Günter Haufe

Univ.-Prof. Dr. rer. nat. Günter Haufe


Contact and Links

Institute of Organic Chemistry
Tel.: +49 251 83-33281
Working group Prof. Haufe
CV Prof. Haufe

Participation in the Cluster of Excellence

CiM Principal Investigator
Coordinator Research Area C
Executive Board Member
Scientific Steering Committee Member

CiM-IMPRS Graduate School Member
Research Area A.5: Surface-Targeted Tracking of Individual Cells In Vivo
Project FF-2013-28: Development of novel, dual purpose, MOBSAM-based, specific inhibitors for MMP-2/9 to image and investigate their activity in inflammatory pathologies in vivo (Lydia Sorokin, Günter Haufe, project time: 07/2013 - 06/2015)


Podcast episode 1: Multiple Sclerosis Showing inflammated areas in the brain without invasion


  • Chen G, Gangadharmath UB, Kasi D, Kolb HC, Liu C, Sinha A, Szardenings AK, Walsh JC, Wang E, Yu C, Zhang W, Kopka K, Haufe G, Schäfers M, Hugenberg V, Wagner S, Hermann S, Breyholz H-J, Faust A. Compounds with matrix-metalloproteinase inhibitory activity and imaging agents thereof. EP 2644601; 02/10/2013.
  • Haufe G, Schilson S, Keul P, Levkau B, Schäfers M. New ligands for targeting of S1P receptors for in vivo imaging and treatment of diseases. EP 2559683; 20/02/2013. WO 2013/026765; 28/02/2013. EP 2744776; 25/06/2014.
  • Haufe G, Hermann S, Hugenberg V, Kolb H, Kopka K, Wagner S, Schäfers M. Compounds with matrix-metalloproteinase inhibitory activity. WO 2013/010573; 24/01/2013.
  • Behrends M, Breyholz H-J, Hermann S, Haufe G, Hugenberg V, Kolb H, Kopka K, Wagner S, Schäfers M. Compounds with matrix-metalloproteinase inhibitory activity. EP 2520573; 07/11/2012.

CiM Papers


Alsibai W, Hahnenkamp A, Eisenblatter M, Riemann B, Schafers M, Bremer C, Haufe G, Holtke C. Fluorescent Non-peptidic RGD Mimetics with High Selectivity for alphaVbeta3 vs alphaIIbbeta3 Integrin Receptor: Novel Probes for in Vivo Optical Imaging. J Med Chem 2014;57: 9971-9982. Abstract
Gerling UIM, Salwiczek M, Cadicamo CD, Erdbrink H, Czekelius C, Grage SL, Wadhwani P, Ulrich AS, Behrends M, Haufe G, Koksch B. Fluorinated amino acids in amyloid formation: a symphony of size, hydrophobicity and α-helix propensity. Chem Sci 2014: 819-830. Abstract
Prasad VP, Wagner S, Keul P, Hermann S, Levkau B, Schafers M, Haufe G. Synthesis of fluorinated analogues of sphingosine-1-phosphate antagonists as potential radiotracers for molecular imaging using positron emission tomography. Bioorg Med Chem 2014;22: 5168-5181. Abstract


Limpachayaporn P, Riemann B, Kopka K, Schober O, Schäfers M, Haufe G. Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7. Eur J Med Chem 2013;64C: 562-578. Abstract
Limpachayaporn P, Schäfers M, Schober O, Kopka K, Haufe G. Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: Nonradioactive counterparts of putative PET-compatible apoptosis imaging agents. Bioorg Med Chem 2013;21: 2025-2036. Abstract
Limpachayaporn P, Wagner S, Kopka K, Hermann S, Schäfers M, Haufe G. Synthesis, 18F-radiolabeling, and in vivo biodistribution studies of N-fluorohydroxybutyl isatin sulfonamides using positron emission tomography. J Med Chem 2013;56: 4509-4520. Abstract
Schinor B, Wibbeling B, Haufe G. Synthesis and pKa values of 2-(3- and 4-pentafluorosulfanylphenyl)-2-fluorocyclopropylamines. J Flourine Chem 2013: 102-109. Abstract


Hugenberg V, Haufe G. Fluoro-Pummerer rearrangement and analogous reactions. J Fluorine Chem 2012;143: 238-262. Abstract
Schrigten D, Breyholz HJ, Wagner S, Hermann S, Schober O, Schäfers M, Haufe G, Kopka K. A new generation of radiofluorinated pyrimidine-2,4,6-triones as MMP-targeted radiotracers for positron emission tomography. J Med Chem 2012: 223-232. Abstract

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