unknown Catabolites with Fourier Transform Mass Spectrometry (FTMS).
J Agric Food Chem. 2012, 60(3), 749-757

Hübner, F.; Harrer, H.; Fraske, A.; Kneifel, S.; Humpf, H.-U.
Large Scale Purification of B-type Fumonisins Using Centrifugal Partition Chromatography (CPC).
Mycotoxin Research 2012, 28(1), 37-43

2011
Mulac, D.; Hüwel, S.; Galla, H.-J.; Humpf, H.-U.
Permeability of ergot alkaloids across the blood-brain barrier in vitro and influence on the barrier integrity.
Mol Nutr Food Res. 2011 doi: 10.1002/mnfr.201100431

Ferse, I.; Langlitz, M.; Kleigrewe, K.; Rzeppa, S.; Lenczyk, M.; Harrer, H.; Cramer, B.; Humpf, H.-U.
Isolation and structure elucidation of two new cytotoxic metabolites from red yeast rice.
Nat Prod Res. 2011

Wu, Q., Lohrey, L.; Cramer, B.; Yuan, Z.; Humpf, H.-U.
Impact of Physicochemical Parameters on the Decomposition of Deoxynivalenol during Extrusion Cooking of Wheat Grits.
J Agric Food Chem. 2011 59(23):12480-5

Kleigrewe, K.; Söhnel, A.-C., Humpf, H.-U.
A new high-performance liquid chromatography-tandem mass spectrometry method based on dispersive solid phase extraction for the determination of the mycotoxin fusarin C in corn ears and processed corn samples.
J Agric Food Chem. 2011 59(19) 10470-10476.

Rzeppa, S.; Von Bargen, C.; Bittner, K.; Humpf, H.-U.
Analysis of Flavan-3-ols and Procyanidins in Food Samples by Reversed Phase High-Performance Liquid Chromatography Coupled to Electrospray Ionization Tandem Mass Spectrometry (RP-HPLC-ESI-MS/MS).
J. Agric. Food Chem. 2011, 59(19) 10594-10603

Lohrey, L.; Murata, T.; Uemura, D.; Humpf, H.-U.
Synthesis of isotopically labeled Fusarium mycotoxin 13C2-moniliformin [1-hydroxycyclobut-1-ene-3,4-dione].
Synlett. 2011, 15, 2242-2244.

Vessecchi, R; Julião Zocolo, G.; Rubio Gouvea, D.; Hübner, F.; Cramer, B.; Rodrigues de Marchi, M.R.; Humpf, H.-U., Lopes, N.P.
Re-examination of the anion derivatives of isoflavones by radical fragmentation in negative electrospray ionization tandem mass spectrometry: experimental and computational studies.
Rapid Commun Mass Spectrom. 2011, 25, 2020-2026.

Mulac, D.; Grote, A.-K.; Kleigrewe, K.; Hans-Ulrich Humpf, H.-U.
Investigation of the Metabolism of Ergot Alkaloids in Cell Culture by Fourier Transformation Mass Spectrometry.
J. Agric. Food Chem. 2011, 59, 7798-7807.

Blaas, N.; Schüürmann, C.; Bartke, N.; Stahl, B.; Humpf, H.-U.
Structure elucidation and quantification of sphingomyelin in human breast milk by HPLC-MS/MS.
J. Agric. Food Chem. 2011, 59, 6018–6024.

Mulac, D.; Humpf, H.-U.
Cytotoxicity and accumulation of ergot alkaloids in human primary cells.
Toxicology 2011, 282, 112-121.

Betz, J.; Bielaszewska, M.; Thies, A.; Humpf, H.-U.; Dreisewerd, K.; Karch, H.; Kim, K.S.; Friedrich, A.W., Müthing, J.
Shiga toxin glycosphingolipid receptors in microvascular and macrovascular endothelial cells: association with membrane lipid raft microdomains that differ by their stability to cholesterol depletion.
J. Lipid Research. 2011, 52, 618-634.

Bauwens, A.; Bielaszewska, M.; Kemper, B.; Langehanenberg, P.; von Bally, G.; Reichelt, R.; Mulac, D.; Humpf, H.-U.; Friedrich, A.W.; Kim, K.S.; Karch, H.; Müthing, J.
Differential cytotoxic actions of Shiga toxin 1 and Shiga toxin 2 on microvascular and macrovascular endothelial cells.
Thromb. Haemost. 2011, 105, 515-528.

Fischbeck, A.; Leucht, K.; Frey-Wagner, I.; Bentz, S.; Pesch, T.; Kellermeier, S.; Krebs, M.; Fried, M.; Rogler, G.; Hausmann, M.; Humpf, H.-U.
Sphingomyelin induces cathepsin D mediated apoptosis in intestinal epithelial cells and increases inflammation in DSS-colitis.
Gut 2011, 60, 55-65.

Franzmann, C, Schröder, J.; Münzing, K.; Wolf, K.; Lindhauer, M.G.; Humpf, H.-U. Distribution of ergot alkaloids and ricinoleic acid in different milling fractions.
Mycotox. Res., 2011, 27, 13-21.

Wiese, C.; Maestrup, E.G.; Schepmann, D.; Grimme, S.; Humpf, H.-U.; Brust, P.; Wünsch, B.
Enantioselective (1) receptor binding and biotransformation of the spirocyclic PET tracer 1'-benzyl-3-(3-fluoropropyl)-3H-spiro[[2]benzofuran-1,4'-piperidine].
Chirality 2011, 23, 148-154.

2010
Beyer, M.; Dänicke, S.; Rohweder, D.; Humpf, H.-U.
Determination of deoxynivalenol-sulfonate (DONS) in cereals by hydrophilic interaction chromatography coupled to tandem mass spectrometry.
Mycotoxin Research, 2010, 26, 109-117.

Hasche, A.; Ferenz, K.B.; Rose, K.; König, S.; Humpf, H.-U.; Klumpp, S.; Krieglstein,J.
Binding of ATP to nerve growth factor: characterization and relevance for bioactivity.
Neurochem. Int., 2010, 56: 276-284.

Franzmann, C.; Wächter, J.; Dittmer, N.; Humpf, H.-U.
Ricinoleic acid as a marker for ergot impurities in rye and rye products.
J Agric Food Chem., 2010, 58, 4223-4229.

Wiemann, P.; Brown, D.W.; Kleigrewe, K.; Bok, J.W.; Keller, N.P.; Humpf, H.-U.; Tudzynski, B.
FfVel1 and FfLae1, components of a Velvet-like complex in Fusarium fujikuroi, affect differentiation, secondary metabolism and virulence.
Mol. Microbiol., 2010, 77, 972–994.

van't Slot, G; Mattern, W.; Rzeppa, S.; Greve, D.; Humpf, H.-U.
Complex Flavonoids in Cocoa: Synthesis and Degradation by Intestinal Microbiota.
J. Agric. Food Chem., 2010, 58, 8879-8886.

Hasslauer, I.; Oehme, A.; Locher, S.; Valotis, A.; Van't Slot, G.; Humpf H.-U.; Schreier, P.
Flavan-3-ol C-glycosides - Preparation and model experiments mimicking their human intestinal transit.
Mol. Nutr. Food. Res., 2010, 54, 1546–1555.

Dänicke, S.; Pahlow, G.; Beyer, M.; Goyarts, T.; Breves, G.; Valenta, H.; Humpf,H.-U.
Investigations on the kinetics of the concentration of deoxynivalenol (DON) and on spoilage by moulds and yeasts of wheat grain preserved with sodium metabisulfite (Na2S2O5, SBS) and propionic acid at various moisture contents.
Arch. Anim. Nutr., 2010, 64, 190-203.

Dänicke, S.; Beyer, M.; Breves, G.; Valenta, H.; Humpf, H.-U.
Effects of oral exposure of pigs to deoxynivalenol (DON) sulfonate (DONS) as the non-toxic derivative of DON on tissue residues of DON and de-epoxy-DON and on DONS blood levels.
Food Addit. Contam. Part A, 2010, 27, 1558-1565.

2009
Schwerdt, G.; Holzinger, H.; Königs, M.; Humpf, H.-U.; Gekle, M.
Effect of ochratoxin A on cell survival and collagen homeostasis in human mesangial cells in primary culture.
Food Chem. Toxicol., 2009, 47, 209-213.

Trebstein, A.; Marschik, S.; Lauber, U.; Humpf, H.-U.
Acetonitrile: the better extractant for the determination of T-2 and HT-2 toxin in cereals using an immunoffinity-based cleanup?
Eur. Food. Res. Technol., 2009, 228, 519–529.

Schwerdt, G.; Königs, M.; Holzinger, H.; Humpf, H.-U.; Gekle, M.
Effects of the mycotoxin fumonisin B(1) on cell death in human kidney cells and human lung fibroblasts in primary culture.
J Appl Toxicol., 2009, 29, 174-182.

Königs, M.; Mulac, D.; Schwerdt, G.; Gekle, M.; Humpf, H.-U.
Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture.
Toxicology, 2009, 258, 106-115.

Beyer, M.; Ferse, I.; Mulac, D.; Würthwein, E.-U.; Humpf, H.-U.
Structural Elucidation of T-2 toxin Thermal Degradation Products and Investigations towards their Occurrence in Retail Food.
J. Agric. Food Chem., 2009, 57, 1867-1875.

Beyer, M.; Ferse, I.; Humpf, H.-U.
Large Scale Production of selected type A trichothecenes: The use of HT 2 toxin and T 2 triol as precursors for the synthesis of d3-T-2 and d3-HT-2 toxin.
Mycotoxin Research, 2009, 25, 41-52.

Wiemann, P.; Willmann, A.; Straeten, M.; Kleigrewe, K.; Beyer, M.; Humpf, H.-U.; Tudzynski, B.
Biosynthesis of the Red Pigment Bikaverin in Fusarium fujikuroi: Genes, Their Function and Regulation.
Mol. Microbiol., 2009, 72, 931-946.

van’t Slot, G.; Humpf, H.-U.
Degradation of catechin, epigallocatechin-3-gallate (EGCG) and related compounds by the intestinal microbiota in the pig cecum-model.
J. Agric. Food Chem., 2009, 57, 8041-8048.

Pfeiffer, E.; Hildebrand, A.; Damm, G.; Rapp, A.; Cramer, B.; Humpf, H.-U.; Metzler,M.
Aromatic hydroxylation is a major metabolic pathway of the mycotoxin zearalenone in vitro.
Mol. Nutr. Food. Res., 2009, 53, 1123-1133.

Fischbeck, A.; Krüger, M.; Blaas, N.; Humpf, H.-U.
Analysis of sphingomyelin in different meat and fish based on normal phase high-performance liquid chromatography (NP-HPLC).
J. Agric. Food Chem. 2009, 57, 9469-9474.

Cramer, B.; Harrer, H., Nakamura, K.; Uemura,, D.; Humpf , H.-U.
Total Synthesis and Cytotoxicity Evaluation of all Ochratoxin A stereoisomers.
Biorg. Med. Chem., 2009, 18, 343-347.

Holl, R.; Jung, B.; Schepmann, D.; Englberger, W.; Grünert, R.; Humpf, H.-U., Bednarski, P.; Wünsch, B.
Synthesis and Pharmacological Evaluation of Novel SNC 80 Analogues with a Bridged Piperazine Ring.
Chem. Med. Chem., 2009, 4, 2111-2122.

2008
Hein, E.; Rose, K.; van’t Slot, G.; Friedrich, A.; Humpf, H.-U.
Deconjugation and degradation of flavonolglycosides by the pig caecal microbiota characterized by fluorescence in situ hybridization (FISH).
J. Agric. Food Chem., 2008, 56, 2281-2290.

Gong, Y.Y.; Torres-Sanchez, L.; Lopez-Carrillo, L.; Peng, J.H.; Sutcliffe, A.E.; White, K.L.; Humpf, H.-U.; Turner, P.C.; Wild, C.P.
Association between tortilla consumption and human urinary fumonisin B1 levels in a Mexican population.
Cancer Epidemiol. Biomarkers Prev., 2008, 17, 688-694.

Trebstein, A.; Seefelder, W.; Lauber, U.; Humpf, H.-U.
Determination of T-2 and HT-2 toxins in cereals including oats after immunoaffinity cleanup by liquid chromatography and fluorescence detection.
J. Agric Food Chem., 2008, 56, 4968-4975.

Königs, M.; Schwerdt, G.; Gekle, M.; Humpf, H.-U.
Effects of the mycotoxin Deoxynivalenol on human primary hepatocytes.
Mol. Nutr. Food Res., 2008, 52, 830-839.

Cramer, B.; Königs, M.; Humpf, H.-U.
Identification and in vitro Cytotoxicity of Ochratoxin A degradation products formed during coffee roasting.
J. Agric. Food Chem., 2008, 56, 5673-5681.

Dänicke, S.; Beineke, A.; Goyarts, T.; Valenta, H.; Beyer, M.; Humpf, H.-U.
Effects of a Fusarium toxin-contaminated triticale, either untreated or treated with sodium metabisulphite (Na2S2O5, SBS), on weaned piglets with a special focus on liver function as determined by the 13C-methacetin breath test.
Arch. Anim. Nutr., 2008, 62, 263-286

2007
Schwerdt, G.; Holzinger, H.; Sauvant, C.; Königs, M.; Humpf, H.-U.; Gekle, M.
Long-term effects of ochratoxin A on fibrosis and cell death in human proximal tubule or fibroblast cells in primary culture.
Toxicology, 2007, 232, 57-67.

Königs, M.; Lenczyk, M.; Schwerdt, G.; Holzinger, H.; Gekle, M.; Humpf, H.-U.
Cytotoxicity, metabolism and cellular uptake of the mycotoxin deoxynivalenol in human proximal tubule cells and lung fibroblasts in primary culture.
Toxicology, 2007, 240, 48-59.

Cramer, B.; Bretz, M.; Humpf, H.-U.
Stable Isotope Dilution Analysis of the Fusarium Mycotoxin Zearalenone.
J. Agric. Food Chem., 2007, 55, 8353-8358.

Brockmeyer, J.; Bielaszewska, M.; Fruth, A.; Bonn, M.L.; Mellmann, A.; Humpf, H.-U.; Karch, H.
Subtypes of the plasmid-encoded serine protease EspP in shiga toxin-producing Escherichia coli: Distribution, secretion and proteolytic activity.
Appl. Environm. Microbiol., 2007, 73, 6351-6359.

Seiferlein, M.; Humpf, H.-U.; Voss, K.A.; Sullards, C.; Allegood, J.C.; Wang, E.; Merrill, A.H., Jr.
Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites.
Mol. Nutr. Food. Res., 2007, 51, 1120-1130.

2006
Labib, Samira; Hummel, Sylvia; Richling, Elke; Humpf, Hans-Ulrich; Schreier, Peter. 
Use of the pig caecum model to mimic the human intestinal metabolism of hispidulin and related compounds.
Mol. Nutr. Food. Res., 2006,  50,  78-86.

Bretz, M.; Beyer, M.; Cramer, B.; Humpf, H.-U.
Stable isotope dilution analysis of the Fusarium mycotoxins deoxynivalenol and 3-acetyldeoxynivalenol.
Mol. Nutr. Food. Res., 2006, 50, 251-260.

Klötzel, M.; Lauber, U.; Humpf, H.-U.
A new solid phase extraction clean-up method for the determination of 12 Type A and B trichothecenes in cereals and cereal based food by LC-MS/MS.
Mol. Nutr. Food. Res. 2006, 50, 261-269.

Knecht, A.; Cramer, B.; Humpf, H.-U.
New Monascus metabolites: Structure elucidation and toxicological properties studied with immortalized human kidney epithelial (IHKE) cells.
Mol. Nutr. Food. Res., 2006, 50, 314-321.

Knecht, A.; Humpf, H.-U.
Cytotoxic and antimitotic effects of N-containing Monascus metabolites studied using immortalized human kidney epithelial (IHKE) cells.
Mol. Nutr. Food. Res., 2006, 50, 406-412.

Keppler, K.; Humpf, H.-U.
Metabolism of quercetin and rutin by the pig caecal microflora prepared by freeze-preservation.
Mol. Nutr. Food. Res., 2006, 50, 686-695.

Bretz, M.; Beyer, M.; Cramer, B.; Knecht, A.; Humpf, H.-U.
Thermal degradation of the Fusarium mycotoxin deoxynivalenol.
J. Agric. Food Chem., 2006, 54, 6445-6451.

Bartke, N.; Fischbeck, A.; Humpf, H.-U.
Analysis of sphingolipids in potato tubers (Solanum tuberosum L.) and sweet potatoes (Ipomoea batatas ( L.) Lam.) by reversed phase high-performance liquid chromatography electrospray tandem mass spectrometry.
Mol. Nutr. Food Res., 2006, 54, 1201-1211.

2005
Bretz, M.; Knecht, A.; Göckler, S.; Humpf, H.-U.
Structural elucidation and analysis of thermal degradation products of the Fusarium mycotoxin nivalenol.
Mol. Nutr. Food Res., 2005, 49, 309-316.

Goßmann, M., Kleta, S.; Humpf, H.-U., Büttner, C.
Untersuchungen zum endophytischen Befall von Fusartium proliferatum (Matsushima) Nirenberg in geernteten Stangen von Spargel (Asparagus officinalis L.).
Gesunde Pflanzen, 2005, 57, 53-58.

Keppler, K.; Humpf, H.-U.
Metabolism of anthocyanins and their phenolic degradation products by the intestinal microflora.
Biorg. Med. Chem., 2005, 13, 5195-5205.

Liu, C.; Liu, F.; Xu, W.; Kofoet, A.; Humpf, H.-U.; Jiang, S.
Occurrence of fumonisin B1 and B2 in asparagus from Shandong province, P.P.
China. Food. Addit. Cont., 2005, 22, 673-676.  

Klötzel, M.; Schmidt, S.; Lauber, U.; Thielert, G.; Humpf, H.-U.
Comparison of different clean-up-procedures for the analysis of deoxynivalenol (DON) in cereal-based food and validation of a reliable HPLC method.
Chromatographia, 2005, 62 , 41-48.

Klötzel, M.; Gutsche, B.; Lauber, U.; Humpf, H.-U.
Determination of 12 type A- and B-trichothecenes in cereals by liquid chromatography - electrospray ionization tandem mass spectrometry.
J. Agric. Food Chem., 2005, 53, 8904-8910.

Bretz, M.; Goeckler, S.; Humpf, H.-U.
Isolation and structural elucidation of thermal degradation products of the Fusarium mycotoxin nivalenol.
Mycotoxin Research, 2005,  21,  15-17.

Bretz, M.; Beyer, M.; Cramer, B.; Humpf, H.-U.
Synthesis of stable isotope labeled 3-acetyldeoxynivalenol.
Mol. Nutr. Food. Res., 2005, 49, 1151-1153.

Knecht, A.; Schwerdt, G.; Gekle, M.; Humpf, H.-U.
Combinatory effects of citrinin and ochratoxin A in immortalized human proximal tubule cells.
Mycotoxin Research, 2005, 21, 176-181.

Fischbeck, A.; Bartke, N.; Humpf, H.-U.
New Applications of the CD Exciton Chirality Method: Stereochemical assignment of organic compounds containing carboxylic acid groups.
Monatshefte für Chemie, 2005, 136, 397-410.


2004
Seefelder, W.; Bartke, N.; Gronauer, T.; Fischer, S.; Humpf, H.-U.
Structural Studies of Sphingolipids, a Class of Chemopreventive Compounds in Food. In: Functional Food: Safety Aspects (Senate Commission on Food Safety, Ed.): Wiley-VCH, Weinheim, 2004, 329-333.

Royer, D.; Humpf, H.-U.; Guy P. A.
Quantitative Analysis of Fusarium Mycotoxins in Maize Using Accelerated Solvent Extraction prior to Liquid Chromatography / Atmospheric Pressure Chemical Ionisation Tandem Mass Spectrometry.
Food Addit. Cont., 2004, 21, 678-692.

Humpf, H.-U.; Voss, K. A.
Effects of thermal food-processing on the chemical structure and toxicity of fumonisin mycotoxins.
Mol. Nutr. Food Res., 2004, 48, 255-269.

2003
Seefelder, W.; Humpf, H.-U.; Schwerdt, G.; Freudinger, R.; Gekle, M.
Induction of Apoptosis in Cultured Human Proximal Tubule Cells by Fumonisins and Fumonisin Metabolites.
Toxicol. Appl. Pharmacol., 2003, 192/2, 146-153.

Wild, D.; Tóth, G.; Humpf, H.-U.
New Monascus Metabolites with a Pyridine Structure in Red Fermented Rice.
J. Agric. Food Chem., 2003, 51, 5493-5496.

Seefelder, W.; Knecht, A.; Humpf, H.-U.
Bound Fumonisin B1: Analysis of Fumonisin-B1 Glyco and Amino Acid Conjugates by Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry.
J. Agric. Food Chem., 2003, 51, 5567-5573.

2002
Weil, K.; Humpf, H.-U.; Schwab, W.; Schreier, P.
Absolute Configuration of 3-Hydroxy Acids Formed by Stenotrophomonas maltophilia: Application of Multidimensional Gas Chromatography and Circular Dichroism Spectroscopy.
Chirality, 2002, 14, 51-58.

Seefelder, W.; Goßmann, M.; Humpf, H.-U.
Analysis of Fumonisin FB1 in Fusarium proliferatum Infected Asparagus Spears and Garlic Tubers from Germany by Liquid Chromatography/Electrospray Ionization-Mass Spectrometry.
J. Agric. Food Chem., 2002, 50, 2778-2781.

Wild, D.; Tóth, G.; Humpf, H.-U.
New Monascus Metabolite Isolated from Red Yeast Rice (Angkak, Red Koji).
J. Agric. Food Chem., 2002,  50, 3999-4002.

Seefelder, W.; Schwerdt, G.; Freudinger, R.; Gekle, M.; Humpf, H.-U. Liquid Chromatography/electrospray Ionization-mass Spectrometry (HPLC-ESI-MS) Method for the Quantification of Sphingosine and Sphinganine in Cell Cultures Exposed to Fumonisins.
J. Chrom. B, 2002, 780/1, 137-144.

Merill, A. H.; Sullards, C.; Allegood, J.; Wang, E.; Linn, S. C., Andras, L.; Liotta, D. C.; Hartl, M., Humpf, H.-U.
Insights into the Modulation of Ceramide Metabolism by Naturally Occurring and Synthetic Sphingolipid Analogs as Monitored by Electrospray Tandem Mass.
In Ceramide Signaling (A.H. Futerman, Ed.), Landes Bioscience, 2002.

Desai, K.; Sullards, C.; Allegood, J.; Wang, E.; Schmelz, E. M.; Hartl, M.; Humpf, H.-U.; Liotta, D. C.; Peng, Q.; Merrill, A. H.
Fumonisins and Fumonisin Analogs as Inhibitors of Ceramide Synthase and Inducers of Apoptosis.
Biochim. Biophys. Acta,  2002,  1585,  188-192.

2001
Humpf, H.-U.
CD Spectroscopy as a Powerful Tool for the Stereochemical Assignment of Carotenoid-Derived Aroma Compounds.
In: Carotenoid Derived Aroma Compounds (R. Rousseff, P. Winterhalter, Eds.),ACS Symposium Series No. 802, 2001.

Bröring, M.; Brandt, C. D.; Lex, J.; Humpf, H.-U.; Bley-Escrich, J.; Gisselbrecht, J.-P.
Molecular and Electronic Structure of (2,2-Bidipyrrinato)nickel(II) Complexes.
Eur. J. Inorg. Chem., 2001, 10, 2549-2556.

Hartl, M.; Humpf, H.-U.
Combined Synthetic/CD Strategy for the Stereochemical Assignment of the Tricarballylic Acid Side Chain of Fumonisin B1.
J. Org. Chem., 2001,  66,  3678-3681.

Adam, W.; Humpf, H.-U.; Roschmann, K. J.; Saha-Möller, C. R.
Enantioselective Epoxidation with Chiral MnIII(salen) Catalysts: Kinetic Resolution of Aryl- Substituted Allylic Alcohols.
J. Org. Chem., 2001, 66, 5796-5800.

Weckerle, B.; Schreier, P.; Humpf, H.-U. A
New One Step Strategy for the Stereochemical Assignment of Acyclic 2- and 3-Sulfanyl-1-alkanols Using the CD Exciton Chirality Method.
J. Org. Chem., 2001, 66, 8160-8164.

Seefelder, W.; Humpf, H.-U.
Formation of Fumonisin Artefacts in Thermal Treated Food.
Mycotox. Res., 2001, 17A, 116-119.

Seefelder, W.; Humpf, H.-U.; Schwerdt, G.; Freudinger, R.; Gekle, M.
Induction of Apoptosis in Cultured Human Proximal Tubule Cells by Fumonisins and Fumonisin Metabolites.
Mycotox. Res., 2001, 17A, 107-111.

Seefelder, W.; Hartl, M.; Humpf, H.-U.
Determination of N-(Carboxymethyl)fumonisin B1 in Corn Products by Liquid Chromatography/Electrospray Ionization- Mass Spectrometry.
J. Agric. Food Chem., 2001, 49, 2146-2151.

2000
Adam, W.; Lukacs, Z.; Viebach, K.; Humpf, H.-U.; Saha-Möller, C. R.; Schreier, P.
Microscale Determination of the Absolute Configuration of α-Aryl-substituted Alcohols by the CD Exciton Chirality Method.
J. Org. Chem., 2000, 65, 186-190.

Hartl, M.; Humpf, H.-U.
2-Naphthol as a Powerful Chromophore for the Configurational Assignment of Carboxylic Acid Groups via the CD Exciton Chirality Method.
Tetrahedron Asymmetry, 2000, 11, 1741-1747.

Humpf, H.-U.; Schmelz, E. M.; Meredith, F. I.; Merrill, A. H.
N-Palmitoyl-HFB1: A New Metabolite of Hydrolyzed Fumonisin (HFB1) in Rat Liver Microsomes.
In: Deutsche Forschungsgemeinschaft, Senate Commission on Food Safety, Symposium: Carcinogenic and Anticarcinogenic Factors in Food (G. Eisenbrand, A. D. Dayan, P. S. Elias, W. Grunow, J. Schlatter, Eds.), Wiley-VCH, Weinheim, 2000, 438-440.

Hartl, M.; Humpf, H.-U.
Toxicity Assessment of Fumonisins Using the Brine Shrimp (Artemia salina)
Bioassay. Food Chem. Tox., 2000, 38, 1097-1102.

Adam, W.; Groer, P.; Humpf, H.-U.; Saha-Möller, C. R.
Synthesis of Optically Active α-Methylene β-Lactams through Lipase-Catalyzed Kinetic Resolution.
J. Org. Chem., 2000, 65, 4919-4922.

Hartl, M.; Humpf, H.-U.
The Brine Shrimp (Artemia salina) Bioassay: A Simple Method to Assess the Toxicity of Fumonisin Mycotoxins.
Mycotox. Res., 2000, 16A, 83.


1999
Degelmann, P.; Becker, M.; Humpf, H.-U.
Determination of Ochratoxin A in Beer by High-Performance Liquid Chromatography.
Chromatographia, 1999, 49, 543-546.

Hartl, M.; Herderich, M.; Humpf, H.-U.
Rapid Determination of Fumonisin FB1 in Corn Products by High-Performance Liquid Chromatography-Electrospray Mass Spectrometry (HPLC-ESP-MS).
Eur. Food Res. Technol., 1999, 209, 348-351.

Hartl, M.; Humpf, H.-U.
Simultaneous Determination of Fumonisin B1 and Hydrolyzed Fumonisin B1 in Corn Products by Liquid Chromatography-Electrospray Ionization Mass Spectrometry (HPLC-ESI-MS).
J. Agric. Food Chem., 1999, 47, 5078-5083.

Hartl, M.; Humpf, H.-U.
Empfindlicher und selektiver Nachweis von hydrolysiertem Fumonisin HFB1 in maishaltigen Lebensmitteln mittels HPLC-ESI-MS.
In: Proceedings, 21. Mykotoxin-Workshop der Gesellschaftaft für Mykotoxinforschung e.V., Jena (H. Rosner, P. Kielstein, Eds.), Bundesinstitut für gesundheitlichen Verbraucherschutz und Veterinärmedizin (BgVV), Jena, 1999, 56-66.

1998
Hör, K.; Gimple, O.; Schreier, P.; Humpf, H.-U.
Absolute Configurational Assignment of Acyclic Carboxylic Acids: A New Strategy in Exciton-Coupled Circular Dichroism.
J. Org. Chem., 1998, 63, 322-325.

Adam, W.; Diaz, M. T.; Fell, R. T.; Groer, P.; Mock-Knoblauch, C.; Saha-Möller, C. R.; Weichhold, O.; Boss, B.; Humpf, H.-U.; Lazarus, M.; Lukacs, Z.; Schreier, P.
Biocatalytic Synthesis of Optically Active Oxyfunctionalized Compounds.
In: Proceedings of the III. International Symposium SFB 347 „Stereoselective Reactions of Metal-Activated Molecules“, Würzburg, September 17-19, 1997 (P. Schreier, H. Werner, Eds.), Vieweg, Braunschweig, 1998, 39-42.

Hör, K.; Hartl, M.; Walford, B.; Gutsche, B.; Humpf, H.-U.
A New Approach in Exciton-Coupled Circular Dichroism (ECCD): Stereochemical Assignment of Natural Products Containing Carboxyl Groups.
In: Natural Product Analysis (P. Schreier, M. Herderich, H.-U. Humpf, W. Schwab, Eds.), Vieweg, Braunschweig, 1998, 322-329.

Hartl, M.; Humpf, H.-U.
Assigning the Absolute Configuration of Fumonisins by the Circular Dichroism Exciton Chirality Method.
Tetrahedron Asymmetry, 1998, 9, 1549-1556.

Humpf, H.-U.; Schmelz, E.-M.; Meredith, F. I.; Vesper, H.; Vales, T. R.; Wang, E.; Menaldino, D. S.; Liotta, D. C.; Merill, A. H., Jr.
Acylation of Naturally Occurring and Synthetic 1-Deoxysphinganines by Ceramide Synthase. Formation of N-Palmitoyl-Aminopentol Produces a Toxic Metabolite of Hydrolyzed Fumonisin, AP1, and a New Category of Ceramide Synthase Inhibitor.
J. Biol. Chem., 1998, 273, 19060-19064.

Adam, W.; Lazarus, M.; Schmerder, A.; Humpf, H.-U.; Saha-Möller, C. R.; Schreier, P.
Synthesis of Optically Active α-Hydroxy Acids by Kinetic Resolution through Lipase-Catalyzed Enantioselective Acetylation.
Eur. J. Org. Chem., 1998, 2013-2018.

Adam, W.; Boland, W.; Hartmann-Schreier, J.; Humpf, H.-U.; Lazarus, M.; Saffert, A.; Saha-Möller, C. R.; Schreier, P.
α-Hydroxylation of Carboxylic Acids with Molecular Oxygen Catalyzed by the α-Oxidase of Peas (Pisum sativum): A Novel Biocatalytic Synthesis of Enantiomerically Pure (R)-2-Hydroxy Acids.
J. Am. Chem. Soc., 1998, 44, 11044-11048.

Roth, M.; Gutsche, B.; Herderich, M.; Humpf, H.-U.; Schreier, P.
Dioxygenation of Long-Chain Alkadien(trien)yl Phenols by Soybean Lipoxygenase.
J. Agric. Food Chem., 1998, 46, 2951-2956.

Humpf, H.-U.; Schmelz, E. M.; Meredith, F. I.; Merrill, A. H.
N-Palmitoyl-HFB1: A New Metabolite of Hydrolyzed Fumonisin (HFB1) in Rat Liver Microsomes.
Rev. Méd. Vét., 1998, 149, 6, 576.

Becker, M.; Degelmann, P.; Herderich, M.; Schreier, P.; Humpf, H.-U.
High-Performance Liquid Chromatography-Electrospray Ionisation-Tandem Mass Spectrometry (HPLC-ESI-MS/MS) for the Analysis of Ochratoxin.
J. Chromatogr., 1998, 818, 2, 260-264.

Hartl, M.; Humpf, H.-U.
Anwendung der Circulardichroismus Spektroskopie als eine schnelle und empfindliche Absolutmethode zur Aufklärung der Stereochemie der Fumonisine.
In: Proceedings, 20. Mykotoxin-Workshop, Detmold (J. Wolff, T. Betsche, Eds.), Institut für Biochemie von Getreide und Kartoffeln der Bundesanstalt für Getreide-, Kartoffel- und Fettforschung, Detmold, 1998, 228-232.


1997
Hoch, U.; Humpf, H.-U.; Schreier, P.; Saha-Möller, C. R.; Adam, W.
Con-figurational Assignment of Optically Active Hydroperoxy Homoallylic Alcohols and the Corresponding Diols by Circular Dichroism and Multidimensional Gas Chromatography.
Chirality, 1997, 9, 69-74.

Gimple, O.; Schreier, P.; Humpf, H.-U.
A New Exciton-Coupled Circular Dichroism Method for Assigning the Absolute Configuration in α- and β-Hydroxy Carboxylic Acids.
Tetrahedron Asymmetry, 1997, 8, 11-14.

Herderich, M.; Richling, E.; Roscher, R.; Schneider, C.; Schwab, W.; Humpf, H. U.; Schreier, P.
Application of Atmospheric Pressure Ionization HPLC-MS/MS for the Analysis of Natural Products.
Chromatographia, 1997, 45, 127-132.

Schneider, C.; Schreier, P.; Humpf, H.-U.
Exciton-Coupled Circular Dichroism (ECCD) in Acyclic Hydroxylated Dienes: A Sensitive Method for the Direct Stereochemical Assignment of Lipoxygenase Products.
Chirality, 1997, 9, 563-567.

Adam, W.; Lazarus, M.; Boss, B.; Humpf, H.-U.; Saha-Möller, C. R.; Schreier, P.
Enzymatic Resolution of Chiral 2-Hydroxy Carboxylic Acids by Enantioselective Oxidation with Molecular Oxygen Catalyzed by the Glycolate Oxidase from Spinach (Spinacia oleracea).
J. Org. Chem., 1997, 62, 7841-7843.

Adam, W.; Humpf, H.-U.; Korb, M. N.; Schreier, P.
The Configurational Assignment of the Optically Active 5-(1-Hydroperoxyethyl)-3-ethoxycarbonyl-2-methylfuran and its Alcohol by Exciton-Coupled Circular Dichroism (ECCD).
Tetrahedron Asymmetry, 1997, 8, 3555-3558.

1996
Schreder, B.; Lukacs, Z.; Schmitt, M.; Schreier, P.; Humpf, H.-U.
1-Naphthoic Acid: A New Type of Asymmetric Chromophore for Exciton-Coupled Circular Dichroism (ECCD).
Tetrahedron Asymmetry, 1996, 7, 1543-1546.

Lukacs, Z.; Schaper, S.; Herderich, M.; Schreier, P.; Humpf, H.-U.
Identification and Determination of Fumonisin FB1 and FB2 in Corn and Corn Products by High Performance Liquid Chromatography - Electrospray-Ionization Tandem Mass Spectrometry (HPLC-ESI-MS/MS).
Chromatographia, 1996, 43, 124-128.

Humpf, H.-U.
Einsatz eines HPLC-MS/MS-Systems zum Nachweis von Fumonisinen in Lebensmitteln.
In: Proceedings, 18. Mykotoxin-Workshop, Kulmbach (M. Gareis, R. Scheuer, Eds.), Institut für Mikrobiologie und Toxikologie der Bundesanstalt für Fleischforschung, Kulmbach, 1996, 21-25.

Adam, W.; Hoch, U.; Humpf, H.-U.; Saha-Möller, C. R.; Schreier, P.
Horseradish Peroxidase (HRP)-Catalyzed Enantioselective Reduction of Racemic Hydroperoxy Homoallylic Alcohols: A Novel Enzymatic Method for the Preparation of Optically Active Unsaturated Diols and Hydroperoxy Alcohols.
J. Chem. Soc., Chem. Commun., 1996, 24, 2701-2702.

1995
Humpf, H.-U.; Berova, N.; Nakanishi, K.; Jarstfer, M. B.; Poulter, D.
Allylic and Homoallylic Exciton Coupled CD: A Sensitive Method for Determining the Absolute Stereochemistry of Natural Products.
J. Org. Chem., 1995, 60, 3539-3542.

Person, V. P.; Monde, K.; Humpf, H.-U.; Berova, N.; Nakanishi, K.
A New Approach in Exciton-Coupled Circular Dichroism (ECCD) - Insertion of an Auxiliary Stereogenic Center.
Chirality, 1995, 7, 128-135.

1994
Humpf, H.-U.; Zhao, N.; Berova, N.; Nakanishi, K.; Schreier, P.
Absolute Stereochemistry of Natural 3,4-Dihydroxy-β-ionone Glycosides by the CD Exciton Chirality Method.
J. Nat. Prod., 1994, 57, 1761-1765.

1993
Wintoch, H.; Humpf, H.-U.; Schreier, P.
Natural Precursor of Isomeric Vitispiranes from Plant Tissues: 3,4-Dihydroxy-7,8-dihydro-β-ionol β-D-glucoside.
In: Progress in Flavour Precursor Studies (P. Schreier, P. Winterhalter, Eds.), 283-285, Allured Publ., Wheaton, 1993.

1992
Humpf, H.-U.; Schreier, P.
3-Hydroxy-5,6-epoxy-β-ionol β-D-Glucopyranoside and 3-Hydroxy-7,8-dihydro-β-ionol β-D-Glucopyranoside: New C13 Norisoprenoid Glucoconjugates from Sloe Tree (Prunus spinosa L.) Leaves.
J. Agric. Food Chem., 1992, 40, 1898-1901.

Humpf, H.-U.; Wintoch, H.; Schreier, P.
3,4-Dihydroxy-7,8-dihydro-β-ionol β-D-Glucopyranoside: Natural Precursor of Isomeric Vitispiranes from Gooseberry (Ribes uva crispa L.) and Whitebeam (Sorbus aria) Leaves.
J. Agric. Food Chem., 1992, 40, 2060-2062.

1991
Humpf, H.-U.; Schreier, P.
Bound Aroma Compounds from the Fruit and the Leaves of Blackberry (Rubus laciniata L.).
J. Agric. Food Chem., 1991, 39, 1830-1832.

Humpf, H.-U.; Winterhalter, P.; Schreier, P.
3,4-Dihydroxy-7,8-dihydro-β-ionone β-D-Glucopyranoside: Natural Precursor of 2,2,6,8-Tetramethyl-7,11-dioxatricyclo [6.2.1.0.1,6]undec-4-ene (Riesling Acetal) and 1,1,6-Trimethyl-1,2-dihydronaph-thalene in Red Currant (Ribes rubrum L.) Leaves.
J. Agric. Food Chem., 1991, 39, 1833-1835.



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Arbeitsgruppe Prof. Dr. Hans-Ulrich Humpf
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