Academics at the Department of Biology

Wissenschaftlicher Werdegang
- Studium der Biologie, Hauptfach Genetik, Martin-Luther-Universität Halle
- Promotion zum Dr. rer.nat., Martin-Luther-Univestität Halle
- Postdoctoral Fellow, Universität Freiburg
- Postdoctoral Fellow, UC Berkeley, USA
- Leiter einer selbständigen Nachwuchsgruppe, Abteilung für Molekulare Botanik, Universität Ulm
- Habilitation, Univesität Ulm
- Professor für Molekulkare Entwicklungsbiologie der Pflanzen, Institut für Botanik und Botanischer Garten, WWU Münster

Lehrschwerpunkte
- Zellbiologie
- Pflanzenphysiologie und pflanzliche Entwicklungsbiologie
- Molekulargenetik und Molekularbiologie

Forschungsschwerpunkte
- Signaltransduktion: Mechanismen und Spezifität von Kalziumsignalen; Funktion von Kalziumbindungsproteinen und Proteinkinasen
- Molekulare Pflanzenphysiologie: Anpassungsreaktionen an abiotischen Stress
- Molekulare Entwicklunsgbiologie: Wechselwirkungen von Lichtsignalen und Induktion generativer Entwicklung
- Molekulargenetik: Regulation der RNA Prozessierung in Chloroplasten

Ausgewählte Projekte
"Functional analysis of a calcium sensor protein/serine-threonine kinase signaling network" within the framework of the AFGN (Arabidopsis Functional Genomics Network)

Calcium signals regulate a wide range of biological responses to external stimuli as well as many physiological processes in plants. The proposed project aims to continue to comprehensively explore the mechanisms of a novel calcium signaling system from Arabidopsis. This system comprises a group of protein kinases (AtCIPKs), which interact with calcineurin B-like calcium sensor proteins (AtCBLs). In general, this project is focused on the functional characterization of this CBL-CIPK interaction network and its contribution to integrate and specifically decode various calcium signals in plant cells. The proposed research for the requested funding period is focused on the following main objectives: (1) Continuation of the molecular characterization of the CBL and CIPK protein families by analyzing their expression, sub-cellular localization, interaction specificity and their biochemical properties. (2) The identification of the specific physiological processes regulated by the different calcium sensor/kinase complexes by the detailed phenotypical and molecular characterization of mutant lines, which have been isolated during the first period of funding. (3) Identification of target proteins by means of yeast interaction assays.

"A systems biological approach to understtanding the control of specificity in Ca2+-signaling systems"

The fact that Ca2+ is a ubiquitous intracellular regulator in signaling pathways raises the important issue of how response specificity is controlled in Ca2+-based signaling systems. We have assembled a multidisciplinary team to take a systems biological approach to investigating this issue. The work will focus on Arabidopsis guard cells as a model because it is a well-characterized system with robust and easily measured outputs. We shall investigate the role of the Ca2+ sensor (CBL)/protein kinase (CIPK) module (comprising 10 CBLs and 25 CIPKs) for interpreting and decoding stimulus induced increases in Ca2+. To do this we shall employ a combination of modeling and genetic manipulation to investigate how specific Ca2+ signals are perceived and interpreted by unique combinations of CBL/CIPK components. We shall use the results from biological experiments to inform model assembly and test hypotheses generated from modeling by experimental manipulation. The results of this work will have major implications for understanding the fundamentals of Ca2+-based signaling in all organisms.

Ausgewählte Kooperationen
- Prof. Dr. Ralph Bock, MPI Golm, Metabolomics analyses of abiotic stress responses
- Prof. Dr. Klaus Harter, Univ. Tübingen, Plant two-component signaling systems
- Prof. Dr. Alistair Hetherington, Univ. Lancaster, Guard cell signaling
- Prof. Dr. Sheng Luan, Univ. Berkeley, The CBL/CIPK signaling system
- Prof. Dr. Christophe Maurel, INRA/CNRS Montpellier, Signaling processes in roots
- Prof. Dr. Tina Romeis, Univ. Berlin, Phosphorylation cascades in calcium signaling
- Prof. Dr. Julian Schroeder, Calcium signaling
- Prof. Dr. Mark Tester, Univ. Adelaide, Molecular analyses of ion transport processes
- Prof. Dr. Jean-Baptiste Thibaud, INRA/CNRS Montpellier, Calcium regulation of ion transport
- Prof. Dr. Shaul Yalovsky, Univ. Tel Aviv, Lipid modification of signaling proteins

Publications

  • Edel K., Marchadier E., Brownlee C., Kudla J., Hetherington A. . ‘The Evolution of Calcium-Based Signalling in Plants.’ Current Biology 27, No. 13: R667-R679. doi: 10.1016/j.cub.2017.05.020.
  • Behera S., Long Y., Schmitz-Thom I., Wang X., Zhang C., Li H., Steinhorst L., Manishankar P., Ren X., Offenborn J., Wu W., Kudla J., Wang Y. . ‘Two spatially and temporally distinct Ca2+ signals convey Arabidopsis thaliana responses to K+ deficiency.’ New Phytologist 213, No. 2: 739-750. doi: 10.1111/nph.14145.
  • Ligaba-Osena A., Fei Z., Liu J., Xu Y., Shaff J., Lee S., Luan S., Kudla J., Kochian L., Piñeros M. . ‘Loss-of-function mutation of the calcium sensor CBL1 increases aluminum sensitivity in Arabidopsis.’ New Phytologist 214, No. 2: 830-841. doi: 10.1111/nph.14420.
  • Li L., Wang F., Yan P., Jing W., Zhang C., Kudla J., Zhang W. . ‘A phosphoinositide-specific phospholipase C pathway elicits stress-induced Ca2+ signals and confers salt tolerance to rice.’ New Phytologist 214, No. 3: 1172-1187. doi: 10.1111/nph.14426.
  • Röschenbleck J, Wicke S, Weinl S, Kudla J, Müller KF. . ‘Genus-wide screening reveals four distinct types of structural plastid genome organization in Pelargonium (Geraniaceae).’ Genome Biology and Evolution 9, No. 1: 64-76. doi: 10.1093/gbe/evw271.
  • Yu J., Meng Z., Liang W., Behera S., Kudla J., Tucker M., Luo Z., Chen M., Xu D., Zhao G., Wang J., Zhang S., Kim Y., Zhang D. . ‘A rice Ca2+ binding protein is required for tapetum function and pollen formation.’ Plant Physiology 172, No. 3: 1772-1786. doi: 10.1104/pp.16.01261.
  • Beckmann L., Edel K., Batistic O., Kudla J. . ‘A calcium sensor-protein kinase signaling module diversified in plants and is retained in all lineages of Bikonta species.’ Scientific Reports 6, No. null. doi: 10.1038/srep31645.
  • Loro G., Wagner S., Doccula F., Behera S., Weinl S., Kudla J., Schwarzländer M., Costa A., Zottini M. . ‘Chloroplast-specific in vivo Ca2+ imaging using yellow Cameleon fluorescent protein sensors reveals organelle-autonomous Ca2+ signatures in the stroma.’ Plant Physiology 171, No. 4: 2317-2330. doi: 10.1104/pp.16.00652.
  • Kudla J., Bock R. . ‘Lighting the way to protein-protein interactions: Recommendations on best practices for bimolecular fluorescence complementation analyses.’ Plant Cell 28, No. 5: 1002-1008. doi: 10.1105/tpc.16.00043.
  • Edel K., Kudla J. . ‘Integration of calcium and ABA signaling.’ Current Opinion in Plant Biology 33, No. null: 83-91. doi: 10.1016/j.pbi.2016.06.010.
  • Costa A., Kudla J. . ‘Colorful insights: Advances in imaging drive novel breakthroughs in Ca2+ signaling.’ Molecular Plant 8, No. 3: 352-355. doi: 10.1016/j.molp.2014.11.020.
  • Manishankar P., Kudla J. . ‘Cold tolerance encoded in one SNP.’ Cell 160, No. 6: 1045-1046. doi: 10.1016/j.cell.2015.02.037.
  • Pandey G., Kanwar P., Singh A., Steinhorst L., Pandey A., Yadav A., Tokas I., Sanyal S., Kim B., Lee S., Cheong Y., Kudla J., Luan S. . ‘Calcineurin B-like protein-interacting protein kinase CIPK21 regulates osmotic and salt stress responses in Arabidopsis.’ Plant Physiology 169, No. 1: 780-792. doi: 10.1104/pp.15.00623.
  • Behera S., Wang N., Zhang C., Schmitz-Thom I., Strohkamp S., Schültke S., Hashimoto K., Xiong L., Kudla J. . ‘Analyses of Ca2+ dynamics using a ubiquitin-10 promoter-driven Yellow Cameleon 3.6 indicator reveal reliable transgene expression and differences in cytoplasmic Ca2+ responses in Arabidopsis and rice (Oryza sativa) roots.’ New Phytologist 206, No. 2: 751-760. doi: 10.1111/nph.13250.
  • Léran S., Edel K., Pervent M., Hashimoto K., Corratge-Faillie C., Offenborn J., Tillard P., Gojon A., Kudla J., Lacombe B. . ‘Nitrate sensing and uptake in Arabidopsis are enhanced by ABI2, a phosphatase inactivated by the stress hormone abscisic acid.’ Science Signaling 8, No. 375. doi: 10.1126/scisignal.aaa4829.
  • Steinhorst L., Mähs A., Ischebeck T., Zhang C., Zhang X., Arendt S., Schültke S., Heilmann I., Kudla J. . ‘Vacuolar CBL-CIPK12 Ca2+-Sensor-Kinase complexes are required for polarized pollen tube growth.’ Current Biology 25, No. 11: 1475-1482. doi: 10.1016/j.cub.2015.03.053.
  • Offenborn J., Waadt R., Kudla J. . ‘Visualization and translocation of ternary Calcineurin-A/Calcineurin-B/Calmodulin-2 protein complexes by dual-color trimolecular fluorescence complementation.’ New Phytologist 208, No. 1: 269-279. doi: 10.1111/nph.13439.
  • Edel K., Kudla J. . ‘Increasing complexity and versatility: How the calcium signaling toolkit was shaped during plant land colonization.’ Cell Calcium 57, No. 3: 231-246. doi: 10.1016/j.ceca.2014.10.013.
  • Röschenbleck J, Albers F, Müller KF, Weinl S, Kudla J. . ‘Phylogenetics, character evolution and a subgeneric revision of the genus Pelargonium (Geraniaceae).’ Phytotaxa 159, No. 2: 31-76.
  • Eckert C, Offenborn JN, Heinz T, Armarego-Marriott T, Schültke S, Zhang C, Hillmer S, Heilmann M, Schumacher K, Bock R, Heilmann I, Kudla J. . ‘The vacuolar calcium sensors CBL2 and CBL3 affect seed size and embryonic development in Arabidopsis thaliana.The Plant journal : for cell and molecular biology 2014. doi: 10.1111/tpj.12456.
  • Andrés Z., Pérez-Hormaeche J., Leidi E., Schlücking K., Steinhorst L., McLachlan D., Schumacher K., Hetherington A., Kudla J., Cubero B., Pardo J. . ‘Control of vacuolar dynamics and regulation of stomatal aperture by tonoplast potassium uptake.’ Proceedings of the National Academy of Sciences of the United States of America 111, No. 17. doi: 10.1073/pnas.1320421111.
  • Zhou H., Lin H., Chen S., Becker K., Yang Y., Zhao J., Kudla J., Schumaker K., Guo Y. . ‘Inhibition of the Arabidopsis Salt Overly Sensitive Pathway by 14-3-3 proteins.’ Plant Cell 26, No. 3: 1166-1182. doi: 10.1105/tpc.113.117069.
  • Steinhorst L., Kudla J. . ‘Signaling in cells and organisms - calcium holds the line.’ Current Opinion in Plant Biology 22, No. null: 14-21. doi: 10.1016/j.pbi.2014.08.003.
  • Waadt R., Schlücking K., Schroeder J.I., Kudla J. . ‘Protein fragment bimolecular fluorescence complementation analyses for the in vivo study of protein-protein interactions and cellular protein complex localizations.’ In Arabidopsis Protocols, edited by Sanchez-Serrano, Jose; Salinas, Julio, 629-658. doi: 10.1007/978-1-62703-580-4_33.
  • Maierhofer T., Diekmann M., Offenborn J., Lind C., Bauer H., Hashimoto K., Al-Rasheid K., Luan S., Kudla J., Geiger D., Hedrich R. . ‘Site-and kinase-specific phosphorylation-mediated activation of SLAC1, a guard cell anion channel stimulated by abscisic acid.’ Science Signaling 7, No. 342. doi: 10.1126/scisignal.2005703.
  • Schlücking K, Edel KH, Köster P, Drerup MM, Eckert C, Steinhorst L, Waadt R, Batistic O, Kudla J. . ‘A New β-Estradiol-Inducible Vector Set that Facilitates Easy Construction and Efficient Expression of Transgenes Reveals CBL3-Dependent Cytoplasm to Tonoplast Translocation of CIPK5.Molecular plant 6, No. 6: 1814-29. doi: 10.1093/mp/sst065.
  • Steinhorst L, Kudla J. . ‘Calcium and reactive oxygen species rule the waves of signaling.Plant physiology 163, No. 2: 471-85. doi: 10.1104/pp.113.222950.
  • Behera S, Krebs M, Loro G, Schumacher K, Costa A, Kudla J. . ‘Ca2+ imaging in plants using genetically encoded Yellow Cameleon Ca2+ indicators.Cold Spring Harbor protocols 2013, No. 8: 700-3. doi: 10.1101/pdb.top066183.
  • Mähs A, Steinhorst L, Han JP, Shen LK, Wang Y, Kudla J. . ‘The calcineurin B-like Ca2+ sensors CBL1 and CBL9 function in pollen germination and pollen tube growth in Arabidopsis.Molecular plant 6, No. 4: 1149-62. doi: 10.1093/mp/sst095.
  • Behera S, Kudla J. . ‘High-resolution imaging of cytoplasmic Ca2+ dynamics in Arabidopsis roots.Cold Spring Harbor protocols 2013, No. 7. doi: 10.1101/pdb.prot073023.
  • Steinhorst L, Kudla J. . ‘Calcium - a central regulator of pollen germination and tube growth.Biochimica et biophysica acta 2013: 1573-81. doi: 10.1016/j.bbamcr.2012.10.009.
  • Behera S, Kudla J. . ‘Live cell imaging of cytoplasmic Ca2+ dynamics in Arabidopsis guard cells.Cold Spring Harbor protocols 2013, No. 7: 665-9. doi: 10.1101/pdb.prot072983.
  • Drerup MM, Schlücking K, Hashimoto K, Manishankar P, Steinhorst L, Kuchitsu K, Kudla J. . ‘The Calcineurin B-like calcium sensors CBL1 and CBL9 together with their interacting protein kinase CIPK26 regulate the Arabidopsis NADPH oxidase RBOHF.Molecular plant 6, No. 2: 559-69. doi: 10.1093/mp/sst009.
  • Bonza M.C., Loro G., Behera S., Wong A., Kudla J., Costa A. . ‘Analyses of Ca2+ accumulation and dynamics in the endoplasmic reticulum of Arabidopsis root cells using a genetically encoded Cameleon sensor.’ Plant Physiology 163, No. 3: 1230-1241. doi: 10.1104/pp.113.226050.
  • Terashima M, Petroutsos D, Hüdig M, Tolstygina I, Trompelt K, Gäbelein P, Fufezan C, Kudla J, Weinl S, Finazzi G, Hippler M. . ‘Calcium-dependent regulation of cyclic photosynthetic electron transfer by a CAS, ANR1, and PGRL1 complex.Proceedings of the National Academy of Sciences of the United States of America 109, No. 43: 17717-22. doi: 10.1073/pnas.1207118109.
  • Batistič O, Rehers M, Akerman A, Schlücking K, Steinhorst L, Yalovsky S, Kudla J. . ‘S-acylation-dependent association of the calcium sensor CBL2 with the vacuolar membrane is essential for proper abscisic acid responses.Cell research 22, No. 7: 1155-68. doi: 10.1038/cr.2012.71.
  • Hashimoto K, Eckert C, Anschuetz U, Scholz M, Held K, Waadt R, Reyer A, Hippler M, Becker D, Kudla J. . ‘Phosphorylation of Calcineurin B-like (CBL) calcium sensor proteins by their CBL-interacting protein kinases (CIPKs) is required for full activity of CBL-CIPK complexes towards their target proteins.The Journal of biological chemistry 2012. doi: 10.1074/jbc.M111.279331.
  • Batistič O, Kudla J. . ‘Analysis of calcium signaling pathways in plants.Biochimica et biophysica acta 2011. doi: 10.1016/j.bbagen.2011.10.012.
  • Krebs M, Held K, Binder A, Hashimoto K, Den Herder G, Parniske M, Kudla J, Schumacher K. . ‘FRET-based genetically encoded sensors allow high-resolution live cell imaging of Ca2+ dynamics.PLANT JOURNAL 2011. doi: 10.1111/j.1365-313X.2011.04780.x.
  • Hashimoto K, Kudla J. . ‘Calcium decoding mechanisms in plants.’ BIOCHEMIE . doi: 10.1016/j.biochi.2011.05.019.
  • Gehl C, Kaufholdt D, Hamisch D, Bikker R, Kudla J, Mendel RR, Hänsch R. . ‘Quantitative analysis of dynamic protein-protein interactions in planta with a floated-leaf luciferase complementation imaging assay (FLuCI assay) using binary GATEWAY-vectors.’ PLANT JOURNAL . doi: 10.1111/j.1365-313X.2011.04607.x.
  • Held K, Pascaud F, Eckert C, Gajdanowicz P, Hashimoto K, Corratgé-Faillie C, Offenborn JN, Lacombe B, Dreyer I, Thibaud JB, Kudla J. . ‘Calcium-dependent modulation and plasma membrane targeting of the AKT2 potassium channel by the CBL4/CIPK6 calcium sensor/protein kinase complex.’ CELL . doi: 10.1038/cr.2011.50.
  • Dodd AN, Kudla J, Sanders D. . ‘The Language of Calcium Signaling.’ ANNUAL REVIEW OF PLANT BIOLOGY 61: 593-620. doi: 10.1146/annurev-arplant-070109-104628.
  • Walter M, Piepenburg K, Schottler MA, Petersen K, Kahlau S, Tiller N, Drechsel O, Weingartner M, Kudla J, Bock R. . ‘Knockout of the plastid RNase E leads to defective RNA processing and chloroplast ribosome deficiency.’ PLANT JOURNAL 64, No. 5: 851-863. doi: 10.1111/j.1365-313X.2010.04377.x.
  • Grefen C, Donald N, Hashimoto K, Kudla J, Schumacher K, Blatt MR. . ‘A ubiquitin-10 promoter-based vector set for fluorescent protein tagging facilitates temporal stability and native protein distribution in transient and stable expression studies.’ PLANT JOURNAL 64, No. 2: 355-365. doi: 10.1111/j.1365-313X.2010.04322.x.
  • International Arabidopsis Informatics Consortium. . ‘An International Bioinformatics Infrastructure to Underpin the Arabidopsis Community.’ PLANT CELL 22, No. 8: 2530-2536.
  • Kudla J, Batistic O, Hashimoto K. . ‘Calcium Signals: The Lead Currency of Plant Information Processing.’ PLANT CELL 22, No. 3: 541-563. doi: 10.1105/tpc.109.072686.
  • Batistic O, Waadt R, Steinhorst L, Held K, Kudla J. . ‘CBL-mediated targeting of CIPKs facilitates the decoding of calcium signals emanating from distinct cellular stores.’ PLANT JOURNAL 61, No. 2: 211-222.
  • Batistic O., Kudla J. . ‘Calcium: Not just another ion.’ In Cell Biology of Metals and Nutrients, edited by Springer, 17-54. doi: 10.1007/978-3-642-10613-2_2.
  • Weinl S, Kudla J. . ‘The CBL-CIPK Ca2+-decoding signaling network: function and perspectives.’ NEW PHYTOLOGIST 184, No. 3: 517-528. doi: 10.1111/j.1469-8137.2009.02938.x.
  • Gehl C, Waadt R, Kudla J, Mendel RR, Hansch R. . ‘New GATEWAY vectors for High Throughput Analyses of Protein-Protein Interactions by Bimolecular Fluorescence Complementation.’ MOLECULAR PLANT 2, No. 5: 1051-1058. doi: 10.1093/mp/ssp040.
  • Geiger D, Becker D, Vosloh D, Gambale F, Palme K, Rehers M, Anschuetz U, Dreyer I, Kudla J, Hedrich R. . ‘Heteromeric AtKC1.AKT1 Channels in Arabidopsis Roots Facilitate Growth under K+-limiting Conditions.’ JOURNAL OF BIOLOGICAL CHEMISTRY 284, No. 32: 21288-21295. doi: 10.1074/jbc.M109.017574.
  • Batistic O, Kudla J. . ‘Plant calcineurin B-like proteins and their interacting protein kinases.’ BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1793, No. 6: 985-992.
  • McLachlan DH, Kudla J, Hetherington AM. . ‘Role of the protein kinase CIPK8 in guard cell signalling.’ COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOG 153A, No. 2: S210S210.
  • Weinl S, Held K, Schlucking K, Steinhorst L, Kuhlgert S, Hippler M, Kudla J. . ‘A plastid protein crucial for Ca2+-regulated stomatal responses.’ NEW PHYTOLOGIST 179, No. 3: 675-686. doi: 10.1111/j.1469-8137.2008.02492.x.
  • Waadt R, Schmidt LK, Lohse M, Hashimoto K, Bock R, Kudla J. . ‘Multicolor bimolecular fluorescence complementation reveals simultaneous formation of alternative CBL/CIPK complexes in planta.’ PLANT JOURNAL 56, No. 3: 505-516. doi: 10.1111/j.1365-313X.2008.03612.x.
  • McLachlan D, Kudla J, Schroeder J, Hetherington A. . ‘Roles of calcium sensor proteins CBL9 and CBL1 in guard cell signalling.’ COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOG 150, No. 3: S194S194.
  • Batistic O, Sorek N, Schültke S, Yalovsky S, Kudla J. . ‘Dual fatty acyl modification determines the localization and plasma membrane targeting of CBL/CIPK Ca2+ signaling complexes in Arabidopsis.’ PLANT CELL 20, No. 5: 1346-1362. doi: 10.1105/tpc.108.058123.
  • Waadt R., Kudla J. . ‘In plant visualization of protein interactions using bimolecular fluorescence complementation (BiFC).’ Cold Spring Harbor Protocols 3, No. 4. doi: 10.1101/pdb.prot4995.
  • Kim BG, Waadt R, Cheong YH, Pandey GK, Dominguez-Solis JR, Schultke S, Lee SC, Kudla J, Luan S. . ‘The calcium sensor CBL10 mediates salt tolerance by regulating ion homeostasis in Arabidopsis.’ PLANT JOURNAL 52, No. 3: 473-484. doi: 10.1111/j.1365-313X.2007.03249.x.
  • Cheong YH, Pandey GK, Grant JJ, Batistic O, Li L, Kim BG, Lee SC, Kudla J, Luan S. . ‘Two calcineurin B-like calcium sensors, interacting with protein kinase CIPK23, regulate leaf transpiration and root potassium uptake in Arabidopsis.’ PLANT JOURNAL 52, No. 2: 223-239. doi: 10.1111/j.1365-313X.2007.03236.x.
  • Kilian J, Whitehead D, Horak J, Wanke D, Weinl S, Batistic O, D'Angelo C, Bornberg-Bauer E, Kudla J, Harter K. . ‘The AtGenExpress global stress expression data set: protocols, evaluation and model data analysis of UV-B light, drought and cold stress responses.The Plant journal : for cell and molecular biology 50, No. 2: 347-63. doi: 10.1111/j.1365-313X.2007.03052.x.
  • D'Angelo C, Weinl S, Batistic O, Pandey GK, Cheong YH, Schultke S, Albrecht V, Ehlert B, Schulz B, Harter K, Luan S, Bock R, Kudla J. . ‘Alternative complex formation of the Ca2+-regulated protein kinase CIPK1 controls abscisic acid-dependent and independent stress responses in Arabidopsis.’ PLANT JOURNAL 48, No. 6: 857-872. doi: 10.1111/j.1365-313X.2006.02921.x.
  • Ahlert D, Piepenburg K, Kudla J, Bock R. . ‘Evolutionary origin of a plant mitochondrial group II intron from a reverse transcriptase/maturase-encoding ancestor.’ JOURNAL OF PLANT RESEARCH 119, No. 4: 363-371. doi: 10.1007/s10265-006-0284-0.
  • Hedrich R, Kudla J. . ‘Calcium signaling plant K+ uptake networks channel.’ CELL 125, No. 7: 1221-1223. doi: 10.1016/j.cell.2006.06.017.
  • Kudla J, Oecking C, Schumacher K, Harter K. . ‘Visualization of protein-protein interactions in plant cells by bimolecular fluorescence complementation.’ COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOG 141, No. 3: S257S258.
  • Batistic O, Kudla J. . ‘Integration and channeling of calcium signaling through the CBL calcium sensor/CIPK protein kinase network.’ PLANTA 219, No. 6: 915-924. doi: 10.1007/s00425-004-1333-3.
  • Hass C, Lohrmann J, Albrecht V, Sweere U, Hummel F, Yoo SD, Hwang I, Zhu T, Schafer E, Kudla J, Harter K. . ‘The response regulator 2 mediates ethylene signalling and hormone signal integration in Arabidopsis.’ EMBO JOURNAL 23, No. 16: 3290-3302. doi: 10.1038/sj.emboj.7600337.
  • Pandey GK, Cheong YH, Kim KN, Grant JJ, Li LG, Hung W, D'Angelo C, Weinl S, Kudla J, Luan S. . ‘The calcium sensor calcineurin B-Like 9 modulates abscisic acid sensitivity and biosynthesis in Arabidopsis.’ PLANT CELL 16, No. 7: 1912-1924. doi: 10.1105/tpc.021311.
  • Kolukisaoglu U, Weinl S, Blazevic D, Batistic O, Kudla J. . ‘Calcium sensors and their interacting protein kinases: Genomics of the Arabidopsis and rice CBL-CIPK signaling networks.’ PLANT PHYSIOLOGY 134, No. 1: 43-58. doi: 10.1104/pp.103.033068.
  • Hass C, Weinl S, Harter K, Kudla J,. . ‘Functional Genomics of Protein Phosphorylation in Arabidopsis thaliana.’ In Plant Functional Genomics, edited by Leister D, 621-641. 1st Ed. Food Products Press.
  • Albrecht V, Weinl S, Blazevic D, D'Angelo C, Batistic O, Kolukisaoglu U, Bock R, Schulz B, Harter K, Kudla J. . ‘The calcium sensor CBL1 integrates plant responses to abiotic stresses.’ PLANT JOURNAL 36, No. 4: 457-470. doi: 10.1046/j.1365-313X.2003.01892.x.
  • Hrabak EM, Chan CWM, Gribskov M, Harper JF, Choi JH, Halford N, Kudla J, Luan S, Nimmo HG, Sussman MR, Thomas M, Walker-Simmons K, Zhu JK, Harmon AC. . ‘The Arabidopsis CDPK-SnRK superfamily of protein kinases.’ PLANT PHYSIOLOGY 132, No. 2: 666-680. doi: 10.1104/pp.102.011999.
  • Luan S, Kudla J, Rodriguez-Concepcion M, Yalovsky S, Gruissem W. . ‘Calmodulins and calcineurin B-like proteins: Calcium sensors for specific signal response coupling in plants.’ PLANT CELL 14: S389S400.
  • Walter M, Kilian J, Kudla J. . ‘PNPase activity determines the efficiency of mRNA 3 '-end processing, the degradation of tRNA and the extent of polyadenylation in chloroplasts.’ EMBO JOURNAL 21, No. 24: 6905-6914. doi: 10.1093/emboj/cdf686.
  • Kudla J, Albertazzi FJ, Blazevic D, Hermann M, Bock R. . ‘Loss of the mitochondrial cox2 intron 1 in a family of monocotyledonous plants and utilization of mitochondrial intron sequences for the construction of a nuclear intron.’ MOLECULAR GENETICS AND GENOMICS 267, No. 2: 223-230.
  • Luan S, Kudla J, Harter K, Gruissem W, Chory J. . ‘Renaming genes and duplication of gene names in the literature.’ PLANT CELL 13, No. 11: 2391-2391. doi: 10.1105/tpc.13.11.2391.
  • Sweere U, Eichenberg K, Lohrmann J, Mira-Rodado V, Baurle I, Kudla J, Nagy F, Schafer E, Harter K. . ‘Interaction of the response regulator ARR4 with phytochrome B in modulating red light signaling.’ SCIENCE 294, No. 5544: 1108-1111. doi: 10.1126/science.1065022.
  • Berdy SE, Kudla J, Gruissem W, Gillaspy GE. . ‘Molecular characterization of At5PTase1, an inositol phosphatase capable of terminating inositol trisphosphate signaling.’ PLANT PHYSIOLOGY 126, No. 2: 801-810. doi: 10.1104/pp.126.2.801.
  • Lohrmann J, Sweere U, Zabaleta E, Baurle I, Keitel C, Kozma-Bognar L, Brennicke A, Schafer E, Kudla J, Harter K. . ‘The response regulator ARR2: a pollen-specific transcription factor involved in the expression of nuclear genes for components of mitochondrial Complex I in Arabidopsis.’ MOLECULAR GENETICS AND GENOMICS 265, No. 1: 2-13.
  • Albrecht V, Ritz O, Linder S, Harter K, Kudla J. . ‘The NAF domain defines a novel protein-protein interaction module conserved in Ca2+-regulated kinases.’ EMBO JOURNAL 20, No. 5: 1051-1063. doi: 10.1093/emboj/20.5.1051.
  • Lohrmann J, Buchholz G, Keitel C, Sweere U, Kircher S, Bäurle I, Kudla J, Schäfer E, Harter K. . ‘Differential expression and nuclear localization of response regulator-like proteins from Arabidopsis thaliana.’ Plant Biology 1, No. 5: 495-505. doi: 10.1111/j.1438-8677.1999.tb00775.x.
  • Shi JR, Kim KN, Ritz O, Albrecht V, Gupta R, Harter K, Luan S, Kudla J. . ‘Novel protein kinases associated with calcineurin B-like calcium sensors in Arabidopsis.’ PLANT CELL 11, No. 12: 2393-2405. doi: 10.1105/tpc.11.12.2393.
  • Hayes R, Kudla J, Gruissem W. . ‘Degrading chloroplast mRNA: The role of polyadenylation.’ Trends in Biochemical Sciences 24, No. 5: 199-202. doi: 10.1016/S0968-0004(99)01388-2.
  • Kudla J, Bock R. . ‘RNA editing in an untranslated region of the Ginkgo chloroplast genome.Gene 234, No. 1: 81-6. doi: 10.1016/S0378-1119(99)00177-8.
  • Kudla J, Xu Q, Harter K, Gruissem W, Luan S. . ‘Genes for calcineurin B-like proteins in Arabidopsis are differentially regulated by stress signals.Proceedings of the National Academy of Sciences of the United States of America 96, No. 8: 4718-23. doi: 10.1073/pnas.96.8.4718.
  • Albertazzi FJ, Kudla J, Bock R. . ‘The cox2 locus of the primitive angiosperm plant Acorus calamus: molecular structure, transcript processing and RNA editing.Molecular & general genetics : MGG 259, No. 6: 591-600.
  • Xu Q, Liang S, Kudla J, Luan S. . ‘Molecular characterization of a plant FKBP12 that does not mediate action of FK506 and rapamycin.The Plant journal : for cell and molecular biology 15, No. 4: 511-9.
  • Kudla J, Hayes R, Gruissem W. . ‘Polyadenylation accelerates degradation of chloroplast mRNA.The EMBO journal 15, No. 24: 7137-46.
  • Luan S, Kudla J, Gruissem W, Schreiber SL. . ‘Molecular characterization of a FKBP-type immunophilin from higher plants.Proceedings of the National Academy of Sciences of the United States of America 93, No. 14: 6964-9. doi: 10.1073/pnas.93.14.6964.
  • Schmidt T, Kudla J. . ‘The molecular structure, chromosomal organization, and interspecies distribution of a family of tandemly repeated DNA sequences of Antirrhinum majus L.Genome / National Research Council Canada = Génome / Conseil national de recherches Canada 39, No. 2: 243-8.
  • Hayes R, Kudla J, Schuster G, Gabay L, Maliga P, Gruissem W. . ‘Chloroplast mRNA 3'-end processing by a high molecular weight protein complex is regulated by nuclear encoded RNA binding proteins.The EMBO journal 15, No. 5: 1132-41.
  • Bock R, Hagemann R, Kössel H, Kudla J. . ‘Tissue- and stage-specific modulation of RNA editing of the psbF and psbL transcript from spinach plastids--a new regulatory mechanism?Molecular & general genetics : MGG 240, No. 2: 238-44. doi: 10.1007/BF00277062.
  • Kössel H., Hoch B., Maier R., Igloi G., Kudla J., Zeltz P., Freyer R., Neckermann K., Ruf S. . ‘RNA editing in chloroplasts of higher plants.’ In Plant Mitochondria, edited by Brennicke A. & Kück U., 55-64. Weinheim: VCH Publishers.
  • Kudla J, Igloi GL, Metzlaff M, Hagemann R, Kössel H. . ‘RNA editing in tobacco chloroplasts leads to the formation of a translatable psbL mRNA by a C to U substitution within the initiation codon.The EMBO journal 11, No. 3: 1099-103.