- Studium der Biologie, Universität Hamburg
- Promotion zum Dr. rer.nat., Universität Hamburg
- Postdoctoral Fellow, Bernhard Nocht Institut für Tropenmedizin (BNI), Hamburg
- Habilitationsstipendiatin der Deutschen Forschungsgemeinschaft
- Habilitation, Universität Hamburg
- Laborleitung, Biochemie, BNI, Hamburg
- Leiterin der selbstständigen Arbeitsgruppe "Helminthen Biochemie", BNI, Hamburg
- Professor für Zoologie, Institut für Tierphysiologie, WWU Münster
- Molekulare und biochemische Parasitologie
- Molekulare Physiologie
- oxidativer Stress
- parasitische Nematoden
(1) Oxidative stress in Caenorhabditis elegans
To elucidate the protective role of glutathione S-transferases (GSTs) in a multicellular organism, we are investigating various GST-classes fromthe model organism Caenorhabditis elegans. This model system was chosen because genetic and transgenetic techniques are well developed and the system lends itself to carry out studies on organismal level under stress conditions. Furthermore, we are testing several stressors to determine whether they can induce resistance to subsequent stress. Here we are interested in analysing whether different stressors induce cross-tolerance, being not specific to the physical nature of the stressor but promoting adaption to subsequent environmental challenges.
(2) Target identification of dormant anthelminthis candidates using the model nematode Caenorhabditis elegans
Parasitic nematodes are responsible for many of the major debilitating chronic diseases of man. Drugs that affect new molecular targets are urgently needed to improve treatment and control by killing macrofilariae. Using an optimized chemogenomics based approach, we are combining new genetic mapping strategies with RNAi-screening to identify novel drug target.
(3) Comparative investigations of lipid binding proteins of parasitic nematodes
Trichinellosis is still present in Europe, especially in Eastern Europe, where hundreds of human trichinellosis cases occur yearly. Among the allergens produced by parasitic nematodes are the Lipid Binding Proteins (LBPs). The high levels of hydrophobic binding proteins in helminths, together with their restricted lipid metabolism suggests that these proteins play an important role in metabolsm and, as such, are putative targets for chemotherapy and vaccine development. the objective of the proposal is to obtain functional, structural and imminological information about Trichinella LBPs using molecular, biochemical and structural methods.
- diverse AGs des Bernhard-Nocht-Institut für Tropenmedizin Hamburg
- Prof. Dr. I. Bankov, Bulgarian Academy of Sciences, Sofia, Bulgaria. Fatty acid binding proteins in parasitic nematodes.
- Prof. Dr. Ricci Department of Chemical Sciences and Technologies, University of Rome "Tor Vergata", Italy. Kinetic analysis of GSTs.
- Prof. Dr. R. Madhubala, Jarwaharlal Nehru University, New Dehli, India. Exploring novel chemotherapeutic strategy for leishmaniasis.
- Dr. M. Perbandt, Prof. Dr. C. Betzel, Deutsches ElektronenSynchrotron, Hamburg. Structure determination of antioxidant enzymes of various parasites.
- Prof. Dr. A. Torda, Bioinformatics, University of Hamburg. Computational modelling.
- Prof. Dr. P. Zimniak, University of Arkansa for Medical Sciences, USA. Glutathione S-transferases from C. elegans