Academics at the Department of Biology

Wissenschaftlicher Werdegang
- 1976-1986 student in the study program "Biology and Biochemistry", University of Saarland, Saarbrücken, Germany
Diploma, Thesis: "Influence of IR-laser light on metabolic rates of cell cultures of Saccheromyces cervisiae"
- March 1987 - June 1989 PhD student at the Max-Planck-Institute for Biophysics, Frankfurt/Main, Germany (Prof. Dr. W. Schwarz)
PhD, Thesis: "Comparison of endogenous glucose uptake systems of Xenopus oocytes with foreign expressed glucose transporters"
- July 1989 - December 1990 Head Research & Development at Heka Electronics, Lambrecht, Germany
- January 1991 - May 1992 Post-doc at the Institute of Veterinary Physiology, Free University of Berlin, Germany (Prof. Dr. W. Clauss)
- June 1992 - March 1993 Post-doc at the Institute of Animal Physiology, Justus-Liebig-University, Giessen, Germany
- April 1993 - March 1999 Assistant professor (C1), Head Cell Biology and Electrophysiology, Institute of Animal Physiology, Justus-Liebig-University, Giessen, Germany
- December 1996 Habilitation in "Animal Physiology", Thesis: "Comparison of endogenous and expressed transport systems in oocytes of Xenopus laevis", Venia legendi
- April 1999 -August 2002 Assistant Professor, Head Electrophysiology, KU Leuven, Belgium, Faculty of Medicine, Department Molecular Biology, Laboratory of Physiology
- Since April 2002 Full Professor, Head of the Transport Group Muenster

Lehrschwerpunkte

Animal Physiology I
Animal Physiology II
Membrane Physiology
Molecular Physiology
Evolution and Biodiversity of the Animals
Physiology of Transport Proteins 04.07.-29.07.05
Electro- and Molecular Physiology

Forschungsschwerpunkte
- Epithelial Na Channel (ENaC)
- CFTR and Cystic Fibrosis
- Ca-inactivated Cl-channel (CaIC)
- Endogenous Ion Channels in Xenopus laevis oocytes

Ausgewählte Projekte
- ENaC
- CFTR
- Na/K-ATPase
http://www.uni-muenster.de/Biologie.Zoophysiologie/electrophys/ElectroResearch.htm

Ausgewählte Publikationen
http://www.uni-muenster.de/Biologie.Zoophysiologie/electrophys/ElectroPub.htm

Ausgewählte Kooperationen

Prof. Dr. M. S. Awayda, Tulane University, New Orleans, USA
Prof. Dr. R. Grygorzcyk, University of Montreal, Canada
Prof. Dr. J.-D. Horisberger, University of Lausanne, Switzerland
Prof. Dr. G. Nagel, University of Wuerzburg, Germany
Prof. Dr. H. Oberleithner, University of Muenster, Germany
Prof. Dr. C. Rudack, UKM Münster, Germany
Prof. Dr. W. Schwarz, MPI for Biophysics, Frankfurt/Main, Germany
Prof. Dr. Willy van Driessche, KU Leuven, Belgium

Publications

  • Hardin, Bertoni, Kleinsmith. . Beckers Welt der Zelle Facheditor der deutschen Ausgabe. 8th Ed. : Pearson.
  • Bangel-Ruland N, Tomczak K, Fernández EF, Leier G, Leciejewski B, Rudolph C, Rosenecker J, Weber WM. . ‘CFTR-mRNA delivery: a novel alternative for cystic fibrosis 'gene therapy'.’ The journal of gene medicine 2013. doi: 10.1002/jgm.2748.
  • Clark KL, Hughes SA, Bulsara P, Coates J, Moores K, Parry J, Carr M, Mayer RJ, Wilson P, Gruenloh C, Levin D, Darton J, Weber WM, Sobczak K, Gill DR, Hyde SC, Davies LA, Pringle IA, Sumner-Jones SG, Jadhav V, Jamison S, Strapps WR, Pickering V and Edbrooke MR. . ‘Pharmacological Characterization of a Novel ENaCalpha siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis.Molecular Therapy–Nucleic Acids 2, No. 65. doi: 10.1038/mtna.2012.57.
  • Leier G, Bangel-Ruland N, Sobczak K, Knieper Y, Weber WM. . ‘Sildenafil acts as potentiator and corrector of CFTR but might be not suitable for the treatment of CF lung disease.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 29, No. 5-6: 775-90. doi: 10.1159/000265129.
  • Bangel-Ruland Nadine, Sobczak Katja, Christmann Tina, Kentrup Dominik, Langhorst Hanna, Kusche-Vihrog Kristina, Weber Wolf-Michael. . ‘Characterization of the epithelial sodium channel delta-subunit in human nasal epithelium.’ American Journal of Respiratory Cell and Molecular Biology , No. 42: 498-505. doi: 10.1165/rcmb.2009-0053OC.
  • Sobczak Katja, Bangel-Ruland Nadine, Leier Geraldine, Weber Wolf-Michael. . ‘Endogenous transport systems in the Xenopus Laevis oocyte plasma membrane.’ Methods , No. 51: 183-189.
  • Lytle, C. F. . Praktikum Allgemeine Zoologie Facheditor der Deutschen Ausgabe.: Pearson Studium.
  • Sobczak Katja, Bangel-Ruland Nadine, Semmler Judith, Lindemann Herman, Heerman Ralf, Weber Wolf-Michael. . „Antisense-Oligonukleotide zur Therapie der Mukoviszidose: Inhibition der ENaC-vermittelten Natriumabsorption in humanen Nasenepithelzellen.“ HNO : 1-7. doi: 10.1007/s00106-009-1957-5.
  • Sobczak Katja, Segal Andrej, Bangel-Ruland Nadine, Semmler Judith, Van Driessche Willy, Lindemann Hermann, Heermann Ralf, Weber Wolf-Michael. . ‘Specific inhibition of ENaC by antisense oligonucleotides for the treatment of Na(+) hyperabsorption in CF.’ Journal of Gene medicine , No. 11: 813-823. doi: 10.1002/jgm.1363.
  • Kusche-Vihrog K, Segal A, Grygorczyk R, Bangel-Ruland N, Van Driessche W, Weber WM. . ‘Expression of ENaC and other transport proteins in Xenopus oocytes is modulated by intracellular Na+.Cellular Physiology and Biochemistry 23, No. 1-3: 9-24. doi: 10.1159/000204076.
  • Silverthorn, D. U. . Physiologie Facheditor der Deutschen Ausgabe.: Pearson Studium.
  • Hickman, C. P. . Zoologie Facheditor der Deutschen Ausgabe.: Pearson Studium.
  • Bangel Nadine, Dahlhoff Christoph, Sobczak Katja, Weber Wolf-Michael, Kusche-Vihrog Kristina. . ‘Upregulated expression of ENaC in human CF nasal epithelium.Journal of Cystic fibrosis 7, No. 3: 197-205. doi: 10.1016/j.jcf.2007.07.012.
  • Sobczak Katja, Willing Anne, Kusche Kristina, Bangel Nadine, Weber Wolf-Michael. . ‘Amiloride-sensitive sodium absorption is different in vertebrates and invertebrates.’ The American Journal of Physiology - Regulatory, Integrative and Comparative Physiology , No. 292: 2318-2327. doi: 10.1152/ajpregu.00549.2006.
  • Kusche K, Bangel N, Mueller C, Hildebrandt J-P, & Weber W-M. . ‘Molecular cloning and sequencing of the Na+/K+-ATPase a-subunit of the medical leech Hirudo medicinalis (Annelida) - implications for modelling protostomian evolution.Journal of Zoological Systematics and Evolutionary Research 43: 339-342. doi: 10.1111/j.1439-0469.2005.00330.x.
  • Segal A, Awayda MS, Eggermont J, Van Driessche W, Weber W-M. . ‘Influence of voltage and extracellular Na+ concentration on amiloride block and transport kinetics of rat ENaC expressed in Xenopus oocytes.’ Pflügers Arch -Europ J Physiol 443: 882-891. doi: 10.1007/s00424-001-0773-x.
  • Segal A, Cucu D, Van Driessche W, Weber W-M. . ‘Rat ENaC expressed in Xenopus laevis oocytes is activated by cAMP and blocked Ni2+.’ FEBS Lett 515: 132-138. doi: 10.1016/S0014-5793(02)02464-X.
  • Weber W-M, Segal A, Vankeerberghen A, Cassiman JJ, Van Driessche W. . ‘Different activation mechanisms of CFTR expressed in Xenopus laevis oocytes.’ Comp Biochem Physiol 130: 521-531. doi: 10.1016/S1095-6433(01)00427-5.
  • Weber W-M, Segal A, Simaels J, Vankeerberghen A, Cassiman JJ, Van Driessche W. . ‘Functional integrity of the vesicle transporting machinery is required for complete activation of CFTR expressed in Xenopus laevis oocytes.’ Pflügers Arch -Europ J Physiol 441: 850-859. doi: 10.1007/s004240000497.
  • Milde H, Weber W-M, Salzet M, Clauss W. . ‘Regulation of Na+ transport across leech skin by peptide hormones and neurotransmitters.’ J Exp Biol 204: 1509-1517.
  • Schnizler M, Mastroberardino L, Reifarth FW, Weber W-M, Verrey F, Clauss W. . ‘cAMP sensitivity conferred to the epithelial Na+ channel by a-subunit cloned from guinea-pig colon.’ Pflügers Arch -Europ J Physiol 439: 579-587. doi: 10.1007/s004240050981.
  • Klimek T, Glanz H, Rückes-Nilges C, Van Driessche W, Weber W-M. . ‘Nicotine induced endocytosis of amiloride-sensitive sodium channels in human nasal epithelium.’ Acta Oto-Laryngol : 286-290.
  • Rückes-Nilges C, Lindemann H, Klimek T, Glanz H, Weber W-M. . ‘Nitric oxide has no beneficial effects on ion transport defects in cystic fibrosis human nasal epithelium.’ Pflügers Arch -Europ J Physiol 441: 133-137. doi: 10.1007/s004240000394.
  • Rückes-Nilges C, Glanz H, Weber U, Möller K, Klimek T, Fryen A, Lindemann H, Münker G, Clauss W,Weber W-M. . „Ionentransport und Mukovisidose.“ HNO 47: 157-166. doi: 10.1007/s001060050375.
  • Rückes-Nilges C, Weber U, Lindemann H, Münker G, Clauss W, Weber W-M. . ‘Minor role of Cl- secretion in non-cystic fibrosis and cystic fibrosis human nasal epithelium.’ Cell Physiol Biochem 9: 1-11. doi: 10.1159/000016298.
  • Weber W-M, Cuppens H, Cassiman JJ, Clauss W, Van Driessche W. . ‘Capacitance measurements reveal different pathways for the activation of CFTR.’ Pflügers Arch.-Europ.J.Physiol 438: 561-569. doi: 10.1007/s004240051076.