Wound Closure in the Fruit Fly: Which Gene Functions Control Migration of Blood Cells?
Cells-in-Motion Podcast | Episode 7
Whenever we hurt ourselves blood cells migrate to the wound in order to close it. The driving force for migration is a network of so called actin proteins. Cell biologist Dr. Sven Bogdan wants to explore which gene functions regulate these proteins so that they make a targeted movement possible. For that he works with the fruit fly Drosophila melanogaster which has been established as a model organism in biology for over 100 years.
The project depends on the cooperation between different scientific disciplines. In order to handle their huge amount of image and video data showing cell movement the biologists need a way to analyze it automatically. That's why the computer scientists headed by Prof. Xiaoyi Jiang have developed a computer program for them which is based on algorithms. Not only does the program visualize and track the cells in their dynamic shape and movement but it also draws conclusions on gene functions regulating the whole process. Due to this mathematical procedure the biologists get statistically relevant data they never could have raised themselves.