Academics at the Department of Biology

Wissenschaftlicher Werdegang
- Biologiestudium: Freie Universität Berlin (1 Jahr Exeter University, UK)
- Promotion MPI für Immunbiologie/Universität Freiburg
- postdoctoral research associate: University of California, San Francisco
- Gruppenleiterin WWU Münster / MPI für Molekulare Biomedizin
- Juniorprofessorin für Zoologie an der WWU Münster (im MPI für Molekulare Biomedizin)

Lehrschwerpunkte

- Entwicklungsbiologie
- Molekulare Genetik
- Vaskuläre Biologie und Angiogenese

Forschungsschwerpunkte

- Angiogenese im Zebrafisch
- Zebrafisch als Model für humane kardiovaskuläre Erkrankungen
- Endothelzellwanderung
- Rolle von Wnt-Signaltransduktion auf Endothelzellentwicklung und Barrierefunktion

Ausgewählte Projekte

-Generation of a functional vascular system is a highly regulated complex process, which is disturebed in a large number of human diseases, like cancer, ischemia or diabetes. We use zebrafisch mutants identified from a genetic screen to identify new genes regulating angiogenesis. Additionally we are identifying the downstream pathway components important for endothelial cell differentiation and migration by microarray and deep sequencing approaches, and consecutive in vivo analysis.
- To understand, vizualize and manipulate the endothelial cell migration in zebrafish embryos we are using and generating a number of transgenic zebrafish lines enabling us to follow (or influence) individual endothelial cells in the living animal (e.g. using confocal time laps imaging)
- Of the signaling pathways regulating angiogenesis, we are currently focussing on the role of canonical Wnt signaling. We are analyzing its influence on endothelial cell specification, migration and blood-brain barrier formation in the embryo as well as in blood-brain barrier function in the adult fish.

Please contact us for further information on individual projects in the lab.

Publications

  • Grainger S, Richter J, Palazón RE, Pouget C, Lonquich B, Wirth S, Grassme KS, Herzog W, Swift MR, Weinstein BM, Traver D, Willert K. . ‘Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells.’ Cell reports 17: 1595-1606. doi: doi: 10.1016/j.celrep.2016.10.027.
  • Hamm MJ, Kirchmaier BC and Herzog W. . ‘Sema3d controls collective endothelial cell migration by distinct mechanisms via Nrp1 and PlxnD1.’ Journal of Cell Biology 215: 415-430.
  • Schuermann A., Helker C.S., Herzog W. . ‘metallothionein 2 regulates endothelial cell migration through transcriptional regulation of vegfc expression.’ Angiogenesis 18: 463-475. doi: doi: 10.1007/s10456-015-9473-6.
  • Helker C.S., Schuermann A., Pollmann C., Chng S.C., Kiefer F., Reversade B. and Herzog W. . ‘The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis.’ eLife 4. doi: doi: 10.7554/eLife.06726.
  • Hultin S, Zheng Y, Mojallal M, Vertuani S, Gentili C, Balland M, Milloud R, Belting HG, Affolter M, Helker CSM, Adams RH, Herzog W, Uhlen P, Majumdar A, and Holmgren L. . ‘AmotL2 links VE-cadherin to contractile actin fibers necessary for aortic lumen expansion.’ Nature Communications 2014. [Accepted]
  • Jiang Q, Lagos-Quintana M, Liu D, Shi Y, Helker C, Herzog W, le Noble F. . ‘miR-30a regulates endothelial tip cell formation and arteriolar branching.Hypertension 62, No. 3: 592-8. doi: 10.1161/HYPERTENSIONAHA.113.01767.
  • Helker CS, Schuermann A, Karpanen T, Zeuschner D, Belting HG, Affolter M, Schulte-Merker S, Herzog W. . ‘The zebrafish common cardinal veins develop by a novel mechanism: lumen ensheathment.Development (Cambridge, England) 140, No. 13: 2776-86. doi: 10.1242/dev.091876.
  • de Pater E, Ciampricotti M, Priller F, Veerkamp J, Strate I, Smith K, Lagendijk AK, Schilling TF, Herzog W, Abdelilah-Seyfried S, Hammerschmidt M, Bakkers J. . ‘Bmp signaling exerts opposite effects on cardiac differentiation.Circulation research 110, No. 4: 578-87. doi: 10.1161/CIRCRESAHA.111.261172.
  • Izumi N, Helker C, Ehling M, Behrens A, Herzog W, Adams RH. . ‘Fbxw7 controls angiogenesis by regulating endothelial Notch activity.PLoS ONE 7, No. 7: e41116.
  • Herzog W, Müller K, Huisken J, Stainier DY. . ‘Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development.Circulation research 104, No. 11: 1260-6. doi: 10.1161/CIRCRESAHA.108.191718.
  • Jin SW, Herzog W, Santoro MM, Mitchell TS, Frantsve J, Jungblut B, Beis D, Scott IC, D'Amico LA, Ober EA, Verkade H, Field HA, Chi NC, Wehman AM, Baier H, Stainier DY. . ‘A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos.Developmental biology 307, No. 1: 29-42. doi: 10.1016/j.ydbio.2007.03.526.